• 한국항해항만학회지
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• 제47권2호
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• pp.85-92
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• 2023

The hardware of an LED lighting control system for coastal lighting at coastal pier entrance consists of a power supply unit, an AVR control unit, a CLCD output unit, an LED control unit, a scenario selection switch unit, and an operation speed display unit. It is made of an 8-channel. The CPU used ATmega128 and the FET was used to control the current signal. To operate the CPU, DC 12V was converted to DC 5V using a regulator 7805. A heat sink was used to remove heat generated in the FET. By connecting the load LED module to the manufactured 8-channel LED lighting control system, the operation was confirmed through various production scenarios. In addition, a control system was designed to show the most suitable color for the atmosphere of the coastal pier according to the input value of temperature and illumination using a fuzzy control system. Computer simulation was then conducted. Results confirmed that fuzzy control did not need to store many data inputs due to characteristics of artificial intelligence and that it could efficiently represent many output values with simple fuzzy rules.

• 전기전자학회논문지
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• 제27권1호
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• pp.12-18
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• 2023

각각의 큐빗(qubit)을 개별적으로 상온의 제어 회로에 연결하는 현재의 회로 기술은 양자 컴퓨터의 확장성, 신뢰성을 갖추는 데 있어 한계를 가지고 있으며, 집적도 측면에서 극저온의 CMOS 기술 기반 인터커넥트 회로 기술을 통해 기존 기술 대비 인터커넥트의 복잡도, 시스템 안정도 및 사이즈, 그리고 가격 경쟁력을 획기적으로 개선할 수 있을 것으로 기대되고 있다. 외부의 전기적 자극에 민감하며 양자 상태를 일정 시간 이상 유지할 수 없는 큐빗의 특성으로 인한 문제를 극복하고, 확장성과 신뢰성을 양자 컴퓨터 실현을 위한 CMOS 기술 기반 집적화된 센싱 및 제어 회로 기술에 대해 소개한다.

• 공학기술논문지
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• 제5권4호
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• pp.349-353
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• 2012

Recently, Mobile multimedia equipments as smart phone and tablet pc requirement is increasing and this market is also being expanded. These mobile equipments require large multi-media function, so more power consumption is required. For these reasons, the needs of power management IC as switching type dc-dc converter and linear regulator have increased. DC-DC buck converter become more important in power management IC because the operating voltage of VLSI system is very low comparing to lithium-ion battery voltage. There are many people to be concerned about digital DC-DC converter without using external passive device recently. Digital controlled DC-DC converter is essential in mobile application to various external circumstance. This paper proposes the DC-DC Buck Converter using the AVR RISC 8-bit micro-processor control. The designed converter receives the input DC 18-30 [V] and the output voltage of DC-DC Converter changes by the feedback circuit using the A/D conversion function. Duty ratio is adjusted to maintain a constant output voltage 12 [V]. Proposed converter using the micro-processor control was compared to a typical boost converter. As a result, the current loss in the proposed converter was reduced about 10.7%. Input voltage and output voltage can be displayed on the LCD display to see the status of the operation.

• IMMUNE NETWORK
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• 제22권1호
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• pp.10.1-10.17
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• 2022

Systemic autoimmune diseases arise from loss of self-tolerance and immune homeostasis between effector and regulator functions. There are many therapeutic modalities for autoimmune diseases ranging from conventional disease-modifying anti-rheumatic drugs and immunosuppressants exerting nonspecific immune suppression to targeted agents including biologic agents and small molecule inhibitors aiming at specific cytokines and intracellular signal pathways. However, such current therapeutic strategies can rarely induce recovery of immune tolerance in autoimmune disease patients. To overcome limitations of conventional treatment modalities, novel approaches using specific cell populations with immune-regulatory properties have been attempted to attenuate autoimmunity. Recently progressed biotechnologies enable sufficient in vitro expansion and proper manipulation of such 'tolerogenic' cell populations to be considered for clinical application. We introduce 3 representative cell types with immunosuppressive features, including mesenchymal stromal cells, Tregs, and myeloid-derived suppressor cells. Their cellular definitions, characteristics, mechanisms of immune regulation, and recent data about preclinical and clinical studies in systemic autoimmune diseases are reviewed here. Challenges and limitations of each cell therapy are also addressed.

