• Korean Journal of Acupuncture
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• 제31권4호
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• pp.247-252
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• 2014

Objectives : The purpose of this study is to report the effect of Oriental medical treatment on a patient with Crohn's disease. Methods : The patient was treated with acupuncture, herb remedy and moxibustion for about 2 weeks. We evaluated the results of the treatment by observing the patient's symptoms and through the Crohn's disease activity index(CDAI) score. Results : After Oriental medical treatment the patient's symptoms such as emesis, heartburn and abdominal pain considerably reduced. The patients CDAI score decreased from 190.8 to 134.2. Conclusions : These results support that Oriental medical treatment can be a help in relieving symptoms of Crohn's disease.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제8권1호
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• pp.70-75
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• 2005

저자들은 기존의 크론병 치료에 호전이 없었던 항문 주위 병변에 0.3 mg/g의 저농도 tacrolimus 연고제를 1일 2회 환부에 도포하는 방법으로 약물에 의한 부작용 발생 없이 병변의 현저한 호전을 보인 3례를 경험하였기에 보고하는 바이다.

• 성인간호학회지
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• 제26권4호
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• pp.383-392
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• 2014

Purpose: The purpose of this study was to describe the degrees of body image, self esteem and Health Related Quality Of Life (HRQOL), and to identify factors related to these variables in patients with Crohn's disease. Methods: A descriptive cross sectional survey design was used. The 148 participants were the patients with Crohn's disease, recruited conveniently from one metropolitan hospital located in Seoul, Korea. The collected data were analyzed with SPSS/WIN program. Results: Patients with severe illness activity reported significantly lower body images than those of the others. Education levels and working states affected self-esteem positively, while the number of operations and illness activity affected self-esteem negatively. Hospitalization and illness activity affected HRQOL negatively. Body image, self esteem, and HRQOL were positively correlated to each other with statistical significance. Illness activity was a common factor to affect body image, self esteem, and HRQOL. Body image was an influential factor on HRQOL as well as illness activity in patients with Crohn's disease. Conclusion: As a result, this study suggested a necessity for developing an intervention study to lower the illness activity and heighten the body image among the patients with Crohn's disease.

• 척추신경추나의학회지
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• 제5권1호
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• pp.57-66
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• 2010

항통을 주소로 내원한 환자의 크론병에 대한 침구(鍼灸)치료로 복통 및 설사의 관해 상태가 되는 양호한 효과를 얻었기에 보고하는 바이다. 다만, 치료 기간이 짧아 증상의 변화의 추적이 필요한 상태이며, 다양한 임상적 연구를 위한 임상사례 데이터가 축적되어야 할 것으로 사료된다.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제21권1호
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• pp.1-11
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• 2018

The emergence of mucosal healing as a treatment goal that could modify the natural course of Crohn's disease and the accumulating evidence showing that biologics are most effective in achieving mucosal healing, along with the success of early treatment regimens for rheumatoid arthritis, have led to the identification of early Crohn's disease and development of the concept of catching the therapeutic window during the early disease course. Thus, an increasing number of pediatric gastroenterologists are adopting an early biologic treatment strategy with or without an immunomodulator. Although early biologic treatment is effective, cost and overtreatment are issues that limit its early use. Currently, there are insufficient data on who will benefit most from early biologics, as well as on who will not need early or even any biologics. For now, top-down biologics should be considered for patients with currently known high-risk factors of poor outcomes. For other patients, close, objective monitoring and accelerating the step-up process by means of a treat-to-target approach seems the best way to catch the therapeutic window in early pediatric Crohn's disease. The individual benefits of immunomodulator addition during early biologic treatment should be weighed against its risks and decision on early combination treatment should be made after comprehensive discussion with each patient and guardian.

• 대한영상의학회지
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• 제84권3호
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• pp.536-549
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• 2023

염증성 장질환의 두 가지 주요 질환으로 크론병과 궤양성 대장염이 있다. 염증성 장질환이 의심될 때, 최근에는 장벽과 장벽 밖을 모두 평가할 수 있고 다른 질환과의 감별에도 도움을 받을 수 있어 CT 소장조영술이 초기 영상검사로 널리 사용되고 있다. 염증성 장질환이 의심되는 경우, 크론병과 궤양성 대장염과의 구분이 필요하며 대부분의 경우 어렵지 않게 구분이 되나 그렇지 않은 경우가 있어 이를 염증성 장질환-미분류(inflammatory bowel diseaseunclassified)로 구분한다. 궤양성 대장염의 경우 CT 소견은 비특이적인 경우가 많아 영상검사만으로 다른 질환과 감별하기 어려운 경우가 많다. 크론병의 경우 특징적인 CT 소견이 진단에 도움이 되는 경우가 많으나 이를 모방하는 질환들이 있으며 특히 결핵성 장염은 여전히 크론병과 감별이 어려울 수 있다. 최근에는 크론병과 유사한 다발성 궤양과 협착이 있는 환자의 일부에서 SLCO2A1이라는 프로스타글란딘 수송체를 암호화하는 유전자의 돌연변이가 질환의 원인인 것으로 밝혀져 크론병과 감별하기 위해 유전자 검사가 시행되고 있다.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제31권3호
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• pp.161-164
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• 2020

