• 대한한의학원전학회지
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• 제24권6호
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• pp.101-110
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• 2011

There are not a few cases in Oriental medicine where a different prescription should be given to some of the patients whose symptoms are similar to each other. In other words, there might happen a misdiagnosis due to an extremely delicate difference in symptoms of the same diseases, causing a patient's condition to get worse or to be even on the brink of death. In such a context, the records in "WooJam JabJeo(愚岑雜著)" are worthwhile to do in-depth research on. Jang-Taegyung described his first-hand experience in major medical treatment very vivaciously during his ages between 25 and 42. Particularly, most of the prescriptions recorded in this book include not only his empirical prescriptions on the patients who life was almost on the brink of death but it also so plentifully contained the process of overcoming the side effect caused by other clinics' misdiagnosis; thus, that this book is drawing attention in that it could be indispensable materials not only in the research on medical history but also for clinical treatment. Particularly, as regards two cases of insanity, this book mentions the reason for using totally different prescription on one case from the other case even though the two cases had a similar symptom, through which we can acquire somewhat concrete experience in curing scenes though indirectly during the period of the Joseon Dynasty. We were able to get the result from the analysis of the two cases of insanity as follows: 1. WooJam, in treating the two cases of insanity due to the severe exacerbation of yang energy, managed to treat the one case by inducing a bowel movement and the other case by inducing urination. Such a different treatment seems to be greatly attributable to the constitutional factor of the two patients. Such an Oriental-medicine-based method of diagnosis and prescription as WooJam's is rarely found in Western medicine-i.e., that's why more thorough research on Oriental medicine is deeply required. 2. In case of the second patient, the patient arrived at insanity due to another clinic's treatment on perspiration on the patient with severe mouth thirst. This medical story once again highlights the importance of a diagnosis in today's Oriental medicine and at the same time it's a good example showing how big the side effect caused by the abuse of medicinal herbs is. The second patient's body fluids ran dry and finally his yang energy got exacerbated all the more due to the treatment by perspiration.

• Journal of Nutrition and Health
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• 제12권1호
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• pp.51-58
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• 1979

It is a general trend everywhere that the uses of vegetable oils are increasing due to the fact that they are effective in curing and preventing symptoms of high blood pressure and various heart failure conditions. At the same time the concept that oxidative rancidity is caused by the oxidation of unsaturated fatty acid moieties whose subsequent decomposition gives rise to various undesirable, sometimes toxic compounds is now well accepted. Linolenic acid (C, 18:3) is one of highly unsaturated and readily oxidizable fatty acid. The content of this essential polyunsaturated fatty acid in perilla seed oil (PSO) was found to be as high as 48% while only 1.5% in sesame seed oil (SSO). In this experiment the oxidative stability of PSO was compared with that of SSO. The experimental test group were as follows: A) Stored at different temperatures, namely $4^{\circ}C,\;30^{\circ}C,$ and $60^{\circ}C,$ B) Stored at room temperature $(20{\pm}5^{\circ}C)$ ; a. protected from sunlight and air, b. exposed to air without sunlight c. exposed to sunlight but protected front air, d. completely exposed to both air and sunlight. The following results were obtained; 1) It was found to be most stable against oxidation to store both PSO and SSO under the low temperature $(4^{\circ}C)$ condition. According to P.V. measurements it was found to be safe to keep both oils up to $30^{\circ}C$ for at least 8 weeks. When exposed to air, sunlight and high temperature $(60^{\circ}C)$, P.V. of PSO reached there peak values, which were much higher than those of SSO. This explains much of its instability as compared to SSO against oxidation. 2) The effect of high temperature $(60^{\circ}C)$ on A.V. was found to be more striking than those of all the other storage conditions. The condition of refrigeration was most effective in keeping A.V. low for both oils as was the case in P.V. 3) For both oils, I.V. decreased throughout the experimental period (8 weeks). The range of decrement was larger for PSO than SSO. 4) There was no significant change in the compositions of fatty acids of SSO caused by various experimental storage conditions. But for PSO the compositions of stearic, oleic and linoleic acid were decreased, whereas linolenic acid was increased proportionally.

