• 제목/요약/키워드: Critical Factor of Using

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패턴된 폴리머를 이용한 중간엽줄기세포의 연골 분화 (Chondrogenic Differentiation of Human Mesenchymal Stem Cells on a Patterned Polymer Surface)

  • 허준석
    • 대한임상검사과학회지
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    • 제47권3호
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    • pp.117-124
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    • 2015
  • 중간엽줄기세포는 손상된 관절연골 치유능력을 가지고 있어 줄기세포 치료 분야에서 대표적인 성체줄기세포로 알려져 있다. 자외선이 조사된 생체 친화성 필름 조성물인 DTOPV (S-triazine bridged p-phenylenevinylene)는 친수성 특성의 표면을 가진 형광 화합물이다. 이전의연구에서 물질표면의 습윤성과 친수성이 세포부착 및 증식에 중요한 역할을 하는 것이 확인 되었으며, 이번 연구에서는 DTOPV를 이용하여 중간엽줄기세포의 연골분화능을 향상시키고자 하였다. 일반 배양용기로 사용하고 있는 TCPS (tissue culture polystyrene)와 자외선이 조사된 패턴된 DTOPV 필름을 이 실험에 사용하였고 TGF (transforming growth factor)-${\beta}3$가 포함된연골분화배지로 중간엽줄기세포를 2주동안 분화유도를 하였다. TCPS에서 배양된 중간엽줄기세포는 단층으로 자라면서 분화가 유도된 반면, 자외선이 조사된 DTOPV 필름 위에서 배양된 세포는덩어리진 구형으로 형태가 변하였으며, 연골세포에 특이적으로 염색되는 Safranine O 염색으로 DTOPV 조건에서 더 붉게 염색됨을 관찰하였다. 또한 연골세포 특이적인 유전자인 Type II collage이 DTOPV 조건에서 더 강하게 발현되는 것을 확인함으로써 TCPS보다 DTOPV에서 연골세포로 분화가 향상된 것을 알 수 있었다. 따라서 자외선이 조사된 생체 친화성 필름 조성물인 DTOPV을 이용한 경우에 일반 배양용기보다 빠르게 연골분화가 이루어짐을 알 수 있었다. 결론적으로 향후 조직공학 분야에서 DTOPV가 중간엽줄기세포의 효과적인 연골분화 물질로서 활용될 수 있는 가능성을 확인 하였으며, 더 나아가 약물 스크리닝과 같은 진단분야에 활용될 수 있음을 알 수 있었다.

한정된 O-D조사자료를 이용한 주 전체의 트럭교통예측방법 개발 (DEVELOPMENT OF STATEWIDE TRUCK TRAFFIC FORECASTING METHOD BY USING LIMITED O-D SURVEY DATA)

