• YAKHAK HOEJI
• /
• v.49 no.2
• /
• pp.174-179
• /
• 2005

The human skin is constantly exposed to environmental irritants such as ultraviolet, smoke, chemicals. Free radicals and reactive oxygen species (ROS) caused by these environmen tal facts play critical roles in cellular damage. These irritants are in themselves damaging to the skin structure but they also participate the immensely complex inflammatory reaction. The purpose of this study was to investigate the skin cell protective effect of Campsis grandiflora extract on the UVB-irradiated human dermal fibroblasts (HDFs). We tested free radical and superoxide scavenging effect in vitro. C. grandiflora extracts had potent radical scavenging effect by 82% at $100{\mu}g/ml$, respectively. For testing intracellular ROS scavenging activity the cultured HDFs were analyzed by increase in DCF fluorescence upon exposure to UVB 20 $MJ/cm^2$ after treatment of C.grandiflora extracts. The results showed that oxidation of CM-DCFDA was inhibited by C.grandiflora extracts effectively and C.grandiflora extracts has a potent free radical scavenging activity in UVB- irradiated HDFs. In ROS imaging using confocal microscope we visualized DCF fluorescence in HDFs directly. In conclusion, our results suggest that C.grandiflora can be effectively used for the prevention of UV-induced adverse skin reactions such as radical production, and skin cell damage.

• Asian Pacific Journal of Cancer Prevention
• /
• v.15 no.8
• /
• pp.3391-3396
• /
• 2014

Background: Vitamin D has been suggested as one of the critical factors for female reproductive health with protective activities against different cancers but there are conflicting facts regarding its role on breast cancer without any clear data on premenopausal cases. This study aimed to evaluate the role of vitamin D from dietary sources and sunlight exposure on the incidence of premenopausal breast cancer. Materials and Methods: We conducted a case control study on 60 newly diagnosed premenopausal breast cancer patients and 116 normal women who lived in Sabzevar and surrounding villages in Razavi, Khorasan, a rural and conservative area of Iran. Results: The mean concentrations of 25-OH vitamin D in cases and controls were $15.2{\pm}8.15$ vs $15.5{\pm}7/45ng/ml$, both well below normal values elsewhere. In fact 50% of analyzed individuals showed very severe or severe vitamin D deficiency and the rest (25%) were detected in suboptimal levels. Although the lack of vitamin D and calcium supplementation increased slightly the risk of premenopausal breast cancer (p=0.009, OR=1.115, CI 95%=1.049-1.187), higher prevalence of weekly egg consumption (86.66% vs 96.55%, p=0.023, OR=0.232, CI 95% 0.065-0.806) showed a slight protective role. The last but the most important risk factor was lack of sunlight exposure because the breast cancer patients had total body coverage from sun (p=0.007, OR=10.131, CI 98% 0.314-78.102). Conclusion: This study pointed out the role of vitamin D and other possible risk factors on the development and growth of breast tumors in this special geographical region. Although this study has revealed the interactions between hormonal and environmental factors in this province of Iran, understanding the deficiency pattern and its contribution to other lifestyle factors elsewhere is also necessary.

• Korean Journal of Community Nutrition
• /
• v.12 no.4
• /
• pp.477-488
• /
• 2007

Prevalence of an obese population has been increasing in Korea. Obesity is considered a major risk factor for chronic degenerative diseases. Specifically, prevalence of obesity is prominent for adult woman in Korea. In many weight control programs, weight change did not often show any beneficial effects for health. These facts discourage people in the program. Thus in this study, the anthropometry, blood pressure, serum biochemical indices and dietary habits were compared by percent body fat change for adult women to show the beneficial effects of the weight control program. Study subjects were 134. Measurements were done before and after the weight control program. Percent Body Fat (PBF) was measured by bioelectrical impedance analysis. Using PBF changes, subjects were grouped as I (more than 1% increase), M (${\pm}1%$ change), and D (more than 1% decrease). Data were analyzed using SPSS 12.0 program. Among the 134 participants, 13 increased their weight and 100 decreased. For PBF, 19 increased and 59 decreased. Statistical significant differences were shown for anthropometric assessments before and after for all weight, fat mass, percent body fat, waist-hip ratio and body mass index. I had increases, and D shows decreases. But the difference of D is large than M. Systolic and diastolic blood pressures decreased in all groups (p < 0.05). Fasting blood glucose decreased in all groups but were statistically significant only in D. Also triglyceride decreased in D (p < 0.05). Thus health conditions showed desirable changes in I < M < D in order. Dietary habit changes were desirable with only D. Weight, BMI and other indicators for obesity is not the real indicator for PBF. Recently it is easy to measure PBF. Thus, for weight control programs and to show benefits of the program, PBF is a good indicator for adult women in Korea.

• Journal of the Korean Chemical Society
• /
• v.22 no.5
• /
• pp.304-310
• /
• 1978

The relative permeabilities, distribution coefficients and diffusion coefficient of some salts which are important components in blood plasma through a poly(HEMA) membrane were measured. The crosslinker which was used for preparing the membrane was tetraethylene glycol dimethacrylate(TEGDMA), the weight percentage of the latter was about 2.8. We found that the diffusion coefficients ($D_m$) of the solutes decrease exponentially with increasing molecular weight, and also that $D_m$'s decrease linearly (except urea) with cylindrical radius (a). These facts were explained by a sieve pore flow model. The relative permeability and diffusion coefficient of urea at various temperature were larger than those of other solutes such as glycine, ${\beta}$-alanine, D-glucose, saccharose and maleic acid. The result indicates that the poly(HEMA) membrane might be suitable for hemodialysis application.

