• Tuberculosis and Respiratory Diseases
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• 제76권1호
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• pp.38-41
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• 2014

Immunoglobulin G4 (IgG4)-related disease is a newly recognized condition characterized by fibroinflammatory lesions with dense lymphoplasmacytic infiltration, storiform-type fibrosis and obliterative phlebitis. The pathogenesis is not fully understood but multiple immune-mediated mechanisms are believed to contribute. This rare disease can involve various organs and pleural involvement is even rarer. We report a case of IgG4-related disease involving pleura. A 66-year-old man presented with cough and sputum production for a week. Chest radiography revealed consolidation and a pleural mass at right hemithorax. Treatment with antibiotics resolved the consolidation and respiratory symptoms disappeared, but the pleural mass was unchanged. Video-assisted thoracoscopic surgery was performed. Histopathology revealed dense lymphoplasmacytic infiltration and storiform fibrosis with numerous IgG4-bearing plasma cells. The serum IgG4 level was also elevated. Further examination ruled out the involvement of any other organ. The patient was discharged without further treatment and there is no evidence of recurrence to date.

• 한국지반환경공학회 논문집
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• 제16권4호
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• pp.23-32
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• 2015

This paper addresses the effects of extreme rainfall on the stability of cut slopes in Yen Bai city, Northern Viet Nam. In this area, natural slopes are excavated to create places for infrastructures and buildings. Cut slopes are usually made without proper site investigations; the design is mostly based on experience. In recent years, many slope failures have occurred along these cuts especially in rainy seasons, resulting in properties damaged and loss of lives. To explain the reason that slope failure often happens during rainy seasons, this research analyzed the influence of extreme rainfalls, initial ground conditions, and soil permeability on the changes of pore water pressure within the typical slope, thereafter determining the impact of these changes on the slope stability factor of safety. The extreme rainfalls were selected based on all of the rainfalls triggering landslide events that have occurred over the period from 1960 to 2009. The factor of safety (FS) was calculated using Bishop's simplified method. The results show that when the maximum infiltration capacity of the slope top soil is less than the rainfall intensity, slope failures may occur 14 hours after the rain starts. And when this happens, the rainfall duration is the deciding factor that affects the slope FS values. In short, cut slopes in Yen Bai may be stable in normal conditions after the excavation, but under the influence of tropical rain storms, their stability is always questionable.

• 한국패류학회지
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• 제9권2호
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• pp.85-93
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• 1993

Contamination of heavy metals in water and sediments along Mantyeong (river) has reached up to critical level, The object of the study is to dlucidate some macroinvertebrates which inhabit along the river in respect to the modulatory role in reducing the pollution. For the purpose, Scapharca subcrenata(sea shell) which is common in numbers and biomass in the area was collected, and cadmium (Cd) was subjected as a reference metal in the experiment. The seashell was dried and autoclaved, followed by pellet preparation under various concentration of Cd: 50,100,250,500 and 1,500 ug /pellet. Mice were fed for 3 months, althrough last group(5 mice), 1,500 ug/pellet, died within 4 weeksof the administration.MT-Cd in liver and kidney increased in correlation with the amont of Cd concentration in pellet, especially in kidney than in liver. Liver and kidney of the mice showed pathological changes such as cellular infiltration and focal necrosis in liver, and peri-tubular cell infiltration or tubular necrosis etc. The changes were more intensive by amount of the Cd. Overall results in the present study suggest that Cd may eventually combine with soluble-protein forming metalloprotein, then reduce the toxicity of heavy metal, How the formed Mt-Cd is discharged from the kidney and the mechanism shall be the further subject to be clarified.

• Nuclear Engineering and Technology
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• 제51권1호
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• pp.257-262
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• 2019

The control of microstructure is critical for the porous fuel particles used for infiltrating actinide nuclides. This study concerns the effect of heating processes on properties and microstructure of the fuel particles. The uniform gel precursor beads were synthesized by a microfluidic sol-gel process and then the porous $CeO_2$ microspheres, as a surrogate for the ceramic nuclear fuel particles, were obtained by heating treatment of the gel precursors. The fabricated $CeO_2$ microspheres have a narrow size distribution and good sphericity due to the feature of microfluidics. The effects of heating processes parameters, such as heating mode and peak temperatures on the properties of microspheres were studied in detail. An optimized heating mode and the peak temperature of $650^{\circ}C$ were selected to produce porous $CeO_2$ microspheres. The optimized heating mode can avoid the appearance of broken or crack microspheres in the heating process, and as-prepared porous microspheres were of suitable pore size distribution and pore volume for loading minor actinide (MA) solution by an infiltration method that is used for fabrication of MA-bearing nuclear fuel beads. After the infiltration process, $1000^{\circ}C$ was selected as the final temperature to improve the compressive strength of microspheres.

