• Title/Summary/Keyword: Cross-sensitivity

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Technical review of discrimination method between strain and temperature on the FBG sensor (FBG 센서의 온도와 변형률 동시 측정기법 기술 분석)

  • Yoon, Hyuk-Jin
    • Proceedings of the KSR Conference
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    • 2008.11b
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    • pp.574-583
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    • 2008
  • FBG(Fiber Bragg grating)s have shown a great potential for sensing applications, and are easily embedded in materials with a negligible impact on the mechanical properties of the host. However, the use of FBG sensors is limited by their simultaneous dependence on strain and temperature, thus only one parameter can be determined from a single grating. This paper reviews various methods to discriminate between strain and temperature effects. To overcome this cross sensitivity using only embedded optical fibers, a number of techniques have been proposed, most of them relying on the deconvolution of two simultaneous measurements.

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Guidance for the Evaluation Method of Drugs of Abused in vitro Diagnostic Devices

  • Kang, Shin-Jung;Choi, Hyun-Ceol;Kim, Ho-Jeong;Park, Sang-Aeh;Chug, Hee-Sun
    • Proceedings of the PSK Conference
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    • 2003.04a
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    • pp.291.1-291.1
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    • 2003
  • The purpose of this study is to provide KFDA's guidance for premarket notification submission and labeling for prescription use drugs of abuse in vitro diagnostic devices. To evaluate in vitro diagnostic devices the following performance characteristics should be described in detail within the submission: analytical sensitivity or minimum detection limit, cutoff concentration, specificity and cross reactivity, interference, precision, method comparison and stability. (omitted)

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Clinical Evaluation of a Rapid Diagnostic Test Kit for Canine Parvovirus and Coronavirus (개 파보바이러스와 코로나바이러스 진단을 위한 신속진단키트의 임상적 유용성)

  • Chaeyeong MIN;Won-Shik KIM;Chom-Kyu CHONG;Yong LIM
    • Korean Journal of Clinical Laboratory Science
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    • v.55 no.1
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    • pp.45-51
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    • 2023
  • Canine parvovirus type 2 (CPV-2) and canine coronavirus (CCoV) are major pathogens that can induce gastroenteritis in dogs. They are highly contagious and have a high morbidity rate. There are no specific treatments available for them to date. Therefore, rapid and accurate diagnosis becomes essential. The rapid diagnostic test (RDT) for animals can be used widely in the field because it is fast and easy to use for diagnosis. Thus, this study aimed to clinically evaluate and confirm the clinical utility of CPV-2/CCoV RDT. The parameters evaluated included the limit of detection (LoD), cross-reactivity, interference, sensitivity, specificity, negative likelihood ratio (NLR), and kappa value. The results revealed that the LoD values for CPV-2 and CCoV were 9.7×10 50% tissue culture infectious dose (TCID50)/mL and 2.5×102 TCID50/mL, respectively. There was no cross-reactivity with nine pathogens or interference by interfering materials. The RDT showed a sensitivity of 90.0%, a specificity of 100.0%, NLR of 0.1, and a kappa value of 0.90 for diagnosing both viruses. In conclusion, CPV-2/CCoV RDT is useful as a screening test because of its high sensitivity, specificity, kappa value, and low NLR.

A New Coloured Substrate for the Determination of $\beta$-Glucan Degrading Enzyme from Malt and Bacillus subtilis K-4-3 (맥아와 Bacillus subtilis B-4-3의 $\beta$-Glucan 분해 효소측정을 위한 새로운 색소기질)

  • 이성택
    • Microbiology and Biotechnology Letters
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    • v.16 no.2
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    • pp.79-84
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    • 1988
  • Dye materials and cross linking agents were used for the determination of $\beta$-glucanase activities. The objective of this study was to prepare the blue coloured substrates which are sensitive, specific and simple for the determination of $\beta$-glucanase in malt and Bacillus subtilis K-4-3 enzymes. This method is based on the principle of measuring colorimetrically the split product of coloured and cross linked substrate. The best coupling of dye stuff of $\beta$-glucan was cibacron blue 3G-A and the colour released can suitably be measured at 623nm. Optimal concentration of dye and cross linking agents was 1.5g and 1.25$m\ell$ under 0.1N NaOH. The sensitivity comparison proved that the stained $\beta$-glucan method is much more sensitive than the DNS method to determine reducing sugar released by the enzyme.

