• Journal of Korean Clinical Nursing Research
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• v.24 no.2
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• pp.235-244
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• 2018

Purpose: This study aimed to examine nurses' knowledge levels and educational needs related to an artificial pacemaker. Methods: Participants were 100 nurses working in cardiovascular departments from two university hospitals in Seoul. This study was a descriptive study using a survey for estimating knowledge levels and educational needs related to an artificial pacemaker among nurses. Data were analyzed by SPSS 23.0 program using frequency, percentage, mean and standard deviation, t-test, and ANOVA. Results: Nurses' knowledge levels were significantly different depending on working units (F=3.32, p=.014) and years of clinical experience (F=2.85, p=.042). Nurses who received education about an artificial pacemaker were higher in the knowledge level of complications after an implantation procedure (t=3.45, p<.001) than nurses who did not receive the education. Conclusion: Discharge education is critical for patients with artificial pacemaker implantation to go back to their daily activities. When developing artificial pacemaker education program for hospital nurses, factors such as nurses' working department and years of clinical experience years and updated information of an artifical pacemaker need to be considered.

• Journal of the Earthquake Engineering Society of Korea
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• v.27 no.6
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• pp.293-301
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• 2023

Existing reinforced concrete buildings with seismically deficient details have premature failure under earthquake loads. The fiber-reinforced polymer column jacket enhances the lateral resisting capacities with additional confining pressures. This paper aims to quantify the retrofit effect varying the confinement and stiffness-related parameters under three earthquake scenarios and establish the retrofit strategy. The retrofit effects were estimated by comparing energy demands between non-retrofitted and retrofitted conditions. The retrofit design parameters are determined considering seismic hazard levels to maximize the retrofit effects. The critical parameters of the retrofit system were determined by the confinement-related parameters at moderate and high seismic levels and the stiffness-related parameters at low seismic levels.

• Information Systems Review
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• v.7 no.2
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• pp.195-211
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• 2005

The purpose of this case study is to suggest the indicators of an informatization maturity level and critical success factors in small and medium automotive parts manufacturers. To achieve this goal, literature reviews and case studies on 7 automotive parts manufacturers that confirmed to implement information systems successfully, were conducted. Based on literature review, the six functional processes including development, production scheduling, purchase, production, order, and support process, were defined. Each process has 5 levels from 1(low level) to 5(high level) depending on the degree of informatization maturity. In addition, critical success factors were discovered with interviews of CEO or CIO. The results of this study can be applied to any companies which are implementing or intended to the information systems near future.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.49 no.5
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• pp.533-540
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• 2016

This study assessed the risk of an oyster-shucking site to establish the hazard analysis critical control point (HACCP) system model by measuring viable cell counts, coliform group Staphylococcus aureus foreign material on oysters, oyster-producing equipment, and washing water. The viable cell count and coliform group levels of the harvested raw oysters were 4.00 log CFU/g and 1.1×10² MPN/100 g, while those of washed oysters were 2.99 log CFU/g and (3.2−4.6) × 10 MPN/100 g, respectively. After washing the oysters, no Escherichia coli or pathogenic bacteria (E. coli O157:H7, Listeria monocytogenes, S. aureus, Salmonella spp., Vibrio parahaemolyticus, and Clostridium perfringens) were detected. Regardless of the location of foreign matter, up to 100% more metallic and non-metallic foreign matter was detected at 1.5 mmΦ than at 3.5 mmΦ, using a metal detector with increased sensitivity. According to the results, the critical control points (CCP) are the washing and metal-detection processes. These results can be used as basic data to improve sanitation at oyster-shucking sites in factories with an HACCP system.

• Journal of Korean Association for Spatial Structures
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• v.23 no.2
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• pp.19-28
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• 2023

Timber structures are susceptible to moisture, contamination, and pest infestation, which can compromise their integrity and pose a significant fire hazard. Despite these drawbacks, timber's lightweight properties, eco-friendliness, and alignment with current architectural trends emphasizing sustainability make it an attractive option for construction. Moreover, timber structures offer economic benefits and provide a natural aesthetic that regulates building temperature and humidity. In recent years, timber domes have gained popularity due to their high recyclability, lightness, and improved fire resistance. Researchers are exploring hybrid timber and steel domes to enhance stability and rigidity. However, shallow dome structures still face challenges related to structural instability. This study investigates stability problems associated with timber domes, the behavior of timber and steel hybrid domes, and the impact of timber member positioning on dome stability and critical load levels. The paper analyzes unstable buckling in single-layer lattice domes using an incremental analysis method. The critical buckling load of the domes is examined based on the arrangement of timber members in the inclined and horizontal directions. The analysis shows that nodal snapping is observed in the case of a concentrated load, whereas snap-back is also observed in the case of a uniform load. Furthermore, the use of inclined timber and horizontal steel members in the lattice dome design provides adequate stability.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.23 no.3
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• pp.19-26
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• 2023

Critical information infrastructure designations for cloud service providers continue to spread around the world as energy, financial services, health, telecommunications, and transportation sectors move to the cloud. In addition, in the case of Ukraine, the removal of restrictions on the use of cloud for national critical facilities and the rapid transition of critical data to the cloud enabled the country to effectively respond to cyberattacks targeting Russian infrastructure. In Korea, the ISMS-P is operated to implement a systematic and comprehensive information protection management system and to improve the level of information protection and personal information protection management in organizations. Control items considering the cloud environment have been modified and added to the audit of companies. However, due to the different technical levels of clouds between domestic and global, it is not easy to obtain information on the findings of cloud providers such as Microsoft for the training of domestic certification auditors on hyperscale scale. Therefore, this paper analyzes findings in hyperscale clouds and suggests ways to improve cloud-specific control items by considering the compatibility of hyperscale environments with ISO/IEC 27001 and SOC(System and Organization Control) security international standards.

