Objective: As one of the most important metabolic organs, the liver plays vital roles in modulating the lipid metabolism. This study was to compare miRNA expression profiles of the Large White liver between two different developmental periods and to identify candidate miRNAs for lipid metabolism. Methods: Eight liver samples were collected from White Large of 70-day fetus (P70) and of 70-day piglets (D70) (with 4 biological repeats at each development period) to construct sRNA libraries. Then the eight prepared sRNA libraries were sequenced using Illumina next-generation sequencing technology on HiSeq 2500 platform. Results: As a result, we obtained 346 known and 187 novel miRNAs. Compared with the D70, 55 down- and 61 up-regulated miRNAs were shown to be significantly differentially expressed (DE). Gene ontology and Kyoto encyclopedia of genes and genomes enrichment analysis indicated that these DE miRNAs were mainly involved in growth, development and diverse metabolic processes. They were predicted to regulate lipid metabolism through adipocytokine signaling pathway, mitogen-activated protein kinase, AMP-activated protein kinase, cyclic adenosine monophosphate, phosphatidylinositol 3 kinase/protein kinase B, and Notch signaling pathway. The four most abundantly expressed miRNAs were miR-122, miR-26a and miR-30a-5p (miR-122 only in P70), which play important roles in lipid metabolism. Integration analysis (details of mRNAs sequencing data were shown in another unpublished paper) revealed that many target genes of the DE miRNAs (miR-181b, miR-145-5p, miR-199a-5p, and miR-98) might be critical regulators in lipid metabolic process, including acyl-CoA synthetase long chain family member 4, ATP-binding casette A4, and stearyl-CoA desaturase. Thus, these miRNAs were the promising candidates for lipid metabolism. Conclusion: Our study provides the main differences in the Large White at miRNA level between two different developmental stages. It supplies a valuable database for the further function and mechanism elucidation of miRNAs in porcine liver development and lipid metabolism.
In this paper, based on the theory of performance studies and community-based theatre, I venture to explicate the socio-political significance of director Yim Jin-Taek's community-based performance called 'madanggut', which is heavily based on elements of indigenous culture. Yim's madanggut utilizes elements of indigenous cultures and searches for 'the Korean ethnic (arche)type' as 'the ideal Korean type' or 'genuine Korean-ness' for the reconstruction of 'the Korean ethnic community.' This paper interrogates the major task of Yim Jin-Taek's madanggut, which ideologically promulgates the idea of ethnocentric patriarchy supported by the traditional (mainly Confucianist) notion of 'community' - inquiring if this type of theatre can provide useful and practical prospects for imagining a more democratic and plural civilian society in Korea today, when the interaction of globalization, nationalism, regionalism, and localism simultaneously impact our everyday life and cultural identification. Regarding the recent global phenomenon of the resurgence of nationalism, I looked at madanggut's use of symbolic resources from the past for imaginative communal bonding as a nation. But, the claimed homogeneity of the national past by means of 'nation conflation' of different social groups is an illusionary conceptualization, and the national historiography silences memories of the marginalized groups and denies their histories. It is certain that in Korea nationalism has historically performed an important function during the colonization and democratization period. Nevertheless, as Yim's Nokdukkot realized, it cannot be overlooked that as a representative of 'the Korean ethnic community,' 'the protecting man/the sacrificial woman' is contradictory to the plural and lateral thinking of participatory democracy in community-building. It is time to think about a new political language that relates individuals to the community and nation. 'The ethnic type' cannot represent the whole nation and the members of the nation should be the examples of the community they belong to for a more democratic society. I have selected Yim's several community-based works mainly from the 1970s to the 1980s since the works provide grounding images, symbols, metaphors, and allegories pertinent to discussing how 'the Korean ethnic community' has been narrativized through the performances of madanggut during the turbulent epoch of globalization. I hope that this paper presents Yim's grounded aesthetics of community-based theatre with fully contoured critical views and ideas.