  • 박만배
    • 대한교통학회:학술대회논문집
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    • 대한교통학회 1995년도 제27회 학술발표회
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    • pp.101-113
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    • 1995
  • The objective of this research is to test the feasibility of developing a statewide truck traffic forecasting methodology for Wisconsin by using Origin-Destination surveys, traffic counts, classification counts, and other data that are routinely collected by the Wisconsin Department of Transportation (WisDOT). Development of a feasible model will permit estimation of future truck traffic for every major link in the network. This will provide the basis for improved estimation of future pavement deterioration. Pavement damage rises exponentially as axle weight increases, and trucks are responsible for most of the traffic-induced damage to pavement. Consequently, forecasts of truck traffic are critical to pavement management systems. The pavement Management Decision Supporting System (PMDSS) prepared by WisDOT in May 1990 combines pavement inventory and performance data with a knowledge base consisting of rules for evaluation, problem identification and rehabilitation recommendation. Without a r.easonable truck traffic forecasting methodology, PMDSS is not able to project pavement performance trends in order to make assessment and recommendations in the future years. However, none of WisDOT's existing forecasting methodologies has been designed specifically for predicting truck movements on a statewide highway network. For this research, the Origin-Destination survey data avaiiable from WisDOT, including two stateline areas, one county, and five cities, are analyzed and the zone-to'||'&'||'not;zone truck trip tables are developed. The resulting Origin-Destination Trip Length Frequency (00 TLF) distributions by trip type are applied to the Gravity Model (GM) for comparison with comparable TLFs from the GM. The gravity model is calibrated to obtain friction factor curves for the three trip types, Internal-Internal (I-I), Internal-External (I-E), and External-External (E-E). ~oth "macro-scale" calibration and "micro-scale" calibration are performed. The comparison of the statewide GM TLF with the 00 TLF for the macro-scale calibration does not provide suitable results because the available 00 survey data do not represent an unbiased sample of statewide truck trips. For the "micro-scale" calibration, "partial" GM trip tables that correspond to the 00 survey trip tables are extracted from the full statewide GM trip table. These "partial" GM trip tables are then merged and a partial GM TLF is created. The GM friction factor curves are adjusted until the partial GM TLF matches the 00 TLF. Three friction factor curves, one for each trip type, resulting from the micro-scale calibration produce a reasonable GM truck trip model. A key methodological issue for GM. calibration involves the use of multiple friction factor curves versus a single friction factor curve for each trip type in order to estimate truck trips with reasonable accuracy. A single friction factor curve for each of the three trip types was found to reproduce the 00 TLFs from the calibration data base. Given the very limited trip generation data available for this research, additional refinement of the gravity model using multiple mction factor curves for each trip type was not warranted. In the traditional urban transportation planning studies, the zonal trip productions and attractions and region-wide OD TLFs are available. However, for this research, the information available for the development .of the GM model is limited to Ground Counts (GC) and a limited set ofOD TLFs. The GM is calibrated using the limited OD data, but the OD data are not adequate to obtain good estimates of truck trip productions and attractions .. Consequently, zonal productions and attractions are estimated using zonal population as a first approximation. Then, Selected Link based (SELINK) analyses are used to adjust the productions and attractions and possibly recalibrate the GM. The SELINK adjustment process involves identifying the origins and destinations of all truck trips that are assigned to a specified "selected link" as the result of a standard traffic assignment. A link adjustment factor is computed as the ratio of the actual volume for the link (ground count) to the total assigned volume. This link adjustment factor is then applied to all of the origin and destination zones of the trips using that "selected link". Selected link based analyses are conducted by using both 16 selected links and 32 selected links. The result of SELINK analysis by u~ing 32 selected links provides the least %RMSE in the screenline volume analysis. In addition, the stability of the GM truck estimating model is preserved by using 32 selected links with three SELINK adjustments, that is, the GM remains calibrated despite substantial changes in the input productions and attractions. The coverage of zones provided by 32 selected links is satisfactory. Increasing the number of repetitions beyond four is not reasonable because the stability of GM model in reproducing the OD TLF reaches its limits. The total volume of truck traffic captured by 32 selected links is 107% of total trip productions. But more importantly, ~ELINK adjustment factors for all of the zones can be computed. Evaluation of the travel demand model resulting from the SELINK adjustments is conducted by using screenline volume analysis, functional class and route specific volume analysis, area specific volume analysis, production and attraction analysis, and Vehicle Miles of Travel (VMT) analysis. Screenline volume analysis by using four screenlines with 28 check points are used for evaluation of the adequacy of the overall model. The total trucks crossing the screenlines are compared to the ground count totals. L V/GC ratios of 0.958 by using 32 selected links and 1.001 by using 16 selected links are obtained. The %RM:SE for the four screenlines is inversely