• 제목/요약/키워드: Cuscuta japonica

검색결과 19건 처리시간 0.024초

황련추출물에 의한 HIV-1 복제 저해 (Inhibition of HIV-1 Replication by Extract of Coptis chinensis)

  • 송만기;이안휘;김영호;이정준;성영철
    • Biomolecules & Therapeutics
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    • 제3권2호
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    • pp.111-115
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    • 1995
  • Natural products, total number of 175, were screened to test for their effect on the replication of human immunodeficiency virus type 1 (HIV-1). Five of them, such as Eriobotrya japonica, Eugenia caryphyllata, Cuscuta chinensis, Glycyrrhiza uralensis, and Coptis chinensis were shown to be effective in inhibiting the replication of HIV-1 in tissue culture and their selectivity indexes were 42, 40, 14, 18 and 65, respectively. To further fractionate Coptis chinensis, which is shown to be highest anti-HIV-1 activity, methanol extracts of Coptis chinensis were fractionated into methylene chloride at pH3, pH10 and water residue. The selectivity Indexes of CH$_2$C1$_2$(pH 3), CH$_2$C1$_2$(pH 10) and water residue were 50, 22 and 98 respectively. Our results show that the water residue of Coptis chinensis was the most effective for anti-HIV-1 activity.

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토사자 에탄올 추출물이 UVB로 유도된 CCD-986Sk cell에서 주름개선 생리지표에 미치는 영향 (fects of Cuscuta Chinensis Lamark Ethanol Extract on Wrinkle Improvement Bio-markers by UVB-induced CCD-986Sk Cell)

  • 주인환;최학주;심부용;민가율;김동희
    • 동의생리병리학회지
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    • 제32권5호
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    • pp.321-327
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    • 2018
  • The purpose of this study was to investigate the effects of Cuscuta chinensis Lamark ethanol extract (CL) on wrinkle improvement. Cuscuta chinensis Lamark is known to contain dried saccharide, alkaloids, flavonoids, lignans and rein glycoside as major components of dried mature seeds of Cuscuta japonica Choisy. In this study, we evaluated the anti-wrinkle effects of CL and investigated bio-markers (e.g ; MMP-1, MMP-3, MMP-9, TIMP-1, type I procollagen) associated with skin wrinkle improvement. We tested the anti-wrinkle effect of CL using human fibroblast called CCD-986Sk cell. We observed an increase in MMPs, TIMP-1, and type 1 pro-collagen CL in CCD-986Sk cells irradiated with UVB at an intensity of $2mJ/cm^2$ for 60 seconds. As a result, CL decreased UVB-induced MMPs levels and mRNA expressions in CCD-986Sk cell. The levels and mRNA expressions of type I procollagen and TIMP-1 were increased by CL. These results suggest that CL has activities on improvement of skin wrinkle, which is induced by UVB radiation. Taken together, this study proposed the possibility of developing herbal medicine and functional herbal cosmetic materials with wrinkle-improving effects of Cuscuta chinensis Lamark.

토사자(Cuscuta japonica Choisy, 菟絲子)의 화장품 약리활성에 관한 연구 (Study of the Cosmeceutical Activities of Cuscuta japonica Choisy)

  • 조우아;천순주;장민정;성지연;정수현;강보연;최은영;정연숙;이준숙;최호정;백욱진;안봉전;이창언;이진태
    • 대한본초학회지
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    • 제21권2호
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    • pp.103-108
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    • 2006
  • Objectives : The cosmeceutical activity of Cuacuta japonica Choisy were investigated for cosmetics industrial application. Methods : Cosmeceutical activities include antioxidant, tyrosinase inhibition effects and nitrite-scavenging ability were examined through the Cuacuta japonica Choisy Results : The result were obtained as follows : The electron donating ability of water and ethanol extract was 69.5%, 78.3% at 1,000ppm. In SOD-like activity, water extract showed low effect, but ethanol extract scored 63.4% at 1,000ppm. In inhibition activity of xanthine oxidase, water extract showed low effect, which is 27.2% at 500ppm, in contrast to ethanol extract high effect: 99.5% at 500ppm, in nitrite-scavenging ability test, 500ppm of C. japonica Choisy water extract showed the effect of 51.3%, while 500ppm of C. japonica Choisy ethanol extract showed the effect of 72.7%. From the test of inhibitory effect of tyrosinase, both water and ethanol extract showed insufficient inhibitory rate. Conclusion : According to all the test results that have been given, it is possible that the extract of C. japonica Choisy can be used as a new natural material of the cosmeceutical industry.

