• International Journal of Oral Biology
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• 제33권2호
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• pp.59-64
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• 2008

This study was designed to investigate the changes in the properties of the neuronal setm cells or progenitor cells associated with age-related decline in neurogenesis of the hippocampal dentate gyrus (DG). Active whole cells cycle marker Ki67 (a marker of whole cell cycle)-positive and S phase marker bromodeoxyuridine (BrdU)-positive. Neural stem cells gradually were reduced in the hippocampal subgranular zone (SGZ) in an age-dependant manner after birth (from P1 month to P1 year). The ratio of BrdUpositivecells/Ki67-positive cells was gradually enhanced in an age-dependent manner. The ratio of Ki67-positive cells/accu-mulating BrdU-positive cells at 3 hrs after BrdU injection was injected once a day for consecutive 5 days gradually decreased during ageing. TUNEL- and caspase 3 (apoptotic terminal caspase)-positive cells gradually decreased in the dentate SGZ during ageing and immunohistochemical findings of glial fibrillary acid protein (GFAP) were not changed during ageing. NeuN, a marker of mature neural cells, and BrdU-double positive cells gradually decreased in an age-dependent manner but differentiating ratio and survival rate of cells were not changed at 4 wks after BrdU injection once a day for consecutive 5 days. The number of BrdU-positive cells migrated from the hippocampal SGZ into granular layer and its migration speed was gradually declined during ageing. These results suggest that the adult neurogenesis in the mouse hippocampal DG gradually decrease through reducing proliferation of neural stem cells accompanying with cells cycle change and reduced cells migration rather than changes of differentiation.

• 한국항행학회논문지
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• 제14권6호
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• pp.831-837
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• 2010

광 시간 분할 다중/파장 분할 다중 (OTDM/WDM; optical time division multiplexing/wavelength division multiplexing) 전송 시스템의 구현을 위한 40 Gbps RZ 형식의 최적 조건을 충격 계수 (duty cycle)와 소광비 (ER; extinction ratio)에 따른 성능 분석과 비교를 통해 도출하였다. 광전송 링크에는 광섬유의 색 분산과 비선형에 의한 신호 왜곡을 보상하기 위해 광 위상 공액기 (OPC; optical phase conjugator)와 inline 분산 제어 (DM; dispersion management)가 적용되었다. ER에 따른 시스템 성능 변화의 영향이 적으면서 동시에 OTDM에 의한 160 Gbps 신호로의 다중화에 적합한 충격 계수는 0.25이라는 것을 확인하였다. 또한 DM의 적용에 있어 중계 거리 당 잉여 분산 (RDPS; residual dispersion per span)을 크게 할수록 동일한 전체 잉여 분산 (NRD; net residual dispersion)에 의해 결정되는 RZ 형식의 성능 개선 정도를 증가시킬 수 있는 것을 알 수 있었다.

• 한국추진공학회지
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• 제23권5호
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• pp.101-106
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• 2019

액체산소/케로신 가스발생기 사이클 엔진의 터빈 노즐목 수트(soot) 침착 특성을 파악하기 위한 변수를 정의하고 한국형발사체 1단 엔진 시험결과에 적용하였다. 터빈 가스의 물성치를 이용한 노즐목의 분출 계수 정의를 하는 방법이 있고 터빈 노즐목 전단과 터빈 배기 노즐목 전단의 압력비와 온도비를 이용하여 분출계수를 정의할 수 있다. 한국형발사체 1단 엔진 시험 결과를 분석한 결과 터빈 노즐목의 분출계수(discharge coefficient)는 시간에 따라 감소하며 동일 엔진에 대한 누적 연소시간에 대해서도 감소하는 경향을 보인다. 누적 시험 초기에는 터빈 노즐목 감소가 그 다음 시험과 연계되지만 일정 시간 이후에는 일정 범위에서 등락을 거듭하는 듯한 특성을 보인다.

• BMB Reports
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• 제55권8호
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• pp.401-406
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• 2022

Ahnak, a large protein first identified as an inhibitor of TGF-β signaling in human neuroblastoma, was recently shown to promote TGF-β in some cancers. The TGF-β signaling pathway regulates cell growth, various biological functions, and cancer growth and metastasis. In this study, we used Ahnak knockout (KO) mice that underwent a 70% partial hepatectomy (PH) to investigate the function of Ahnak in TGF-β signaling during liver regeneration. At the indicated time points after PH, we analyzed the mRNA and protein expression of the TGF -β/Smad signaling pathway and cell cycle-related factors, evaluated the cell cycle through proliferating cell nuclear antigen (PCNA) immunostaining, analyzed the mitotic index by hematoxylin and eosin staining. We also measured the ratio of liver tissue weight to body weight. Activation of TGF-β signaling was confirmed by analyzing the levels of phospho-Smad 2 and 3 in the liver at the indicated time points after PH and was lower in Ahnak KO mice than in WT mice. The expression levels of cyclin B1, D1, and E1; proteins in the Rb/E2F transcriptional pathway, which regulates the cell cycle; and the numbers of PCNA-positive cells were increased in Ahnak KO mice and showed tendencies opposite that of TGF-β expression. During postoperative regeneration, the liver weight to body weight ratio tended to increase faster in Ahnak KO mice. However, 7 days after PH, both groups of mice showed similar rates of regeneration, following which their active regeneration stopped. Analysis of hepatocytes undergoing mitosis showed that there were more mitotic cells in Ahnak KO mice, consistent with the weight ratio. Our findings suggest that Ahnak enhances TGF-β signaling during postoperative liver regeneration, resulting in cell cycle disruption; this highlights a novel role of Ahnak in liver regeneration. These results provide new insight into liver regeneration and potential treatment targets for liver diseases that require surgical treatment.