• 폴리머
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• 제25권1호
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• pp.142-150
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• 2001

그 동안 고무산업 현장에서는 유기용제계 고무 접착제를 사용하여 왔으며 이로인해 품질의 불균일성과 화재위험성 및 인체유해성이 상존하여 왔다. 이를 해결하기 위해 비휘발성, 고인화점인 탄화수소계 원료를 사용하여 새로운 용액을 개발하였으며 이 용액은 인체에 대한 유해성이 매우 적으며 증발이 되지 않으므로 화재위험 및 환경적인 문제를 해결할 수 있었다. 새로운 용액은 기존 제품에 사용되어 온 고무계 binder대신 고무면으로 비휘발성 용제가 침투, 팽윤 현상을 일으켜 고무면 끼리 접착을 유도하는 새로운 개념의 제품이며 접착력 유지 시간이 기존 제품에 비해 현저히 개선되었다. 또한 내구력 면에서도 기존품과 비교할 때 유사한 양상을 보이므로 팽윤 현상으로 인한 물성저하가 나타나지 않았으며 각종 첨가제와도 반응성이 없는 안정한 제품이었다. 기존품의 경우 가교 후 절단면에서 가스로 인한 균열이 발생한 반면 새로운 제품의 경우는 이러한 현상이 발생하지 않았다.

• Restorative Dentistry and Endodontics
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• 제20권1호
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• pp.193-213
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• 1995

The purpose of this study is to investigate a possible contribution of nonspecific esterases, which occur in the oral cavity, to the degradation of ester bonds in polymethacrylates. One of the problems connected with the use of composite resins for restorations is their inadequate resistance to wear. It has been shown that methacrylate hydrolysis can be catalyzed by enzymes and that a carboxylic hydrolase (porcine liver esterase) catalyzed the hydrolysis of several mono - and dimethacrylates. The softening effect on a BISGMA/TEGDMA polymer induced by hydrolase will accelerate the in vivo wear of the polymer. Porcine liver esterase (EC 3.1.1.1) 3.2 mol/L $(NH_4)_2$ $SO_4$ was obtained from Sigma Chemical Company. The esterase activity of one unit is defined as the amount of enzyme capable of hydrolyzing $l{\mu}mol$ ethyl butyrate per min at pH 8.0 AT $25^{\circ}C$. Phosphate buffer, 10mmol/L, pH 7.0, was made by adjustment of a solution of $Na_2HPO_4$ with $H_3PO_4$. Composite resins used in this study are Silux Plus, Z-100, Durafil VS, and Prisma APH. Cylindrical specimens, 14mm in diameter and 3mm thick, of Silux Plus, Z-100, Durafil VS, Prisma APH were polymerized under the celluloid strip. 60 specimens were divided into 2 groups. One group was emersed only in buffer solution, the other group was emersed in buffer and enzyme solution. Silux Plus and Z-100 were divided into 2 subgroups, one subgroup was cured only Visilux 2. And the other subgroup was cured Visilux 2 and Triaid II. Thereafter, specimens were polished to its best achievable surface according to manufacture's directions. The Vickers hardness of the specimens was measured after 1, 2, 4, 7, 9, 15, 50 days. The solutions were changed after each measurement. Composite resin surfaces were evaluated for the surface roughness with profilometer (${\alpha}$-step 200, Tencor instruments, USA) after 1 and 50 days. And then surfaces of specimens were pictured with stereosopy after 1 and 50 days. The results were as follows. 1. The surface hardness of Silux plus, durafil VS, and Prisma APH were decreased with time. But, the surface hardness of Z-100 was not decreased. 2. The surface hardness of all composite resins was decreased by esterase. 3. Composite resins, which were light-cured by Visilux 2 and concomitantly baked by oven, showed more hardened surface than light-cured by Visilux 2 only. 4. Significant surface changes were occured in Silux plus after esterase treatment.

• 한국건설순환자원학회논문집
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• 제2권1호
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• pp.60-65
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• 2014

최근 산업부산물의 재활용과 지구온난화와 같은 환경오염 문제 해결방안으로 알칼리 활성 슬래그(AAS) 콘크리트에 관한 많은 연구가 이루어지고 있다. AAS 콘크리트는 고강도 발현이 가능하며 내구성 또한 우수한 것으로 알려져 있다. 그러나 빠른 알칼리반응으로 인하여 매우 큰 수축이 발생함에도 불구하고 고강도 AAS 콘크리트의 자기수축 거동에 대한 연구는 매우 부족한 실정이다. 따라서, 본 연구에서는 물-결합재비가 0.40, 0.45, 0.50이고 알칼리 활성화제 첨가량이 $Na_2O$=5, 6, 7%인 AAS 모르타르 배합을 실시하여 굳지 않은 모르타르 특성(플로우, 응결시간)과 압축강도, 자기수축을 측정하였다. 실험 결과, 일반 콘크리트에 비해 매우 큰 자기수축이 발생하였고 W/B가 낮고 알칼리 활성화제 첨가량이 많을수록 자기 수축량이 증가하는 것을 알 수 있었다. 따라서 고강도 알칼리 활성 슬래그 콘크리트의 자기 수축을 줄이기 위해서는 수축 저감제의 사용 및 적절한 양생이 필요하다고 판단된다.