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Effects of olfactory self- and cross-adaptation on perceiving odor in a moth

  • Qian, Kai;Chen, Haibin;Wan, Xinlong
    • International Journal of Industrial Entomology and Biomaterials
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    • v.32 no.2
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    • pp.60-68
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    • 2016
  • Pheromone orientation in moths is an exemplar of olfactory sensitivity. To avoid cross mating, the responses of males to pheromone blends must be high specificity and temporal resolution. We tested the effects of olfactory self- and cross-adaptation of pheromone compounds and mixtures in Spodoptera litura moths by electroantennogram (EAG) recordings. The challenge of S. litura antennae to a pulse train of its own pheromone blends of Z9,E11-14:OAc and Z9,E12-14:OAc with 200 ms on/off and 1 s on/off indicated that the repetitive stimulation by 200 ms on/off with high dosages resulted in greater adaptation than that by 1 s on/off with low dosages and the adaptation index of Z9,E11-14:OAc in all treatments is significantly larger than that of Z9,E12-14:OAc, suggesting that high dosages with more frequent stimulation prefer to induce sensory adaptations and a different odor coding exist between the two components in the antennal periphery in this moth. The cross-adaptation EAG test among the two pheromone compounds and Z7-12:OAc and Z9-14:OH from congeneric species of S. litura showed that each of these compounds adapted the antenna more to that specific compound. The significantly higher adaptation to Z7-12:OAc and Z9-14:OH than to the pheromone components of S. litura induced by themselves suggested that both of them are coded by specific odor receptor neurons which are different from those tuned to the pheromone components of S. litura . Thus, we proposed that Z7-12:OAc and Z9-14:OH may play an important role in avoidance of heterospecific mating between S. litura and its sympatric moth species.

Correctum : Effects of olfactory self- and cross-adaptation on perceiving odor in a moth

  • Qian, Kai;Chen, Haibin;Wan, Xinlong
    • International Journal of Industrial Entomology and Biomaterials
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    • v.33 no.2
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    • pp.149-149
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    • 2016
  • Pheromone orientation in moths is an exemplar of olfactory sensitivity. To avoid cross mating, the responses of males to pheromone blends must be high specificity and temporal resolution. We tested the effects of olfactory self-and cross-adaptation of pheromone compounds and mixtures in Spodoptera litura moths by electroantennogram (EAG) recordings. The challenge of S. litura antennae to a pulse train of its own pheromone blends of Z9,E11-14:OAc and Z9,E12-14:OAc with 200 ms on/off and 1 s on/off indicated that the repetitive stimulation by 200 ms on/off with high dosages resulted in greater adaptation than that by 1 s on/off with low dosages and the adaptation index of Z9,E11-14:OAc in all treatments is significantly larger than that of Z9,E12-14:OAc, suggesting that high dosages with more frequent stimulation prefer to induce sensory adaptations and a different odor coding exist between the two components in the antennal periphery in this moth. The cross-adaptation EAG test among the two pheromone compounds and Z7-12:OAc and Z9-14:OH from congeneric species of S. litura showed that each of these compounds adapted the antenna more to that specific compound. The significantly higher adaptation to Z7-12:OAc and Z9-14:OH than to the pheromone components of S. litura induced by themselves suggested that both of them are coded by specific odor receptor neurons which are different from those tuned to the pheromone components of S. litura. Thus, we proposed that Z7-12:OAc and Z9-14:OH may play an important role in avoidance of heterospecific mating between S. litura and its sympatric moth species.

