• Title/Summary/Keyword: Cycle Based Evaluation

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Application of Cumulus Cells as Factors to Predict the Outcome of IVF-ET (체외수정시술의 결과를 예측할 수 있는 인자로서 난구세포의 활용에 관한 연구)

  • Kim, Kwang-Dae;Kim, Ki-Hyung;Na, Yong-Jin;Lee, Kyu-Sup
    • Clinical and Experimental Reproductive Medicine
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    • v.26 no.3
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    • pp.419-432
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    • 1999
  • Objective: To establish the evaluation system of the quality of oocytes on the basis of the incidence of cumulus cells apoptosis, to investigate the relationships beween the incidence of cumulus cells and the outcomes of IVF-ET. Method: Thirth-four cycles undergoing controlled ovarian hyperstimulation for IVF-ET with tubal infertility (23 cycles) or unexplained infertility (11 cycles) were included in this study. Cumulus cell masses surrounding mature oocyte and co-culture of embryos with autologous cumulus cells during IVF-ET process. The incidence of apoptosis in cumulus cells was assessed by apoptosis detection kit fluorescein. The effect of co-culture using cumulus cells and the incidence of cumulus cells apoptosis. Results: The results were as follows: 1. The incidence of apoptosis in cumulus cells markedly increased in patients aged 40 or over, while the fertilization rate was greatly decreased in those age group. 2. Apoptosis in cumulus cells was found in both the fertilized oocytes and unfertilized oocytes, but the incidence of apoptosis was higher in unfertilized oocytes. 3. There is no clear correlation between apoptosis in cumulus cells and the number of oocytes retrieved. However, the incidence of apoptosis was increased when the number of oocytes retrieved was 5 and fewer in comparison with $6{\sim}10$. 4. Embryo grade was significantly affected by the incidence of apoptosis in cumulus cells. 5. Pregnancy rate of IVF-ET per cycle was 29.4%, and the pregnant group had the higher fertilization rate and a significantly lower incidence of apoptosis in cumulus cells compared with the nonpregnant group. 6. When cumulus cells were used as helper cells in the co-culture of the embryo, in vitro activity of cumulus cells based on morphological change and proliferation did not influence the quality of embryo, but was closely associated with the implantation rate and pregnancy rate, which was enhanced when morphological changes and proliferation of cumulus cells was more active. 7. This difference in the outcome of IVF-ET according to in vitro activity of cumulus cells used for co-cultue was not associated with the incidence of apoptosis in cumulus cells; but rather had likely relations with the different secretion pattern of protein, which may be an embryo trophic factor by cumulus cells. Conclusion: These results suggest that the incidence of apoptosis in cumulus cells can be used in predicting oocyte qualities and the outcomes of IVF-ET. And the effect of co-culture largely depends on the in vitro activity of cumulus cells as well.

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CO2 Emissions Evaluation for Steel Reinforced Concrete Columns Based on the Optimal Structural Design (최적구조설계를 이용한 SRC 기둥의 CO2 배출량 평가)

  • Choi, Se Woon;Jeon, Ji Hye;Lee, Hwanyoung;Kim, Yousok;Park, Hyo Seon
    • Journal of the Computational Structural Engineering Institute of Korea
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    • v.26 no.5
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    • pp.335-342
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    • 2013
  • Since the seriousness of environmental pollution came to the fore recently, various efforts have been made globally for the reduction of the environmental load. In particular, in the field of construction, an industry responsible for a considerable amount of pollution, studies have been actively conducted to reduce $CO_2$ emissions and energy consumption. However, most conventional research about pollution as it relates to construction is focused on the maintenance stages where $CO_2$ emissions are the greatest. Research related to the design stage is in its infancy, as it has only been conducted thus far on steel buildings and RC buildings. In fact, in order to achieve environmentally friendly construction considering the Life Cycle Assessment(LCA), the building design should be derived to reduce the $CO_2$ emissions from the early building design stage, and structural engineers should be able to suggest a design plan considering its environmental friendliness. In this study, optimal structural design method for steel reinforced concrete(SRC) columns considering $CO_2$ emissions is presented. The trends of $CO_2$ emissions in SRC columns according to the variations of steel shapes, concrete strengths and loads are investigated.