• 한국신뢰성학회지:신뢰성응용연구
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• 제11권4호
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• pp.433-445
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• 2011

Duty cycle is determined as the ratio of operating time to total time. Duty cycle in reliability prediction is one of the significant factors to be considered. In duty cycle application, non-operating time failure rate has been easily ignored even though the failure rate in non-operating period has not been proved to be small enough. Ignorance of non-operating time failure rate can result in over-estimated system reliability calculation. Furthermore, utilization of duty cycle in reliability prediction has not been evaluated in its effectiveness. In order to address these problems, two reliability models, such as MIL-HDBK-217F and RIAC-HDBK-217Plus, were used to analyze non-operating time failure rate. This research has proved that applying duty cycle in 217F model is not reasonable by the quantitative comparison and analysis.

• 설비공학논문집
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• 제25권10호
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• pp.548-554
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• 2013

A thermodynamic analysis of the R404A refrigeration system with an internal heat exchanger using R744 as a secondary refrigerant is presented in this paper to optimize the design for operating parameters of the system. The main results are summarized as follows: The COP increases with increasing subcooling and superheating degree of R404A, internal heat exchanger and compression efficiency of the R404A cycle and evaporating temperature of the R744 cycle and decreasing temperature difference of the cascade heat exchanger and condensing temperature of the R404A cycle. The mass flow ratio decreases with increasing evaporating temperature of the R744 cycle and internal heat exchanger efficiency of the R404A cycle and decreasing subcooling and superheating degree of the R744 cycle, temperature difference of the cascade heat exchanger and condensing temperature of the R404A cycle.

• 한국수소및신에너지학회논문집
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• 제23권5호
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• pp.521-529
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• 2012

Since the energy demand for refrigeration and air-conditioning has greatly increased all over the world, thermally activated refrigeration cycle has attracted much attention. This study carries out a performance analysis of a vapor compression cycle (VCC) driven by organic Rankine cycle (ORC) utilizing low-temperature heat source in the form of sensible heat. The ORC is assumed to produce minimum net work which is required to drive the VCC without generating an excess electricity. Effects of important system parameters such as turbine inlet pressure, condensing temperature, and evaporating temperature on the system variables such as mass flow ratio, net work production, and coefficient of performance (COP) are thoroughly investigated. The effect of choice of working fluid on COP is also considered. Results show that net work production and COP increase with increasing turbine inlet pressure or decreasing condensing temperature. Out of the five kinds of organic fluids considered $C_4H_{10}$ gives a relatively high COP in the range of low turbine inlet pressure.

• 상하수도학회지
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• 제35권2호
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• pp.163-174
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• 2021

Heatwaves are one of the most common phenomena originating from changes in the urban thermal environment. They are caused mainly by the evapotranspiration decrease of surface impermeable areas from increases in temperature and reflected heat, leading to a dry urban environment that can deteriorate aspects of everyday life. This study aimed to calculate daily maximum ground surface temperature affecting heatwaves, to quantify the effects of urban thermal environment control through water cycle restoration while validating its feasibility. The maximum surface temperature regression equation according to the impermeable area ratios of urban land cover types was derived. The estimated values from daily maximum ground surface temperature regression equation were compared with actual measured values to validate the calculation method's feasibility. The land cover classification and derivation of specific parameters were conducted by classifying land cover into buildings, roads, rivers, and lands. Detailed parameters were classified by the river area ratio, land impermeable area ratio, and green area ratio of each land-cover type, with the exception of the rivers, to derive the maximum surface temperature regression equation of each land cover type. The regression equation feasibility assessment showed that the estimated maximum surface temperature values were within the level of significance. The maximum surface temperature decreased by 0.0450℃ when the green area ratio increased by 1% and increased by 0.0321℃ when the impermeable area ratio increased by 1%. It was determined that the surface reduction effect through increases in the green area ratio was 29% higher than the increasing effect of surface temperature due to the impermeable land ratio.

• 오토저널
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• 제5권1호
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• pp.89-93
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• 1983

This paper describes on experimental investigation into the heat dissipation of Diesel engine, placing emphasis on the variations of compression ratio and cooling water temperature. The engine used for this test was a vertical single-cylinder four-cycle type, having a direct injection. Engine performance and heat transfer rates was tested under the compression ratio 14.3 and 17.4. In this study, the results showed that output and transfer rates of engine decrease in accordance with the decrease of compression ratio. The effect of cooling water temperature and injection delay of fuel on the heat dissipation brings about the decrease of heat transfer rates from cylinder to cooling water.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2002년도 하계종합학술대회 논문집(2)
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• pp.357-360
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• 2002

This paper is proposed about an efficient pipelined architecture for 3D graphics accelerator to reduce Cache miss ratio. Because cache miss takes a considerable time, about 20∼30 cycle, we reduce cache miss ratio to use pre-fetch. As a result of simulation, we figure out that the miss ratio of cache depends on the size of tile, cache memory and auxiliary cache memory. We can save 6.6% cache miss ratio maximumly.