• Investigative Magnetic Resonance Imaging
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• 제2권1호
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• pp.73-82
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• 1998

목적 : 간특정 MR 조영제를 이요하여 간세포의 세포막을 통한 물분자의 교환 및 세포막 투과율을 정확히 측정 할 수 있는 MR 기법을 개발하고자 하였다. 대상 및 방법 : 쥐의 간세포를 분리하여 낸 후 NMR 측정을 시도하엿다. 모든 실험은 0.02MHz부터 60 MHz까지 양성자의 Larmor 주파수를 변화시킬 수 있는 IBM형 field cycling relaxometer를 사용하여 시행하였으며 spin-echo 펄스열을 사용하여 T1 자기이완시간을 측정하였다. 전오도의 간특정 조영제인 Gd-EOB-DTPA를 함유하고 있는 간세포 샘플로부터 획득한 T1 데이터를 연속분포 분석법을 사용하여 분석하였으며 이때 이론적 모델로는 Two compartmental exchange 모델을 이용하였다. 결과 : 간세포내의 물분자의 평균 거주시간은 약 250 msec이며 간세포막의 투과율에 대한 최저치는 $(1.3{\pm}0.1){\;}{\times}{\;}10^{-3}cm/sec$ 이었다. 자기이완시간의 연속적인 분포도를 구할 수 있는 CONTIN 분석기법을 적용한 결과 확산적 물분자 교환이 일어남을 밝혔고 이러한 확산적 교환의 정도가 간세포의 경우 세포내 공간에서는 작지 않다는 사실을 규명 할 수 있었다. 결론 : 연속분포 분석기법을 적용하는 경우 Gd-EOB-DTPA는 간세포에서의 물분자의 교환정도 및 세포막의 물분자에 대한 투과율을 측정하는데 매우 유용한 방법임을 확인하였고 간세포에서의 물분자의 교환속도는 적혈구에서의 물분자 교환 속도에 비해 매우 느리다는 사실을 확인하였다. 따라서 조직 특정 조영제는 해당 조직 혹은 세포의 세포막 투과율과 같은 생리학적 정보를 알아낼 수 있는 기능적 조영제로서의 유용성을 입증할 수 있었다.

• 한국소성가공학회:학술대회논문집
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• 한국소성가공학회 2007년도 춘계학술대회 논문집
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• pp.199-204
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• 2007

Hot embossing, one of Nanoimprint Lithography(NIL) techniques, has been getting attention as an alternative candidate of next generation patterning technologies by the advantages of simplicity and low cost compared to conventional photolithographies. A typical hot embossing usually, however, takes more than ten minutes for one cycle of the process because of a long thermal cycling. Over the last few years a number of studies have been made to reduce the cycle time for hot embossing or similar patterning processes. The target of this research is to develop an induction heating apparatus for heating a metallic micro patterning mold at very high speed with the large-area uniformity of temperature distribution. It was found that a 0.5 mm-thick nickel mold can be heated from $25^{\circ}C$ to $150^{\circ}C$ within 1.5 seconds with the temperature variation of ${\pm}5^{\circ}C$ in 4-inch diameter area, using the induction heating apparatus.

• 한국항해학회지
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• 제17권3호
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• pp.69-76
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• 1993

In harbour the practical shiphandlers should have a expert knowledge of systematically reducing head-way and keeping ship's positions to the final position with confidence and under control. But now in the practical approaches we do not have any special maneuvers of controlling the ship effi-ciently regarding the headway and approaches except some existing reduction of speeds according to the Weight-to-Power Ratio, use of astern power and Rudder Cycling. Consequently this study put Woo's Super Rudder Controlling originally developed by Captain Woo, Ph. D. to practical use as a special maneuvers in the port approaches. The conclusions of this paper are drawn as follows : 1) Optimum standard and desirable controls in combination of three engine speeds with three yaw ang-les were proposed for the practical shiphandlers, 2) According to simulation of the pilotships the Super advances are 10.5 ship lengths for Full full full maneuvers, and 7.9 ship lengths for Full half maneuvers approximately, 3) Approach maneuvers to anchorages by trying Woo's Super Rudder Controlling saved about 30% of total standby time in comparison with the existing Weight-to-Power Ratio maneuvers in the Pusan and Kwang Yang ports.

• BMB Reports
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• 제48권12호
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• pp.677-684
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• 2015

Cardiovascular function is regulated by the rhythmicity of circadian, infradian and ultradian clocks. Specific time scales of different cell types drive their functions: circadian gene regulation at hours scale, activation-inactivation cycles of ion channels at millisecond scales, the heart's beating rate at hundreds of millisecond scales, and low frequency autonomic signaling at cycles of tens of seconds. Heart rate and rhythm are modulated by a hierarchical clock system: autonomic signaling from the brain releases neurotransmitters from the vagus and sympathetic nerves to the heart's pacemaker cells and activate receptors on the cell. These receptors activating ultradian clock functions embedded within pacemaker cells include sarcoplasmic reticulum rhythmic spontaneous Ca²⁺ cycling, rhythmic ion channel current activation and inactivation, and rhythmic oscillatory mitochondria ATP production. Here we summarize the evidence that intrinsic pacemaker cell mechanisms are the end effector of the hierarchical brain-heart circadian clock system.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2004년도 추계학술대회 논문집
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• pp.935-938
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• 2004