proportional to the average ground count totals by screenline .. The magnitude of %RM:SE for the four screenlines resulting from the fourth and last GM run by using 32 and 16 selected links is 22% and 31 % respectively. These results are similar to the overall %RMSE achieved for the 32 and 16 selected links themselves of 19% and 33% respectively. This implies that the SELINICanalysis results are reasonable for all sections of the state.Functional class and route specific volume analysis is possible by using the available 154 classification count check points. The truck traffic crossing the Interstate highways (ISH) with 37 check points, the US highways (USH) with 50 check points, and the State highways (STH) with 67 check points is compared to the actual ground count totals. The magnitude of the overall link volume to ground count ratio by route does not provide any specific pattern of over or underestimate. However, the %R11SE for the ISH shows the least value while that for the STH shows the largest value. This pattern is consistent with the screenline analysis and the overall relationship between %RMSE and ground count volume groups. Area specific volume analysis provides another broad statewide measure of the performance of the overall model. The truck traffic in the North area with 26 check points, the West area with 36 check points, the East area with 29 check points, and the South area with 64 check points are compared to the actual ground count totals. The four areas show similar results. No specific patterns in the L V/GC ratio by area are found. In addition, the %RMSE is computed for each of the four areas. The %RMSEs for the North, West, East, and South areas are 92%, 49%, 27%, and 35% respectively, whereas, the average ground counts are 481, 1383, 1532, and 3154 respectively. As for the screenline and volume range analyses, the %RMSE is inversely related to average link volume. 'The SELINK adjustments of productions and attractions resulted in a very substantial reduction in the total in-state zonal productions and attractions. The initial in-state zonal trip generation model can now be revised with a new trip production's trip rate (total adjusted productions/total population) and a new trip attraction's trip rate. Revised zonal production and attraction adjustment factors can then be developed that only reflect the impact of the SELINK adjustments that cause mcreases or , decreases from the revised zonal estimate of productions and attractions. Analysis of the revised production adjustment factors is conducted by plotting the factors on the state map. The east area of the state including the counties of Brown, Outagamie, Shawano, Wmnebago, Fond du Lac, Marathon shows comparatively large values of the revised adjustment factors. Overall, both small and large values of the revised adjustment factors are scattered around Wisconsin. This suggests that more independent variables beyond just 226; population are needed for the development of the heavy truck trip generation model. More independent variables including zonal employment data (office employees and manufacturing employees) by industry type, zonal private trucks 226; owned and zonal income data which are not available currently should be considered. A plot of frequency distribution of the in-state zones as a function of the revised production and attraction adjustment factors shows the overall " adjustment resulting from the SELINK analysis process. Overall, the revised SELINK adjustments show that the productions for many zones are reduced by, a factor of 0.5 to 0.8 while the productions for ~ relatively few zones are increased by factors from 1.1 to 4 with most of the factors in the 3.0 range. No obvious explanation for the frequency distribution could be found. The revised SELINK adjustments overall appear to be reasonable. The heavy truck VMT analysis is conducted by comparing the 1990 heavy truck VMT that is forecasted by the GM truck forecasting model, 2.975 billions, with the WisDOT computed data. This gives an estimate that is 18.3% less than the WisDOT computation of 3.642 billions of VMT. The WisDOT estimates are based on the sampling the link volumes for USH, 8TH, and CTH. This implies potential error in sampling the average link volume. The WisDOT estimate of heavy truck VMT cannot be tabulated by the three trip types, I-I, I-E ('||'&'||'pound;-I), and E-E. In contrast, the GM forecasting model shows that the proportion ofE-E VMT out of total VMT is 21.24%. In addition, tabulation of heavy truck VMT by route functional class shows that the proportion of truck traffic traversing the freeways and expressways is 76.5%. Only 14.1% of total freeway truck traffic is I-I trips, while 80% of total collector truck traffic is I-I trips. This implies that freeways are traversed mainly by I-E and E-E truck traffic while collectors are used mainly by I-I truck traffic. Other tabulations such as average heavy truck speed by trip type, average travel distance by trip type and the VMT distribution by trip type, route functional class and travel speed are useful information for highway planners to understand the characteristics of statewide heavy truck trip patternS. Heavy truck volumes for the target year 2010 are forecasted by using the GM truck forecasting model. Four scenarios are used. Fo~ better forecasting, ground count- based segment adjustment factors are developed and applied. ISH 90 '||'&'||' 94 and USH 41 are used as example routes. The forecasting results by using the ground count-based segment adjustment factors are satisfactory for long range planning purposes, but additional ground counts would be useful for USH 41. Sensitivity analysis provides estimates of the impacts of the alternative growth rates including information about changes in the trip types using key routes. The network'||'&'||'not;based GMcan easily model scenarios with different rates of growth in rural versus . . urban areas, small versus large cities, and in-state zones versus external stations. cities, and in-state zones versus external stations.