• Journal of Christian Education in Korea
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• v.72
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• pp.25-48
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• 2022

This essay is a critical study of the three models of practical theology that emerged in the second half of the 20th century: the critical correlational model (Sherrill, Browning), the hermeneutical model (Groome, Gerkin), and the faith community formation model (Westerhoff, Campbell). This essay first explores the central ideas of practical theologians who adhere to each of the three models and focuses on Christian education, pastoral counseling, and homiletics. This essay then critically evaluates the three models in accordance to the following four themes: how practical theology has 1) responded to the challenges of postmodernity, 2) engaged in dialogue with different types of theology, 3) participated in interdisciplinary dialogue, and 4) understood Christian practice. In conclusion, this essay suggests that the essential tasks of contemporary Christian education as practical theology include: 1) providing an active response to many challenges of postmodern, postsecular, postdigital, and posthuman era, 2) engaging in interactive dialogue with diverse forms of theology, and 3) facilitating interdisciplinary dialogue based on transversal rationality, and 4) establishing of the concept of Christian practice at the individual, ecclesial, social, public, ecological, and digital levels.

• Molecules and Cells
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• v.27 no.1
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• pp.15-19
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• 2009

Notch signaling is controlled at multiple levels. In particular, stabilized Notch receptor activation directly affects the transcriptional activations of Notch target genes. Although some progress has been made in terms of defining the regulatory mechanism that alters Notch stability, it has not been determined whether Notch1/NICD stability is regulated by $GSK-3{\alpha}$. Here, we show that Notch1/NICD levels are significantly regulated by $GSK-3{\beta}$ and by $GSK-3{\alpha}$. Treatment with LiCl (a specific GSK-3 inhibitor) or the overexpression of the kinase-inactive forms of $GSK-3{\alpha}/{\beta}$ significantly increased Notch1/NICD levels. Endogenous NICD levels were also increased by either $GSK-3{\alpha}/{\beta}$- or $GSK-3{\alpha}$-specific siRNA. Furthermore, it was found that $GSK-3{\alpha}$ binds to Notch1. Deletion analysis showed that at least three Thr residues in Notch1 (Thr-1851, 2123, and 2125) are critical for its response to LiCl, which increased not only the transcriptional activity of endogenous NICD but also Hes1 mRNA levels. Taken together, our results indicate that $GSK-3{\alpha}$ is a negative regulator of Notch1/NICD.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.3
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• pp.1285-1292
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• 2016

Background: It is well established that mutations in the BRCA1 gene are a major risk factor for breast cancer. Induction of cancer cell death and inhibition of survival are the main principles of cancer therapy. In this context, autophagy may have dual roles in cancer, acting on the one hand as a tumor suppressor and on the other as a mechanism of cell survival that can promote the growth of established tumors. Therefore, understanding the role of autophagy in cancer treatment is critical. Moreover, defects in apoptosis, programmed cell death, may lead to increased resistance to chemotherapy. Purpose: The aim of the present study was to detect BRCA1 gene mutations in order to throw more light on their roles as risk factors for breast cancer in Egypt. Secondly the role of autophagy and apoptosis in determining response to a fluorouracil, doxorubicin, cyclophosphamide (FAC) regimen was investigated. Materials and Methods: Forty-five female breast cancer cases and thirty apparently healthy females were enrolled in the present study. Serum levels of autophagic biomarkers, Beclin 1 and LC3 as well as the serum levels of apoptosis biomarkers Bcl-2 and Caspase-3 were measured before and after chemotherapy. Results: BRCA1 mutations were found in 5 (16.7%) and 44 (99.8%) of the controls and cancer patients, the most frequent being 5382insC followed by C61G and 185 delAG. The results revealed that chemotherapy caused elevation in serum concentration levels of the autophagic biomarkers (Beclin 1 and LC3). This elevation was associated with a significant decrease in serum concentration levels of Bcl-2 and significant increase in caspase-3 concentration levels (apoptotic markers). Conclusions: The results of the present study indicate a very high level of BRCA mutations in breast cancer cases in Egypt and point to involvement of autophagic and apoptotic machinery activation in response to FAC chemotherapy.

• Fisheries and Aquatic Sciences
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• v.16 no.3
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• pp.137-142
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• 2013

To understand critical aspects of paralytic shellfish poisoning (PSP) in a chief area of bivalve production in Korea, seasonal variation in PSP toxins in bivalves collected from Jinhae Bay, Korea in 2009 was surveyed by the pre-column high-performance liquid chromatography oxidation method. We also confirmed the profiles of major bivalves such as oysters Crassostrea gigas and mussels Mytilus galloprovincialis in Jinhae Bay. PSP toxins in the bivalves showed remarkable seasonal variation. PSP toxin levels were detected from April to May in 2009, and the highest total toxin levels at all stations were recorded in May. The major toxins in bivalves were gonyautoxin [GTX] 1&4 and C 1&2; in oysters GTX 2&3 were also detected as major components. GTX 1&4, which showed the highest PSP toxin levels at each station, accounted for the highest proportions of toxin components in mussels and oysters (64.5-71.3% and 41.4-42.4%, respectively). It was also confirmed that the highest toxicity (in ${\mu}g$ saxitoxin [STX] eq/g) was derived from GTX 1&4. The highest total toxicity (in ${\mu}g$ STX eq/g) was approximately 2-8-fold higher in mussels than in oysters collected from the same station. PSP toxin levels in bivalves differed significantly according to the sample collection station. However, the profiles of toxins in the bivalves did not show significant differences during the survey period according to sample collection station. This study shows that PSP toxin levels in some samples from Jinhae Bay were above the regulatory limit in Korea during a specific period in spring.