Journal of Periodontal and Implant Science

Korean Academy of Periodontology (대한치주과학회)
권호 표지

The effect of LiF-maleic acid added calcium aluminate hone cement & CA-PMMA composite bone cement on the healing of calvarial defect6)

LiF-maleic acid 첨가 calcium aluminate 골시멘트 및 CA-PMMA 복합 골시멘트가 백서 두개골 결손부 치유에 미치는 영향

  • Shin, Jung-A (Department of Periodontology, College of Dentistry, Yonsei University, Research Institute for Periodontal Regeneration, Brain Korea 21 project for Medical Science) ;
  • Yun, Jeong-Ho (Department of Periodontology, College of Dentistry, Yonsei University, Research Institute for Periodontal Regeneration, Brain Korea 21 project for Medical Science) ;
  • Oh, Seung-Han (Department of Ceramic Engineering, Yonsei University) ;
  • Baik, Jeong-Won (Department of Periodontology, College of Dentistry, Yonsei University, Research Institute for Periodontal Regeneration, Brain Korea 21 project for Medical Science) ;
  • Choi, Se-Young (Department of Ceramic Engineering, Yonsei University) ;
  • Kim, Chong-Kwan (Department of Periodontology, College of Dentistry, Yonsei University, Research Institute for Periodontal Regeneration, Brain Korea 21 project for Medical Science) ;
  • Choi, Seong-Ho (Department of Periodontology, College of Dentistry, Yonsei University, Research Institute for Periodontal Regeneration, Brain Korea 21 project for Medical Science)
  • 신정아 (연세대학교 치과대학 치주과학교실, 치주조직재생연구소, BK21 의과학사업단) ;
  • 윤정호 (연세대학교 치과대학 치주과학교실, 치주조직재생연구소, BK21 의과학사업단) ;
  • 오승한 (연세대학교 공과대학 세라믹공학과) ;
  • 백정원 (연세대학교 치과대학 치주과학교실, 치주조직재생연구소, BK21 의과학사업단) ;
  • 최세영 (연세대학교 공과대학 세라믹공학과) ;
  • 김종관 (연세대학교 치과대학 치주과학교실, 치주조직재생연구소, BK21 의과학사업단) ;
  • 최성호 (연세대학교 치과대학 치주과학교실, 치주조직재생연구소, BK21 의과학사업단)
  • Published : 2002.12.31
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Abstract

The purpose of this study was to evaluate histologically the effect of LiF-maleic acid added calcium aluminate(LM-CA) bone cement & CA-PMMA composite bone cement on the healing of calvarial defect in Sprague-Dawley rats. The critical size defects were surgically produced in the calvarial bone using the 8mm trephine bur. The rats were divided in three groups : In the control group, nothing was applied into the defect of each rat. LM-CA bone cement was implanted in the experimental group 1 and CA-PMMA composite bone cement was implanted in the experimental group 2. Rats were sacrificed at 2, 8 weeks after surgical procedure. The specimens were examined by histologic analysis, especially about the bone-cement interface and the response of surrounding tissue. The results are as follows; 1. In the control group, inflammatory infiltration was observed at 2 weeks. At 8 weeks, periosteum and duramater were continuously joined together in the defect area. But the center of defect area was filled up with the loose connective tissue. 2. In the experimental group 1, the bonding between implanted bone cement and the existing bone was seen, which more increased in 8 weeks than 2 weeks. Inflammatory infiltration and the dispersion of implanted bone cement particles were seen in both 2 weeks and 8 weeks. 3. In the experimental group 2, implanted bone itself had a dimensional stability and no bonding between implanted bone cement and the existing bone was seen in both 2 weeks and 8 weeks. Implanted bone cement was encapsulated by fibrous connective tissue. In addition, inflammatory infiltration was seen around implanted bone cement. On the basis of these results, when LM-CA bone cement or CA-PMMA composite bone cement was implanted in rat calvarial defect, LM-CA bone cement can be used as a bioactive bone graft material due to ability of bonding to the existing bone and CA-PMMA can be used as a graft material for augmentation of bone-volume due to dimensional stability.

Keywords

References

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