• The KIPS Transactions:PartD
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• v.8D no.4
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• pp.305-312
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• 2001

Recently, high-dimensional index structures have been required for similarity search in such database applications s multimedia database and data warehousing. In this paper, we propose a new cell-based signature tree, called CS-tree, which supports efficient storage and retrieval on high-dimensional feature vectors. The proposed CS-tree partitions a high-dimensional feature space into a group of cells and represents a feature vector as its corresponding cell signature. By using cell signatures rather than real feature vectors, it is possible to reduce the height of our CS-tree, leading to efficient retrieval performance. In addition, we present a similarity search algorithm for efficiently pruning the search space based on cells. Finally, we compare the performance of our CS-tree with that of the X-tree being considered as an efficient high-dimensional index structure, in terms of insertion time, retrieval time for a k-nearest neighbor query, and storage overhead. It is shown from experimental results that our CS-tree is better on retrieval performance than the X-tree.

• Mycobiology
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• v.46 no.4
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• pp.388-395
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• 2018

Radionuclides were deposited at forest areas in eastern parts of Japan following the Fukushima Daiichi Nuclear Power Plant incident in March 2011. Ectomycorrhizal (EM) fungi have important effects on radiocaesium dynamics in forest ecosystems. We examined the effect of colonization by the EM fungus Astraeus hygrometricus on the uptake of cesium (Cs) and potassium (K) by Pinus densiflora seedlings. Pine seedlings exhibited enhanced growth after the EM formation due to the colonization by A. hygrometricus. Additionally, the shoot Cs concentration increased after the EM formation when Cs was not added to the medium. This suggests that A. hygrometricus might be able to solubilize Cs fixed to soil particles. Moreover, the shoot K concentration increased significantly after the EM formation when Cs was added. However, there were no significant differences in the root K concentration between EM and non-EM seedlings. These results suggest that different mechanisms control the transfer of Cs and K from the root to the shoot of pine seedlings.

• Journal of The Korean Association of Information Education
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• v.23 no.6
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• pp.655-663
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• 2019

Recent interest in software education has naturally led to interest in computer science. Computer science is the study of theory and principle of computer and computational systems. This knowledge and concept of computer science is fundamental to software education. Recently, "Computer Science (CS) Unplugged", which is an educational method for introducing students to concepts of computer science without using a computer, has been widely used in classes around the world. CS Unplugged is a method for learning the basic principles of computer science through diverse playing activities. The problem, however, is that these CS unplugged activities take place in class without an analysis of how closely they relate to the core subjects learned in real computer science. Therefore, in this study, we will study on the comparison between the core contents of computer science and the core contents of computer science contained in the various activities of CS Unplugged.

• Journal of Korean Society for Quality Management
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• v.50 no.4
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• pp.863-876
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• 2022

Purpose: The purpose of this study is to propose the product quality satisfaction index based on multiple linear regression using customer reviews. Methods: The proposed framework is composed of four steps. First, we collect online reviews and divide it into insight phrases. The insight phrases are classified using product attribute dictionary and sentiment analysis is conducted. Second, the importance of attributes is calculated in consideration of both regression coefficient and frequency. Third, the positive rate is calculated concerning sentiment analysis result. Therefore, the quality satisfaction index is measured by the weighted sum of importance and positive rate in the last step. Results: We conduct a case study using 2-years(2020, 2021) of Samsung TV reviews to confirm the effectiveness of the proposed methodology. As a result, we found that Picture quality is the most crucial attribute in TV evaluation. The importance of Gaming and content has grown up as the positive rate has also increased. Therefore, the overall satisfaction of TV has increased in 2021 compared to 2020. Conclusion: The result of this study shows that the proposed index reveals the customer's mind efficiently and can be explained by the importance and positive rate of each attribute. By using the proposed index, companies are able to improve and the priority of improvement can be determined.

