• Molecules and Cells
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• 제42권4호
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• pp.292-300
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• 2019

Immunometabolism, defined as the interaction of metabolic pathways with the immune system, influences the pathogenesis of metabolic diseases. Metformin and carbon monoxide (CO) are two pharmacological agents known to ameliorate metabolic disorders. There are notable similarities and differences in the reported effects of metformin and CO on immunometabolism. Metformin, an anti-diabetes drug, has positive effects on metabolism and can exert anti-inflammatory and anti-cancer effects via adenosine monophosphate-activated protein kinase (AMPK)-dependent and AMPK-independent mechanisms. CO, an endogenous product of heme oxygenase-1 (HO-1), can exert anti-inflammatory and antioxidant effects at low concentration. CO can confer cytoprotection in metabolic disorders and cancer via selective activation of the protein kinase R-like endoplasmic reticulum (ER) kinase (PERK) pathway. Both metformin and CO can induce mitochondrial stress to produce a mild elevation of mitochondrial ROS (mtROS) by distinct mechanisms. Metformin inhibits complex I of the mitochondrial electron transport chain (ETC), while CO inhibits ETC complex IV. Both metformin and CO can differentially induce several protein factors, including fibroblast growth factor 21 (FGF21) and sestrin2 (SESN2), which maintain metabolic homeostasis; nuclear factor erythroid 2-related factor 2 (Nrf2), a master regulator of the antioxidant response; and REDD1, which exhibits an anticancer effect. However, metformin and CO regulate these effects via different pathways. Metformin stimulates p53- and AMPK-dependent pathways whereas CO can selectively trigger the PERK-dependent signaling pathway. Although further studies are needed to identify the mechanistic differences between metformin and CO, pharmacological application of these agents may represent useful strategies to ameliorate metabolic diseases associated with altered immunometabolism.

• 한국정보통신학회논문지
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• 제23권8호
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• pp.950-958
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• 2019

공유경제의 등장은 디지털 기술을 사회혁신에 활용하는, 디지털 사회혁신을 사회문제의 새로운 해결책으로 주목 받게 하고 있다. 그런데 또 한편으로는 부스러기 공유경제, 주문경제처럼 디지털 기술의 부정적 영향을 우려하는 목소리도 있다. 본 연구는 디지털 사회혁신에 의해 창출되는 가치의 성격과 원천 그리고 작동방식을 밝힘으로써 제기된 의문과 우려에 대한 답을 구해보고자 한다. 먼저 사회혁신이 창출하는 비즈니스 가치의 성격과 원천에 대해 논의하고 디지털 기술에 의해서 창출되는 비즈니스 가치의 성격과 원천을 검토한다. 기부, 연대, 공유라는 사회혁신 활동 창출 가치의 원천, 그리고 디지털 기술이 만들어내는 가치의 원천인 효율성과 효과성을 알아보고 소비자/사용자의 역할을 논의한다. 실제 디지털 사회혁신 성공사례인 행복주차골목 리빙랩의 비즈니스 모델 분석을 통해 창출되는 가치들이 실제 현장에서 어떤 방식으로 발생하고 구현되는지 알아본다.

• 응용통계연구
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• 제34권5호
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• pp.823-835
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• 2021

지역별 인구의 분포에 영향을 미치는 요인의 파악은 국가의 사회, 경제, 문화적 발전 위한 정부의 인구정책 수립에 매우 중요하다. 본 연구에서는 2019년 인구주택 총조사 자료를 기반으로 대한민국 국토를 서울, 대도시, 기타지역의 세 지역으로 나누어 각 지역에서 소지역의 인구 크기에 영향을 미치는 요인들을 살펴 보았다. 인구 자료의 특징은 매우 비대칭적이며 이분산성을 가지므로 조건부 평균에 초점을 맞추는 일반적인 회귀모형 대신 분포에 대한 가정이 필요하지 않은 분위회귀모형을 사용하여 인구의 크기에 따라 변화하는 각 요인의 세부적인 영향을 살펴보았다. 분석결과 서울, 대도시, 기타지역에 따라 그리고 같은 지역 내에서도 세부 지역의 인구크기에 따라 요인의 영향이 매우 달라짐을 확인하였다. 이 결과들은 인구관련 변수들이 지역 마다 매우 이질적인 성질을 가지고 있으며 따라서 획일적인 인구정책이 아닌 지역 특성에 맞는 맞춤형 인구정책을 수립해야 할 필요성을 시사한다.