Qualitative Research on Integrated Support Through Health, Medical and Welfare Network - Based on the Experience of 301 Network Service Users in Seoul Northern Municipal Hospital - (보건의료복지 네트워크를 통한 통합적 지원에 관한 질적 연구 - 서울특별시 북부병원 301네트워크 사업 이용자 경험을 중심으로 -)

  • Ha, Ji Seoun;Kim, Jeung Hyun;Lim, Jung Hyun;Kim, Jung Yun
    • Korean Journal of Social Welfare
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    • v.69 no.2
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    • pp.143-169
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    • 2017
  • The purpose of this study was to explore the implications of the integrated support through the 'health - medical - welfare' network and the specific context of the operation through the experiences of the users who participated in the 301 network project of Seoul northern municipal hospital. To do this, In-depth interviews were carried out with 10 research participants. The data was analyzed by general qualitative research methods. As a result of analysis, users lost their willingness because of living in a vicious cycle of poverty and illness before participating in 301 network services, but through the participation of the service, they were able to receive the integrated support of 'cure-care-life stability'. These experiences ultimately led to the regeneration of the will of their lives. At the basis of this experience were operating strategies and conditions such as the formation of a diverse professional team, the establishment of a linkage system within and outside the hospital, the establishment of a treatment linkage system through the acquisition of treatment subsidies, and the linkage of resources at mediation level. As the attempt to integrate 'health, medical and welfare' with well-coordinated strategies and conditions showed the possibility of complementing the limitation of the health welfare support system in Korea, the extension of the related business was suggested. For this, it suggested the more stable stabilization of the linkage system and the improvement of the institutional aspect.

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The Analysis of Liquefaction Evaluation in Ground Using Artificial Neural Network (인공신경망을 이용한 지반의 액상화 가능성 판별)

  • Lee, Song;Park, Hyung-Kyu
    • Journal of the Korean Geotechnical Society
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    • v.18 no.5
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    • pp.37-42
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    • 2002
  • Artificial neural networks are efficient computing techniques that are widely used to solve complex problems in many fields. In this paper a liquefaction potential was estimated by using a back propagation neural network model applicated to cyclic triaxial test data, soil parameters and site investigation data. Training and testing of the network were based on a database of 43 cyclic triaxial test data from 00 sites. The neural networks are trained by modifying the weights of the neurons in response to the errors between the actual output values and the target output value. Training was done iteratively until the average sum squared errors over all the training patterns were minimized. This generally occurred after about 15,000 cycles of training. The accuracy from 72% to 98% was shown for the model equipped with two hidden layers and ten input variables. Important effective input variables have been identified as the NOC,$D_10$ and (N$_1$)$_60$. The study showed that the neural network model predicted a CSR(Cyclic shear stress Ratio) of silty-sand reasonably well. Analyzed results indicate that the neural-network model is more reliable than simplified method using N value of SPT.

A Study on The Family Life Education(II) -special Reference to marital life education- (가족생활 교육 프로그램 개발을 위한 기초연구(II)-부부교육을 중심으로-)

  • 오윤자
    • Journal of Families and Better Life
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    • v.10 no.2
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    • pp.209-229
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    • 1992
  • The purpose of this study is to develop Family Life Education program for Marital education in Korea. In order to realize the about research purpose, this study is divided into three sections. First, nature conception and contents f Family Life Education, second, patterns and models for Family Life Education Program in USA and Korea, and Third, the future of Family Life Education. Family Life Education (FLE) is an education originated in reaction to changing social conditions, industrialization and urbanization, it deals with the perceived inadequacies of families to cope with these changes, thereby reduction social problems involved with, and improving family life. With and assumption that the studies about FLE have not been so active in Korea, the present thesis examines the FLE in Korea. The necessity of marital education in Korea Is based upon the theories of FLE in the United States of America. Also, it atempts to formulate a tentative plan for the promotion of a FLE program in Korea. The concept of FLE in Korea was manifested in the social educational law and life-span education. specified as 4th among ten presidential regulations. It is defined as " the Life-span developmental education to enhance the quality of human life, to solve family problems, to develop an individual's potentiality and to strengthen the family relations. of the FLE programs, the marital education is considered one of the furcial wubjects becaused it is the core of the family life. With this premise, FLE tries to wupport the healthy mrital relations. subsequently helping to explore the family potentiality and to strengthen family ties. The objects of the FLE program are unmarried, pre-marred , and married persons. For the married persons, the FLE program should be arranged in accordance with their rrital status divided by the family life cycle so that they may prevent possible family problems at each stage of the family life. Also, to prevent the problems occurred in the course of carrying out family functions, the FLE program should be provided with on the basis of a family unit, thereby improving the quality of the family functions. The FLE is to hep persons begin smoothly the adaption process for a successful marital relations. For the FLE to be practised more widely systematically, research on family education--that is basic study, research and production and evaluation or the FLE to be carried out by research institute wholly responsible for it-- should be done first.