• Journal of Science and Technology Studies
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• v.18 no.2
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• pp.43-93
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• 2018

The concept of citizen science(CS) is defined as "scientific work carried out by citizens." Here, 'citizen' means someone who has knowledge of everyday life, regardless of whether they have formal expertise in a related field. This definition may encompass scientists, as many scientists participate in scientific democracy and use their expertise in a citizen-oriented manner. That work is derived from their citizenship, so their scientific work is CS. CS in Korea has expanded from the Korea Pollution Research Institute, which was founded in 1982, to the Center for Democracy in Science & Technology, which was founded in 1997. Furthermore, in recent years, government agencies have started using CS approach. In this paper, I introduce Korean CS and examine its accomplishments and difficulties through eight cases. I show that Korea's CS activities have made a significant impact on Korean society and the experience of these activities has implications for the future directions of CS. I do so by examining four modes of CS and explore practical messages for more varied roles of CS. Until now CS has been mainly considered in the context of "CS as education" or "CS as movement" in Korea. However, governance and the platform mode of social decision-making or research, though still rare, have recently emerged as additional CS activities. Although it cannot be said with certainty that CS is better, it is undoubtedly better the more varieties of its modes coexist. The four types of CS will contribute individually or complementarily to social learning. Thus, because of its distinctive potential, CS is not exhausted by the supplementary concept of science.

• Archives of Pharmacal Research
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• v.27 no.6
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• pp.662-669
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• 2004

The highly water-soluble monomethoxypoly(ethyleneglycol) (mPEG) prod rugs of cyciosporin A(CsA) were synthesized. These prod rugs were prepared by initially preparing intermediate in the form of carbonate at the 3'-positions of CsA with chloromethyl chloroformate, in the pres-ence of a base to provide a 3'-carbonated CsA intermediate. Reaction of the CsA intermediate with mPEG derivative in the presence of a base provides the desired water-soluble prod rugs. As a model, we chose molecular weight 5 kDa mPEG in the reaction with CsA to give water soluble prodrugs. To prove that the prod rug is decomposed in the body to produce CsA, the enzymatic hydrolysis test was conducted using human liver homogenate at $37^{\circ}C$. The prodrug was decomposed in human liver homogenate to produce the active material, CsA, and the hydrolysis half-life ($t_{1/2}$) of the prodrug, KI-306 was 2.2 minutes at $37^{\circ}C$. However, a demon-stration of non-enzymatic conversion in pH 7.4 phosphate buffer was provided by the fact that the half-life ($t_{1/2}$) is 21 hours at 37$^{\circ}C$. The hydrolysis test in rat whole blood was also conducted. The hydrolysis was seen with half-life ($t_{1/2}$) of about 9.9, 65.0, 14.2, 3.4, 2.1 9.5, and 1.6 minutes for KI-306, 309, 312, 313, 315, 316, and 317, respectively. This is the ideal for CsA prodrug. The pharmacokinetic study of the prodrug, KI-306, in comparison to the commer-cial product (Sandimmune Neoral Solution) was also carried out after single oral dose. Each rat received 7 mg／kg of CsA equivalent dose. Especially, the prodrug KI-306 exhibits higher AUC and $C_{max}$ than the conventional Neoral. The AUC and $C_{max}$ were increased nearly 1.5 fold. The kinetic value was also seen with $T_{max}$ of about 1.43 and 2.44 hours for KI-306 and Neoral, respectively.

• Clean Technology
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• v.23 no.4
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• pp.413-420
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• 2017

The batch experiments and response surface methodology (RSM) have been applied to the investigation of the Cs adsorption with zeolite X synthesized using coal fly ash generated from the thermal power plant. Regression equation formulated for Cs adsorption was represented as a function of response variables. The model was highly relevant because the decision coefficient ($r^2$) was 0.9630. It was confirmed from the statistical results that the removal efficiency of Cs was affected by the order of experimental factors as pH > Cs concentration > temperature. The adsorption kinetics were more accurately represented by a pseudo second-order model. The maximum adsorption capacity calculated from the Langmuir isotherm model was $151.52mg\;g^{-1}$ at 293 K. Also, according to the thermodynamic parameters calculated from Vant Hoff equation, it could be confirmed that the adsorption reaction was an endothermic reaction and a spontaneous process.

