• 한국지능시스템학회논문지
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• 제18권2호
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• pp.216-222
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• 2008

본 논문은 배경복잡성, 조명변화, 무질서한 라인, 문자와 배경색의 유사성 등에 취약한 기존 연구의 단점을 보완하기 위해 컬러분할과 LoG연산자의 폐곡선 에지 특징 및 합성논리모델을 이용한 다중 문자 검출 알고리즘을 제안하였다. 제안된 다중 문자 검출 알고리즘은 특징 검출, 문자형성, 문자검출 단계로 구성된다. 본 논문에서 제안한 새로운 다중 문자 검출 알고리즘은 웨이브렛, 형태학과 허프변환을 이용한 전처리 후 각 컬러영역을 순차적 AND 연산 및 OR연산을 수행함으로써 완전한 문자가 아닌 불완전 문자부분마저도 취합하여 검출률을 높일 수 있는 효율적인 방법임을 확인하였다. 또한 영상의 크기나 해상도, 기울어짐 등에 상관없이 문자영역이 첨가된 자연 영상을 대상으로 하며, 동일 영상에 대하여 기존의 문자 검출 알고리즘과 비교함으로써 제안알고리즘이 검출률면에서 우수함을 확인하였다.

• Journal of Veterinary Science
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• 제22권6호
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• pp.41.1-41.14
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• 2021

Background: Our previously prepared ceftiofur (CEF) hydrochloride oily suspension shows potential wide applications for controlling swine Streptococcus suis infections, while the irrational dose has not been formulated. Objectives: The rational dose regimens of CEF oily suspension against S. suis were systematically studied using a pharmacokinetic-pharmacodynamic model method. Methods: The healthy and infected pigs were intramuscularly administered CEF hydrochloride oily suspension at a single dose of 5 mg/kg, and then the plasma and pulmonary epithelial lining fluid (PELF) were collected at different times. The minimum inhibitory concentration (MIC), minimal bactericidal concentration, mutant prevention concentration (MPC), post-antibiotic effect (PAE), and time-killing curves were determined. Subsequently, the area under the curve by the MIC (AUC_0-24h/MIC) values of desfuroylceftiofur (DFC) in the PELF was obtained by integrating in vivo pharmacokinetic data of the infected pigs and ex vivo pharmacodynamic data using the sigmoid E_max (Hill) equation. The dose was calculated based on the AUC_0-24h/MIC values for bacteriostatic action, bactericidal action, and bacterial elimination. Results: The peak concentration, the area under the concentration-time curve, and the time to peak for PELF's DFC were 24.76 ± 0.92 ㎍/mL, 811.99 ± 54.70 ㎍·h/mL, and 8.00 h in healthy pigs, and 33.04 ± 0.99 ㎍/mL, 735.85 ± 26.20 ㎍·h/mL, and 8.00 h in infected pigs, respectively. The MIC of PELF's DFC against S. suis strain was 0.25 ㎍/mL. There was strong concentration-dependent activity as determined by MPC, PAE, and the time-killing curves. The AUC_0-24h/MIC values of PELF's DFC for bacteriostatic activity, bactericidal activity, and virtual eradication of bacteria were 6.54 h, 9.69 h, and 11.49 h, respectively. Thus, a dosage regimen of 1.94 mg/kg every 72 h could be sufficient to reach bactericidal activity. Conclusions: A rational dosage regimen was recommended, and it could assist in increasing the treatment effectiveness of CEF hydrochloride oily suspension against S. Suis infections.

• 한국화재소방학회논문지
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• 제33권6호
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• pp.20-27
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• 2019

본 연구는 화재 시 열출력 급상승 구간에 대한 정확한 열방출율을 예측하기 위한 새로운 함수를 개발하여 제안하는 것을 목적으로 하였다. 현재 화재공학에서 사용되고 있는 'αt²' 곡선은 화재시스템 공학 관점에서 비효율적이며 실효성 저하를 초래하므로 열방출율의 예측오차를 최소화시킬 필요가 있다. 'αt²'과 비교하여 보다 논리적인 배경과 형태적으로 유사성을 가진 로지스틱 함수 이론을 기반으로 화재 급성장 구간은 물론 화재 초기 단계까지 적용 가능한 새로운 예측 함수를 개발하였다. 개발된 함수는 더 넓은 화재성장 구간에서 정확도 높은 예측결과를 갖는 것으로 본 연구에서 증명되었다. 이 연구결과는 향후 화재성장패턴 연구의 개발과 함께 화재공학의 발전을 위해 적용될 것이다.