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Stewartia pseudocamellia and Torilis japonica Extracts Inhibit RANKL-induced Osteoclastogenesis in RAW 264.7 Cells

  • Anh-Thu Nguyen;Chun Soo Na;Ki-Young Kim
    • 대한화학회지
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    • 제67권2호
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    • pp.120-128
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    • 2023
  • Osteoporosis is a disease that causes the weakening of bone by increasing porosity, which often results in fractures. Osteoporosis treatment measures include the use of Bisphosphonates and estrogen. However, these treatments cannot be used in the long term as these treatments have adverse side effects. Therefore, there is a need to identify better and safer treatment options. For this, 63 plant extracts were screened and among them, six extracts showed high anti-osteoclastic activity with low cytotoxicity. Of these six extracts, three extracts, Cudrania tricuspidata (P371), Ulmus davidiana var. japonica (P401), and Torilis japonica (P411), showed more than 50 percent osteoclast inhibition. While the remaining, Stewartia pseudocamellia extracts I and II (P370, P397) and Cuscuta chinensis (P418), showed moderate or between 40-50 percent osteoclast inhibition. Among all the extracts, Torilis japonica (P411) showed the highest inhibitory action against osteoclast development. Torilis japonica (P411) primary components include Kaempferol, Quercetin, and Luteolin, all proven to inhibit osteoclastogenesis. Stewartia pseudocamellia extracts I and II (P370 and P397) showed moderate or 44% osteoclast inhibition. Stewartia pseudocamellia extract II (P397) enhanced the growth of RAW 264.7 cells by 19%. Torilis japonica (P411) and Stewartia pseudocamellia extract II (P397) suppressed the expression of osteoclast-specific genes in RANKL-induced osteoclastogenesis in RAW 246.7 cells. Torilis japonica (P411) extracts even increased osteoblast-specific RUNX2 gene expression. This results provide that six extracts could be used as a potential treatment option for osteoporosis disease with the extracts of Torilis japonica (P411) and Stewartia pseudocamellia (P397) as an ideal candidates. However, the combination of the extract with higher osteoclastic inhibition and less toxic effects with further analysis should be recommended.

창원시 주요지역의 식물상 및 보전관리방안 (Conservation Management Methods and Vascular Plants of Major Sites in Changwon-si)