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A Survey on the Persons in Charge for Economic Estimation Analysis and Improvement of BTL Projects (BTL사업의 경제성 평가 현황조사 및 개선을 위한 실무자 설문조사연구)

  • Lee, Chun-Kyong;Cho, Bong-Ho;Park, Tae-Keun
    • Korean Journal of Construction Engineering and Management
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    • v.8 no.4
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    • pp.73-80
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    • 2007
  • As BTL(Build-Transfer-Lease) private investment business benchmarking PHI(Private Finance Initiative) of USA and Japan is introduces to Korea since 2005, as a part of supplying high leveled public service and early expanding required facilities for SOC, Value for Money on private investment business from treasury investment business at the beginning gets to be needed. Accordingly, this survey has been conducted in order to analyse BTL projects status, propriety of economic analysis method(VFM analysis, calculation of estimated business expenses, valuation of bidding price, etc.) by business advance phases from the viewpoint of person in charge, necessity of improvement and alternative plants. As the result of conducting cross tabulation analysis and correlation analysis by occupational group, BTL project advance phases and alternative plans for improvement, it is necessary ye prepare standardized service level against business expense and basis for calculating and evaluation operation expenses. Based on the necessity of quantitative analysis (LCC analysis) of VFM, standard for calculating management, maintenance and administration expenses is required. In addition, reliable economic valuation system considering domestic BTL environment should be setup, for business efficiency.

Microstructure, Tensile Strength and Probabilistic Fatigue Life Evaluation of Gray Cast Iron (회주철의 미세구조와 인장거동 분석 및 확률론적 피로수명평가)

  • Sung, Yong Hyeon;Han, Seung-Wook;Choi, Nak-Sam
    • Transactions of the Korean Society of Mechanical Engineers A
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    • v.41 no.8
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    • pp.721-728
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    • 2017
  • High-grade gray cast iron (HCI350) was prepared by adding Cr, Mo and Cu to the gray cast iron (GC300). Their microstructure, mechanical properties and fatigue strength were studied. Cast iron was made from round bar and plate-type castings, and was cut and polished to measure the percentage of each microstructure. The size of flake graphite decreased due to additives, while the structure of high density pearlite increased in volume percentage improving the tensile strength and fatigue strength. Based on the fatigue life data obtained from the fatigue test results, the probability - stress - life (P-S-N) curve was calculated using the 2-parameter Weibull distribution to which the maximum likelihood method was applied. The P-S-N curve showed that the fatigue strength of HCI350 was significantly improved and the dispersion of life data was lower than that of GC300. However, the fatigue life according to fatigue stress alleviation increased further. Data for reliability life design was presented by quantitatively showing the allowable stress value for the required life cycle number using the calculated P-S-N curve.

Comparison of automatic and manual chamber methods for measuring soil respiration in a temperate broad-leaved forest