• Tuberculosis and Respiratory Diseases
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• 제65권5호
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• pp.405-409
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• 2008

본 예는 Churg-Strauss 증후군에서의 폐침윤은 주로 폐실질에 호산구성 폐렴, 괴사성 혈관염 및 육아종성 염증의 형태로 발현이 되나 기관 기관지 내 점막 병변으로도 발현될 수 있음을 보여 주었다. 저자들은 기관지 천식과 반복되는 비염의 병력을 가진 33세 남자가 호흡곤란을 주소로 내원하여 Churg-Strauss 증후군으로 진단되었고 동반된 기관지 내시경상 기관과 기관지내 점막 병변이 스테로이드로 치료하면서 호전된 1예를 경험하였기에 보고하는 바이다.

• 생명과학회지
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• 제26권5호
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• pp.592-602
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• 2016

풀사료를 주식으로 하며 자유롭게 방목되는 호주산 소와 곡물사료를 주식으로 하며 상대적으로 제한된 면적의 축사에서 사육되는 한국산 소의 두 가지 근육에서 디스트로핀 단백질 발현 수준을 비교하였다. 총 244 두의 식용소 도체로부터 양국에서 같은 부위의 골격근 조직을 채취하고 10% 중성 포르말린을 이용해 고정하였다. 본 연구에서 지방 침착률이 골격근 막 관련 단백질들의 소실과 밀접한 연관이 있다는 점을 발견하였는데, 특히 디스트로핀이 지방이 침착된 골격근에서 가장 유의적으로 감소하는 것을 확인하였다. 이와 동시에 CD36이 지방이 침착된 골격근에서 가장 풍부하게 발현하는 것도 확인하였다. 이렇게 정상 골격근의 구조를 유지하는 데 필요한 세포골격 단백질들의 소실에는 산화적 스트레스에서부터 사료의 종류에 따른 산화 지질 및 운동, 기후, 성장 기간 등의 환경에 이르기까지 다양한 사육 조건들이 영향을 미쳤을 것으로 여겨졌다. 디스트로핀은 근형질막 관련 단백질들 중에 근이영양증이나 근육 변성과 관계된 가장 민감한 막 단백질이다. 그러므로 본 연구는 사람의 근이영양증 관련 연구를 비롯해 동물모델을 이용하여 근육질환의 기전을 찾는 연구에도 중요한 초석이 될 것으로 보이며, 나아가 근이영양증 기전 규명을 위한 기초연구뿐만이 아니라 치료를 위한 실용화 연구에도 응용될 수 있을 것으로 사료된다.

• 한국습지학회지
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• 제18권2호
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• pp.166-172
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• 2016

전 지구 지표 순환 분석을 위하여 지표와 대기 사이의 에너지 교환에 대한 분석이 필수적이다. 이러한 에너지 교환의 정량화를 위하여 다양한 지면 모형에 대한 연구가 진행되고 있다. 다양한 모형들 중 Common Land Model(CLM)과 Variable Infiltration Capacity(VIC) 모형을 활용한 연구가 활발히 수행되고 있다. CLM은 발전된 지면 모형의 형태로 적은 사용자 변수로 현실적인 결과를 산출한다는 장점이 있다. VIC 모형 또한 대표적인 지면 모형 중 하나로 에너지 인자 및 유출량 모의를 위하여 전 세계적으로 다양한 분야에서 활용되고 있다. 본 연구에서는 미국 캘리포니아 주 SS-CZO 사이트를 대상으로 CLM과 VIC 모형을 활용하여 주요 에너지 인자 인 순복사량, 현열, 잠열을 모의하였다. 순복사량과 현열 모두 두 모형에서 양호한 결과를 보이나, 강우 발생 시 CLM은 잠열과 현열을 과소모의하는 경향을 나타내었다. 잠열은 CLM의 모의 결과가 잠열을 과소모의 한 VIC 모형에 비하여 관측된 잠열의 경향을 더 잘 모의하는 것으로 나타났다. 이러한 에너지 인자 모의 및 모형의 장단점에 대한 분석을 통하여 CLM과 VIC 모형의 활용가능성 및 다양한 모형 활용의 필요성을 확인하였다.