• 한국정보통신학회논문지
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• 제12권1호
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• pp.1-9
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• 2008

소프트웨어의 테스트노력 곡선으로서 현재까지는 로지스틱 곡선이 가장 이상적인 것으로 연구되고 있다. 테스트 단계중에 소요되는 테스트노력의 양에 대한 결함 검출비를 현재의 결함 내용에 비례하는 것으로 가정하여 소프트웨어 신뢰도 성장 모델을 비동차 포아송 프로세스(NHPP)로 공식화하되, 이 모델을 이용하여 소프트웨어 신뢰도 척도에 대한 데이터 분석기법을 개발한다. 모든 소프트웨어 개발 환경에서 지금까지 제시된 여러 곡선 중 하나에 의해서 테스트노력 소요 곡선을 표현하는 것은 적절하지 못하다는 것이 밝혀지고 있다. 그러므로, 본 논문에서는 로지스틱 테스트노력 곡선이 소프트웨어의 개발/테스트 노력곡선으로 적절하게 표현될 수 있다는 것과 실제 데이터를 근거로 하여 적용하여서 예측성이 매우 좋은 능력을 가지고 있다는 것을 보이고자 한다.

• 한국멀티미디어학회논문지
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• 제9권9호
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• pp.1150-1159
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• 2006

본 논문에서는 지오데식 동적 윤곽선 모델을 이용하여 뇌실 영역을 검출하기 위하여 기존의 에지지시함수를 대신한 영역 기반의 곡선진행억제 함수를 제안하였다. 제안한 곡선 진행 억제 함수는 뇌실 영역의 검출에 매우 효과적이었으며, 이 함수는 MRI 영상에서 밝게 나타나는 뇌실 영역의 평균 밝기를 기반으로 한다. 본 논문에서는 제안한 방법이 기존의 방법보다 뇌실 영역을 잘 검출할 수 있음을 다양한 척도를 이용하여 수치적으로 비교하였다. 실제 정상과 뇌종양에 의한 뇌질환 영상에 적용시켜 뇌실 검출 과정을 시각적으로 비교하여 우수성을 검증하였다.

• 한국미생물·생명공학회지
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• 제25권4호
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• pp.414-419
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• 1997

In order to develop an enzyme-linked immunosorbent assay (ELISA) for deoxynivalenol (DON) in com, we produced a specific monocl- onal antibody and established ELISA conditions. After the spleen cells from mice immunized with DON-bovine serum albumin conjugate were fused with S$_{p}$2/0 myeloma cells, a hybridoma cell 3G7 producing anti-DON antibody was screened by ELISA. From the standard curve of competitive direct ELISA (cdELISA) using 3G7 monoclonal antibody and DON-HRP conjugate, the detection range of DON showed 3-3,000 ng/ml (ppb). The monoclonal antibody showed some cross-reactivities against DON analogues such as 15 acetyl-DON (110%), nivalenol (5.0%), 3 acetyl-DON (1.7%), fusarenon-x (0.72%), and T-2 (0.59%). When the cdELISA was applied to the spiked coms after extracting with 60% methanol and diluting 5- fold with washing buffer, the assay recoveries of DON were 313, 163, 106, and 88.9% (av., 168%) in the levels of 200, 600, 2,000, and 6,000ng/g, respectively. For the quantitation of DON in coms, 30 samples kept under two different storage conditions of cold and room temperature were assayed by cdELISA. The mean detection concentrations were 595 (detection range, 0-2,750) and 2,448 (detection range, 0-4,500) ppb, respectively.