• Ocean Systems Engineering
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• 제6권3호
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• pp.265-287
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• 2016

The change of the global performance of a turret-moored FPSO (Floating Production Storage Offloading) with DP (Dynamic Positioning) control is simulated, analyzed, and compared for two different internal turret location cases; bow and midship. Both collinear and non-collinear 100-yr GOM (Gulf of Mexico) storm environments and three cases (mooring-only, with DP position control, with DP position+heading control) are considered. The horizontal trajectory, 6DOF (degree of freedom) motions, fairlead mooring and riser tension, and fuel consumptions are compared. The PID (Proportional-Integral-Derivative) controller based on LQR (linear quadratic regulator) theory and the thrust-allocation algorithm which is based on the penalty optimization theory are implemented in the fully-coupled time-domain hull-mooring-riser-DP simulation program. Both in collinear and non-collinear 100-yr WWC (wind-wave-current) environments, the advantage of mid-ship turret is demonstrated by the significant reduction in heave at the turret location due to the minimal coupling with pitch mode, which is beneficial to mooring and riser design. However, in the non-collinear WWC environment, the mid-turret case exhibits unfavorable weathervaning characteristics, which can be reduced by employing DP position and heading controls as demonstrated in the present case studies. The present study also reveals the plausible cause of the failure of mid-turret Gryphon Alpha FPSO in milder environment than its survival condition.

• Asian Pacific Journal of Cancer Prevention
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• 제15권17호
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• pp.7163-7167
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• 2014

Background: Associations between the rs6010620 polymorphism in the regulator of telomere elongation helicase1 (RTEL1) gene and glioma have been widely reported but the results were not inconclusive. The aim of the current study was to investigate the association between the rs6010620 polymorphism in RTEL1 gene and risk of glioma by meta-analysis. Materials and Methods: We searched PubMed, Embase, Wanfang Weipu and CNKI (China National Knowledge Infrastructure) databases, which included all research published 05 May 2014. A total of 8,292 cases and 12,419 controls from 14 case-control studies involving the rs6010620 polymorphism in the RTEL1 gene were included. Statistical analysis was performed using STATA 12.0 software. Results: The results indicated that the rs6010620 polymorphism in RTEL1 gene was indeed associated with risk of glioma (OR=1.474, 95%CI=1.282-1.694, p<0.001). On subgroup analysis by ethnicity, we found associations between the rs6010620 polymorphism in the RTEL1 gene and risk of glioma in both Caucasians and Asians. Conclusions: The current meta-analysis suggested that the rs6010620 polymorphism in the RTEL1 gene might increase risk of glioma. In future, larger case-control studies are needed to confirm our results.

• Molecules and Cells
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• 제40권10호
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• pp.706-713
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• 2017

Osteoclasts are bone-resorbing cells that are derived from hematopoietic precursor cells and require macrophage-colony stimulating factor and receptor activator of nuclear factor-${\kappa}B$ ligand (RANKL) for their survival, proliferation, differentiation, and activation. The binding of RANKL to its receptor RANK triggers osteoclast precursors to differentiate into osteoclasts. This process depends on RANKL-RANK signaling, which is temporally regulated by various adaptor proteins and kinases. Here we summarize the current understanding of the mechanisms that regulate RANK signaling during osteoclastogenesis. In the early stage, RANK signaling is mediated by recruiting adaptor molecules such as tumor necrosis factor receptorassociated factor 6 (TRAF6), which leads to the activation of mitogen-activated protein kinases (MAPKs), and the transcription factors nuclear factor-${\kappa}B$ (NF-${\kappa}B$) and activator protein-1 (AP-1). Activated NF-${\kappa}B$ induces the nuclear factor of activated T-cells cytoplasmic 1 (NFATc1), which is the key osteoclastogenesis regulator. In the intermediate stage of signaling, the co-stimulatory signal induces $Ca^{2+}$ oscillation via activated phospholipase $C{\gamma}2$ ($PLC{\gamma}2$) together with c-Fos/AP-1, wherein $Ca^{2+}$ signaling facilitates the robust production of NFATc1. In the late stage of osteoclastogenesis, NFATc1 translocates into the nucleus where it induces numerous osteoclast-specific target genes that are responsible for cell fusion and function.