• Journal of Periodontal and Implant Science
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• 제32권4호
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• pp.753-767
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• 2002

The purpose of this study was to evaluate histologically the effect of LiF-maleic acid added calcium aluminate(LM-CA) bone cement & CA-PMMA composite bone cement on the healing of calvarial defect in Sprague-Dawley rats. The critical size defects were surgically produced in the calvarial bone using the 8mm trephine bur. The rats were divided in three groups : In the control group, nothing was applied into the defect of each rat. LM-CA bone cement was implanted in the experimental group 1 and CA-PMMA composite bone cement was implanted in the experimental group 2. Rats were sacrificed at 2, 8 weeks after surgical procedure. The specimens were examined by histologic analysis, especially about the bone-cement interface and the response of surrounding tissue. The results are as follows; 1. In the control group, inflammatory infiltration was observed at 2 weeks. At 8 weeks, periosteum and duramater were continuously joined together in the defect area. But the center of defect area was filled up with the loose connective tissue. 2. In the experimental group 1, the bonding between implanted bone cement and the existing bone was seen, which more increased in 8 weeks than 2 weeks. Inflammatory infiltration and the dispersion of implanted bone cement particles were seen in both 2 weeks and 8 weeks. 3. In the experimental group 2, implanted bone itself had a dimensional stability and no bonding between implanted bone cement and the existing bone was seen in both 2 weeks and 8 weeks. Implanted bone cement was encapsulated by fibrous connective tissue. In addition, inflammatory infiltration was seen around implanted bone cement. On the basis of these results, when LM-CA bone cement or CA-PMMA composite bone cement was implanted in rat calvarial defect, LM-CA bone cement can be used as a bioactive bone graft material due to ability of bonding to the existing bone and CA-PMMA can be used as a graft material for augmentation of bone-volume due to dimensional stability.

• 한국지반환경공학회 논문집
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• 제17권12호
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• pp.5-16
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• 2016

This study aims to assess the influence of rainfall patterns on shallow landslides initiation. Doing so, five typical rainfall patterns with the same cumulative amount and intensity components comprising Advanced (A1 and A2), Centralized (C), and Delayed (D1 and D2) were designed based on a historical rainstorm event in Jinbu. Mt area. Those patterns were incorporated as the hydrological conditions into the Transient Rainfall Infiltration and Grid-based Regional Slope-stability Model (TRIGRS) to assess their influences on groundwater pressure and changes in the stability of the slope. The results revealed that not only the cumulative rainfall thresholds necessary to initiate landslides, but also the rate at which the factor of safety decreases and the time required to reach the critical state, are governed by rainfall patterns. The sooner the peak rainfall intensity, the smaller the cumulative rainfall threshold, and the shorter the time until landslide occurrence. Left-skewed patterns were found to have a greater effect on landslide initiation. Specifically, among five rainfalls, pattern (A1) produced the most critical state. The severity of response was followed by patterns A2, C, D1, and D2. Our conclusion is that rainfall patterns have a significant effect on the cumulative rainfall threshold, the build-up of groundwater pressure, and the occurrence of shallow landslides.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2016년도 학술발표회
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• pp.202-202
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• 2016

Despite the potentially major influence of rainstorm patterns on the prediction of shallow landslides, this relationship has not yet received significant attention. In this study, five typical temporal rainstorm patterns with the same cumulative amount and intensity components comprising Advanced (A1 and A2), Centralized (C), and Delayed (D1 and D2) were designed based on a historical rainstorm event occurred in 2006 in Mt. Jinbu area. The patterns were incorporated as the hydrological conditions into the Transient Rainfall Infiltration and Grid-based Regional Slope-stability Model (TRIGRS), in order to assess their influences on pore pressure variation and changes in the stability of the covering soil layer in the study area. The results revealed that not only the cumulative rainfall thresholds necessary to initiate landslides, but also the rate at which the factor of safety (FS) decreases and the time required to reach the critical state, are governed by rainstorm pattern. The sooner the peak rainfall intensity occurs, the smaller the cumulative rainfall threshold, and the shorter the time until landslide occurrence. Left-skewed rainfall patterns were found to have a greater effect on landslide initiation. More specifically, among the five different patterns, the Advanced storm pattern (A1) produced the most critical state, as it resulted in the highest pore pressure across the entire area for the shortest duration; the severity of response was then followed by patterns A2, C, D1, and D2. Thus, it can be concluded that rainfall patterns have a significant effect on the cumulative rainfall threshold, the build-up of pore pressure, and the occurrence of shallow landslides, both in space and time.