  • 오현경;강현미;최송현
    • 한국환경복원기술학회지
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    • 제15권4호
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    • pp.23-40
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    • 2012
  • The vascular plants of major sites in Changwon-si were listed 456 taxa (9.3% of all 4,881 taxa of vascular plants); 112 families, 293 genera, 371 species, 2 subspecies, 66 varieties and 17 forms. The vascular plants of Changwon-cheon were listed 133 taxa, Junam reservoir were listed 90 taxa, Seongju-sa were listed 293 taxa, and Yungji park were listed 164 taxa. Divided into 456 taxa; woody plants were 160 taxa (35.1%) and herbaceous plants were 296 taxa (64.9%). Furthermore, therophytes (Th) were 111 taxa (24.3%), hemicryptophytes (H) were 75 taxa (16.4%), megaphanerophytes (MM) were 63 taxa (13.8%) showed high proportional ratio in life form. Based on the list of rare plants by the Korea Forest Service and Korea National Arboretum, 10 taxa (1.8% of all 571 taxa of rare plants); Aristolochia contorta (LC), Euryale ferox (VU), Melothrua japonica (LC), Utricularia pilosa (CR), Hydrocharis dubia (LC), Carex idzuroei (DD), Acorus calamus var. angustatus (LC), etc. Based on the list of endemic plants by the Korea National Arboretum, 10 taxa (3.0% of all 328 taxa of endemic plants); Salix pseudolasiogyne, Philadelphus incanus, Indigofera koreana, Lespedeza ${\times}$ maritima, Stewartia pseudocamellia, Weigela subsessilis, Carex okamotoi, etc. Based on the list of specific plants by floral region were total 43 taxa (4.0% of all 1,071 taxa of specific plants); 4 taxa (Euryale ferox, Hydrocharis dubia, Carex idzuroei, etc.) in class IV, 9 taxa (Ilex crenata, Acer palmatum, Stewartia pseudocamellia, Melothria japonica, Fatsia japonica, etc.) in class III, 3 taxa (Caltha palustris var. membranacea, Nymphoides indica, etc.) in class II, 26 taxa (Cyrtomium fortunei, Chloranthus japonicus, Quercus variabilis, Ulmus parvifolia, Aphananthe aspera, etc.) in class I. Based on the list of naturalized plants, 48 taxa (Rumex crispus, Chenopodium album var. album, Amaranthus patulus, Phytolacca american, Brassica juncea var. integrifolia, Potentilla paradoxa, Robinia pseudoacacia, Euphorbia maculata, Oenothera odorata, Cuscuta pentagona, Veronica persica, Plantago lanceolata, Diodia teres, Helianthus tuberosus, Dactylis glomerata, etc.), naturalization rate was 10.5% of all 456 taxa of vascular plants and urbanization index was 15.0% of all 321 taxa of naturalized plants. Ecosystem disturbing wild plants were 3 taxa (Rumex acetocella, Solanum carolinense, Ambrosia artemisiifolia).

Stereoscope를 이용한 미세종자류 한약재 외부형태 감별연구(제1보(報)) - 청상자(靑葙子) 계관자(鷄冠子) 토사자(菟絲子) 자소자(紫蘇子) (Identification of Morphological Appearance of Fine Seed Herbs Using Stereoscope (Report I) - Celosiae Semen, Celoisae Cristatae Semen, Cuscutae Semen, Perillae Semen)

  • 지창윤;김태주;이승호;김영식;이금산;김정훈;최고야;주영승
    • 대한한의학회지
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    • 제34권3호
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    • pp.1-12
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    • 2013
  • Objectives: This was study about identifying fine seed herbs that are highly mixed together: Celosiae Semen, Celoisae Cristatae Semen, Cuscutae Semen, Perillae Semen. Methods: In non-distinctive herbs through sensory test, we can find accurate discriminative points by using a stereoscope. As a result, a new discriminative key was completed. Results: We identified a comparison of herbs which are mixed up in distribution. 1) In the case of Celosiae Semen and Celoisae Cristatae Semen, Celoisae Cristatae Semen which is mixed up is bigger and more glossy and especially have the sunk umbilicus. 2) In the case of Cuscutae Semen and Perillae Semen, Perillae Semen is discriminated by characteristic morado netting surface and impression of fruit stalk in the single-ended. 3) In the case of Cuscutae Semen which is distributed in three species, we discriminated by beak shape, location of umbilicus and vomiting thread shape or not when put in water. (1) Cuscuta chinensis has a weak beaky shape, an umbilicus in center and is vomiting thread shape when put in water. (2) C. australis has very weak beaky shape, an umbilicus beneath and is vomiting thread shape when put in water. (3) C. japonica has clear beaky shape, an umbilicus beneath and is not vomiting thread shape when put in water. Conclusions: A stereoscope can be effectively used for identifying fine seed herbs hardly distinguishable by sensory tests.

