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The effect of LiF-maleic acid added calcium aluminate hone cement & CA-PMMA composite bone cement on the healing of calvarial defect6)  

Shin, Jung-A (Department of Periodontology, College of Dentistry, Yonsei University, Research Institute for Periodontal Regeneration, Brain Korea 21 project for Medical Science)
Yun, Jeong-Ho (Department of Periodontology, College of Dentistry, Yonsei University, Research Institute for Periodontal Regeneration, Brain Korea 21 project for Medical Science)
Oh, Seung-Han (Department of Ceramic Engineering, Yonsei University)
Baik, Jeong-Won (Department of Periodontology, College of Dentistry, Yonsei University, Research Institute for Periodontal Regeneration, Brain Korea 21 project for Medical Science)
Choi, Se-Young (Department of Ceramic Engineering, Yonsei University)
Kim, Chong-Kwan (Department of Periodontology, College of Dentistry, Yonsei University, Research Institute for Periodontal Regeneration, Brain Korea 21 project for Medical Science)
Choi, Seong-Ho (Department of Periodontology, College of Dentistry, Yonsei University, Research Institute for Periodontal Regeneration, Brain Korea 21 project for Medical Science)
Publication Information
Journal of Periodontal and Implant Science / v.32, no.4, 2002 , pp. 753-767 More about this Journal
Abstract
The purpose of this study was to evaluate histologically the effect of LiF-maleic acid added calcium aluminate(LM-CA) bone cement & CA-PMMA composite bone cement on the healing of calvarial defect in Sprague-Dawley rats. The critical size defects were surgically produced in the calvarial bone using the 8mm trephine bur. The rats were divided in three groups : In the control group, nothing was applied into the defect of each rat. LM-CA bone cement was implanted in the experimental group 1 and CA-PMMA composite bone cement was implanted in the experimental group 2. Rats were sacrificed at 2, 8 weeks after surgical procedure. The specimens were examined by histologic analysis, especially about the bone-cement interface and the response of surrounding tissue. The results are as follows; 1. In the control group, inflammatory infiltration was observed at 2 weeks. At 8 weeks, periosteum and duramater were continuously joined together in the defect area. But the center of defect area was filled up with the loose connective tissue. 2. In the experimental group 1, the bonding between implanted bone cement and the existing bone was seen, which more increased in 8 weeks than 2 weeks. Inflammatory infiltration and the dispersion of implanted bone cement particles were seen in both 2 weeks and 8 weeks. 3. In the experimental group 2, implanted bone itself had a dimensional stability and no bonding between implanted bone cement and the existing bone was seen in both 2 weeks and 8 weeks. Implanted bone cement was encapsulated by fibrous connective tissue. In addition, inflammatory infiltration was seen around implanted bone cement. On the basis of these results, when LM-CA bone cement or CA-PMMA composite bone cement was implanted in rat calvarial defect, LM-CA bone cement can be used as a bioactive bone graft material due to ability of bonding to the existing bone and CA-PMMA can be used as a graft material for augmentation of bone-volume due to dimensional stability.
Keywords
calcium aluminaate bone cement; PMMA; calvarial defect;
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1 Schallhorn RG, Hiatt WH, Boyce W. Iliac transplants in periodontal therapy. J Periodontol 1970;41:566   DOI
2 Melloning JT, Donor selection, testing, and inactivation of the HIV virus in freeze-dried bone allografts. Pract Perio Aesthet Dent 1995;7:13
3 Hench LL. Bioceramics: From concept to clinic. J Am Ceram Soc 1991;74:1487-1510   DOI
4 Wagner WC, Bagchi A, Groh CL. Setting accelerators for a calcium aluminate using amalgam substitute J Dent Res 1997;76(special issue) :420
5 Nicholson JW. Adhesive dental materials and their durability. Int J Adhesion & Adhesive 2000;20:11-16   DOI   ScienceOn