Establishment of DeCART/MIG stochastic sampling code system and Application to UAM and BEAVRS benchmarks

  • Ho Jin Park;Jin Young Cho
    • Nuclear Engineering and Technology
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    • v.55 no.4
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    • pp.1563-1570
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    • 2023
  • In this study, a DeCART/MIG uncertainty quantification (UQ) analysis code system with a multicorrelated cross section stochastic sampling (S.S.) module was established and verified through the UAM (Uncertainty Analysis in Modeling) and the BEAVRS (Benchmark for Evaluation And Validation of Reactor Simulations) benchmark calculations. For the S.S. calculations, a sample of 500 DeCART multigroup cross section sets for two major actinides, i.e., 235U and 238U, were generated by the MIG code and covariance data from the ENDF/B-VII.1 evaluated nuclear data library. In the three pin problems (i.e. TMI-1, PB2, and Koz-6) from the UAM benchmark, the uncertainties in kinf by the DeCART/MIG S.S. calculations agreed very well with the sensitivity and uncertainty (S/U) perturbation results by DeCART/MUSAD and the S/U direct subtraction (S/U-DS) results by the DeCART/MIG. From these results, it was concluded that the multi-group cross section sampling module of the MIG code works correctly and accurately. In the BEAVRS whole benchmark problems, the uncertainties in the control rod bank worth, isothermal temperature coefficient, power distribution, and critical boron concentration due to cross section uncertainties were calculated by the DeCART/MIG code system. Overall, the uncertainties in these design parameters were less than the general design review criteria of a typical pressurized water reactor start-up case. This newly-developed DeCART/MIG UQ analysis code system by the S.S. method can be widely utilized as uncertainty analysis and margin estimation tools for developing and designing new advanced nuclear reactors.

Comparative Studies on Serological Tests for Actinobacillus pleuropneumoniae Infection in Swine (돼지에서 Actinobacillus pleuropneumoniae의 혈청학적 진단법에 대한 비교연구)

  • 심항섭;우종태;조중현;전무형
    • Korean Journal of Veterinary Service
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    • v.17 no.2
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    • pp.95-113
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    • 1994
  • To establish an effective diagnostic measure for detection of the antibodies against Actinobacillus pleuropneumoniae, the methods for tube agglutination test (TAT), plate agglutination test (PAT), micro-agglutination test(MAT) and agar-gel immunodiffusion test(ID) were improved and standarized, and the comparative studies were carried out. The results obtained through the experiments were summarized as follows. 1. The rabbit hyperimmune sera to reference serotypes 1 to 6 were cross-tested with TAT, PAT, MAT and ID. In the homologous systems, the range of antibody titers in TAT was 80 to 640, showing the cross-reaction in serotypes 3, 4, 5 and 6. The range of antibody titers in PAT was 4 to 64, showing the cross-reaction in serotypes 3, 4, 5 and 6. In ID, the range of antigen titers was 8 to 32, and cross-reaction was observed in serotype 5. 2. The optimal concentration of antigen in PAT and MAT were 100mg /ml and 1.25mg /ml respectively. The most sensitive reaction in MAT was observed in 52$^{\circ}C$ for 18hrs. 3. In ID, the most promising antigen and the buffer for agar-gel were EDTA-treated antigen and 0.05M tris buffer (pH 7.2), respectively. 4. By the tests for 200 swine sera, it was found that the frequency of positive reaction were 203 in TAT, 240 in PAT and 163 in ID. 5. When compared the titers of TAT with those of MAT for 200 swine sera, MAT showed the higher titer than TAT being increased by relative correlation. Int was found that the titer for positive readings were 20 in TAT and 40 in MAT. 6. when compared the results of ID with those of TAT for 200 swine sera, all sera with TAT titer under 10 were negative in ID. Of the sera with TAT titer 20 and 40, 55.1% nd 91.8% were positive in ID, respectively. All sera with TAT titer above 80 were positive in ID. In comparison of ID and MAT, all sera with MAT titer under 20 were negative in ID. Of the sera with MAT titer 40 and 80, 24.7% and 93.9% were positive in ID, respectively. All sera with MAT titer over 160 showed positive in ID. 7. In conclusion, the established MAT showed high sensitivity but low specificity, wherease ID revealed low sensitivity but high specificity.