• 보존과학회지
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• 제30권1호
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• pp.103-109
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• 2014

본 연구는 토 도기 보존 처리과정에 있어서 결손부위를 복원하는 재료의 문제점과 단점 등을 보완한 재료를 개발하고자 하였다. 우선 기존 재료의 문제점으로는 높은 수축률과 낮은 접착력으로 인한 2 차 파손의 문제, 심한 황변현상으로 인한 이질감의 문제, 재료의 비가역성으로 인한 재용해의 문제 및 높은 강도로 인한 가공성의 문제, 작업 과정 중 긴 경화 시간으로 인한 처짐 현상 및 도구나 장갑에 묻어 유물의 표면을 오염시키는 문제 등이 있다. 이러한 문제점을 해결하기 위해 현재 사용되고 있는 토 도기 복원 재료들 중 Epoxy 수지를 중심으로 종류 및 물성을 파악한 후 개발 목표를 설정하였다. 개발 된 Epoxy는 5 분 내외에 경화가 이루어지는 토기 복원용 Epoxy Putty이다. 토기 복원 방법에 있어서 Epoxy Putty의 경우 페이스트(Paste) 형태로 빠르게 경화되어 작업의 편리성을 높였으며, 표면 오염 등의 단점을 보완하였다. 또한 Epoxy 원액에 백색의 Micro-balloon을 사용함으로 인해 Coloring에 용이하고 경량화하도록 하였으며, 저수축 및 가공성이 우수한 복원 재료를 개발하였다.

• 콘크리트학회논문집
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• 제27권6호
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• pp.641-649
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• 2015

본 연구는 선행연구에서 도출한 다량의 광물질 혼화재를 사용한 고강도 콘크리트(HVMAC)의 내구성을 3성분계 콘크리트(TBC)와 시멘트만 사용한 콘크리트(NC)에 대해서 비교 평가하고자 하였다. 내구성 평가 종류는 염화물 침투 저항성, 동결융해 저항성, 두가지 전처리 조건으로 비교 평가한 탄산화 저항성, 5% 황산($H_2SO_4$), 10% 황산나트륨($Na_2SO_4$) 및 10% 황산마그네슘($MgSO_4$) 용액을 선정하여 황산 및 황산염 저항성 평가를 수행하였다. HVMAC는 모든 재령에서 우수한 염화물 침투 저항성을 나타내었고, 동결융해에 대한 내구성 지수가 100%에 가까운 우수한 결과를 나타내었다. 탄산화 저항성 평가 결과, HVMAC가 TBC보다 저감효과가 있었으며, 양생기간을 증가시켰을 때 콘크리트 내부조직을 치밀하게 만들어 탄산화 저항성을 향상시켰다. 황산 및 황산염 저항성 평가에서 HVMAC가 가장 우수한 것으로 나타났다. 다량의 혼화재 적용에 따른 수산화칼슘 생성량과 $C_3A$가 적어 황산 및 황산염에 의한 열화가 저감된 효과로 강도 감소 및 질량 변화가 작게 나타난 것으로 확인되었다.

• 유기물자원화
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• 제11권2호
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• pp.66-73
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• 2003

석유화학공장폐수 슬러지를 폐석고와 시멘트, fly ash 및 고화제 등을 배합하여 성형하면 시멘트벽돌 및 보통시멘트의 압축강도 기준을 초과함으로 제조된 고화체는 벽돌, 블록, 경량골재, 노반재 등으로 활용이 가능할 것으로 판단되었다. 실험 결과 다음의 결과를 얻었다. 시멘트량을 전체 중량비의 20%인 1.29kg에서 fly ash/슬러지의 배합비의 모든 조건과 시멘트량을 전체 중량비의 15%인 0.9kg에서 fly ash/슬러지의 배합비가 0.31~0.45일 때, 시멘트벽돌 및 보통시멘트의 압축강도 기준을 초과하였다. 제조된 고화체(제품)의 유해성 평가를 위해서 침출수 중의 $Cr^{+6}$, Cu, Zn, Cd, Pb의 용출농도를 실시한 결과 모든 대상시료의 중금속 농도는 배출허용기준치 이내를 유지하여 유해물질로 인한 문제는 없을 것으로 판단되었다. 고화체를 시멘트벽돌 및 보통시멘트에 준해서 활용이 가능한 제조조건에서 제조원가를 조사하였다. 조사결과 자원화시설의 고화체 제조능력을 연간 약 18,000톤을 기준으로 할 때, 총괄원가 및 톤당제조원가는 각각 678,664천원 및 37,704원으로 조사되었다.

