• Journal of Applied Biological Chemistry
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• v.65 no.1
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• pp.49-55
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• 2022

Biorenovation is a method for converting materials using the enzyme properties of microorganisms. Natural products converted by that method increase physiological activity or reduce cytotoxicity. In this study, we investigated the anti-inflammatory activity of crypsinus hastatus prothallium (CH) and biorenovated CH prothallium (CHB) using RAW 264.7 cells stimulated with lipopolysaccharide (LPS). CHB inhibited the production of nitric oxide, prostaglandin E₂ and cytokines (interleukin-6, interleukin-1β, tumor necrosis factor-α) compared to CH at a concentration of 50-200 ㎍/mL. In addition, CHB concentration of 200 ㎍/mL inhibited the expression of inducible nitric oxide synthase and cyclooxygenase-2 protein by LPS stimulation to the level of the untreated control group. These results indicate that CHB could be a novel anti-inflammatory agent for cosmetic and pharmaceutical ingredients.It also suggests that the application of biorenovation has potential usefulness in developing anti-inflammatory materials. It also suggests that the application of bio-renovation has potential usefulness in the development of inflammatory material. We applied Biorenovation technology to Distylium racemosum extract (DR) to generate Distylium racemosum biorenovation product (DRB), and investigated the anti-inflammatory properties of DRB in lipopolysaccharide (LPS)-treated RAW264.7 macrophages. We are applying technology to Biorenovation Distylium racemosum extract (DR) Distylium racemosum was to create a biorenovation product (DRB), lipopolysaccharide (LPS) investigated the anti-inflammatory properties of DRB in RAW264.7 macrophages treated for.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.16 no.1
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• pp.109-130
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• 2013

This study is to offer the raw data for conservation and restoration of national park by surveying and analysing the vascular plants in the Gayasan national park. The flora were summarized as 102 families, 328 genera, 469 species, 4 subspecies, 59 varieties and 9 forms. The endangered plants designated by Ministry of Environment were 2 taxa; Pedicularis hallaisanensis Hurus. and Gymnadenia conopsea for. albiflora Y.N.Lee. The rare plants designated by Korea Forest Service were 13 taxa; Crypsinus hastatus (Thunb.) Copel., Ligusticum tachiroei (Franch. & Sav.) M. Hiroe & Constance, Primula modesta var. fauriae (Franch.) Takeda, Lilium distichum Nakai ex Kamibay and so forth. The korean endemic plants were 15 taxa; Betula ermanii Cham., Carpinus laxiflora (Siebold & Zucc.) Blume, Stewartia pseudocamellia Maxim., Galium koreanum (Nakai) Nakai, Heloniopsis koreana Fuse, N.S. Lee & M.N. Tamura and so forth. The specific plants by floristic region were 66 taxa; Betula chinensis Maxim., Spiraea fritschiana Schneid., Vaccinium hirtum var. koreanum (Nakai) Kitam., Cimicifuga heracleifolia Kom., Adoxa moschatellina L. and so forth. The plants with approval for delivering oversea were 22 taxa; Salix hallaisanensis H.L$\acute{e}$v., Sanguisorba argutidens Nakai, Viola albida Palib., Weigela subsessilis (Nakai) L.H.Bailey and so forth. The naturalized plants were 30 taxa; Chenopodium album L., Lepidium apetalum Willd., Trifolium pratense L., Bidens frondosa L., Helianthus tuberosus L. and so forth.

• Korean Journal of Plant Taxonomy
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• v.39 no.4
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• pp.277-291
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• 2009

The flora in the region of Songnisan National Park ($N36^{\circ}28^{\prime}05^{{\prime}{\prime}}{\sim}36^{\circ}46^{\prime}38^{{\prime}{\prime}}$, $E\;127^{\circ}47^{\prime}06^{{\prime}{\prime}}{\sim}127^{\circ}57^{\prime}50^{{\prime}{\prime}}$) was surveyed from April 2000 to July 2006. Vascular plants in 26 collections included a total of 723 taxa: 115 families, 392 genera, 629 species, 4 subspecies, 72 varieties and 18 forms. Ninety-three of these taxa were first records for the region. In the flora of Songnisan National Park, 27 taxa were Korean endemic plants, 19 taxa were rare and endangered plants as designated by the Korea Forest Service. Forty-five of the taxa were with the levels III, IV, V in the floristic regional indicator plants which was designated by Korean Ministry of Environment, and 29 taxa were alien plants now naturalized in Korea. Owing to their unusual phytogeography and low number of populations, the taxa Crypsinus hastatus (Thunb.) Copel., Paeonia japonica (Makino) Miyabe & Takeda, Jeffersonia dubia (Maxim.) Benth. & Hook.f. ex Baker & S.Moore, Bupleurum euphorbioides Nakai, Phacellanthus tubiflorus Siebold & Zucc., Lilium cernuum Kom., Gastrodia elata Blume and Cephalanthera erecta var. subaphylla (Miyabe & Kud ) Ohwi were considered the most important. Based on these results, it is clear that appropriate plans to conserve the natural habitat of Songnisan National Park must be made immediately.