40종(種) 한약재(韓藥材)의 adenosine diphosphate에 의한 혈소판(血小板) 응집(凝集) 저해작용(沮害作用) 검색(檢索) (Screening of inhibitory effect of 40 herbs on platelet aggregation induced by ADP)

  • 조영주;김성훈
    • 혜화의학회지
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    • 제5권1호
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    • pp.185-198
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    • 1996
  • After evaluation of antithrombotic effect of 40 herbs on platelet aggregation induced by ADP(Adenosine diphosphate), these results were obtained as follows: 1. Crude drugs exerting over 30 % of in Chinemys reevesii (Gray)hibition on platelet aggregation induced by ADP were Ganoderma japonicum (Fr.) Lloyd., Panax ginseng C. A. Mey., Gastrodia elata Bl., Thea sinensis, Chinemys reevesii (Gray), Cuscuta chinensis Lam., Cervus nippon Temminck., Biota orientalis (L.) Endl., Coriolus versicolor, Cinnamomum cassia Presl., Sophora flavescens Ait., Amomum villosum Lour., Carthamus tinctorius L., Rubus chingii Hu., Poria cocos (Schw.) Wolf., Laminana japonica Aresch., Ligustrum lucidum Ait., Angelica sineusis (Oliv.), Cyperus rotundas L., Ginkgo biloba L., Zingiber officinale Rosc., Prunus persica (L.) Batsch., Schizandra chinensis (Turcz.) Baill. and Plantago asiatica L.. 2. Of crude drugs having showed over 50% of inhibitory effect on platelet aggregation, at the concentration of $100{\mu}g/m{\ell}$, the inhibitory rates were 82.2% in Ganoderma japonicum (Fr.) Lloyd., 55% in Panax ginseng C. A. Mey., 50.8% in Gastrodia elata Bl., while at the concentration of $200{\mu}g/m{\ell}$, antithrombotic rates were 89.4% in Ganoderma japonicum (Fr.) Lloyd., 59.2% in Panax ginseng C. A. Mey., 57.9% in Thea sinensis, 52.7% in Gastrodia elata Bl.. These results suggest that the study sholuld be necessary on antithrombotic effect of solvent fractions of Ganoderma japonicum (Fr.) Lloyd., Panax ginseng C. A. Mey., Gastrodia elaha B1. and Thea sinensis and isolation of effective compound from above drugs.

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잡초(雜草)에 함유(含有)된 생리활성물질(生理活性物質) 탐색(探索) I (Screening of Biologically Active Compounds from Weeds I)

