• The KIPS Transactions:PartD
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• v.9D no.6
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• pp.1083-1090
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• 2002

The software development methodology has not caught up with the rapid change of information technology. Most of the software development projects use structural methodology or information engineering methodology. If established software development methodologies don't reflect technologies applied to the project, the project may be performed ineffectively. This paper describes a model in which we can apply a new information technology to an already existed structural methodology or information engineering methodology. This model uses the technique of the divide and conquer that software development life cycle is divided into phases, each phase is divided into viewpoint- areas and the software development processes of a new information technology are applied to each small area. By using the design phase this paper shows application example, in which I applied web-based development processes to CS@RoadMap Methodology of KCC Information & Communication, a system provider in Korea. The CS@RoadMap Methodology reflecting the Web technology, Web@RoadMap Methodology, has been applied to the public-domain projects.

• Journal of Communications and Networks
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• v.18 no.2
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• pp.150-161
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• 2016

Coordinated multi-point transmission (CoMP) techniques are being touted as enabling technologies for interference mitigation in next generation heterogeneous wireless networks (HetNets). In this paper, we present a comparative performance study of uplink (UL) CoMP algorithms for the 3GPP LTE HetNets. Focusing on a distributed and functionally-split architecture, we consider six distinct UL-CoMP algorithms: 1. Joint reception in the frequency-domain (JRFD) 2. Two-stage equalization (TSEQ) 3. Log-likelihood ratio exchange (LLR-E) 4. Symmetric TSEQ (S-TSEQ) 5. Transport block selection diversity (TBSD) 6. Coordinated scheduling with adaptive interference mitigation (CS-AIM) where JRFD, TSEQ, S-TSEQ, TBSD and CS-AIM are our main contributions in this paper, and quantify their relative performances via the post-processing signal-to-interference-plus-noise ratio distributions.We also compare the CoMP-specific front-haul rate requirements for all the schemes considered in this paper. Our results indicate that, with a linear minimum mean-square error receiver, the JRFD and TSEQ have identical performances, whereas S-TSEQ relaxes the front-haul latency requirements while approaching the performance of TSEQ. Furthermore, in a HetNet environment, we find that CS-AIM provides an attractive alternative to TBSD and LLR-E with a significantly reduced CoMP-specific front-haul rate requirement.

• Journal of Convergence for Information Technology
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• v.9 no.8
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• pp.1-8
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• 2019

Dialog system is becoming a new dominant interaction way between human and computer. It allows people to be provided with various services through natural language. The dialog system has a common structure of a pipeline consisting of several modules (e.g., speech recognition, natural language understanding, and dialog management). In this paper, we tackle a task of domain classification for the natural language understanding module by employing machine learning models such as convolutional neural network and random forest. For our dataset of seven service domains, we showed that the random forest model achieved the best performance (F1 score 0.97). As a future work, we will keep finding a better approach for domain classification by investigating other machine learning models.

• Journal of Convergence Society for SMB
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• v.6 no.4
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• pp.151-156
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• 2016

It has been constantly demanding for effective way to improve software development productivity and automation. In this paper, we did research to configure the component assets to reuse design information from the design phase domains based on the DMI. It is necessary abstracted information architecture of an independent platform development environment to reuse design information on the design stage. Also, It should be based on a well-designed to support the design architecture of the application domain. Therefore, in this paper, I want to use the DMI architecture that can be represented by formal level of architectural design information platform and application domain area. It is able to decomposition architecture asset with the part design information from the design phase composition or a high level of abstraction on DMI. Therefore, the metadata structure of the asset architecture will support a structure which can reuse the structure-based design of the domain areas.

• BMB Reports
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• v.30 no.3
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• pp.177-181
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• 1997

We constructed a single-chain immunoglobulin in which the carboxyl end of the heavy chain variable domain is covalently joined to the amino terminus of the light chain variable domain via peptide linker and the carboxyl end of the light chain variable domain is linked to human ${\gamma}1$ Fc region through the hinge region. The molecule was expressed in Chinese hamster ovary cells, assembled into a dimeric molecule and secreted into the culture medium. The dimeric molecule (2E11) was purified from the culture supernatant by affinity chromatography on Protein G-Sepharose column. The size of the unreduced or reduced protein was the expected molecular weight of approximately 120 or 60 kDa, respectively, as assessed by SDS-polyacrylamide gel electrophoresis. The antigen-binding affinity of 2E11 was almost the same as that of a native antibody counterpart (CS131A), suggesting that the single-chain immunoglobulin may function like a native antibody.