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Risk Stratification for Serosal Invasion Using Preoperative Predictors in Patients with Advanced Gastric Cancer

  • Park, Sung-Sil;Min, Jae-Seok;Lee, Kyu-Jae;Jin, Sung-Ho;Park, Sunhoo;Bang, Ho-Yoon;Yu, Hwang-Jong;Lee, Jong-Inn
    • Journal of Gastric Cancer
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    • 제12권3호
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    • pp.149-155
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    • 2012
  • Purpose: Although serosal invasion is a critical predisposing factor for peritoneal dissemination in advanced gastric cancer, the accuracy of preoperative assessment using routine imaging studies is unsatisfactory. This study was conducted to identify high-risk group for serosal invasion using preoperative factors in patients with advanced gastric cancer. Materials and Methods: We retrospectively analyzed clinicopathological features of 3,529 advanced gastric cancer patients with Borrmann type I/II/III who underwent gastrectomy at Korea Cancer Center Hospital between 1991 and 2005. We stratified patients into low-(${\leq}40%$), intermediate-(40~70%), and high-risk (>70%) groups, according to the probability of serosal invasion. Results: Borrmann type, size, longitudinal and circumferential location, and histology of tumors were independent risk factors for serosal invasion. Most tumors of whole stomach location or encircling type had serosal invasion, so they belonged to high-risk group. Patients were subdivided into 12 subgroups in combination of Borrmann type, size, and histology. A subgroup with Borrmann type II, large size (${\geq}7$ cm), and undifferentiated histology and 2 subgroups with Borrmann type III, large size, and regardless of histology belonged to high-risk group and corresponded to 25% of eligible patients. Conclusions: This study have documented high-risk group for serosal invasion using preoperative predictors. And risk stratification for serosal invasion through the combination with imaging studies may collaboratively improve the accuracy of preoperative assessment, reduce the number of eligible patients for further staging laparoscopy, and optimize therapeutic strategy for each individual patient prior to surgery.

Piezocone 시험을 이용한 해성점토의 수평압밀 특성 연구 (Horizontal Consolidation Characteristics of Marine Clay Using Piezocone Test)

  • 이강운;윤길림;채영수
    • 한국지반공학회논문집
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    • 제19권5호
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    • pp.133-144
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    • 2003
  • 국내 남해안 해성점토 지반의 압밀특성을 파악하고자 Piezocone 시험으로 평가한 수평방향 압밀계수와 표준압밀 시험결과를 비교하였다. 기존에 제안된 수평방향 압밀계수 추정 방법들은 상호간의 편차가 클 뿐만 아니라 실내 압밀 시험값과 비교해도 그 차가 커서 사용하기에는 많은 불확실성을 갖고 있는 것으로 알려져 있다. 제안된 방법중에서 Torstensson(1977)의 구형모델과 공동확장이론, 수정 Cam-Clay모델의 한계상태이론을 적용한 Burns and Mayne의 방법(1998)은 본 연구지역과 같은 고소성 지반에서 신뢰성이 높은 것으로 나타났다. 이중 Burns and Mayne의 방법(1998)을 사용하여 소산시험결과를 정규화한 분석결과에 따르면 50% 압밀시의 시간계수($T_{50}$)는 0.015로 추정되었다. 또한 본 연구 지반조건과 유사현장의 시험성과를 활용하여 비교 분석한 결과 새롭게 제안한 Bums and Mayne의 방법(1998)은 실내 시험값에 비해 약 1.5배 작은 것으로 나타났다. 이러한 연구결과는 표준압밀시험 결과차가 상호간에 3~4배 차를 보이는 것을 감안할 때 상당히 양호한 것으로 나타났다. 이외에도 또 다른 차원에서 소산시험결과로부터 압밀계수를 직접 산정하는 방법으로서 국내에서 널리 사용중인 Robertson 등(1992)의 제안방법을 이용하여 새로운 도표를 제안하였다. 제안된 도표는 Burns and Mayne(1998)의 이론적 방법을 활용한 방법으로서 소성이 높은 지반에서 활용할 경우 신뢰성이 높은 것으로 나타났다.