  • 김창진;강병화;이인경;류인자;박동진;이강현;이현선;유익동
    • 한국잡초학회지
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    • 제14권1호
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    • pp.16-22
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    • 1994
  • 경기도 광주군 및 연천군 일원에서 채취한 93종의 잡초종(雜草種)을 대상으로 항균활성(抗園活性), 항종양활성(抗腫瘍活性), 항산화활성(抗酸化活性), 제초활성(除草活性) 등 몇가지 생리활성(生理活性)을 조사함으로써 제초(雜草)의 유용적(有用的)인 측면(則面)의 확인 뿐 아니라 나아가서 잡초(雜草)로부터 새로운 생리활성물질탐색(生理活性物質探索)의 가능성(可能性)을 제시하고자 하였다. 곰팡이에 있어서 사과나무 점무늬낙엽병균(落葉病菌)에 대해서는 새삼, 고추 역병균(疫病菌)에 대해서는 돼지풀과 쥐손이풀, 참깨 역병균(疫病菌)에 대해서는 쑥부쟁이와 미국쑥부쟁이가 항균활성(抗菌活性)을 나타내었다. 세균에 있어서는 돼지풀, 쑥, 사철쑥, 여뀌바늘, 구절초, 쥐손이풀, 미국가막사리 등이 비교적 항균활성(抗菌活性)의 범위(範圍)가 넓었으며 개비름, 비름, 망초, 물질경이, 쇠무릎, 물봉선, 벼룩나물 등이 Gram 양성세균인 Bacillus subtilis PCI219에 대하여 선택적(選擇的)인 항균활성(抗菌活性)을 나타내었다. 그리고 새삼, 개가장, 갈대, 쉽사리, 기름나물 등이 세포벽(細胞壁) 결손(缺損) 변이주(變異洙)인 Pseudomonas aeruginosa N10 균주에 대하여 선택적(選擇的)인 항균활성(抗菌活性)을 나타내었다. K562 세포(細胞)에 대한 protein kinase C 활성(活性)으로 조사한 antibleb 활성(活性)은 큰개여뀌, 사철쑥, 국화방망이, 개가장, 쥐손이풀, 바늘사초 등에서 나타났으며 특히 큰개여뀌에서는 조시료(粗試料) 상태에서 10mg/ml 농도(濃度)에서도 강한 활성(活性)을 나타내었다. 항산화활성(抗酸化活性)에 있어서는 바디나물, 쇠뜨기, 승마, 큰개여뀌, 쥐손이풀, 달맞이꽃, 방동사니대가리 등이 비교적 강한 활성(活性을) 나타내었으며 제초활성(除草活性)에 있어서는 여뀌바늘, 기름나물 등이 비교적 강한 활성(活性)을 나타내었다.

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변산반도국립공원 내 미선나무 아개체군의 생태적 특성과 관리제언 (Ecological Characteristics and Management Proposal of Abeliophyllum distichum Subpopulations in the Byeonsanbando National Park)

  • 임동옥;황인천;최현우;김용식
    • 한국환경생태학회지
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    • 제23권2호
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    • pp.116-126
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    • 2009
  • 본 연구는 전라북도 부안군 변산반도국립공원 내 3개 지역에 분포하는 우리나라의 희귀 및 멸종위기식물인 미선나무아개체군을 대상으로 생태적 특성 분석과 관리방안을 강구하기 위한 것이다. 변산반도국립공원에 위치한 미선나무아개체군 중 부안댐 제방하부 지역과 상서면 청림리 산록에 자생군락을 천연기념물 제370호로 지정한 반면, 가마소지역의 미선나무아개체군은 이식한 집단이다. 미선나무 아개체군 중 가마소 아개체군의 식생은 감나무, 오동나무 및 산뽕나무가 교목상이나, 부안댐 하부의 아개체군은 굴참나무가 우점하고 있다. 미선나무 자생지인 청림리 아개체군은 미선나무를 제외한 관목이상의 목본수종을 모두 제거한 상태였다. 미선나무 아개체군에서 확인한 식물종은 65과 143속 164종 17변종 1품종 등 총 182분류군이며, 가마소 지역, 부안댐 제방하부지역 및 청림리 지역은 각각 75종, 102종 및 89종이다. 미선나무 아개체군 동향은 가마소지역과 부안댐 하부 자생지에서 맹아의 수가 $1{\sim}2$개인 개체가 87%이상이고, 나머지는 3개였으며, 총 개체 수는 각 766개체와 59개체였다. 반면, 청림리의 경우 맹아의 수가 $1{\sim}2$개인 개체가 74.8%, 3개는 16% 그리고 $4{\sim}11$개가 9.2%로 총 838개체를 확인하였다. 교목을 인위적으로 제거한 미선나무 자생지에는 흰명아주, 돌소루쟁이, 미국자리공, 나팔꽃, 배풍등, 망초 및 개망초 등 귀화식물이 침입하였으며, 미선나무 어린 개체보다 성장이 빨라 미선나무를 피압한 상태이다. 미선나무의 자생지 보전을 위한 우선순위로 미선나무 단일종이나 수림 하에 분포하는 원 자생지의 모습 그대로를 유지하는 것이 서식지 관리에 바람직한지는 더 많은 연구가 필요하다.