• Radiation Oncology Journal
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• v.11 no.1
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• pp.133-141
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• 1993

From Jan.1982 to Dec.1990, 77 patients with rectal cancer were treated with curative surgical resection followed by postoperative adjuvant irradiation alone or combined with chemotherapy at the Department of Radiation Oncology, Korea University Hospital (KUH). Fifty-four (54/77, $70.1{\%}$) patients underwent abdominoperineal resection , 20 (20/77, $26{\%}$) patients underwent low anterior resection, and 3 (3/77, $3.9{\%}$,) patients had wide excision only. Thirty-nine (39/77, $50.5{\%}$) received sequential chemotherapy (2 cycles to 12 cycles). The 5-year survival rate for the entire group was $43{\%}:\;78.2{\%}$ in B2+B3, $39.4{\%}$ in stage C1+C2+C3. Survival rates decreased with increasing penetration of the bowel wall by tumor and the presence of regional lymph node metastasis. Those patients survival who underwent an abdominoperineal resection also experienced a significant decrease in compared to low anterior resection ($23.1{\%}$ vs. $63.8{\%}$ in 5-year survival, p <0.05). Local failure occurred in 15 ($19.5{\%}$) out of the 77 patients overall, 1($5.3{\%}$) of 19 in stage B2+B3, and 14 ($24.1{\%}$,) of 58 in stage C1+C2+C3. Presacral area was most common site of local failufre (8/17, $47.1{\%}$). Distant failure occurred in 13 ($16.9{\%}$) of 77 patients. The most frequent site of distant failure was the lung followed by the liver, the bone, and the brain. Combined locoregional and distant failure occurred in 2 ($2.6{\%}$) of 77 patients. Pathological confirmation of perirectal fat and/or regional lymph node involvement resulted in a singificant decrease in survival and local control.

• Clinical and Experimental Reproductive Medicine
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• v.24 no.1
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• pp.83-93
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• 1997

Although IVF-ET is widely applied in the treatment of couples with male factor infertility, it may fail in many infertile couples with normal semen parameters, and certain couples cannot be accepted for standard IVF-ET due to unfertilization or extremely low fertilization rate of oocytes. Recently, several procedures of microassisted fertilization (MAF) using micromanipulation have been introduced, and pregnancies and births have been obtained after partial zona dissection (PZD), subzonal insertion (SUZI), and intracytoplasmic sperm injection (ICSI). This clinical study was performed to develop and establish ICSI as an effective procedure of MAF in infertile couples who could not undergo standard IVF-ET repetitively because of failure in fertilization or extremely low fertilization rate of oocytes with the conventional fertilization technique in the previous IVF-ET cycles. From March, 1995 to May, 1996, 27 cycles of IVF-ET with ICSI in 19 infertile patients were included in study group, and the outcomes of ICSI were analyzed according to fertilization rate, cumulative embryo score (CES), and pregnancy rate. The number of oocytes retrieved after controlled ovarian hyperstimulation (COH) was $10.50{\pm}6.13$ in 30 previous cycles, and $10.57{\pm}5.53$ in 27 ICSI cycles. In ICSI cycles, the number of oocytes optimal for ICSI procedure was $7.89{\pm}4.30$, and the fertilization rate of $67.9{\pm}20.2%$ could be obtained after ICSI. The number of embryos transferred was $1.43{\pm}2.40$ in previous cycles, and $4.36{\pm}1.77$ with the mean CES of $41.8{\pm}27.4$ in ICSI cycles. In ICSI cycles, the overall pregnancy rate was 29.6% (8/27) per cycle and 42.1% (8/19) per patient with the clinical pregnancy rate of 22.2% (6/27) per cycle and 31.6% (6/19) per patient. In conclusion, MAF of human oocytes with ICSI is a promising fertilization method for IVF-ET patients, especially with the past history of failure in fertilization or low fertilization rate of oocytes in the previous IVF-ET cycles, and ICSI using micromanipulation procedures applied to human oocytes will provide a range of novel techniques which may dramatically improve the pregnancy rate in IVF-ET program and contribute much to effective management of infertile couples.