6 Charnley J. Anchorage of femoral head prosthesis to shaft of femur. J Bone Joint Surg 1960;42B:28-30
7 Lewis G. Properties of acrylic bone cement: State of the art review. J Biomed Mater Res(Appl Biomater) 1997;38:155-182   DOI   ScienceOn
8 ISO 10993, Biological evaluation of medical devices. Part 4: selection of tests for interaction with blood. ISO, Geneva, 1992
9 Kim CK, Choi EJ, Cho KS, Chai JK, Wikesj? U.M.E. Periodontal repair in intrabony defects treated with a calcium carbonate implant and guided tissue regeneration. J Periodontal 1996;67(12):1301-1306   DOI   ScienceOn
10 Schmitz JP, Hollinger JO. The critical size defect as an experimental model for craniornandibulo-facial nonunions. Clin Orthop 1986;205:299-308
11 Selvig KA. Discussion: Animal models in reconstructive therapy. J Periodontal 1994;65:1169-1172   DOI   ScienceOn
12 Freeman E, Turnbull RS. The role of osseous coagulum as a graft material . J Perio Res 1973;8:229-235   DOI
13 Klawitter JJ, Hulbert SF. Application of porous ceramics for the attachment of load bearing internal orthopedic applications. J Biomed Mater Res Symposium 1971;2:161-229
14 Uchida A, Nade S, McCartney ER, Ching W. The use of ceramics for bone replacement : a comparative study of three different porous ceramics. J Bone Joint Surg 1984;66-B:269-275
15 Schliephake H, Kage T. Enhancement of bone regeneration using resorbable ceramics and a polymer-ceramic composite material. J Biomed Mater Res 2001;56(1):128-136   DOI   ScienceOn
16 Hikkila JT, Aho AJ, Kangasniemi I, Yli-Urpo A. Polymethylmethacrylate composites : Disturbed bone formation at the surface of bioactive glass and hydroxyapatitie. Biomaterials 1996;17:1755-1760   DOI   ScienceOn
17 Mousa WF, Kobayashi M, Shinzato S, Kamimura M, Neo M, Yoshihara S, Nakamura T. Biological and mechanical properties of PMMA-based bioactive bone cements. Biomaterials 2000;21:2137-2146   DOI   ScienceOn
18 Kokubo T, Hayashi T, Sakka S, Kitsugi T, Yamamuro T. Bonding between bioactive glasses, glass-ceramic or ceramics in a simulated body fluid. J Ceram Soc Jpn 1987;95(8):785-791
19 Hammer III JE, Reed OM, Greulich RC. Ceramic root implantation in baboons. J Biomed Mater Res Symposium 1972;3:1-13   DOI
20 오승한. 결손골 수복용 Calcium aluminate 골시멘트의 경화거동 및 기계적.생물학적 특성에 관한 연구. 박사학위 논문, 연세대학교 대학원. 서울, 2002
21 Buck B, Malinin T, Brown M. Bone transplantation and human immunodeficiency virus : an estimate of risk for acquired irnmunodeficiency syndrome(AIDS). Clin Orthop 1989;240:129
22 Kokubo K. Recent progress in glass-based materials for biomedical applications. J ceram Soc Japan 1991;99:965-973   DOI
23 LeGeros RZ. Calcium phosphates in oral biology and medicine. Karger, Singapore, 1991:69-81
24 Ohura K, Nakamura T, Yamamuro T, Kokubo T, Ebisawa Y, Kotoura Y, Oka M. Bone-bonding ability of P205-free CaO-SiO2 glasses. J Biomed Mater Res 1991;25:357-365   DOI   PUBMED
25 Becker W, Becker BE, Caffesse R. Acomparison of demineralized freeze-dried bone and autologous bone to induce bone formation in human extraction sockets. J Periodontal 1994;65:1128-1133   DOI   ScienceOn
26 Shinzato S, Kobayashi M, Mousa WF, Kamimura M, Neo M, Kitamura Y, Kokubo T, Nakamura T. Bioactive polymethyl methacrylate-based bone cement: Comparison of glass beads, apatite- and wollastonite-containing glass-ceramic, and hydoxyapatite fillers on mechanical and biological properties. J Biomed Mater Res 2000;51(2):258-272   DOI   ScienceOn
27 Hiatt WH, Schallhom RG. Human Allografts of Iliac Cancellous Bone and Marrow in Periodontal Osseous Defects. I. Rationale and Methodology J PeriodontoI 1971;42:642-651
28 Kim CY, Clark AE, Hench LL. Early stages of calcium phosphate layer formation in bioglasses, J Noncryst Solids 1989;113:195-202   DOI   ScienceOn
29 Takagi K, Urist MR. The reaction of the dura to Bone Morphogenetic Protein(BMP) in repair of skull defects. Ann Surg 1982;196:100-109   DOI   ScienceOn