• Safety and Health at Work
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• 제12권2호
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• pp.268-271
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• 2021

Lung granulomas are uncommon in Thailand. The disease typically develops from an occupational environment and is mostly caused by infection. Herein is a case report of a female patient, aged 48, working as a nurse in an Accident and Emergency Department at a hospital. Eighteen years prior to admission the patient was diagnosed with myasthenia gravis and pulmonary tuberculosis. The chest X-ray and CT scans showed a solitary pulmonary nodule in the lower left lung. The patient received an open thoracotomy with a left lobectomy. Granulomatous and nonseptate hyphae were found in the pathology diagnosis. The patient was thus diagnosed as having a lung granuloma. The galactomannan antigen test was positive. The solitary pulmonary nodule-found from the use of a Polymerase Chain Reaction (PCR) test-was an Aspergillus spp. The fungus culture was collected from air samples. The air samples were collected by the impaction technique using a microbial air sampler. Three types of Aspergillus spp. were found as well as Penicillium spp. and Monilia sitophila. The Aspergillus spp. was a match for the patient's disease. The patient was diagnosed as having a lung granuloma possibly Aspergillus nodule which was caused by airborne Aspergillus spp. from the occupational environment.

• 적정기술학회지
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• 제7권1호
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• pp.26-32
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• 2021

콜드체인의 마지막 단계인 백신전달 과정에서 대부분 얼음을 넣은 단열컨테이너로 온도를 조절하며, 백신의 온도 조절이 적절하지 않아 낭비되는 백신의 양이 상당하다. 예방접종을 관리하고 운영하는데 온도 데이터가 중요하며, 본 연구에서는 실시간 백신전달 모니터링 시스템을 개발하였다. 휴대용 백신 냉장고의 온도, 위치 및 전력 소비 데이터를 수집하기 위해 문자(Short Message Service) 통신 방법을 사용하였고, 한국과 탄자니아(아루샤 및 킬리만자로 지역)에서 시스템을 테스트하였다. 개발된 백신 냉장고는 문자통신을 통해 데이터 손실없이 실시간으로 백신상태를 모니터링을 할 수 있었다. 백신의 상태 및 데이터는 클라우드 서버를 통해 웹 기반 유저 인터페이스에서 확인할 수 있었다.

• 자원리싸이클링
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• 제31권3호
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• pp.27-39
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• 2022

리튬이차전지의 수요는 1990년대 이후로 휴대용 전자 기기 시장과 함께 지속적으로 증가되어 왔으며, 최근 전기 자동차 시장의 급격한 확장에 따라 리튬이차전지 또한 전 세계적으로 수요가 급증하였다. 이는 가까운 미래에 천연자원으로부터의 리튬 공급량을 앞설 것이며, 리튬 자원 수급의 불안정을 초래할 수 있다. 지속적으로 축적되는 수명이 다 한 폐전지 또한 환경적으로 큰 문제를 야기할 수 있다. 이러한 문제를 해결하기 위해, 사용된 리튬이차전지의 재활용은 매우 중요한 기술적 과제이다. 본 연구에서는 건식 공정을 이용한 리튬이차전지의 재활용 공정과 함께 리튬 회수를 위한 추가 공정에 대해 조사하였다. 전지 재활용을 위한 건식 제련의 지속적인 연구는 리튬 및 유가 금속의 회수율을 크게 향상시켜 전기 자동차 및 휴대용 전자기기의 필수 부품인 리튬이차전지의 시장 안정화에 크게 기여할 것이다.

• Journal of Veterinary Science
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• 제21권3호
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• pp.50.1-50.16
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• 2020

Background: Porcine parvovirus (PPV) is a single-stranded DNA virus that causes porcine reproductive failure. It is of critical importance to study PPV pathogenesis for the prevention and control of the disease. NS1, a PPV non-structural protein, is participated in viral DNA replication, transcriptional regulation, and cytotoxicity. Our previous research showed that PPV can activate nuclear factor kappa B (NF-κB) signaling pathway and then up-regulate the expression of interleukin (IL)-6. Objectives: Herein, the purpose of this study is to determine whether the non-structural protein NS1 of PPV also has the same function. Methods: Real-time quantitative reverse transcription polymerase chain reaction (RT-qPCR), enzyme-linked immunosorbent assay, western blot, immunofluorescence assay and small interfering RNA (siRNA) were used. Results: Our findings demonstrated that PPV NS1 protein can up-regulate the expression levels of IL-6 and tumor necrosis factor-alpha in a dose-dependent manner. Moreover, PPV NS1 protein was found to induce the phosphorylation of IκBα, then leading to the phosphorylation and nuclear translocation of NF-κB. In addition, the NS1 protein activated the upstream pathways of NF-κB. Meanwhile, TLR2-siRNA assay showed TLR2 plays an important role in the activation of NF-κB signaling pathway induced by PPV-NS1. Conclusions: These findings indicated that PPV NS1 protein induced the up-regulated of IL-6 expression through activating the TLR2 and NF-κB signaling pathways. In conclusion, these findings provide a new avenue to study the innate immune mechanism of PPV infection.