• 대한물리치료과학회지
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• 제10권1호
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• pp.158-169
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• 2003

The present study examined that in vivo test is investigated in sham-operated(control group) and aldosterone-analogue deoxycorticosterone acetate (DOCA)-salt hypertensive animals(experimental group) and that the antihypertensive effect was induced by silver spike point(SSP) low frequency electrical stimulation at meridian points(CV-3, -4, Ki-12, SP-6, LR-3, BL-25, -28, -32, -52), specifically, such as diuretic action in 24 hour urine analysis from normal volunteer. The $Na^+$ and $Ca^{2+}$ ions were significantly increased in aldosterone-analogue DOCA-salt hypertensive rats than that in sham-operated rats. However, the $K^+$ ions were significantly decreased in aldosterone-analogue DOCA-salt hypertensive rats than that in sham-operated rats. The current of 1 Hz continue type of SSP low frequency electrical stimulation significantly increased in excretion of urine $Na^+$ and $K^+$ ions from normal volunteer. However, the excretion of $Ca^{2+}$ ion were significantly decreased by SSP electrical stimulation in volunteer. These results suggest that the development of aldosterone analogue-DOCA-salt hypertension is associated with changed $Na^+$, $K^+$ and $Ca^{2+}$ ions of urine. which directly affects blood pressure. Therefore, the hypertension is a risk factor on cardiovascular disease. Moreover, These results demonstrate that the SSP low frequency electrical stimulation, especially current of 1 Hz continue type, significantly regulates $Na^+$, $Ca^{2+}$ and $K^+$ ions from volunteer. Therefore, the SSP low frequency electrical stimulation is a good regulator through a diuretic action of aldosterone-induced hypertension.

• 전자공학회논문지
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• 제50권11호
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• pp.130-137
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• 2013

본 논문은 생체신호 측정을 위한 저전력/저면적 AFE(analog front-end)에 관한 것이다. 제안된 AFE는 계측증폭기(IA), 대역 통과 필터(BPF), 가변 이득 증폭기(VGA), SAR 타입 A/D 변환기로 구성된다. 전류 분할 기법을 이용한 작은 gm (LGM) 회로와 고 이득 증폭기로 구성된 Miller 커패시터 등가 기술을 이용하여, 외부 수동소자를 사용하지 않고 AC-coupling을 구현하였다. 응용에 따른 BPF의 고역 차단 주파수 변화는 전압 조절기(regulator)를 이용한 출력 전압 변화를 이용하여 $g_m$을 변화하여 구현 시켰다. 내장된 ADC는 커패시터 분할 기법을 적용한 이중 배열 커패시터 방식의 D/A변환기와 비동기 제어 방식을 이용하여 저 전력과 저 면적으로 구현하였다. 일반 CMOS 0.18um 공정을 이용하여 칩으로 제작하였고, 전체 칩 면적은 PAD등을 모두 포함하여 $650um{\times}350 um$이다. 제안된 AFE의 전류 소모는 1.8V에서 6.3uA이다.

• The Korean Journal of Physiology and Pharmacology
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• 제5권3호
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• pp.231-241
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• 2001

The mammalian cortical collecting duct (CCD) plays a major role in regulating renal NaCl reabsorption, which is important in $Na^+$ and $Cl^-$ homeostasis. The M-1 cell line, derived from the mouse cortical collecting duct, has been used as a mammalian model of the study on the electrolytes transport in CCD. M-1 cells were grown on collagen-coated permeable support and short circuit current $(I_{sc})$ was measured. M-1 cells developed amiloride-sensitive current $5{\sim}7$ days after seeding. Apical and basolateral addition of ATP induced increase in $I_{sc}$ in M-1 cells, which was partly retained in $Na^+-free$ or $Cl^--free$ solution, indicating that ATP increased $Na^+$ absorption and $Cl^-$ secretion in M-1 cells. $Cl^-$ secretion was mediated by the activation of apical cystic fibrosis transmembrane regulator (CFTR) chloride channels and $Ca^{2+}-activated$ chloride channels, but $Na^+$ absorption was not mediated by activation of epithelal sodium channel (ENaC). ATP increased cAMP content in M-1 cells. The RT-PCR analysis demonstrated that M-1 cells express $P2Y_2,\;P2X_3\;and\;P2Y_4$ receptors. These results showed that ATP regulates $Na^+$ and $Cl^-$ transports via multiple P2 purinoceptors on the apical and basolateral membranes in M-1 cells.