• 한국응용과학기술학회지
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• 제15권2호
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• pp.25-32
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• 1998

The emulsion stability of W/O emulsion prepared by D phase emulsification during storage and handling is studied by using phase diagrams. The process of D phase emulsification begins with the formation of isotropic surfactant solution, followed by formation of oil-in-surfactant (O/D) gel emulsion by dispersion of octamethylcyclotetrasiloxane(OMCS) in the surfactant solution. Polyols were essential components for this purpose. To understand the function of polyols, the solution behavior of nonionic surfactant/oil/water/polyol systems were investigated by the ternary phase diagrams of polyoxyethylene oleyl ether/OMCS/propylene glycol(PG) aqueous solutions. The addition of PG increased the solubility of oil in the isotropic surfactant phase. D phase emulsification method has been applied to a new type of cosmetics. By using this emulsification technique, O/W emulsion were formed without a need for adjust of HLB. Fine and stable W/O emulsions were prepared by D phase emulsion.

• 대한화장품학회지
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• 제38권4호
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• pp.263-270
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• 2012

아스코르빅산(비타민 C)은 수용액상에서 공기와 빛, 알칼리 등에 의해 쉽게 불안정화되는 성질이 있어 화장품에 적용에 있어서 제한적이다. 아스코르빅산은 수용액상에서 불안정성에 영향을 주는 가장 중요한 인자인 공기, 특히 산소와 열, 빛 등의 외부환경에 민감하게 반응하여 산화에 의해 쉽게 분해되는 문제점이 있다. 본 연구에서는 이러한 아스코르빅산의 안정성을 증가시키고자 폴리올과 유화방법을 변화시켜 안정화하는 연구를 수행하였고 실온과 고온에서 색상과 아스코르빅산의 함량변화를 HPLC로 측정하여 비교하였다. 그 결과 실험한 조건들 중 폴리올은 글리세린을 사용한 경우 아스코르빅산의 안정화 가장 좋았으며 비수유화방법을 사용한 경우에 있어서 가장 안정하였다. 이러한 결과들로부터 아스코르빅산이 본 실험의 비수유화로 안정성이 증가하며 안정한 화장품을 만드는 데 적용이 가능하다.

• 공업화학
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• 제10권6호
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• pp.809-813
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• 1999

D상 유화법을 적용하고 상도를 이용하여 유화메커니즘을 설명하였다. D상 유화작용은 등방성 계면활성제 용액의 형성과 함께 시작되며 계면활성제 용액에 octamethyl cyclotetrasiloxane(OMCS)의 분산으로 계면활성제중 오일(O/D) 겔 유화물의 형성에 의해 진행된다. 폴리올은 이 실험목적상 필수성분이다. 폴리올의 기능을 이해하기 위해 비이온 계면활성제/오일/물/폴리올계의 용액거동을 폴리옥시에틸렌올레일에테르/OMCS/프로필렌글리콜(PG)의 수용액인 3성분의 상도를 이용하여 조사하였다. 등방성 계면활성제상에서 오일의 용해도는 PG를 가함에 따라 증가하였다. D상 유화물은 OMCS의 농도가 70~90% 범위에서와 계면장력이 2.0~3.0 dyne/cm 범위에서만 형성되었으며, D상 유화물은 $10{\mu}m$ 정도 크기의 균일한 구상으로 O/W 형이었다.

• Macromolecular Research
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• 제17권3호
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• pp.168-173
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• 2009

This study reports the preparation and characterization of nanohydrogels by using sodium alginate as a model material. Alginate nanohydrogels (ANH) were prepared by emulsification-diffusion method in a w/o system with 1,2-diacyl-sn-glycero- 3-phosphocholin as the lipophilic surfactant. The effects of the alginate to surfactant ratio and the remaining water contents on the mean particle size and swellability of ANHs were investigated in terms of the concentration, agitation speed, and agitation time. The feasibility of using nanohydrogels and their controllability were proved by the water the absorbency of ANHs during a 7-day evaluation by dynamic light scattering. In this work, the mean particle sizes of ANHs could be controlled from 49.2 nm (measured in ethanol phase) to $1.9{\mu}m$ (measured in water phase, after 7 days of water absorption).

• Food Science and Biotechnology
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• 제18권2호
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• pp.299-306
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• 2009

The purpose of this study was to prepare stable water-in-corn oil (W/O) emulsion droplets coated by polyglycerol polyricinoleate (PGPR). W/O emulsions (20 wt% aqueous phase, 80 wt% oil phase containing 8 wt% PGPR) were produced by high pressure homogenization (Emulsions 1), however, appreciable amount of relatively large water droplets (d>$10{\mu}m$) were found. To facilitate droplet disruption, viscosity of each phase was adjusted: (i) increased the viscosity of aqueous phase by adding 0.1 wt% xanthan (Emulsions 2); (ii) decreased the viscosity of oil phase and aqueous phase by heating them separately at $50^{\circ}C$ for 1 hr immediately before emulsification (Emulsions 3). Homogenizing at the elevated temperature clearly led to a smaller water droplet size, whereas xanthan neither improved nor adversely affected on the microstructures of the emulsions. In addition, the Emulsions 3 had good stability to droplet aggregation under shearing stress, thermal processing, and long term storage.