시맨틱 웹 기술혁신의 채택과 확산: 질적연구접근법 (The Adoption and Diffusion of Semantic Web Technology Innovation: Qualitative Research Approach)

  • 주재훈
    • Asia pacific journal of information systems
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    • 제19권1호
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    • pp.33-62
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    • 2009
  • Internet computing is a disruptive IT innovation. Semantic Web can be considered as an IT innovation because the Semantic Web technology possesses the potential to reduce information overload and enable semantic integration, using capabilities such as semantics and machine-processability. How should organizations adopt the Semantic Web? What factors affect the adoption and diffusion of Semantic Web innovation? Most studies on adoption and diffusion of innovation use empirical analysis as a quantitative research methodology in the post-implementation stage. There is criticism that the positivist requiring theoretical rigor can sacrifice relevance to practice. Rapid advances in technology require studies relevant to practice. In particular, it is realistically impossible to conduct quantitative approach for factors affecting adoption of the Semantic Web because the Semantic Web is in its infancy. However, in an early stage of introduction of the Semantic Web, it is necessary to give a model and some guidelines and for adoption and diffusion of the technology innovation to practitioners and researchers. Thus, the purpose of this study is to present a model of adoption and diffusion of the Semantic Web and to offer propositions as guidelines for successful adoption through a qualitative research method including multiple case studies and in-depth interviews. The researcher conducted interviews with 15 people based on face-to face and 2 interviews by telephone and e-mail to collect data to saturate the categories. Nine interviews including 2 telephone interviews were from nine user organizations adopting the technology innovation and the others were from three supply organizations. Semi-structured interviews were used to collect data. The interviews were recorded on digital voice recorder memory and subsequently transcribed verbatim. 196 pages of transcripts were obtained from about 12 hours interviews. Triangulation of evidence was achieved by examining each organization website and various documents, such as brochures and white papers. The researcher read the transcripts several times and underlined core words, phrases, or sentences. Then, data analysis used the procedure of open coding, in which the researcher forms initial categories of information about the phenomenon being studied by segmenting information. QSR NVivo version 8.0 was used to categorize sentences including similar concepts. 47 categories derived from interview data were grouped into 21 categories from which six factors were named. Five factors affecting adoption of the Semantic Web were identified. The first factor is demand pull including requirements for improving search and integration services of the existing systems and for creating new services. Second, environmental conduciveness, reference models, uncertainty, technology maturity, potential business value, government sponsorship programs, promising prospects for technology demand, complexity and trialability affect the adoption of the Semantic Web from the perspective of technology push. Third, absorptive capacity is an important role of the adoption. Fourth, suppler's competence includes communication with and training for users, and absorptive capacity of supply organization. Fifth, over-expectance which results in the gap between user's expectation level and perceived benefits has a negative impact on the adoption of the Semantic Web. Finally, the factor including critical mass of ontology, budget. visible effects is identified as a determinant affecting routinization and infusion. The researcher suggested a model of adoption and diffusion of the Semantic Web, representing relationships between six factors and adoption/diffusion as dependent variables. Six propositions are derived from the adoption/diffusion model to offer some guidelines to practitioners and a research model to further studies. Proposition 1 : Demand pull has an influence on the adoption of the Semantic Web. Proposition 1-1 : The stronger the degree of requirements for improving existing services, the more successfully the Semantic Web is adopted. Proposition 1-2 : The stronger the degree of requirements for new services, the more successfully the Semantic Web is adopted. Proposition 2 : Technology push has an influence on the adoption of the Semantic Web. Proposition 2-1 : From the perceptive of user organizations, the technology push forces such as environmental conduciveness, reference models, potential business value, and government sponsorship programs have a positive impact on the adoption of the Semantic Web while uncertainty and lower technology maturity have a negative impact on its adoption. Proposition 2-2 : From the perceptive of suppliers, the technology push forces such as environmental conduciveness, reference models, potential business value, government sponsorship programs, and promising prospects for technology demand have a positive impact on the adoption of the Semantic Web while uncertainty, lower technology maturity, complexity and lower trialability have a negative impact on its adoption. Proposition 3 : The absorptive capacities such as organizational formal support systems, officer's or manager's competency analyzing technology characteristics, their passion or willingness, and top management support are positively associated with successful adoption of the Semantic Web innovation from the perceptive of user organizations. Proposition 4 : Supplier's competence has a positive impact on the absorptive capacities of user organizations and technology push forces. Proposition 5 : The greater the gap of expectation between users and suppliers, the later the Semantic Web is adopted. Proposition 6 : The post-adoption activities such as budget allocation, reaching critical mass, and sharing ontology to offer sustainable services are positively associated with successful routinization and infusion of the Semantic Web innovation from the perceptive of user organizations.