• Journal of Soil and Groundwater Environment
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• v.19 no.3
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• pp.1-14
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• 2014

It is necessary to decide the pumping rate and pumping well location together with the capture zone in order to determine an appropriate groundwater remediation strategy to manage the contaminated groundwater. The relationship between the capture zone and the drawdown radius of influence ($ROI_s$) was considered. $ROI_{cs}$ is defined as the distance where the criteria of drawdown is cs meter from pumping well in this paper. A method to decide the required pumping rate for the remediation of contaminated groundwater in order to create appropriate $ROI_{cs}$ is suggested by using the Theis equation (1935) and Cooper-Jacob equation (1946). It was shown in this study that $ROI_{cs}$ is in proportion to the pumping rate and the criteria of drawdown, which decides $ROI_{cs}$, is inversely proportional to Ti value (transmissivity ${\times}$ hydraulic gradient). The pumping rate which creates the required $ROI_{cs}$ could be planned through the relationship between the $ROI_{cs}$ and pumping rates ($ROI_{cs}$-Q curve) of the field sites 1, 2 and 3. If the drawdown is investigated along with Ti value and pumping rate at a specific site where pump and treat remediation is planned, it is expected that the required criteria of drawdown can be evaluated by using the relationship between the cs and Ti (cs-Ti curve).

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.21
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• pp.9529-9534
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• 2014

Background: Cancer staging enables planning for the best treatments, evaluation of prognosis, and predictions for survival. The Collaborative Stage (CS) system makes it possible to significantly reduce the proportion of patients labeled at an "unknown" stage as well as discrepancies among different staging systems. This study aims to analyze the factors that influence the accuracy and validity of CS data. Materials and Methods: Data were randomly selected (233 cases) from stomach cancer cases enrolled for CS survey at the Korea Central Cancer Registry. Two questionnaires were used to assess CS values for each case and to review the cancer registration environment for each hospital. Data were analyzed in terms of the relationships between the time spent for acquisition and registration of CS information, environments relating to cancer registration in the hospitals, and document sources of CS information for each item. Results: The time for extracting and registering data was found to be shorter when the hospitals had prior experience gained from participating in a CS pilot study and when they were equipped with full-time cancer registrars. Evaluation of the CS information according to medical record sources found that the percentage of items missing for Site Specific Factor (SSF) was 30% higher than for other CS variables. Errors in CS coding were found in variables such as "CS Extension," "CS Lymph Nodes," "CS Metastasis at Diagnosis," and "SSF25 Involvement of Cardia and Distance from Esophagogastric Junction (EGJ)." Conclusions: To build CS system data that are reliable for cancer registration and clinical research, the following components are required: 1) training programs for medical records administrators; 2) supporting materials to promote active participation; and 3) format development to improve registration validity.

• Korean Circulation Journal
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• v.48 no.12
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• pp.1135-1144
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• 2018

Background and Objectives: Mitochondria play a key role in the pathophysiology of heart failure and mitochondrial permeability transition pore (MPTP) play a critical role in cell death and a critical target for cardioprotection. The aim of this study was to evaluate the protective effects of cyclosporine A (CsA), one of MPTP blockers, and morphological changes of mitochondria and MPTP related proteins in monocrotaline (MCT) induced pulmonary arterial hypertension (PAH). Methods: Eight weeks old Sprague-Dawley rats were randomized to control, MCT (60 mg/kg) and MCT plus CsA (10 mg/kg/day) treatment groups. Four weeks later, right ventricular hypertrophy (RVH) and morphological changes of right ventricle (RV) were done. Western blot and reverse transcription polymerase chain reaction (RT-PCR) for MPTP related protein were performed. Results: In electron microscopy, CsA treatment prevented MCT-induced mitochondrial disruption of RV. RVH was significantly increased in MCT group compared to that of the controls but RVH was more increased with CsA treatment. Thickened medial wall thickness of pulmonary arteriole in PAH was not changed after CsA treatment. In western blot, caspase-3 was significantly increased in MCT group, and was attenuated in CsA treatment. There were no significant differences in voltage-dependent anion channel, adenine nucleotide translocator 1 and cyclophilin D expression in western blot and RT-PCR between the 3 groups. Conclusions: CsA reduces MCT induced RV mitochondrial damage. Although, MPTP blocking does not reverse pulmonary pathology, it may reduce RV dysfunction in PAH. The results suggest that it could serve as an adjunctive therapy to PAH treatment.