• Steel and Composite Structures
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• v.49 no.3
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• pp.337-348
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• 2023

Successive wetting and drying cycles of concrete due to weather changes can endanger the safety of engineering structures over time. Considering wetting and drying cycles in concrete tests can lead to a more correct and reliable design of engineering structures. This study aims to provide a model that can be used to estimate the resistance properties of concrete under different wetting and drying cycles. Complex sample preparation methods, the necessity for highly accurate and sensitive instruments, early sample failure, and brittle samples all contribute to the difficulty of measuring the strength of concrete in the laboratory. To address these problems, in this study, the potential ability of six machine learning techniques, including ANN, SVM, RF, KNN, XGBoost, and NB, to predict the concrete's tensile strength was investigated by applying 240 datasets obtained using the Brazilian test (80% for training and 20% for test). In conducting the test, the effect of additives such as glass and polypropylene, as well as the effect of wetting and drying cycles on the tensile strength of concrete, was investigated. Finally, the statistical analysis results revealed that the XGBoost model was the most robust one with R2 = 0.9155, mean absolute error (MAE) = 0.1080 Mpa, and variance accounted for (VAF) = 91.54% to predict the concrete tensile strength. This work's significance is that it allows civil engineers to accurately estimate the tensile strength of different types of concrete. In this way, the high time and cost required for the laboratory tests can be eliminated.

• International Journal of Concrete Structures and Materials
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• v.8 no.1
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• pp.43-59
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• 2014

Many bridges are subject to lateral damage for their girders due to impact by over-height vehicles collision. In this study, the optimum configurations of carbon fiber reinforced polymers (CFRP) laminates were investigated to repair the laterally damaged prestressed concrete (PS) bridge girders. Experimental and analytical investigations were conducted to study the flexural behavior of 13 half-scale AASHTO type II PS girders under both static and fatigue loading. Lateral impact damage due to vehicle collision was simulated by sawing through the concrete of the bottom flange and slicing through one of the prestressing strands. The damaged concrete was repaired and CFRP systems (longitudinal soffit laminates and evenly spaced transverse U-wraps) were applied to restore the original flexural capacity and mitigate debonding of soffit CFRP longitudinal laminates. In addition to the static load tests for ten girders, three more girders were tested under fatigue loading cycles to investigate the behavior under simulated traffic conditions. Measurements of the applied load, the deflection at five different locations, strains along the cross-section height at mid-span, and multiple strains longitudinally along the bottom soffit were recorded. The study investigated and recommended the proper CFRP repair design in terms of the CFRP longitudinal layers and U-wrapping spacing to obtain flexural capacity improvement and desired failure modes for the repaired girders. Test results showed that with proper detailing, CFRP systems can be designed to restore the lost flexural capacity, sustain the fatigue load cycles, and maintain the desired failure mode.

• Clinical and Experimental Reproductive Medicine
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• v.40 no.1
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• pp.38-41
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• 2013

Liver damage induced by ovarian stimulation has been demonstrated in some cases reported in the literature. However, there has never been a fruitful debate on this topic. The present manuscript tried to fill this gap. We reported a case of a 35-year-old nulliparous woman admitted to our obstetric emergency room for severe pre-eclampsia. She had been subjected to four cycles of controlled ovarian stimulation for intrauterine insemination. At 32 weeks of gestation, she developed severe pre-eclampsia, which led to HELLP syndrome complicated by fatal liver failure. The etiological link between ovarian stimulation and HELLP syndrome is intriguing. Further investigations are needed to understand whether repeated ovarian stimulation may represent a risk factor in pre-eclamptic patients.

• Journal of Korean Foot and Ankle Society
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• v.24 no.2
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• pp.94-97
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• 2020

Purpose: Fatigue breakage of cortical screws sometimes occurs after syndesmosis fixation, regardless of the period of screw retention. This study compared the fatigue strength of a novel screw design to conventional cortical screws in the fixed state of syndesmosis. Materials and Methods: Twelve sawbone models were tested mechanically to determine the fatigue strength of three screw designs. The first group was composed of cortical screws, while the second and third groups were newly-designed screws. The second group was composed of screws with a 2.4-mm diameter thread-free portion of the mid-shank while the third group had a 2.0-mm diameter thread-free mid-shank. A 400 N load was applied repetitively to a fibula model and the number of cycles until screw failure was recorded. Four screws from each group were tested, giving a total of 12 fatigue tests. Results: The average cycles until screw failure for groups 1, 2, and 3 were 8,134, 63,186, and 2,581, respectively. The second group showed the highest fatigue strength (p=0.018). The other two screw designs showed similar fatigue strength (p=0.401). Conclusion: New screw designs with a thread-free portion in the mid-shank could reduce the occurrence of fatigue breakage after syndesmosis fixation.