• 생명과학회지
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• 제19권1호
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• pp.9-14
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• 2009

전립선암은 현대 남성들에게 걸리기 쉬운 질병으로 나이가 들수록 발병의 위험이 증가하는 질환으로 현재 우리나라에서도 점점 증가하는 추세이다. 전립선암 치료법들은 치료영역이 제한적이고 재발할 가능성이 높아 근본적인 치료법으로는 사용되지는 못하므로 새로운 전립선암 치료 방법이 필요하다. 이에 본 연구에서는 100 여 가지의 한약재 methanol 추출물을 이용하여 MTT 방법으로 전립선암 세포주인 PC-3 세포에 대한 항증식 효과를 탐색하였으며 그 결과, A. sylvestris가 가장 강한 항증식 활성을 보였다. A. sylvestris의 methanol 추출물로부터 저해물질을 분리하기 위하여 100% methanol에서 2-3일 추출하고 난 뒤, ethyl acetate로 추출하고 silica gel, reverse phase-18, Sephadex LH-20 등의 컬럼 크로마토그래피를 이용하여 분리하였다. 최종적으로 활성분획을 HPLC로 분리하고 $4^{\circ}C$에서 methanal 용액에서 입방체 형태의 결정을 얻었으며 NMR 분광법과 이화학적 특성을 분석한 결과, deoxypodophyllotoxin 으로 동정되었다. 순수 분리된 deoxypodophyllotoxin은 전립선암의 세포주 PC-3 세포에서 처리 농도와 처리 시간 의존적인 항증식 효과를 보였다.

• 한국의사학회지
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• 제17권2호
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• pp.111-127
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• 2004

This paper is mainly on the rsearch of the prescriptions of "Sanbeon-bang(刪 繁方)". For the research of prescription, investigated "Sanbeon-bang" from the side of symptoms of a disease, number of drugstuffs, table of contents, drugstuffs and acupuncture and moxibustion. With these investigation, made out a few tables, and with these tables made an attempt to understand the whole prescriptions of "Sanbeon-bang". "Sanbeon-bang" is of rich contents in internal medicine. Among internal medicine, related to Oro-Yukgeuk-Chilsang(五勞-六極-七傷) was most abundant. So we can guess "Sanbeon-bang" was a medical book specialized in exhaustion syndromes. It also deals with the Samcho-syndromes, as investigate from medical comments, has the perfect system of prescription in relative. From the investigation of the combination of drugstuffs, ascertained that, the number of simple prescription composed of one drugstuff was 38, combinational prescription composed of two drugstuffs was 9, minor prescription composed of three to five drugstuffs was 47, midum prescription composed of six to ten drugstuffs was 95, major prescription composed of eleven to twenty drugstuffs was 45, and mixed prescription composed over twenty drugstuffs was 1. Mentionable unique prescriptions in internal use were the forms of keeping in mouth. In external use they were fumigants, suppositories, powdered medicines, spraying the granular medication into the nasal cavity and eyedrops. And were abundant in soft extract(ointment) and plaster. In addition, there were the recordings of 18 types of cellulitis, types of incurable cellulitis and curing an illness by a charm. By the way, when comparing "Sanbeon-bang" with "Cheongeum-bang", all of which was quoted a lot in "Oedaebiyo-bang", "Cheongeum-bang" rather took medical comments of "Sanbeon-bang" than prescription. Although there were some prescriptons in "Sanbeon-bang" at the same category, "Cheongeum-bang" took another prescriptions which are more complexed than those of "Sanbeon-bang". In the same way, when comparing "Cheongeum-bang" with "Sonjinin-Cheongeum-bang(孫眞人千金方)", which didn't go through the correction of GyojeongUiseoguk of Bug-Song goverment, "Cheongeum-bang" often didn't take the prescriptions of "Sonjinin-Cheongeum-bang". Hence we can guess, "Cheongeumyo-bang" may have added a lot of prescriptions when undergoing the correction of of GyojeongUiseoguk. The total number of species of drugstuffs in "Sanbeon-bang" from the investigation was 284. The plant drugs were 208 species, the animal were 31 species, the minerals were 19 species and the other were 26 species. The prescriptions related to acupuncture and moxibustion in "Sanbeon-bang" were only moxibustional prescriptions. Which appeared one time per exhaustion and steaming of bone syndrome, Oro-Yukgeuk-Chilsang and Samcho syndrome. Appeared six times in muscle syndromes. But I cannot imagine the original form of acupuncture and moxibustion in "Sanbeon-bang" for deficiency of data.