전산화단층촬영에서 촬영 목적 부위와 주변 결정장기에 대한 피폭선량 평가: 선량 권고량 중심으로 (Evaluation of Radiation Exposure Dose for Examination Purposes other than the Critical Organ from Computed Tomography: A base on the Dose Reference Level (DRL))

  • 이서영;김경리;하혜경;임인철;이재승;박형후;곽병준;유윤식
    • 한국방사선학회논문지
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    • 제7권2호
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    • pp.121-129
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    • 2013
  • 최근 다중검출기 CT의 보편화 된 사용으로 환자의 피폭선량이 증가하고 있다. 따라서 광자극발광선량계를 이용해 촬영 목적 부위와 주변 결정장기에 대한 환자의 피폭선량을 측정하고 그에 따른 생물학적 효과를 예측하여 저감화 방안을 제시하고자 하였다. ICRP에서 권고한 표준안을 대상으로 만들어진 인체 모형 표준 팬텀에 교정상수를 부여받은 OSD 선량계를 측정하고자 하는 좌 우 수정체, 갑상선, 촬영의 중심점, 생식선에 부착하여 각 검사 부위별 노출 조건과 동일한 상태에서 환자의 피폭 선량을 모사하였다. OSL 선량계의 평균 교정상수는 $1.0058{\pm}0.0074$이었으며 검사 부위별 주변 결정장기의 등가선량은 좌 우측 수정체의 경우 직접 피폭이 약 50mGy로 최대였으며 간접 피폭되는 경우 0.24mGy, 원거리에서는 0.005mGy미만의 기준 준위 이하로 측정되었다. 갑상선의 경우 두부 검사에서 10.89mGy로 최대였으며 흉부에서 7.75mGy, 복부 및 요추부, 골반부에서는 기준 미만이었다. 생식선의 경우 골반검사에서 21.98mGy로 최대였으며 간접 피폭되는 검사에서 기준 준위 미만에서 6.92mGy까지 피폭되었다. CT 검사에서 DRL에 대한 저감화 방법은 국제기구에서 권고하고 있는 방사선 방어 원칙에 대한 정당한 해석과 제도적 뒷받침이 필요하다. 따라서 환자의 피폭을 최소화하기 위해서는 정당성을 충족하여야 하며 환자의 피폭선량에 미치는 영향들을 체계화하고 조직의 불필요한 피폭을 최소화 하여야 한다.

