• Structural Engineering and Mechanics
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• v.70 no.2
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• pp.199-207
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• 2019

In this paper, a semi-analytical method will be discussed for free vibration analysis of rotating beams with variable cross sectional area. For this purpose, the rotating beam is discretized through applying the transfer matrix method and assumed the axial force is constant for each element. Then, the transfer matrix is derived based on Euler-Bernoulli's beam differential equation and applying boundary conditions. In the following, the frequencies of the rotating beam with constant and variable cross sections are determined using the transfer matrix method in several case studies. In order to eliminate numerical difficulties in the transfer matrix method, the Riccati transfer matrix is employed for high rotation speed and high modes. The results are compared with the results of the finite elements method and Rayleigh-Ritz method which show good agreement in spite of low computational cost.

• Biomaterials and Biomechanics in Bioengineering
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• v.1 no.3
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• pp.163-174
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• 2014

The objective of this study is to prepare an artificial extracellular matrix (ECM) for cell culture by using polymer hydrogels. The polymer used is a cytocompatible water-soluble phospholipid polymer: poly[2-methacryloyloxyethyl phosphorylcholine (MPC)-n-butyl methacrylate-p-nitrophenyloxycarbonyl poly(ethylene oxide) methacrylate (MEONP)] (PMBN). The hydrogels are prepared using a cross-linking reaction between PMBN and diamine compounds, which can easily react to the MEONP moiety under mild conditions. The most favorable diamine is the bis(3-aminopropyl) poly(ethylene oxide) (APEO). The effects of cross-linking density and the chemical structure of cross-linking molecules on the mechanical properties of the hydrogel are evaluated. The storage modulus of the hydrogel is tailored by tuning the PMBN concentration and the MEONP/amino group ratio. The porous structure of the hydrogel networks depends not only on these parameters but also on the reaction temperature. We prepare a hydrogel with $40-50{\mu}m$ diameter pores and more than 90 wt% swelling. The permeation of proteins through the hydrogel increases dramatically with an increase in pore size. To induce cell adhesion, the cell-attaching oligopeptide, RGDS, is immobilized onto the hydrogel using MEONP residue. Bovine pulmonary artery endothelial cells (BPAECs) are cultured on the hydrogel matrix and are able to migrate into the artificial matrix. Hence, the RGDS-modified PMBN hydrogel matrix with cross-linked APEO functions as an artificial ECM for growing cells for applications in tissue engineering.

• Communications for Statistical Applications and Methods
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• v.29 no.6
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• pp.655-664
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• 2022

On the motivation by an integrative study of multi-omics data, we are interested in estimating the structure of the sparse cross correlation matrix of two high-dimensional random vectors. We rewrite the problem as a multiple testing problem and propose a new method to estimate the sparse structure of the cross correlation matrix. To do so, we test the correlation coefficients simultaneously and threshold the correlation coefficients by controlling FRD at a predetermined level α. Further, we apply the proposed method and an alternative adaptive thresholding procedure by Cai and Liu (2016) to the integrative analysis of the protein expression data (X) and the mRNA expression data (Y) in TCGA breast cancer cohort. By varying the FDR level α, we show that the new procedure is consistently more efficient in estimating the sparse structure of cross correlation matrix than the alternative one.

• Composites Research
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• v.32 no.5
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• pp.243-248
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• 2019

As demand of light weight in the automotive industry has increased, the cowl cross member has been investigated using various methods to change the material. Conventionally, a cowl cross member has been made of steel and aluminum, but recently researchers tested multi-material such as aluminum and plastic. We studied a new model of the cowl cross member made of composite and non ferrous materials. For products with a high degree of freedom in design, generally, the method of topology optimization is advantageous and for the partial bracket part of the cowl cross member had a degree of freedom in the design, a topology optimization is appropriate. Considering the characteristics of the cowl cross members, we need research to minimize the weight while having the performance of noise, vibration and harshness(NVH). Taking the mounting status of the product into consideration, we used an assembly model to optimize the cowl cross member. But this method took too much time so we considered simple cowl cross member assemble conditions using the direct matrix input method(DMI) with the Craig-Bampton Nodal Method. This method is capable of considering the status of the assembly without assembling the model, which reduced the solving time and increased the accuracy comparison with a cowl cross member without DMI.

• Steel and Composite Structures
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• v.2 no.3
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• pp.223-236
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• 2002

An analytical procedure based on the transfer matrix method to estimate not only the natural frequencies but also vibration mode shapes of the thin-walled members composed of interconnected cylindrical shell panels is presented. The transfer matrix is derived from the differential equations for the cylindrical shell panels. The point matrix relating the state vectors between consecutive shell panels are used to allow the transfer procedures over the cross section of the members. As a result, the interactions between the shell panels of the cross sections of the members can be considered. Although the transfer matrix method is naturally a solution procedure for the one-dimensional problems, this method is well applied to thin-walled members by introducing the trigonometric series into the governing equations of the problem. The natural frequencies and vibration mode shapes of the thin-walled members composed of number of interconnected cylindrical shell panels are observed in this analysis. In addition, the effects of the number of shell panels on the natural frequencies and vibration mode shapes are also examined.