• International Journal of Computer Science & Network Security
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• 제23권9호
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• pp.77-90
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• 2023

Today, crops face many characteristics/diseases. Insect damage is one of the main characteristics/diseases. Insecticides are not always effective because they can be toxic to some birds. It will also disrupt the natural food chain for animals. A common practice of plant scientists is to visually assess plant damage (leaves, stems) due to disease based on the percentage of disease. Plants suffer from various diseases at any stage of their development. For farmers and agricultural professionals, disease management is a critical issue that requires immediate attention. It requires urgent diagnosis and preventive measures to maintain quality and minimize losses. Many researchers have provided plant disease detection techniques to support rapid disease diagnosis. In this review paper, we mainly focus on artificial intelligence (AI) technology, image processing technology (IP), deep learning technology (DL), vector machine (SVM) technology, the network Convergent neuronal (CNN) content Detailed description of the identification of different types of diseases in tomato and potato plants based on image retrieval technology (CBIR). It also includes the various types of diseases that typically exist in tomato and potato. Content-based Image Retrieval (CBIR) technologies should be used as a supplementary tool to enhance search accuracy by encouraging you to access collections of extra knowledge so that it can be useful. CBIR systems mainly use colour, form, and texture as core features, such that they work on the first level of the lowest level. This is the most sophisticated methods used to diagnose diseases of tomato plants.

• Asia Marketing Journal
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• 제14권3호
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• pp.185-197
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• 2012

Caffe Bene, one of the most notable coffeehouse chain brands in Republic of Korea, gives us some thought-provoking issues in terms of sustainable success. Despite harsh competition among various coffeehouse brands, Caffe Bene has been accomplished astonishing outcomes in domestic market and now ranked 2^nd place in sales among the global coffeehouse franchise in 2010 and 2011. These achievements were possible mainly because Caffe Bene adopted distinctive shop design, maintained aggressive marketing strategy, developed new menu, and combined the unique Korean culture with ordinary concept of café to make its place attractive. However, since Korean coffeehouse market is getting saturated and consumers are becoming savvy about coffee, Caffe Bene needs to find a new solution to overcome growth stagnation. Besides, many experts pointed out that irrational increase in the number of stores might hurt its business in the aspect of managing distribution channel and providing consistent services. Also, customers of Caffe Bene have shown that it has to complement its critical weaknesses: inferior coffee taste and relatively high price for a cup of coffee. Especially, some people view that the company is shifting its high rental fee, interior cost and PPL marketing cost to consumers by charging high price for coffee. To get over the problems, Caffe Bene is currently using C/S Consumer Management System though experts are questioning about the efficacy because of the conflict between purpose of the system and the headquarters' plan. Present CEO Kim also announced that the company will complete its logistics system in the latter half of 2012 to provide stores with more high quality coffee beans to improve taste of coffee. Thus, in this case, we describe how Caffe Bene succeeded in Korean market and enumerate its key success factors. Also, we specify the long-term goals of Caffe Bene and introduce the current policies and strategies to show how the company is working on to achieve its ultimate goal. By reading and analyzing this business case, students could get useful insights regarding franchise management and think about issues on competing in a saturated market. Also, it would be worthwhile to generate creative solutions for the problems that Caffe Bene is now facing to broaden the practical perspective.

• 국제학술발표논문집
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• The 8th International Conference on Construction Engineering and Project Management
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• pp.343-352
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• 2020

Modular integrated construction (MiC) is an innovative construction method where components of a building are manufactured in an offsite factory, trucked to the job site in sections, set in place with cranes, and assembled together to form a whole building. Where circumstances merit, favorable conditions exist and implemented effectively; MiC improves project performance. However, several key factors need to converge during implementation to realize the full benefits of MiC. Thus, a thorough understanding of the factors which are critical to the success of MiC projects is imperative. Drawing on a systematic review of 47 empirical studies, this research identified 25 key success factors (KSFs) for MiC projects. Of these, the five topmost cited KSFs for MiC projects include effective working collaboration and communication among project participants; standardization, optimization, automation and benchmarking of best practices; effective supply chain management; early design freeze and completion; and efficient procurement method and contracting. The study further proposed a conceptual model of the KSFs, highlighting the interdependences of people, processes, and technology-related KSFs for the effective accomplishment of MiC projects. The set of KSFs is practically relevant as they constitute a checklist of items for management to address and deal with during the planning and execution of MiC projects. They also provide a useful basis for future empirical studies tailored towards measuring the performance and success of MiC projects. MiC project participants and stakeholders will find this research useful in reducing failure risks and achieving more desired performance outcomes. One potential impact of the study is that it may inform, guide, and improve the successful implementation of MiC projects in the construction industry. However, the rigor of the analysis and relative importance ranking of the KSFs were limited due to the absence of data.