장기요양서비스 수요의 결정요인 (Determinants of Demand for Long-Term Care)

  • 정완교
    • KDI Journal of Economic Policy
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    • 제31권1호
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    • pp.139-167
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    • 2009
  • 본 논문은 65세 이상 고령인구의 수와 노인들의 건강상태 등만을 중심으로 한 기존의 연구에 더하여, 노인장기요양보험제도 제2차 시범사업의 자료를 이용한 계량분석을 통해 장기요양서비스 수요의 결정요인을 분석하였다. 분석 결과에 따르면, 우선 노인장기요양보험제도상 장기요양서비스 이용에 대한 보험 적용 대상자를 정하는 등급판정에 일상생활활동에서의 장애가 노인들이 많이 앓고 있는 고혈압, 관절염, 치매 등의 질환을 통제하고서도 통계적으로 유의한 영향을 미쳤다. 또한 노인들의 건강상태, 여성, 기초생활수급자 여부, 노인가구 형태, 노인가구의 월평균 소득 등이 장기요양서비스이용 및 이용 양태에 통계적으로 유의한 영향을 미치는 것으로 나타났다. 특히, 노인가구의 월평균 소득을 통제하고서도 장기요양서비스를 무료로 이용할 수 있는 기초생활수급 대상 노인들의 재가서비스 이용확률이 높게 나타나는데, 이는 소득과 더불어 장기요양서비스의 가격도 장기요양서비스 이용을 결정하는 중요한 요인임을 의미한다.

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자가 말초혈액 조혈모세포 채집에 영향을 주는 관련요인 (Factors Influencing Peripheral Blood Stem Cell Collection)

  • 최용숙;김광성;김연순;황미정;조형숙;김수미
    • 종양간호연구
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    • 제8권1호
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    • pp.1-7
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    • 2008
  • Purpose: Peripheral blood stem cell transplantation (PBSCT) has been widely used. The optimal time for collection is a critical factor to obtain proper counts of CD34 cell by peripheral blood stem cell collection (PBSC). The purpose of this study was to identify the factors influencing peripheral blood stem cell collection in order to figure out the more effective timing for PBSC. Method: The subjects of this study were 189 patients undergoing 3 leukapheresis from January 28, 2005 to December 31,2006. Group's characteristics, checkup opinion of pre-peripheral blood on the day of harvest & outcome of PBSC were analyzed and evaluated using SAS statistics program after grouping patients as below; group 1-CD34 cell counts $<2{\times}10^6/kg$ (n=97); group $2-2{\times}10^6/kg$ ${\leq}CD34$ cell counts $<4{\times}10^6/kg$ (n=26); group 3-CD34 cell counts ${\geq}4{\times}10^6/kg$ (n=63). Results: Based on outcome of peripheral blood stem cell according to diagnosis, acute myelocytic leukemia (AML) was 65.5% at Group 1, Lymphoma was 21.7% at Group 2 and multiple myeloma (MM) was 70.8% at Group 3. There were significant differences in CD34 cell counts according to diagnosis (p=0.00004). Type of cytokine mobilization according to diagnosis, Lenograsim was using 62.5% of MM & 38.2% of AML and filgrastim is using 22.0% of AML only. Circular peripheral blood CD34 cell counts prior to harvest was $258.1/{\mu}L$ at Group 3 which was much higher comparing to Group 1 ($10.5/{\mu}L$) and Group 2 ($39.9/{\mu}L$) (p<0.001). TNC counts of collected peripheral blood stem cell was $15.36{\times}10^6/kg$ at Group 3 and it's much higher than Group 2 ($13.16{\times}10^6/kg$) and Group 1 ($12.36{\times}10^6/kg$) (p=0.083). There was no significant difference in MNC counts inbetween 3 groups. Conclusions: Circular peripheral blood CD34+ cell counts prior to harvest was much higher at Group 3 than Group 1 and Group 2. Therefore, the number of CD34+ cells on the day of harvest can be used as an accurate predictor for peripheral blood stem cell.