  • Lee, Jae-Seok
    • Journal of Ecology and Environment
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    • v.42 no.4
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    • pp.272-277
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    • 2018
  • Background: Studying the ecosystem carbon cycle requires analysis of interrelationships between soil respiration (Rs) and the environment to evaluate the balance. Various methods and instruments have been used to measure Rs. The closed chamber method, which is currently widely used to determine Rs, creates a closed space on the soil surface, measures $CO_2$ concentration in the inner space, and calculates Rs from the increase. Accordingly, the method is divided into automatic or manual chamber methods (ACM and MCM, respectively). However, errors of these methods and differences in instruments are unclear. Therefore, we evaluated the characteristics and difference of Rs values calculated using both methods with actual data. Results: Both methods determined seasonal variation patterns of Rs, reflecting overall changes in soil temperature (Ts). ACM clearly showed detailed changes in Rs, but MCM did not, because such small changes are unknown as Rs values are collected monthly. Additionally, Rs measured using MCM was higher than that using ACM and differed depending on measured plots, but showed similar tendencies with all measurement times and plots. Contrastingly, MCM Rs values in August for plot 4 were very high compared with ACM Rs values because of soil disturbances that easily occur during MCM measurements. Comparing Rs values calculated using monthly means with those calculated using MCM, the ACM calculated values for monthly averages were higher or lower than those of similar measurement times using the MCM. The difference between the ACM and MCM was attributed to greater or lesser differences. These Rs values estimated the carbon released into the atmosphere during measurement periods to be approximately 57% higher with MCM than with ACM, at 5.1 and $7.9C\;ton\;ha^{-1}$, respectively. Conclusion: ACM calculated average values based on various Rs values as high and low for measurement periods, but the MCM produced only specific values for measurement times as representative values. Therefore, MCM may exhibit large errors in selection differences during Rs measurements. Therefore, to reduce this error using MCM, the time and frequency of measurement should be set to obtain Rs under various environmental conditions. Contrastingly, the MCM measurement is obtained during $CO_2$ evaluation in the soil owing to soil disturbance caused by measuring equipment, so close attention should be paid to measurements. This is because the measurement process is disturbed by high $CO_2$ soil concentration, and even small soil disturbances could release high levels into the chamber, causing large Rs errors. Therefore, the MCM should be adequately mastered before using the device to measure Rs.

Basic Research for Preparation of a Disabled-Inclusive Public Disaster Management System (장애포괄적 재난관리체계 마련을 위한 기초 연구)

  • Kim, Soungwan;Roh, Sungmin
    • 재활복지
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    • v.20 no.1
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    • pp.1-22
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    • 2016
  • This research aimed to examine the problems in a current national emergency management system that does not consider the disabled in the face of manmade catastrophes and natural disasters, and to conduct an expert opinion survey to explore the direction of disabled-inclusive public disaster management system. As a result of the analysis, the respondents of the survey revealed a need for a designated government department for disaster management systems for the disabled and the experts preferred the Ministry of Public Safety and Security (50%) than the Ministry of Health and Welfare (37.5%). However, 12.5% of the surveyed experts perceived cooperation between the two Ministries, rather than selecting a certain ministry, as necessary to establish a disaster management system for the disabled. Additionally, the experts recognized the response period (43.8%) of the disaster management life cycle to be the most important phase. Thus, at the disaster response period, the experts suggested utilizing an emergency alarm system to effectively rescue the disabled in the face of disaster. Based on this discussion, the paper explores ways to establish a disabled-inclusive public disaster management system.

International Research Status on Spent Nuclear Fuel Structural Integrity Tests Considering Vibration and Shock Loads Under Normal Conditions of Transport (정상운반조건의 진동 및 충격하중을 고려한 사용후핵연료의 구조적 건전성 시험평가 해외연구현황)

  • Lim, JaeHoon;Cho, Sang Soon;Choi, Woo-seok
    • Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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    • v.17 no.2
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    • pp.167-181
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    • 2019
  • Currently, the development of evaluation technology for vibration and shock load characteristics and spent nuclear fuel structural integrity under normal conditions of transport is being conducted in the Republic of Korea. This is the first such research conducted in the Republic of Korea and, thus, previous international studies need to be investigated and will be referred to in the ongoing project. Before 2000, several studies related to measurement of vibration and shock loads on spent nuclear fuel were conducted in the US. US national research institutes conducted uniaxial fuel assembly shaker tests, concrete block tests, and multi-axis fuel assembly tests between 2009 and 2016. In 2017, multi-modal transportation tests including road, sea, and rail transport were also performed by research institutes from the US, Spain and the Republic of Korea. Therefore, test preparation procedures, acceleration and strain measurement results, and finite-element and multi-body dynamics analysis were investigated. Based on the measured strain data, the preliminary conclusion was obtained that the measured strain was too small to cause damage to spent nuclear fuel rods. However, this conclusion is a preliminary conclusion that only reviews part of the results; a detailed review is being conducted in the US. The investigation of international studies on spent nuclear fuel structural integrity tests considering vibration and shock loads under normal conditions of transport in the US will be useful data for the project being conducted in the Republic of Korea.