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PRINCIPAL COMPONENTS BASED SUPPORT VECTOR REGRESSION MODEL FOR ON-LINE INSTRUMENT CALIBRATION MONITORING IN NPPS

  • Seo, In-Yong;Ha, Bok-Nam;Lee, Sung-Woo;Shin, Chang-Hoon;Kim, Seong-Jun
    • Nuclear Engineering and Technology
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    • v.42 no.2
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    • pp.219-230
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    • 2010
  • In nuclear power plants (NPPs), periodic sensor calibrations are required to assure that sensors are operating correctly. By checking the sensor's operating status at every fuel outage, faulty sensors may remain undetected for periods of up to 24 months. Moreover, typically, only a few faulty sensors are found to be calibrated. For the safe operation of NPP and the reduction of unnecessary calibration, on-line instrument calibration monitoring is needed. In this study, principal component-based auto-associative support vector regression (PCSVR) using response surface methodology (RSM) is proposed for the sensor signal validation of NPPs. This paper describes the design of a PCSVR-based sensor validation system for a power generation system. RSM is employed to determine the optimal values of SVR hyperparameters and is compared to the genetic algorithm (GA). The proposed PCSVR model is confirmed with the actual plant data of Kori Nuclear Power Plant Unit 3 and is compared with the Auto-Associative support vector regression (AASVR) and the auto-associative neural network (AANN) model. The auto-sensitivity of AASVR is improved by around six times by using a PCA, resulting in good detection of sensor drift. Compared to AANN, accuracy and cross-sensitivity are better while the auto-sensitivity is almost the same. Meanwhile, the proposed RSM for the optimization of the PCSVR algorithm performs even better in terms of accuracy, auto-sensitivity, and averaged maximum error, except in averaged RMS error, and this method is much more time efficient compared to the conventional GA method.

Sensitivity Analysis of Polarimetric Observations by Two Different Pulse Lengths of Dual-Polarization Weather Radar (펄스길이에 따른 이중편파변수의 민감도 분석)

  • Lee, Jeong-Eun;Jung, Sung-Hwa;Kim, Jong-Seong;Jang, KunIl
    • Atmosphere
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    • v.29 no.2
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    • pp.197-211
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    • 2019
  • The observational sensitivity of dual-polarization weather radar was quantitatively analyzed by using two different pulse widths. For this purpose, test radar scan strategy which consisted of consecutive radar scan using long (LP: $2{\mu}s$) and short (SP: $1{\mu}s$) pulses at the same elevation angle was employed. The test scan strategy was conducted at three operational S-band dual-polarization radars (KSN, JNI, and GSN) of Korea Meteorological Administration (KMA). First, the minimum detectable reflectivity (MDR) was analyzed as a function of range using large data set of reflectivity ($Z_H$) obtained from JNI and GSN radars. The MDR of LP was as much as 7~22 dB smaller than that of SP. The LP could measure $Z_H$ greater than 0 dBZ within the maximum observational range of 240 km. Secondly, polarimetric observations and the spatial extent of radar echo between two pulses were compared. The cross-polar correlation coefficient (${\rho}_{hv}$) from LP was greater than that from SP at weak reflectivity (0~20 dBZ). The ratio of $Z_H$ (> 0 dBZ) and ${\rho}_{hv}$(> 0.95) bin to total bin calculated from LP were greater than those from SP (maximum 7.1% and 13.2%). Thirdly, the frequency of $Z_H$ (FOR) during three precipitation events was analyzed. The FOR of LP was greater than that of SP, and the difference in FOR between them increased with increasing range. We conclude that the use of LP can enhance the sensitivity of polarimetric observations and is more suitable for detecting weak echoes.