The purpose of this study is to identify the main factors helping university students sucessfully adapt to campus life and achieve academic accomplishment through a critical period in personal development. For this purpose, the analysis verifying influence of self leadership as an individual trait variable and social support as a socio environmental trait variable on academic achievement of university students and the mediating effect of school adjustment among them was conducted. Total 271 responses collected by implementing a questionnaire survey in "S", a four-year private university located in Seoul, were used for the analysis. The validity of the measurement was verified through confirmatory factor analysis and the relationship among the variables was examined through structural model equation, bootstrap and sobel test. The major finding of this study are as follows. First, this study confirmed the causal relationship of self leadership and social support impacting on academic achievement of university students. This result suggests that an integrated approach taking into account both individual and socio environmental factors is necessary to support academic achievement of university students. Second, it was proved that self leadership and social support indirectly influences academic achievement through school adjustment. This demonstrates that school adjustment is an important predictor of academic achievement as well as plays a major role in mediating among self leadership, social support and academic achievement. In conclusion, the results of this study conveys its significance in suggesting the necessity to provide insititutional support on individual trait and socio environmental factor enabling university students sucessfully to adapt to campus life and achieve academic achievement.
This study aims to analyze the environment for the open-source records system and to identify the risk and requirements for the success of the strategy in Korea. For this, Chapter 2 presented a review of the strategic benefits of open source to public organizations, developers, and users. It also discussed the process of cooperatively developing and releasing the source code and the technology infrastructure supporting open source. In Chapter 3, six representative open-source projects in the field of records management were selected, and case studies were conducted. To derive comprehensive implications, we have divided the main development body of open-source projects into international organizations, international cooperation systems, national archives, and software development companies. We also analyzed the background and purpose of each project, the agents of development and funding, the governance model, the development period and cost, the business model and software architecture, the community composition, and the licensing strategy. Through this, we have derived four critical success factors. In terms of technology, a component-based design was required; therefore, we proposed a microservice architecture and a model-view-controller design pattern. Next, it was necessary to reestablish system requirements of records center and archives. Moreover, we also proposed a dual licensing strategy to allow developers to easily participate in open-source projects. Lastly, we emphasized a strong governance structure and an effective cooperation framework to create a sustainable community. For a record system to be open-source successfully in an organization-centered market, the roles of software developers and end users should be exercised more in the community. To achieve this, it is important to build various collaborative tools and development infrastructure from a planning stage to a centralized one.
This study aims to suggest the academic roles and direction of the social welfare for the elderly in Journal of the Korean Gerontological Society. For this purpose the trends of research on the social welfare for the elderly were analyzed by means of reviewing articles published from 1980 to 2008 in Journal of the Korean Gerontological Society. Out of all published articles, 215 articles were selected on the basis of unanimity among 3 reviewers including this author. First, in 1980s there were very limited numbers of articles. It had been mainly introduced foreign and domestic institutions of social welfare for the elderly and focused on the serious issues for the elderly in aging society. Secondly, in 1990s, there were explosive increases of research in elder welfare studies. The subjects of the articles were diversified and research methods were sophisticated in this period. Thirdly, it showed that the numbers, subjects, and research methods of the articles concerning social welfare for the elderly were enriched and differentiated during 2000-2004. Lastly, the research trends have focused on the issues of successful aging, quality of life, and psychological well-being in consideration of the quality of life for the elderly up to now since 2005. But the research trends have had some limitations in showing only application of theories and models or in simply introducing the knowledge in Western countries. It is necessary to have clear academic identity which can be faithful to Korean Gerontological studies.
This study attempted to test whether or not students' collaborative argumentation and explanation activity while using concept mapping did improve understanding on texts. Total of 52 college students participated in this study. They were randomly assigned to one of four experimental conditions. The experiment lasted for two or three weeks and students were tested on comprehension level of a text material that they have studied over the period. As a result, with two independent factors of explanation and collaboration, there was a significant interaction effect without main effects. That is, individual did better when they did have to explain what they were doing. However, this is not the case when students collaborate. Students in the paired condition, they did better when they do not have to explain what they were doing with concept maps. This study showed efficiency with using computerized software does not always guarantee higher understanding on text materials. Instructional contexts and variables, collaboration and explanation, needs to be considered. Collaborating with others and explaining their own learning processes should be carefully designed when they are combined with concept mapping contexts. How to minimize learning obstacles from discussing ideas with others are a critical issue for future research.