• 약학회지
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• 제40권1호
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• pp.41-45
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• 1996

A high performance liquid chromatography using photoreduction fluorescence detection was described for the analysis of saikosaponins. Saikosaponins were separated on an $NH_2$ column using acetonitrile and aqueous 2-tert-butylanthraquinone(t-BAQ) as mobile phase. Column effluent was passed through a 40cm PTFE capillary tube coiled around a 10W UV lamp to reduce t-BAQ to a highly fluorescent dihydroxyanthracene derivative which was detected by a fluorescence detector. The optimal concentration of t-BAQ was found to be $6{\times}10^{-5}M$ and the optimal reaction time to be 2 seconds. The detection limit for saikosaponin a and d by this method was found to be about 280ng and 80ng. The dynamic linear range was over two orders and the correlation coefficient of the calibration curve of them was 0.998.

• Imaging Science in Dentistry
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• 제33권2호
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• pp.91-95
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• 2003

Purpose : To compare the diagnostic accuracy of proximal caries detection between Kodak Insight film and the Biomedisys CDX2000HQ digital (CCD) sensor. Materials and Methods: 156 proximal surfaces of extracted teeth, 78 of which had chemical artificial caries, were used in this study. Four observers interpreted the radiographs using a five-point confidence rating scale to record their diagnoses. The results were analyzed by receiver operating characteristic curves, ANOVA and Kappa values. Result: Analysis using receiver operating characteristic curves revealed the areas under each curve which indicated a diagnostic accuracy of 0.951 in Insight and 0.952 in CDX2000HQ digital sensor. ANOVA revealed no significant differences between the two images with respect to caries detection. Kappa values indicated that the mean intra-observer agreement was 0.85 and inter-observer agreement 0.71 in conventional radiography. In digital radiography, the mean intra-observer agreement was 0.84 and inter-observer agreement 0.72. Conclusion: The results suggest that no significant difference exists between the two modalities for artificial caries detection and that CDX2000HQ was as good as Insight film for this purpose.

• Bulletin of the Korean Chemical Society
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• 제25권6호
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• pp.900-906
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• 2004

An RPLC-postcolumn detection method has been developed for the fluorimetric determination of dichloroacetamide (DCAD) in water. After ammonia and DCAD were separated on a $C_{18}$ nonpolar stationary phase with 2.5% methanol-0.02 M phosphate buffer at pH 3, the column eluant was reacted with post column reagents, o-phthaldialdehyde (OPA) and sulfite ion at pH 11.5, to produce a highly fluorescent isoindole fluorophore, which was measured with a fluorescence detector ( ${\lambda}_{ex}$ = 363 nm, ${\lambda}_{em}$ = 425 nm). With the optimized conditions for RPLC and the postcolumn derivatization, the calibration curve was found to be linear in the concentration ranges of 0.5 and 20 ${\mu}$M for DCAD, and the detection limit for DCAD was 0.18 ${\mu}$M (23${\mu}$g/L). This corresponded to 18 pmol per 100 ${\mu}$L injection volume for a signal-to-noise ratio of 3, and the repeatability and reproducibility of this method were 1.0% and 2.5% for five replicate analyzes of 2 ${\mu}$M DCAD, respectively. The degradation yields DCAD to ammonia were 94 and 99%, and the percent recoveries of DCAD from 4 and 6 ${\mu}$M DCAD-spiked tap water were shown mean more than 97%.

• 대한전기학회논문지:시스템및제어부문D
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• 제50권4호
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• pp.201-207
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• 2001

This paper describes an automated detection algorithm of ST-T episodes using global curvature which can connect the isoelectric level in ECG and can eliminate not only the slope of ST segment, but also difference of the baseline and global curve. This above method of baseline correction is very faster than the classical baseline correction methods. The optimal values of parameters for baseline correction were found as the value having the highest detection rate of ST episode. The features as input of backpropagation Neural Network were extracted from the whole ST segment. The European ST-T database was used as training and test data. Finally, ST elevation, ST depression and normal ST were classified. The average ST episode sensitivity and predictivity were 85.42%, 80.29%, respectively. This result shows the high speed and reliability in ST episode detection. In conclusion, the proposed method showed the possibility in various applications for the Holter system.