• Korean Journal of Metals and Materials
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• v.47 no.12
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• pp.842-851
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• 2009

The long-term reliability of Sn-0.3wt%Ag-0.7wt%Cu solder joints was evaluated and compared with Sn-3.0wt%Ag-0.5wt%Cu under thermal shock conditions. Test vehicles were prepared to use Sn-0.3Ag-0.7Cu and Sn-3.0Ag-0.5Cu solder alloys. To compare the shear strength of the solder joints, 0603, 1005, 1608, 2012, 3216 and 4232 multi-layer ceramic chip capacitors were used. A reflow soldering process was utilized in the preparation of the test vehicles involving a FR-4 material-based printed circuit board (PCB). To compare the shear strength degradation following the thermal shock cycles, a thermal shock test was conducted up to 2,000 cycles at temperatures ranging from $-40^{\circ}C$ to $85^{\circ}C$, with a dwell time of 30 min at each temperature. The shear strength of the solder joints of the chip capacitors was measured at every 500 cycles in each case. The intermetallic compounds (IMCs) of the solder joint interfaces werealso analyzed by scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopy (EDS). The results showed that the reliability of Sn-0.3Ag-0.7Cu solder joints was very close to that of Sn-3.0Ag-0.5Cu. Consequently, it was confirmed that Sn-0.3Ag-0.7Cu solder alloy with a low silver content can be replaced with Sn-3.0Ag-0.5Cu.

• 한국방재학회:학술대회논문집
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• 2008.02a
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• pp.457-460
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• 2008

CFRP plates has been established as an effective method for rehabilitation and strengthening of concrete structures. The CFRP reinforcements are bonded to beams and slabs using structural adhesives. Adhesive strength can be affected by environmental exposure. During freezing-and-thawing cycling, temperature-induced stresses in the adhesive layer, due to differential thermal expansion between the CFRP and the substrate concrete, may lead to bond damage and contribute to or cause premature CFRP composite separation. This paper presents the results of experimental program undertaken to investigate the effects of freeze-thaw cycling (from -18 to $4^{\circ}C$) on the behavior and failure characteristics of RC beams strengthened in shear with CFRP plate using acoustic emission (AE) technique.

• Explosives and Blasting
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• v.29 no.1
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• pp.10-16
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• 2011

To make large slopes or rock structures stable, supporting systems, such as anchor bolt, rock bolt and spiral bolt which are developed recently, are commonly used. In this study, in-situ pull-out tests were carried out to compare the characteristics of rock bolt that is most widely used with ones of spiral bolt that is newly developed. Re-pull-out test for the spiral bolt in which loading and unloading cycles are repeated three times showed that the maximum pull-out load is almost constant irrespective of the number of loading cycles, which may be due to no failure between spiral bolt and filler. On the other hand, the maximum pull-out load for the conventional rock bolt decreases with the number of loading cycles due to the partial failure between rock bolt and filler.

• Proceedings of the Korean Institute of Surface Engineering Conference
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• 2018.06a
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• pp.72-72
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• 2018

A dynamic fatigue characteristic of dental implant system has been evaluated with applying single axial compressive shear loading based on the ISO 14801 standard. For the advanced dynamic fatigue test, multi-directional force and motion needed to be accompanied for more information of mechanical properties as based on mastication in oral environment. In this study, we have prepared loading and motion protocol for the multi-directional fatigue test of dental implant system with single (Apical/Occlusal; AO), and additional mastication motion (Lingual/Facial; LF, Mesial/Distal; MD). As following the prepared protocol (with modification of ISO 14801), fatigue test was conducted to verify the worst case results for the development of highly stabilized dental implant system. Mechanical testing was performed using an universal testing machine (MTS Bionix 858, MN, USA) for static compression and single directional loading fatigue, while the multi-directional loading was performed with joint simulator (ADL-Force 5, MA, USA) under load control. Basically, all mechanical test was performed according to the ISO 14801:2016 standard. Static compression test was performed to identify the maximum fracture force with loading speed of 1.0 mm/min. A dynamic fatigue test was performed with 40 % value of maximum fracture force and 5 Hz loading frequency. A single directional fatigue test was performed with only apical/occlusal (AO) force application, while multi directional fatigue tests were applied $2^{\circ}$ of facial/lingual (FL) or mesial/distal (MD) movement. Fatigue failure cycles were entirely different between applying single-directional loading and multi-directional loading. As a comparison of these loading factor, the failure cycle was around 5 times lower than single-directional loading while applied multi-directional loading. Also, the displacement change with accumulated multi-directional fatigue cycles was higher than that of single directional cycles.