This paper describes the quantitative analysis on the improvement of equilibrium sensory using virtual bicycle system. We have used a virtual bicycle system that combines virtual reality technology with a bicycle. In this experiment, 10 subjects were tested to investigate the influencing factors on equilibrium sensory. Straight road and curved road driving at several factors including cycling time, number of times of path deviation, and center of pressure(COP) were extracted and evaluated to quantify the extent of control. Also, To improve the effect of balance training, we investigated the usefulness of virtual feedback information by weight shift. The result showed that the system could be effective for equilibrium sensory rehabilitation training device. The analysis method might also have wider applicability to the rehabilitation field.

• Journal of the korean society of oceanography
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• 제39권1호
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• pp.14-19
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• 2004

Difference of Dissolved Inorganic Phosphorus (DIP), Dissolved Inorganic Nitrogen (DIN) and Dissolved Silicate (DSi) budgets in the Bohai Sea between 1982 and 1992 related the decrease of the Yellow River discharge is discussed on the basis of observed data. The estuarine circulation in the Bohai Sea had been weakened from 1982 to 1992 due to the decrease of the Yellow River discharge and the average residence time of fresh water had become longer. DIN concentration increased but DIP and DSi concentrations decreased from 1982 to 1992 in the Bohai Sea. Primary production was regulated mainly by water temperature and DIN concentration in 1982 but it was regulated mainly by DIP concentration in 1992. Primary production was larger than decomposition plus bottom release and nitrogen fixation was larger than denitrification in 1982. However, decomposition plus bottom release was larger than primary production and denitrification was larger than nitrogen fixation in 1992 in the Bohai Sea.

• 한국대기환경학회지
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• 제26권2호
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• pp.107-117
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• 2010

The atmospheric geochemistry of mercury is generalls represented by gaseous elemental phase that exhibits the high environmental mobility and relatively long atmospheric residence time (c.a., 1 year) with its high chemical stability. In the recognition of the environmental significance of its global cycling, enormous efforts have been devoted to the measurements of Hg exchange across air-soil boundary. To be able to describe the fundamental aspects on this subject, the current development in the measurements of atmospheric exchange rates of mercury has been summarized using the current database reported worldwide. As a first step, different techniques commonly employed in its measurements are introduced with the discussions on their merits and disadvantages. Then, the results derived from various field measurement campaigns are also compared and discussed. The direction for the future study of mercury is presented at last.

• 한국농공학회논문집
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• 제52권2호
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• pp.19-25
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• 2010

This study was conducted to determine the resilient modulus (Mr) and the unconfined compressive strength (UCS) of two recycled roadway materials such as recycled pavement material (RPM) and road surface gravel (RSG) with or without cement kiln dust (CKD). The recycled materials were blended with two CKD contents (5, 10 %) and 28 day curing time. Mr and UCS tests were also conducted after 10cycles of freezing and thawing to asses the impact of freeze-thaw cycling. Mr was determined conducting by the laboratory test method described by NCHRP 1-28A. Stabilized RPM and RSG had a modulus and a strength higher than unstabilized RPM and RSG. Mr and UCS of RPM and RSG mixed with CKD increased with increasing CKD content. The results indicated that the addition of CKD could be improved the strength and the stiffness of RPM and RSG. Therefore, RPM, RSG and CKD could be used as an effective materials in the reconstruction of roads.

• Bulletin of the Korean Chemical Society
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• 제32권9호
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• pp.3333-3337
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• 2011

$ZnMn_2O_4$ has been prepared by a mechanochemical process using a mixture of $Mn_2O_3$ and ZnO as starting materials, and investigated as a possible anode material for lithium-ion batteries. The phase evolution and morphologies of the ball-milled and annealed powders are characterized by X-ray diffraction (XRD) and scanning electron microscopy (SEM) with energy dispersive microanalysis (EDX), respectively. The solid-state reaction for the formation of $ZnMn_2O_4$, under the given experimental conditions, is achieved in a short time (30 min), and the prepared samples exhibit excellent electrochemical performances including an enhanced initial coulombic efficiency, high reversible capacity, and stable capacity retention with cycling.

• KIEAE Journal
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• 제2권2호
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• pp.23-31
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• 2002

The purpose of this study is to suggest an environmentally friendly energy system of ecological architecture, with the reference to foreign cases, judge feasibility of it. The ecological architecture is very similar to the natural ecosystem. There is growing international scientific consensus that human activities are having a discernible effect on the global climate. Therefore, with a precise understanding of the concept of ecological approach and concrete perception of the necessity it, an establishment of planning which recognizes the ecological architecture as a organism a same time, ensures diversity, stability and cycling stemmed from the ecosystem to various activities through a ecological structure shall bring the introduction of substantial ecological architecture into domestic realm. As a result, in this Age of industrial science, We are proposing useful materials and suggestion regarding the ecological architecture planning of korean cities, by preestimating the characteristics of a city heading toward the Age of the new ecological environment.