Crohn's disease is a chronic inflammatory disease that involves the upper and lower gastrointestinal tracts, including the oral cavity. For the conventional treatment of inflammatory bowel diseases, steroids are usually used as induction therapy, and azathioprine is used as maintenance therapy. Steroids are associated with various side effects. Under rare circumstances, they can even cause psychotic symptoms, and reports on steroid-induced psychosis in the pediatric population are few. Here, we report the first case of steroid-induced psychosis in a 16-year-old female with Crohn's disease administered with steroids as induction therapy in South Korea. She showed psychotic symptoms, including auditory hallucination, loosening of association, and idea of reference, after 2 weeks of administering prednisolone 60 mg/day. One week after steroid discontinuation, the patient gradually recovered and was treated with quetiapine. Therefore, pediatricians should be aware of serious psychiatric adverse effects when administering corticosteroids for various indications.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제16권1호
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• pp.53-60
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• 2013

In Crohn's disease, mild gastrointestinal bleeding often occurs; however massive gastrointestinal hemorrhage, which can have a dramatic effect on a patient's vital sign, is rare. This could result in potentially life-threatening complications, which can lead to death. Massive hemorrhagic Crohn's disease is not well known and for this reason, they are a diagnostic and therapeutic challenge. Various diagnostic and therapeutic methods are currently being developed and used. The surgical method is often used only as a last measure since this approach has the risk of serious complications that may endanger patients. However, if massive bleeding continues even after all therapeutic methods are used, the surgical method must be implemented. In this case, all therapeutic methods were found to be ineffective; therefore, surgery was used as a last option. Ultimately, the surgical method was found to be successfully used to treat life-threatening hemorrhagic Crohn's disease.

• 사상체질의학회지
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• 제24권2호
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• pp.61-70
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• 2012

1. Objectives : The aim of this study was to report significant improvement of chronic diarrhea and hematochezia after treatment with Dojeokgangki-tang in a Soyangin Patient with Crohn's Disease. 2. Methods : The patient's subjective and objective symptoms were observed daily throughout the hospitalization period, and the Crohn's disease activity index(CDAI) was calculated to gauge the progress or lack of progress. 3. Results : The symptoms of diarrhea and hematochezia disappeared by the end of the hospitalization period without recurrence, and the CDAI score dropped from 92.5 to 47. 4. Conclusions : A patient with Crohn's disease, who was in the state of repetitive relapse and remission after long term clinical courses was treated with Dojeokgangki-tang in a short period and the the symptoms of diarrhea and hematochezia disappeared without recurrence. Then the patient could stop taking corticosteriods and taper off immune-suppressing drugs.

• 대한간호학회지
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• 제42권2호
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• pp.207-216
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• 2012

Purpose: This study was conducted to determine the risk factors among patients with depression with Crohn's disease. Methods: Data were collected by questionnaire from 276 patients who were diagnosed with Crohn's disease at a tertiary hospital located in Seoul. Measurements included patients' demographic characteristics, clinical characteristics, depression level, and health-related quality of life. Data were analyzed using t-test, $X^2$-test, Wilcoxon rank sum test, and logistic regression analyses. Results: The incidence rate of depression (BDI-II${\geq}$14scores) was 31.9% (n=88). Univariate analysis revealed that being a woman, school graduation status, economic status (low), BMI(<$18.5Kg/m^2$), disease duration (${\geq}3$ years), CDAI (${\geq}150$ scores), frequency of hospital admission (${\geq}2$), extra-intestinal manifestation (arthralgia, stomatitis), administration of 5-aminosalicylic acid, and disease related quality of life (SIBDQ<50 scores) were associated with depression. Multivariate analysis revealed that economic status (low), school graduation status, and quality of life (SIBDQ<50 scores) were more likely to report high level of depression. Conclusion: Future research should consider managing depression as an essential component of comprehensive care for patients with Crohn's disease. In addition, further research is needed to develop strategies to better improve quality of life among patients with Crohn's disease who are depressed.