30 Hentrich RL, Graves GA, Stein HG, Bajpai PK. An evaluation of inert and resorbable ceramics for future clinical orthopedic applications. J Biomed Mater Res 1971;5:25-51   DOI   PUBMED
31 Zimehl R, Hannig M. Non metallic restorative materials based on glass ionomer cement recent trends and developments. Coll & Surf 2000;163:55-62   DOI   ScienceOn
32 Bosch C, Melsen B, Vargervik K. Importance of the critical-sized bone defect in testing bone-regenerating materials. J Craniofac Surg 1998;9(4):310-316.   DOI   ScienceOn
33 Schmitz JP, Schwarz Z, Hollinger JO, Boyan BD. Charaterization of rat calvarial nonunion defects. Acta Anat 1990;138:185-192   DOI
34 Bronzo JD. The Biomedical Engineering Handbook. CRC Press, New York 1995:552-580
35 Caton J, Mota L, Gandini L, Laskaris B. Nonhuman primate models for testing the efficacy and safety of periodontal regeneration procedures. J Periodontal 1994;65:1143-1150   DOI   ScienceOn
36 Jarcho M, Kay JF, Gumaer KI, Doremus RH, Drobeck HP. Tissue, cellular and subcellular events at a bone ceramic hydroxyapatite interface. J Bioeng;1977;1:79-92   PUBMED
37 Barry TI, Clinton DJ, Wilson AD. The structure of a glass-ionomer cement and its relationship to the setting process. J Dent Res 1979;3:1072-1079
38 Oh SH, Choi SY, Lee YK, Kim KN. The loss bone regeneration materials based on high alumina cement: The influence in simulated body fluid and artificial saliva, 52nd PCRM Meet. Am Ceram Soc 2000
39 Zander HA, Polson AM, Heijle CD. Goals of periodontal therapy. J periodontol, 1976;47:261   DOI
40 Dragoo MR, Sullivan HC. A clinical and histological evaluation of autogenous iliac bone grafts in humans II. External root resorption. J Periodontol 1973;A4:614
41 Kokubo T. Surface chemistry of bioactive glass-ceramics. J Noncryst Solids 1990;120:138-151   DOI   ScienceOn
42 McGee TD. Bone Replacement and Grafting with a Biologically Active Ceramic Composite. Kor J Ceram 2001; 7(1):41-44   과학기술학회마을   ScienceOn
43 정의원, 서종진, 최성호, 조규성, 채중규, 김종관. 백서 두개골 결손부에서 키토산의 골조직 재생 유도 효과. 대한치주과학회지 2000;30(4): 851-868   과학기술학회마을   ScienceOn
44 Nade S, Armstrong L, McCartney ER, Baggaley B. Osteogenesis after bone and bone marrow transplantation : the ability of ceramic materials to sustain osteogenesis from transplanted bone marrow cells. Preliminary studies. Clin Orthop 1983;181:217-225
45 Carranza FA. Glickman's clinical periodontology, 7th edition, W.B. Sander Co. 1990
46 Freeman MAR. Bradley GW. Ravell PA. Observation upon the interface between bone and polymethylmethacrylate cement. J Bone Joint Surg 1982;64-B:489-493
47 Park JS, Suh JJ, Choi SH, Moon IS, Cho KS, Kim CK, Chai JK. Effects of bioactive glass implantation in intrabony periodontoal defects on pretreatment clinical parameters. J Periodontal 2000;16
48 Smith L. Ceramic-Plastic material as a bone substitute. Arch Surg 1963;87:653-661   DOI   PUBMED   ScienceOn
49 Hench LL, Andersson O. Bioactive glasses, In: L. L. Hench and J. Wilson (Editors), An introduction to bioceramics. World Scientific Publishing co., New Jersey, 1993:41-62
50 김성태, 전길자, 임소형, 조규성, 김종관, 최성호. 백서 두개골 결손부에서 홍화씨 추출물의 골조직 재생 유도 효과. 대한치주과학회지 2000;30(4):835-850   과학기술학회마을   ScienceOn
51 ISO 7405, Dentistry - preclinical evaluation of biocompatibility of medical devices used in dentistry - test methods for dental materials. ISO, Geneva, 1997
52 Kokubo T, Ito Z, Huang T, Hayashi T, Sakka S. Ca, P-rich layer formed on high-strength bioactive glass-ceramics A-W. J Biomed Mater Res 1990;24:331-343   DOI   PUBMED
53 Kim CK, Chai JK, Cho KS, Moon IS, Choi SH, Sottosanti JS, Wikesj? U.M.E. Periodontal repair in intrabony defects treated with a calcium sulfate implant defects treated with a calcium sulfate implant and calcium sulfate barrier. J Periodontal 1998;69(12):1317-1324   DOI   ScienceOn
54 Hench LL, Splinter RJ, Allen WC, Greenlee TK. Bonding mechanisms at the interface of ceramic prosthetic materials. J Biomed Mater Res Symp 1971;2:117-141
55 Ebisawa Y, Kokubo T, Ohura K, Yamamuro T. Bioactivity of CaO-SiO2-based glasses: In vitro evaluation. J Mater Sci Mater Med 1990;1:239-244   DOI