• Journal of the Korean Society of Marine Environment & Safety
• /
• v.20 no.5
• /
• pp.593-600
• /
• 2014

In this paper, Radar cross section (RCS) calculations of advanced naval vessels model with RCS reduction methods are simulated and RCS results are discussed. Especially, this paper are mainly focusing on the facts influencing on RCS, the ways minimizing RCS and material characteristics of RCS changing-rate. RCS analysis results are given for a DDG-1000 type advanced naval vessels, which show that as the elevation angle increased 10 degree, the mean RCS value increased 23.91 dBsm. Also, as the superstructure angle increased 6 degree, the mean RCS value reduced 1.27 dBsm. Finally, the radar absorbing material attachment at the front and back superstructure have been reduced 2.27 dBsm in terms of mean RCS value.

• Journal of the Korean Institute of Telematics and Electronics T
• /
• v.35T no.3
• /
• pp.128-133
• /
• 1998

This paper is study on performance analysis of modulator using direct digital frequency synthesizer of Initial Clock Accumulating Method. It has been generally used for PLL or digital frequency synthesizing method to be synthesizd randomly chosen frequency state. In order to improve disadvantage of two methods, we constructed modulator system using DDFS of Initial Clock Accumulating Method. We also confirmed the coherence frequency hopping state and possibility of phase control. The results obtained from the experiments are as follows; First, the synthesized output frequency is proportional to the sampling frequency, according to index, K. Second, the difference of the gain between the basic frequency and the harmonic frequencies was more than 50 [dB], that is, this means facts that is reduced the harmonic frequency factor. Third, coherence frequency hopping state is confirmed by PN code sequence. Here, we confirmed the proposed method cut switching time, this verify facts that is the best characteristic of the frequency hopping. We also verified the fact that the phase varies as the adder is operated set or reset.

• Korean Journal of Computational Design and Engineering
• /
• v.15 no.4
• /
• pp.297-305
• /
• 2010

Medical image acquisition techniques such as CT and MRI have disadvantages in that the numerous time and efforts are needed. Furthermore, a great amount of radiation exposure is an inherent proberty of the CT imaging technique, a number of side-effects are expected from such method. To improve such conventional methods, a number of novel methods that can obtain 3D medical images from a few X-ray images, such as algebraic reconstruction technique (ART), have been developed. Such methods deform a generic model of the internal body part and fit them into the X-ray images to obtain the 3D model; the initial shape, therefore, affects the entire fitting process in a great deal. From this fact, we propose a novel method that can generate a 3D vertebraic generic model based on the statistical database of CT scans in this study. Moreover, we also discuss a method to generate patient-tailored generic model using the facts obtained from the statistical analysis. To do so, the mesh topologies of CT-scanned 3D vertebra models are modified to be identical to each other, and the database is constructed based on them. Furthermore, from the results of a statistical analysis on the database, the tendency of shape distribution is characterized, and the modeling parameters are extracted. By using these modeling parameters for generating the patient-tailored generic model, the computational speed and accuracy of ART can greatly be improved. Furthermore, although this study only includes an application to the C1 (Atlas) vertebra, the entire framework of our method can be applied to other body parts generally. Therefore, it is expected that the proposed method can benefit the various medical imaging applications.

• Proceedings of the KSR Conference
• /
• 2011.10a
• /
• pp.2205-2216
• /
• 2011

Governments seek to advance public industry had planed to decreased by 50% of KORAIL management deficit in 2010, The transition to a profit in 2012. In addition. The government will not achieve the goal by 2010, management announced plans to review the case, and privatization. Office of unprofitable station and vehicle maintenance, maintenance work to make cost savings through outsourcing hed discussed how to create KORAIL advancement. April 2011 the government, "A study on th Efficiency of Conventional Railway Infrastructure Maintenance R&D Report" progresses, conventional railway infrastructure maintenance has focused attention on the field. However, the general maintenance of railway facilities without the knowledge and safety awareness, as compared to foreign railway personnel, and productivity has pointed out the contradiction. Economy and efficiency of the railway in order to pursue a public awareness and safety and professionalism is required. In this study, the conventional railway infrastructure maintenance in accordance with Facts would like to introduce efficiency measures.

• Architectural research
• /
• v.14 no.2
• /
• pp.67-73
• /
• 2012

The purpose of this study is to reveal the meaning of ramp of Le Corbusier's Carpenter Center for the Visual Arts focused on experience of architectural promenade. The Carpenter Center was completed in 1964, only a year earlier than the death of Le Corbusier and also, this building is the only building actually constructed in North America. Despite these important facts, the meanings of the ideas of this building have not been paid attention as much as other buildings constructed at the same period, such as, Venice Hospital and Un Pavillion D'exposition in Zurich. In his book, 'Oeuvre Complete 1957-1965', Le Corbusier mentioned Carpenter Center as an architectural experiments of his ideas. The study of carpenter center will be an important architectural subject to clarify the meaning of his later works and ideas.

• Proceedings of the Korean Society of Machine Tool Engineers Conference
• /
• 2004.04a
• /
• pp.354-358
• /
• 2004

There was not the evident analysis about the cutting process of CNC machining, and wouldn't be difficult to estimate the result of machining for the various cutting conditions. Therefore they were not founded the systemic technology about the optimum cutting conditions and selection of cutting tools. So this study have investigated the common facts for needs through the end-mill cutting machining by Machining-Centers or High-speed cutting machines, and developed the user-centered intelligent decision system to selection of the methodology about cutting conditions to improve the machining efficiency of end-mill cutting process.