• The Transactions of the Korean Institute of Electrical Engineers
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• v.41 no.5
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• pp.541-550
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• 1992

The fourth harmonic conversion(FHC) efficiency of high-power Nd laser pulse with wavelength of 1.054x10S0-6Tm using two KDP crystals(doubler adn quadrupler) was simulated numerically. Simulation results show that for the perfect phase-matching condition the FHC efficiency were 60-70% for several hundreds MW/cmS02T class and over 70% for GW/cmS02T class laser pulses. And the overall characteristics of FHC were discussed in terms of effects of input intensity, crystal length, and mismatch angle Δ$\theta$. Optimum method to FHC was type-II doubler & type-I quadrupler KDP crystal because type-II KDP doubler crystal has wide tolerance of acceptance matching-angle.

• Korean Journal of Crystallography
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• v.14 no.2
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• pp.115-121
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• 2003

• Journal of the Korean Graphic Arts Communication Society
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• v.16 no.1
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• pp.1-11
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• 1998

Recently the study of the application of liquid crystal in industrial fields has developed rapidly. It is well known that the encapsulated liquid crystal is advantageous than raw liquid crystal for protection of surface pollution. This paper describes a new class of thermal sensor. It is that the liquid crystal polymer composite(LCPC) films consisting of a continuous LC phase embedded in a three-dimensional network of polymer matrix are formed by photopolymerization-induced phase separation. In this works, it has been demonstrated that consiste of a 8:2 mixture of chiral nematic liquid crystal and HX-620 has the greatest domain and it was best discoloration.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.21 no.1
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• pp.133-143
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• 1997

Piezoelastic materials have recently attracted considerable attention because of their potential use in intelligent structural systems. In this paper, we treat a transient piezothermoelastic problem in a hexagonal plate of crystal class 6mm subjected to antisymmetric heating temperature. We analyze this problem by use of the potential function method. Numerical calculations are carried out for a cadmium selenide solid, and the results are presented graphically in comparison with those derived from the similar problem in a cadmium selenide plate subjected to symmetric heating temperature for a symmetry transient problem.

• 한국초전도학회:학술대회논문집
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• v.13
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• pp.33-33
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• 2003

• Proceedings of the Korea Crystallographic Association Conference
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• 2002.11a
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• pp.4-4
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• 2002

PDZ domains bind to short segments within target proteins in a sequence-specific fashion. GRIP/ABP family proteins contain six to seven PDZ domains and interact via its sixth PDZ domain (class Ⅱ) with the C-termini of various proteins, including liprin-α. In addition the PDZ456 domain mediates the formation of homo- and heteromultimers of GRIP proteins. To better understand the structural basis of peptide recognition by a class Ⅱ PDZ domain and DZ-mediated multimerization, we determined the crystal structures of the GRIPI PDZ6 domain, alone and in complex with a synthetic C-terminal octapeptide of human liprin-α, at resolutions of 1.5 Å and 1.8 Å, respectively. Remarkably, unlike other class Ⅱ PDZ domains, Ile736 at αB5 rather than conserved Leu732 at αB1 makes a direct hydrophobic contact with the side chain of the Tyr at the -2 position of the ligand. Moreover, the peptide-bound structure of PDZ6 shows a slight reorientation of helix αB, indicating that the second hydrophobic pocket undergoes a conformational adaptation to accommodate the bulkiness of the Tyr's side chain, and forms an antiparallel dimer through an interface located at a site distal to the peptide-binding groove. This configuration may enable formation of GRIP multimers and efficient clustering of GRIP-binding proteins.

• Bulletin of the Korean Chemical Society
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• v.33 no.11
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• pp.3875-3878
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• 2012

• Proceedings of the Materials Research Society of Korea Conference
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• 1998.08a
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• pp.56.1-56
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• 1998

• Journal of the Korean Chemical Society
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• v.62 no.5
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• pp.352-357
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• 2018

Celecoxib (4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide) is a cyclooxygenase-2 inhibitor used in the treatment of arthritis, acute pain, and dysmenorrhoea. Celecoxib is a Biopharmaceutics Classification System (BCS) class II compound whose oral bioavailability is highly limited owing to its poor aqueous solubility. Several polymorphs of celecoxib have been identified as Form I, Form II, and Form III with melting points of about $162.8^{\circ}C$, $161.5^{\circ}C$, and $160.8^{\circ}C$, respectively. Form IV was generated from the precipitated suspension in the presence of HPMC (Hydroxypropyl methylcellulose) and Polysorbate 80. A rapid rate of dissolution is useful because the rate of dissolution of a drug typically increases its bioavailability. The aim of this study was to investigate the possibility of production of new crystal form of celecoxib that has higher solubility than Form III. New crystal form of celecoxib (Form A) has been isolated by recrystallization and characterized by differential scanning calorimetry (DSC), thermogravimetric (TG) analysis and powder X-ray diffractometry (PXRD). Form A was dissolved faster than Form III. At 30 minutes, the dissolution of Form A was 97.3%, whereas the dissolution of Form III was 82.2% (p < 0.1). After storage of three months at $20^{\circ}C$, in 24% RH (Relative Humidity), the crystal form was not transformed.

• Molecules and Cells
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• v.43 no.9
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• pp.831-840
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• 2020

The β-class of carbonic anhydrases (β-CAs) are zinc metalloenzymes widely distributed in the fungal kingdom that play essential roles in growth, survival, differentiation, and virulence by catalyzing the reversible interconversion of carbon dioxide (CO₂) and bicarbonate (HCO₃^-). Herein, we report the biochemical and crystallographic characterization of the β-CA CafA from the fungal pathogen Aspergillus fumigatus, the main causative agent of invasive aspergillosis. CafA exhibited apparent in vitro CO₂ hydration activity in neutral to weak alkaline conditions, but little activity at acidic pH. The high-resolution crystal structure of CafA revealed a tetramer comprising a dimer of dimers, in which the catalytic zinc ion is tetrahedrally coordinated by three conserved residues (C119, H175, C178) and an acetate anion presumably acquired from the crystallization solution, indicating a freely accessible "open" conformation. Furthermore, knowledge of the structure of CafA in complex with the potent inhibitor acetazolamide, together with its functional intolerance of nitrate (NO₃^-) ions, could be exploited to develop new antifungal agents for the treatment of invasive aspergillosis.