• 제목/요약/키워드: Cross-over trials

검색결과 36건 처리시간 0.026초

청감실험을 통한 철도소음의 자율신경 및 심혈관계통 영향도 연구 (The Research of Railway Noise through Auditory Experiments Focused on the Autonomic Nervous System and Cardiovascular System)

  • 이재관;윤은선;장채미;제세영;장서일
    • 한국소음진동공학회논문집
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    • 제26권6_spc호
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    • pp.674-679
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    • 2016
  • According to the conventional studies on the noise and cardiovascular effect, railway noise is better associated with hypertension and adverse cardiovascular events than road traffic noise. But the underlying mechanisms remain unclear. We investigated the hypothesis that exposure to acute railway noise would the unfavorable effect of cardiovascular and autonomic system in healthy young subjects. Using a randomized, sham-controlled cross-over design, ten subjects were assigned to receive either an exposure to high speed train noise (84 dB) for 30 minutes or a control condition (non noise), separated by two days. Blood pressure, heart rate, augmentation index and heart rate variability as indices of cardiovascular and autonomic system function were measured at baseline, during, and recovery from two trials. The results show that exposure to acute railway noise significantly increased diastolic blood pressure and augmentation index, which may cause of adverse cardiovascular effects.

The Effect of Elastic Tape on Lower Extremity Muscle Activity in Squats of Young Female Adults: A Cross-sectional Pilot Study

  • Namjeong Cho;Yangrae Kim
    • 한국전문물리치료학회지
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    • 제30권3호
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    • pp.169-173
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    • 2023
  • Background: In terms of physical performance, elastic tape (ET) is known to contribute to injury prevention and performance enhancement. Objects: This study aimed to compare and analyze the effect on lower extremity muscle activity of young adult women with and without ET during squats. Methods: In this study, six healthy, young women were recruited as participants in a university laboratory. Participants were allocated to two groups of three after measuring muscle activity in a pre-test, and the experiment was conducted for a total of two weeks (two sessions). First, 10 half squats were taped once in the first week, and 10 half squats were performed without taping in the second week. The other group did this in reverse and measured muscle activity after the squat was over. Results: As a result of this study, there was no significant difference in the quadriceps with or without ET (Z = -0.11, p > 0.05). Similarly, no significant difference was found in hamstring (Z = -0.31, p > 0.05). Conclusion: No beneficial effect was found on changes in muscle activity following ET application during squats. Further studies require randomized controlled trials that increase the number of participants and the intensity of the intervention, and measure pain, function, and performance rather than muscle properties depending on the biomechanical lifting mechanism.

Mid-infrared (MIR) spectroscopy for the detection of cow's milk in buffalo milk

  • Anna Antonella, Spina;Carlotta, Ceniti;Cristian, Piras;Bruno, Tilocca;Domenico, Britti;Valeria Maria, Morittu
    • Journal of Animal Science and Technology
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    • 제64권3호
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    • pp.531-538
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    • 2022
  • In Italy, buffalo mozzarella is a largely sold and consumed dairy product. The fraudulent adulteration of buffalo milk with cheaper and more available milk of other species is very frequent. In the present study, Fourier transform infrared spectroscopy (FTIR), in combination with multivariate analysis by partial least square (PLS) regression, was applied to quantitatively detect the adulteration of buffalo milk with cow milk by using a fully automatic equipment dedicated to the routine analysis of the milk composition. To enhance the heterogeneity, cow and buffalo bulk milk was collected for a period of over three years from different dairy farms. A total of 119 samples were used for the analysis to generate 17 different concentrations of buffalo-cow milk mixtures. This procedure was used to enhance variability and to properly randomize the trials. The obtained calibration model showed an R2 ≥ 0.99 (R2 cal. = 0.99861; root mean square error of cross-validation [RMSEC] = 2.04; R2 val. = 0.99803; root mean square error of prediction [RMSEP] = 2.84; root mean square error of cross-validation [RMSECV] = 2.44) suggesting that this method could be successfully applied in the routine analysis of buffalo milk composition, providing rapid screening for possible adulteration with cow's milk at no additional cost.