The Journal of the Korean Institute of Forest Recreation
/
v.22
no.4
/
pp.1-9
/
2018
This study aimed to improve the quality of forest healing program through analyses of the program activities given at National Healing Forest and surveys conducted by Korea Forest Service. 99 DB data of the healing forest that were surveyed by KFS (August 2015~April 2016) were collected in order to affirm the activities. We analysed DB based on the format of the survey by target, 6 healing factors, location, season, time periods, operation hours and multifaceted evaluation. The results showed that the activities in the forest healing program targeted general public and the factor that was considered the most was psychotherapy factor. Healing forest trails were used as a location, spring, summer and fall as season, morning and afternoon as time period for the majority of the activities. The running time was 60 minutes. The multifaceted evaluation revealed that dynamic activities were preferred the most in development of programs. According to the results of the forest healing programs, it seems to be critical to enhance forest healing instructors' diversified professionalism. However, this will only be achievable once further investigations regarding forest healing effects by types of illnesses are conducted and provide solid foundation for such professionalism.
Modern Neo-Confucianism was formed as a school by solving the modern problems in China through accepting western philosophies with Chinese basic philosophies since New Cultural Movement. Marxism, Liberalism, and Modern Neo-Confucianism are called three representatives of Chinese modern philosophies. Since the People's Republic of China was founded in 1949, Modern Neo-Confucianists have tried to keep their philosophy and cultural conservatism in Hong Kong and Taiwan. Modern Neo-Confucianism which had been prohibited before 1978 was brought again to people's attention in the middle of 1980s by their active lectures and writings. Furthermore, the study on Modern Neo-Confucianism was supported by the Chinese government in 1987. China was trying to find the way to enhance Chinese tradition and to develop China to a modern society at the same time through the study on Modern Neo-Confucianism. The purpose of Modern Neo-Confucianism is to keep Chinese tradition which was broken off, to develop China to a modern society, to control the problems caused by capitalism socially, and ultimately to strengthen socialism in China in the political aspect. The study on Modern Neo-Confucianism in the 1980s focused on introducing, organizing, and understanding Modern Neo-Confucianism as its early stage. This study was led by Marxists with their methods and viewpoints. Even though the acceptance and understanding of Modern Neo-Confucianism was limited in a short period, the study on Modern Neo-Confucianism in the 1980s propagated Modern Neo-Confucianism. Modern Neo-Confucianism also played an important role to grow the argument about the critical succession of Chinese tradition and to reconsider the fact that modernization does not mean only westernization.
The main causes of the July 2013 OZ 214 accident were poorly performed approach and the failure to recognize the autothrottle in the HOLD position which the automated speed control was not provided. The pilots late decision for go-around was also a critical factor leading to the accident. The B777 POM restricts the use of FLCH mode beyond the FAF. This research utilized the QAR data of an airline's B777 fleet in the period of two years where 44 cases were found. In many cases, the FLCH mode was used for rapid descent from an higher than normal situation. In addition, in the base turn, continuous use of FLCH mode even when the path was below the glide path were observed. Airports with elevation above 500 ft MSL had a higher rate of occurrence. In this research, the proper descent planning and vertical path monitoring, and the adherence to the limitation set in the manuals and the stabilized approach criteria were re-emphasized as mitigation to reduce event occurences.
Purpose: This study aims to examine the quality of tuberculosis (TB) care after the 1st to 3rd national quality assessment (QA) program for TB healthcare service in Korea was conducted. Methods: We analyzed Health Insurance Review & Assessment Service (HIRA) claims data of new TB patients during the period of January to June from 2018-2020. The new TB patients were defined as TB patients reported to Korea Centers for Disease Control and Prevention Agency (KCDA). The unit of analysis was the patient. Chi-square tests were used to analyze the differences in indicator value according to the types of medical facilities. The QA indicators of TB care were divided into 3 areas consisting of the following 7 quality indicators: 4 indicators of diagnosis test (the rate of acid-fast bacilli smear, the rate of acid-fast bacilli culture, the rate of Mycobacterium tuberculosis-polymerase chain reaction, drug susceptibility test), 1 compliance of treatment guideline, and 2 indicators of care management of TB patients (encounter rate, day of therapy). Results: The QA program for TB care was conducted among 8,246 patients from 534 facilities in 2020. The value of the 7 quality indicators was shown to increase as a result of the QA program. The indicators of the diagnostic test were all higher than 95%, with the exception of the drug susceptibility test which was 84.8%. Both indicators for care management of TB patients were 88.5%. Conclusion: The quality of TB care has been improving with the implementation of the QA program. In order to continue to improve the quality of TB care, it will be necessary to disclose the results of the QA program in medical facilities in the future.
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