• Journal of Convergence for Information Technology
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• v.9 no.9
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• pp.1-12
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• 2019

A dialog system becomes a new way of communication between human and computer. The dialog system takes human voice as an input, and gives a proper response in voice or perform an action. Although there are several well-known products of dialog system (e.g., Amazon Echo, Naver Wave), they commonly suffer from a problem of out-of-domain utterances. If it poorly detects out-of-domain utterances, then it will significantly harm the user satisfactory. There have been some studies aimed at solving this problem, but it is still necessary to study about this intensively. In this paper, we give an overview of the previous studies of out-of-domain detection in terms of three point of view: dataset, feature, and method. As there were relatively smaller studies of this topic due to the lack of datasets, we believe that the most important next research step is to construct and share a large dataset for dialog system, and thereafter try state-of-the-art techniques upon the dataset.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.18 no.2
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• pp.113-121
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• 2005

In order to resolve a common numerical integration inaccuracy of meshfree methods, we introduce an improved natural clement method called Petrov-Galerkin natural element method(PG-NEM). While Laplace basis function is being taken for the trial shape function, the test shape function in the present method is differently defined such that its support becomes a union of Delaunay triangles. This approach eliminates the inconsistency of tile support of integrand function with the regular integration domain, and which preserves both simplicity and accuracy in the numerical integration. In this paper, the validity of the PG-NEM is verified through the representative benchmark problems in 2-d linear elasticity. For the comparison, we also analyze the problems using the conventional Bubnov-Galerkin natural element method(BG-NEM) and constant strain finite clement method(CS-FEM). From the patch test and assessment on convergence rate, we can confirm the superiority of the proposed meshfree method.

• Journal of Life Science
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• v.32 no.3
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• pp.210-221
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• 2022

This study investigated the mechanisms underlying the anti-cancer effects of non-steroidal anti-inflammatory drugs (NSAIDs) in human cancer cells in combination with either N-[N-(3, 5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester (DAPT), a γ-secretase inhibitor, or MHY2245, a new synthetic sirtuin 1 inhibitor. The results showed both DAPT and MHY2245 as novel chemosensitizers of human colon cancer KM12 and human hepatocellular carcinoma SNU475 cells to NSAIDs involving celecoxib and 2, 5-dimethyl celecoxib. The NSAID-induced cytotoxicity of these cells was significantly increased by DAPT and MHY2245 in a cyclooxygenase-2 independent manner. In addition, DAPT and MHY2245 reduced levels of p62, Notch1 intracellular domain, and multiple cancer stemness (CS)-related markers including Notch1, CD44, CD133, octamer-binding transcription factor 4, mutated p53 and c-Myc. However, the level of activating transcription factor 4 (ATF4) was enhanced, probably indicating the down-regulation of multiple CS-related markers by DAPT or MHY2245-mediated autophagy induction. Moreover, the NSAID-mediated reduction of p62/nuclear factor erythroid-derived 2-like 2 and CS-related marker proteins and the up-regulation of C/EBP homologous protein (CHOP)/ATF4 were accelerated by DAPT and MHY2245. As such, the combination of NSAID and either DAPT or MHY2245 resulted in higher cytotoxicity than NSAID alone by accelerating the down-regulation of multiple CS-related markers and PARP activation, indicating that both inhibitors promote NSAID-mediated autophagic cell death, possibly through the CHOP/ATF4 pathway. In conclusion, either combination strategy may be useful for the effective treatment of human cancer cells expressing CS-related markers.

• Journal of Convergence for Information Technology
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• v.9 no.9
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• pp.52-57
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• 2019

DNS stands for 'Domain Name System' and uses IP addresses to identify devices connected to the network on the network. IP is a protocol that registers and manages aliases such as IPs because it is difficult for general users to remember. In recent years, the abuse of such DNS is increasing abroad, and behind the scenes, called 'DNS pionage,' are developing and evolving new rules and malware. DNSpionage attack is abusing DNS system such as Increasing hacking success rate, leading to fake sites, changing or forged data. As a result it is increasing the damage cases. As the global DNS system is expanding to the extent that it is out of control. Therefore, in this research, the countermeasures of DNSpionage attack is proposed to contribute to build a secure and efficient DNS system.

• Nuclear Engineering and Technology
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• v.56 no.2
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• pp.745-752
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• 2024

A method for gamma/neutron event classification based on frequency-domain analysis for mixed radiation environments is proposed. In contrast to the traditional charge comparison method for pulse-shape discrimination, which requires baseline removal and pulse alignment, our method does not need any preprocessing of the digitized data, apart from removing saturated traces in sporadic pile-up scenarios. It also features the identification of neutron events in the detector's full energy range with a single device, from thermal neutrons to fast neutrons, including low-energy pulses, and still provides a superior figure-of-merit for classification. The proposed frequency-domain analysis consists of computing the fast Fourier transform of a triggered trace and integrating it through a simplified version of the transform magnitude components that distinguish the neutron features from those of the gamma photons. Owing to this simplification, the proposed method may be easily ported to a real-time embedded deployment based on Field-Programmable Gate Arrays or Digital Signal Processors. We target an off-the-shelf detector based on a small CLYC (Cs2LiYCl6:Ce) crystal coupled to a silicon photomultiplier with an integrated bias and preamplifier, aiming at lightweight embedded mixed radiation monitors and dosimeter applications.