식용 자색고구마 신품종 '연자미' (A New Purple Sweetpotato Cultivar for Table Use 'Yeonjami')

  • 이준설;안영섭;정미남;김학신;정광호;방진기;송연상;심형권;한선경;서세정
    • 한국육종학회지
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    • 제42권6호
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    • pp.679-683
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    • 2010
  • '연자미'는 국립식량과학원 바이오에너지작물센터에서 2008년에 육성한 식용 자색고구마 신품종으로 주요 특성과 수량성을 요약하면 다음과 같다. 1. 넝쿨길이는 284cm로 길며. 넝쿨색은 녹자색, 잎모양은 심장형, 잎색은 녹색을 띤다. 또한 잎뒷면의 엽맥색은 녹색으로 자색을 포함하지 않으며, 끝잎색은 녹색, 잎자루색은 녹색이다. 2. 괴근 모양은 장방추형으로 껍질색은 자색을 띤다. 육색은 대조품종 '신자미'가 농자색인데 비하여 자색이다. 상품성을 좌우하는 표피의 형태는 골파짐이 없이 메끄럽다. 3. 토양 병해충에 대한 저항성을 조사한 결과 대조품종인 '신자미'에 비하여 선충 및 덩굴쪼김병은 중강, 검은썩음병과 연부병도 중강을 나타낸다. 또한 저장 중 부패율은 4.2%로 저장성이 강하다. 4. 품질특성은 '신자미'에 비하여 식미가 우수하다. 육질은 중간질이며 당도가 15.3 $Brix^{\circ}$로 '신자미'보다 높다. 폴리페놀함량 및 항산화활성이 높아 기능성이 우수하다. 5. 수량은 조기재배의 경우 26.9 t/ha으로 '신자미'에 비하여 108%로 수량이 증수된다. 만기 및 적기재배는 25.9 t/ha으로 '신자미' 대비 115%로 수량이 높다.

네트워크 분석을 통한 국내 변증 연구의 동향 (Research Trends of Pattern Identification of Korean Medicine Using the Network Analysis)

  • 진희정;이재철;장은수
    • 한국콘텐츠학회논문지
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    • 제14권12호
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    • pp.1037-1046
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    • 2014
  • 본 연구는 네트워크 분석을 통해 국내 '변증' 연구의 동향을 살펴보기 위한 것이다. 분석은 년간 논문 수, 저널별 논문 수, 연구 분류별 논문 수 등을 살펴보았으며, 네트워크 분석은 키워드 쌍을 사용하여 수행하였다. OASIS(Oriental Medicine Advanced Searching Integrated System) 시스템에서 검색한 810건의 논문 중에서 368건의 논문을 분석에 사용하였다. 결과적으로, 최근 10년간 변증 관련 논문은 증가하였으며, "Korean journal of oriental physiology & pathology" 저널과 "Journal of korean oriental internal medicine" 저널이 변증관련 가장 많은 논문을 출판하였다. 연구 분류별로 살펴보면, 단면연구가 144편으로 가장 많았고, 환자 사례보고가 71편이었다. 무작위임상시험의 경우에는 단지 3편의 논문만이 있었다. 변증연구에서는 troke, pattern analysis, blood stasis 키워드가 많이 주요 네트워크를 이루었다.

Effects of mobile texting and gaming on gait with obstructions under different illumination levels

  • Cha, Jaeyun;Kim, Hyunjin;Park, Jaemyoung;Song, Changho
    • Physical Therapy Rehabilitation Science
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    • 제4권1호
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    • pp.32-37
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    • 2015
  • Objective: This study was conducted to test the effects of mobile texting and gaming on gait with obstructions under different illumination levels. Design: Cross-sectional study. Methods: Twelve healthy adults aged 20 to 36 years (mean 23.5 years) were tested under six different conditions. All participants used touchscreen smartphones. Testing conditions included: 1) Walking with an obstruction under a bright illumination level; 2) walking with an obstruction with a low level of illumination; 3) walking with an obstruction while texting under a bright illumination level; 4) walking with an obstruction while texting with a low level of illumination; 5) walking with an obstruction while gaming under a bright illumination level; and 6) walking with an obstruction while gaming with a low level of illumination. All participants were asked to text the Korean national anthem by their own phone and play Temple Run 2 using an iPhone 5. Gait variances were measured over a distance of 3 m, and the mean value after three trials was used. A gait analyzer was used to measure the data. Results: Compared to normal gait with obstruction, gait speed, step length, stride length, step time, stride time, cadence while texting and gaming showed significant differences (p<0.05). Differences between the illumination levels included gait speed, step length, stride length, and step time (p<0.05) with no significant differences in stride time and cadence. Conclusions: Dual-tasking using a smartphone under low levels of illumination lowers the quality of gait with obstructions.