• Asian Journal of Innovation and Policy
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• v.8 no.1
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• pp.73-96
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• 2019

This study suggests a new approach for identifying core robot tech-nologies based on technological cross-impact. Specifically, the approach applies data mining techniques and multi-criteria decision-making methods to the co-classification information of registered patents on the robots. First, a cross-impact matrix is constructed with the confidence values by applying association rule mining (ARM) to the co-classification information of patents. Analytic network process (ANP) is applied to the co-classification frequency matrix for deriving weights of each robot technology. Then, a technique for order performance by similarity to ideal solution (TOPSIS) is employed to the derived cross-impact matrix and weights for identifying core robot technologies from the overall cross-impact perspective. It is expected that the proposed approach could help robot technology managers to formulate strategy and policy for technology planning of robot area.

• Archives of Plastic Surgery
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• v.35 no.3
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• pp.248-254
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• 2008

Purpose: Human acellular dermal matrix(ADM) is widely used in the treatment of congenital anomalies and soft tissue deficiencies. But it is rapidly degraded in the body and does not provide satisfactory results. There is a need to improve collagen fiber stability through various methods and ultimately regulate the speed of degradation. Methods: The ADMs were added with various cross-linking agents called glutaraldehyde, dimethyl 3,3'-dithiobispropionimidate to produce cross-linked acellular dermal matrices. 1,4-butanediol diglycidyl ether solution was applied with a pH of 4.5 and 9.0, respectively. The stability of cross-linked dermal matrix was observed by measuring the shrinkage temperature and the degradation rates. The cross- and non-cross linked dermis were placed in the rat abdomen and obtained after 8, 12 and 16 weeks. Results: The shrinkage temperature significantly increased and the degradation rate significantly decreased, compared to the control(p<0.05). All of cross-linked dermises were observed grossly in 16 weeks, but most of non-cross linked dermis were absorbed in 8 weeks. Histologically, the control group ADM was found to have been infiltrated with fibroblasts and most of dermal stroma were transformed into the host collagen fibers. However, infiltration of fibroblasts in the experiment was insignificant and the original collagen structure was intact. Conclusion: Collagen cross-linking increases the structural stability and decreases degradation of acellular dermis. Therefore, decrease in body absorption and increase in duration can be expected.

• Archives of Plastic Surgery
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• v.35 no.1
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• pp.7-12
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• 2008

Purpose: Since the report of artificial dermis manufacturing method using collagen by Yannas in 1980, collagen has been effectively used as dermal substitute with its merits such as, lower antigeneicity, controllable biodegradation rate, and minimal inflammatory cytotoxic properties in the dermal tissue engineering field. However, weak mechanical durability was the main drawback of collagen dermal substitute. To improve its stability, mechanical or chemical cross-linking was used. Despite of such process, its clinical use was restricted due to weak durability. To improve the durability of collagen matrix, we designed elastin-incorporated collagen matrix and compared its durability with conventional collagen matrix. Methods: 15mm diameter with 4mm thick collagen dermal matrix was made according to Yannas protocol by mixing 0.5% bovine collagen and chondroitin-6-sulfate followed by degassing, freeze drying, dehydrodermal cross-linking and chemical cross-linking procedure. In elastin incorporated collagen matrix, same procedure was performed by mixing elastin to previous collagen matrix in 4:1 ratio(collagen 80% elastin 20%). In comparison of the two dermal matrix in vitro tests, matrix contracture rate, strain, tensile strength, was measured and stiffness was calculated from comparative analysis. Results: In terms of matrix contracture, the elastin-incorperated added collagen dermis matrix showed 1.2 times more contraction compared to conventional collagen matrix. However, tensile strength showed 1.6 times and stiffness showed 1.6 times increase in elastin-incorporated matrix. Conclusion: Elastin incorperated collagen matrix manufactured by our team showed increased durability due to improvement in tensile strength and stiffness compared to previous collagen matrix($Integra^{(R)}$).

• Wind and Structures
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• v.5 no.2_3_4
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• pp.209-226
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• 2002

When predicting unsteady flow and pressure fields around a structure in a turbulent boundary layer by Large Eddy Simulation (LES), velocity fluctuations of turbulence (inflow turbulence), which reproduce statistical characteristics of the turbulent boundary layer, must be given at the inflow boundary. However, research has just started on development of a method for generating inflow turbulence that satisfies the prescribed turbulence statistics, and many issues still remain to be resolved. In our previous study, we proposed a method for generating inflow turbulence and confirmed its applicability by LES of an isotropic turbulence. In this study, the generation method was applied to a turbulent boundary layer developed over a flat plate, and the reproducibility of turbulence statistics predicted by LES computation was examined. Statistical characteristics of a turbulent boundary layer developed over a flat plate were investigated by a wind tunnel test for modeling the cross-spectral density matrix for use as targets of inflow turbulence generation for LES computation. Furthermore, we investigated how the degree of correspondence of the cross-spectral density matrix of the generated inflow turbulence with the target cross-spectral density matrix estimated by the wind tunnel test influenced the LES results for the turbulent boundary layer. The results of this study confirmed that the reproduction of cross-spectra of the normal components of the inflow turbulence generation is very important in reproducing power spectra, spatial correlation and turbulence statistics of wind velocity in LES.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.43 no.10 s.352
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• pp.18-26
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• 2006

In this paper, we propose new beamforming algorithm which overcomes signal cancellation effect even high cross correlation existing between target and interfering signal. Using the proposed method, we show that direction of arrival (DOA) of interfering signal can be estimated using correlation matrix and the cross-correlation can be eliminated in the correlation matrix of input signal. The proposed method gives high performance enhancement compared with the spatial averaging method in our computer simulation results.