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퍼지 온톨로지를 이용한 선호도 기반 공급사슬 파트너 선정 (Preference-based Supply Chain Partner Selection Using Fuzzy Ontology)

  • 이해경;고창성;김태운
    • 지능정보연구
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    • 제17권1호
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    • pp.37-52
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    • 2011
  • 공급사슬관리(SCM)는 공급사슬의 가치를 높이고 변화하는 환경에 더 민첩하게 적응할 수 있는 전략적인 접근방식이다. 공급사슬 파트너 간에 중단 없는 파트너쉽과 가치 창출을 위해서는 정보와 지식의 공유 및 적절한 파트너 선정기준이 적용되어야 한다. 따라서 파트너 선정 기준은 제품의 품질과 신뢰도를 유지하기 위해서 아주 중요하다. 제품의 각 부품은 적절한 공급 파트너를 통해서 공급된다. 파트너를 선정하는 기준은 기술적 능력, 품질, 가격, 지속성 등 여러 요인이 있다. 실제로 파트너 선정기준은 구성부품의 특성에 따라서 변화할 수 있다. 그 부품이 핵심 구성품이면 품질이 가격에 비해서 최고 우선순위가 된다. 표준부품은 낮은 가격이 우선순위를 가진다. 간혹 긴급 주문과 같은 예기치 못한 상황이 발생하면 우선순위가 변하게 된다. 따라서 SCM 파트너 선정 기준은 구성부품의 특성과 상황에 따라서 동적으로 결정 되어진다. 이 연구의 목적은 상황과 부품의 특성에 따라서 공급사슬 파트너쉽을 위한 온톨로지 모델을 제시하고자 하는 것이다. 변수의 불확실성은 퍼지이론을 이용하여 나타내고자 하였다. 부품별 우선순위와 상황변수는 웹 온톨로지 언어(OWL : Web Ontology Language)를 이용하여 모델링 하였다. 부품의 우선순위는 퍼지로직을 이용한 퍼지소속함수로 변환 되어진다. 온톨로지의 추론을 위해서 SWRL(Semantic Web Rule Language)을 이용하였다. 제안된 모델의 구현을 위해서 자동차 구성품인 스타트모터 부품을 대상으로 온톨로지를 구축하고 구성 부품별 우선순위에 따른 공급 파트너를 선정하는 과정을 제시하였다.

이중철심을 이용한 병렬연결된 자기결합형 초전도한류기의 전류제한 및 회복특성 (Current Limiting and Recovery Characteristics of Two Magnetically Coupled Type SFCL with Two Coils Connected in Parallel Using Dual Iron Cores)

  • 고석철;임성훈
    • 한국산학기술학회논문지
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    • 제17권5호
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    • pp.717-722
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    • 2016
  • 본 논문은 고장발생 초기 고장전류의 크기에 따라 피크전류제한 기능을 갖도록 하나의 철심에 기존 1차 코일과 2차 코일이 병렬로 연결된 초전도 소자 1과 추가적인 철심을 사용하여 3차 권선에 초전도 소자 2가 연결된 자기결합형 초전도한류기를 제안하였다. 이중 철심을 이용하여 코일 1과 코일 2간 병렬로 연결한 자기결합형 초전도한류기가 고장발생시 피크전류를 초전도 소자 1만이 분담하는 것을 확인할 수 있었다. 그 이유는 초기 사고전류의 순간적인 요소가 커서 초전도 소자 1이 ?치되어 작동하였으나, 코일 3에 흐르는 전류가 임계전류를 초과하지 않았고, 이로 인해 초전도 소자 2가 ?치되어 작동하지 않았기 때문이다. 사고 시 피크전류를 순차적인 초전도 소자로 제한하기 위해서는 코일 1이 낮은 자기인덕턴스 값을 갖고 있으면서도 코일 2보다 코일 3이 보다 높은 자기인덕턴스 값을 갖도록 설계해야 할 것이다. 또한, 고장 발생 초기 사고전류의 크기를 결정하는 고장조건 중의 하나인 1차 코일과 2차 코일간의 권선비가 0.25일 때 두 SFCL의 전류제한 및 회복특성에 대한 검증을 선로단락실험을 통해 분석되었다. 이 단락실험의 분석결과, 가극결선인 경우가 감극결선한 경우보다도 전류제한 및 회복특성이 더욱 우수함을 확인할 수 있었다.