Daily walnut intake improves metabolic syndrome status and increases circulating adiponectin levels: randomized controlled crossover trial

  • Hwang, Hyo-Jeong;Liu, Yanan;Kim, Hyun-Sook;Lee, Heeseung;Lim, Yunsook;Park, Hyunjin
    • Nutrition Research and Practice
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    • 제13권2호
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    • pp.105-114
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    • 2019
  • BACKGROUND/OBJECTIVES: Several previous studies have investigated whether regular walnut consumption positively changes heart-health-related parameters. The aim of this study was to investigate the effects of daily walnut intake on metabolic syndrome (MetS) status and other metabolic parameters among subjects with MetS. SUBJECTS/METHODS: This study was a two-arm, randomized, controlled crossover study with 16 weeks of each intervention (45 g of walnuts or iso-caloric white bread) with a 6 week washout period between interventions. Korean adults with MetS (n = 119) were randomly assigned to one of two sequences; 84 subjects completed the trial. At each clinic visit (at 0, 16, 22, and 38 weeks), MetS components, metabolic parameters including lipid profile, hemoglobin A1c (HbA1c), adiponectin, leptin, and apolipoprotein B, as well as anthropometric and bioimpedance data were obtained. RESULTS: Daily walnut consumption for 16 weeks improved MetS status, resulting in 28.6%-52.8% reversion rates for individual MetS components and 51.2% of participants with MetS at baseline reverted to a normal status after the walnut intervention. Significant improvements after walnut intake, compared to control intervention, in high-density lipoprotein cholesterol (HDL-C) (P = 0.028), fasting glucose (P = 0.013), HbA1c (P = 0.021), and adiponectin (P = 0.019) were observed after adjustment for gender, age, body mass index, and sequence using a linear mixed model. CONCLUSION: A dietary supplement of 45 g of walnuts for 16 weeks favorably changed MetS status by increasing the concentration of HDL-C and decreasing fasting glucose level. Furthermore, consuming walnuts on a daily basis changed HbA1c and circulating adiponectin levels among the subjects with MetS. This trial is registered at ClinicalTrials.gov as NCT03267901.

Minimally Invasive Procedure versus Conventional Redo Sternotomy for Mitral Valve Surgery in Patients with Previous Cardiac Surgery: A Systematic Review and Meta-Analysis

  • Muhammad Ali Tariq;Minhail Khalid Malik;Qazi Shurjeel Uddin;Zahabia Altaf;Mariam Zafar
    • Journal of Chest Surgery
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    • 제56권6호
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    • pp.374-386
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    • 2023
  • Background: The heightened morbidity and mortality associated with repeat cardiac surgery are well documented. Redo median sternotomy (MS) and minimally invasive valve surgery are options for patients with prior cardiac surgery who require mitral valve surgery (MVS). We conducted a systematic review and meta-analysis comparing the outcomes of redo MS and minimally invasive MVS (MIMVS) in this population. Methods: We searched PubMed, EMBASE, and Scopus for studies comparing outcomes of redo MS and MIMVS for MVS. To calculate risk ratios (RRs) for binary outcomes and weighted mean differences (MDs) for continuous data, we employed a random-effects model. Results: We included 12 retrospective observational studies, comprising 4157 participants (675 for MIMVS; 3482 for redo MS). Reductions in mortality (RR, 0.54; 95% confidence interval [CI], 0.37-0.80), length of hospital stay (MD, -4.23; 95% CI, -5.77 to -2.68), length of intensive care unit (ICU) stay (MD, -2.02; 95% CI, -3.17 to -0.88), and new-onset acute kidney injury (AKI) risk (odds ratio, 0.34; 95% CI, 0.19 to 0.61) were statistically significant and favored MIMVS (p<0.05). No significant differences were observed in aortic cross-clamp time, cardiopulmonary bypass time, or risk of perioperative stroke, new-onset atrial fibrillation, surgical site infection, or reoperation for bleeding (p>0.05). Conclusion: The current literature, which primarily consists of retrospective comparisons, underscores certain benefits of MIMVS over redo MS. These include decreased mortality, shorter hospital and ICU stays, and reduced AKI risk. Given the lack of high-quality evidence, prospective randomized control trials with adequate power are necessary to investigate long-term outcomes.