• 한국응용과학기술학회지
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• 제17권3호
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• pp.167-173
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• 2000

The process variables for the manufacture of translucent microemulsion prepared with 2-octyl dodecanol, 12-hydroxy stearic acid cholesteryl , POE(40)HCO and 1,3-butandiol were examined initially (primary emulsion) and following aging for three months. The techniques empolyed in this study were particle size, turbidity, interfacial tension and microfluidizer. Particle size analysis and turbidity measurement to evaluate the emulsion stability were used. It was concluded that the process of the emulsification was an important indicator of the stability of the translucent microemulsion. From the particle size and and turbidity measurement of translucent microemulsion, adding the surfactant to the oil phase before the emulsification was found to be the most important factor for the stability of emulsions. We found that interfacial tension of the adding the surfactant to the oil phase is lower than that of the adding the surfactant to aqueous phase. In spite of hydrophilic surfactant, adding the surfactant to aqueous phase produced inferior emulsion to that to oil phase.

• 멤브레인
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• 제27권6호
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• pp.511-518
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• 2017

막유화(membrane emulsification, ME)는 SPG 막과 같이 균일한 크기의 세공을 갖는 막을 사용하여 좁은 입도분포의 에멀젼을 제조하는 기술이다. 본 연구에서는 막유화법으로 형성시킨 다중 에멀젼을 사용하여 폴리카프로락톤(PCL) 마이크로캡슐의 제조를 연구하였다. 먼저 초음파 유화기로 $W_1/O$ 단일 에멀젼을 제조한 후, premix 막유화를 적용하여 $W_1/O/W_2$ 다중 에멀젼을 형성시킨 후 용매 증발을 통해 모델 약물인 BSA가 담지된 PCL 마이크로캡슐을 제조하였다. 연속상에 대한 분산상의 비율(D/C ratio), PCL 농도, 유화제 농도, 모델 약물의 농도, 막간 압력차 등 막유화 변수가 제조된 마이크로캡슐의 입경과 입도 분포에 미치는 영향을 실험하였다. Premix-ME를 적용하여 평균 입경 $5{\sim}6{\mu}m$의 균일한 크기를 갖는 모델 약물 BSA의 함침량이 약 26%인 다중 코어형 PCL 마이크로캡슐을 제조할 수 있었다.

• 한국환경과학회지
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• 제7권6호
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• pp.875-881
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• 1998

Microemulsion is prepared by the method of phase inversion emulsification with d-limonene that is environmental friendly substance and nontoxic to human body as dispersed phase. Emulsifier used for preparation of microemulsion is nonionic surfactants, polyoxyethylene nonylphenyl ether. Stability of prepared microemulsion was estimated by the various method of ξ-potential, hydrodynamic diameter and electric conductivity. When d-limonene is emulsified by NP series, microemulsion is most stable and narrowly distributed at HLB value of 12.3(either one emulsifier or mixed emulsifiers). Stability of microemulsion is increased as the amount of emulsifiers is increased at same HLB value of 12.3. In the case of using the same amount of emulsifiers, number of produced micelle are relatively large as hydrodynamic diameter is small. Therefore, the state of microemulsion is stable and the electric conductivity is increased. One can determine that higher electric conductivity value means that microemulsion has more micelles and is more stable.

• 대한화장품학회지
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• 제27권1호
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• pp.3-15
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• 2001

The bilayer forming ability of pseudo-ceramide PC104 in octanoic acid/water/n-octyl $\beta$-D-glucoside mixtures was investigated through the phase diagram. Because of its low solubility in water and of its crystallization, pseudoceramide PC104 was dissolved in octanoic acid, which is nontoxic additive for foods and cosmetics. The mixtures formed four different phases (L1, L2, LC and two phases). Depending on the concentration of PC104 in octanoic acid, the region of each phase was extended or contracted. On the contrary to the region of L2, regions of lamellar phase and L1 phase were expanded. The bilayer-forming ability of PC104 was explained on the basis of concentration of PC104 at interface and interaction between PC104 and octanoic acid. From FT-IR results, it was found that the interactions of PC104’s polar head group with octanoic acid increased as the amount of PC104 in octanoic acid increased. Also emulsion size and size distribution have been studied depending upon the emulsification path. droplets of emulsion prepared from lamellar phase were smaller and more homogeneous compared to those of emulsions formed from L2 phase.

• Macromolecular Research
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• 제17권12호
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• pp.1010-1014
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• 2009

Monodispersed microparticles with a poly(D,L-lactide-co-glycolide) (PLGA) core and a poly(ethyl 2-cyanoacrylate) (PE2CA) shell were prepared by Shirasu porous glass (SPG) membrane emulsification to reduce the initial burst release of doxorubicin (DOX). Solution mixtures with different weight ratios of PLGA polymer and E2CA monomer were permeated under pressure through an SPG membrane with $1.9\;{\mu}m$ pore size into a continuous water phase with sodium lauryl sulfate as a surfactant. Core-shell structured microparticles were formed by the mechanism of anionic interfacial polymerization of E2CA and precipitation of both polymers. The average diameter of the resulting microparticles with various PLGA:E2CA ratios ranged from 1.42 to $2.73\;{\mu}m$. The morphology and core-shell structure of the microparticles were observed by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The DOX release profiles revealed that the microparticles with an equivalent PLGA:E2CA weight ratio of 1:1 exhibited the optimal condition to reduce the initial burst of DOX. The initial release rate of DOX was dependent on the PLGA:E2CA ratio, and was minimized at a 1:1 ratio.