출혈성 쇼크를 일으킨 흰쥐에서 인공신경망과 지원벡터기계를 이용한 생존율 비교 (Comparison of Survival Prediction of Rats with Hemorrhagic Shocks Using Artificial Neural Network and Support Vector Machine)

  • 장경환;유태근;남기창;최재림;권민경;김덕원
    • 전자공학회논문지SC
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    • 제48권2호
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    • pp.47-55
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    • 2011
  • 전 세계적으로 상해로 인한 사망자 중 1/3의 직접적인 사망 원인은 출혈성 쇼크이다. 그러나 초기 쇼크에서 이를 정확히 예측할 수 있다면 신속한 치료가 가능하여 그 피해를 줄일 수 있다. 본 논문의 목적은 흰쥐의 대퇴부정맥을 통해 일정량의 출혈을 시키면서 변화하는 생리적 변수인 심박수, 수축기 혈압, 평균 동맥압, 호흡수, 체온 데이터로 최적의 생존 예측 모델을 제시하여 출혈성 쇼크를 조기 진단하는 것이다. 예측 모델로는 최근 많이 연구되는 인공신경망과 지원벡터기계 방법을 사용하였다. 과대적합을 피하고 최적의 모델을 선정하기 위해 10-fold cross validation을 수행하였을 때, 인공신경망의 경우 은닉노드 수가 3개인 모델이 가장 우수한 성능을 보였고, 지원벡터기계에서는 가우시안 커널함수를 이용한 모델이 가장 우수한 성능을 보였다. 평가 데이터 세트를 이용하여 각각의 생존 예측 모델을 평가한 결과 인공신경망의 경우 민감도 88.9 %, 특이도 96.7 %와 정확도 92.0 %를 보였고, 지원벡터기계의 경우 민감도 97.8 %, 특이도 95.0 %와 정확도 96.7 %를 보였다. 따라서 출혈에 따른 흰쥐의 생존 예측에서 지원벡터기계가 인공신경망보다 더 우수한 성능을 보이는 것을 확인하였다.

바이오에탄올용 고구마 신품종 '대유미' (A New Sweetpotato Cultivar for Use of Bioethanol 'Daeyumi')

  • 이준설;안영섭;정미남;김학신;정광호;방진기;송연상;심형권;한선경;서세정
    • 한국육종학회지
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    • 제42권6호
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    • pp.674-678
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    • 2010
  • '대유미'는 국립식량과학원 바이오에너지작물센터에서 2008년에 육성한 바이오에탄올용 고구마 신품종으로 주요 특성과 수량성을 요약하면 다음과 같다. 1. 넝쿨색은 녹색, 잎모양은 심장형, 잎색은 녹색을 띤다. 또한 엽맥색은 녹색으로 자색을 포함하지 않으며, 끝잎색은 녹색, 잎자루색은 녹색이다. 2. 괴근 모양은 방추형으로 껍질색은 홍색을 띤다. 육색은 대조품종 '율미'가 담홍색인데 비하여 농황색이다. 상품성을 좌우하는 표피의 형태는 골파짐이 없이 메끄럽다. 3. 토양 병해충에 대한 저항성을 조사한 결과 대조품종인 '율미'에 비하여 선충 및 덩굴쪼김병은 '중강', 검은썩음병과 연부병도 '중강'을 나타낸다. 또한 저장 중 부패율은 3.0%로 저장성이 강하다. 4. 전분가는 25.9%로 높고, 에탄올 수량은 418 (L/톤, 건조고구마)으로 높다. 총당 함량은 '대유미'가 2.46 g/100 g(dw)으로 '율미'에 비하여 62% 수준이다. 당 종류별로는 Sucrose가 2.08 g/100 g (dw)으로 가장 많이 함유되어 있다. 5. 전분의 최고점도(Peak viscosity)가 높아 전분의 탄력성이 좋으며, 응집점도는 노화도가 빠르다. 호화개시 온도는 $76.2^{\circ}C$로 낮은 온도에서 호화된다. 6. 수량은 조기재배의 25.0 t/ha, 만기 및 적기재배는 27.80t/ha으로 수량이 높다.