• Proceedings of the Korean Institute Of Construction Engineering and Management
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• 2008.11a
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• pp.733-737
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• 2008

Construction supply chain management focused on materials in construction industry plays a critical role which controls the success and failure of a project. For the efficiency of construction supply chain management, the framework which provides project participants with the information originated from whole construction logistics steps without the omission and discontinuation of information flow is required. The new management framework that can support this environment is necessary because of setting up the complicated and distributed environment including logistics information management by intelligent equipment, co-working management with pre-framework legacy system and various devices(UMPC and PDA etc.) as the information confirmation and electrical transmission tool between the project participants different from former construction supply chain management environment while recently developing ubiquitous technologies such as RFID/USN and intelligent equipment to support logistics process. Therefore, the objective of this study is to introduce the concept of SOA (Service Oriented Architecture) as an alternative of effective information integration under the complex and distributed environment and to propose the SOA-based application model for building intelligent construction supply chain management framework.

• Journal of Korea Trade
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• v.25 no.3
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• pp.21-47
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• 2021

Purpose - Offshoring has emerged as one of the major trends in international trade and has become one of the strategies for achieving competitiveness in the global market. In spite of this, the expected gains of offshoring can be offset by hidden costs and risks, such as those associated with the COVID-19 pandemic, the trade war between the USA and China, and the ongoing trade dispute between Korea and Japan. To obviate such business failure and prevent critical business blunders, offshoring strategies that efficiently consider both risk elements and potential wealth creation are urgently need. The first purpose of this study is to contribute to the development of more advanced offshoring strategies to help host countries select the best locations to manage supply chain risks and create unique value. The second purpose is to specifically analyze the current status of Korea and provide Korean companies with implications to be considered when deciding whether to offshore or re-shore. Design/methodology - A Network DEA model was applied to measure the comparative location efficiency of national competencies for offshoring strategy from perspectives of wealth creation opportunities (profitability and marketability) and supply chain risk management. The location efficiencies are compared among a total 70 countries selected from the Global Competitiveness Index (GCI) and globally attractive locations outlined by Kearney (2017). For the secondary analysis of efficiency, a t-test examining the nature of competitive advantage and the level of sophistication in production processes was implemented in three divisions. We then analyzed differences in offshoring performance in terms of the identified national traits. Moreover, Tobit regression analysis is conducted to investigate the correlation between value-added business activities and each divisional efficiency, seeking to determine how each degree of value-added business activity influences the increase in offshoring productivity. Findings - Regarding overall location efficiency for offshoring performance, only the USA and Italy were identified as being efficient as host countries for offshoring, under circumstances of advanced development, such as productivity and risk management. Korea ranks 13th among 70 countries. The determinants of national competitiveness depend on national traits (the nature of competitive advantage and business sophistication). Countries with labor/resource advantages and labor-intensive industries are more competitive in terms of marketability than others. In contrast, countries with strong technology-intensive industries benefit offshoring companies, particularly in the technology sector, with the added advantage of supply chain risk management. As the perception of a value chain is broader in a country, it can achieve both production sophistication and competitive advantages such as marketability and SCRM. Originality/value - Existing studies focus on offshoring effectiveness from a company perspective. This paper contributes to comparing country efficiency in producing core competencies related to an offshoring strategy and also segments countries into three performance-based considerations associated with the global offshoring market. It also details Korea's position as an offshoring location according to national efficiency and competency.

• Oncology Letters
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• v.17 no.3
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• pp.3589-3598
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• 2019

Colorectal cancer (CRC) is a complex disease involving numerous genetic abnormalities. One of the major characteristics of CRC is enhanced Wnt signaling caused by loss-of-function mutations in the adenomatous polyposis coli (APC) gene. Previously, it has been demonstrated that the majority of malignant phenotypes following APC deletion in adult murine small intestines could be rescued when Myc, a downstream target of the Wnt pathway, was deleted. This indicated that Myc is a critical regulator of CRC development following APC loss. Previous studies reported that cyclic adenosine 3',5'-monophosphate (cAMP) can influence the AKT/mammalian target of rapamycin (mTOR) survival pathway in cancer and Myc is a critical downstream molecule of AKT/mTOR signaling. Phosphodiesterase 4D (PDE4D), a member of the cAMP-specific PDE4 family, has been associated with drug resistance in CRC. However, the association between PDE4D and Myc remains unclear. To investigate the potential role of PDE4D in Myc regulation in CRC, the present study evaluated the expression levels of PDE4 subtypes in DLD-1 CRC cells. Additionally, the effects of PDE4 inhibitors on Myc expression and oncogenic properties were analyzed by western blot analysis, reverse transcription-quantitative polymerase chain reaction, colony formation and soft agar assays. It was demonstrated that cAMP/PDE4D signals serve a critical role in regulating Myc expression in DLD-1 CRC cells. Furthermore, PDE4D was identified to be a main hydrolyzer of cAMP and suppression of PDE4D using selective inhibitors of PDE4 increased intracellular cAMP levels, which resulted in a marked decrease in the oncogenic properties of DLD-1 cells, including colony formation, cell proliferation and anchorage-independent growth. Notably, the current data imply that cAMP represses Myc expression via the downregulation of AKT/mTOR signaling, which was abolished by high PDE4D activities in DLD-1 cells. Additionally, a natural polyphenol resveratrol in combination with forskolin elevated the concentration of cAMP and enhanced the expression of Myc and the malignant phenotype of DLD-1 cells, reproducing the effect of known chemical inhibitors of PDE4. In conclusion, the present study identified that cAMP/PDE4D signaling is a critical regulator of Myc expression in DLD-1 and possibly other CRC cells.

• Journal of Internet Computing and Services
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• v.3 no.5
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• pp.1-8
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• 2002

Because XML is a W3C standard and has characteristics like platform-independent, it has a critical role in e-commerce. Business rules and procedures should be standardized for efficient B2B integration, But a lot of companies are its own XML documents instead of standard document, Therefore many organizations try to make standards for e-commerce based on framework. Also, in case use supply chain administration system, because document transmit between corporation use on-line, need messaging system that can transfer XML message In this paper, XML messaging system is designed and implemented. Client requests service in XML and server returns response in XML in this system, So we con more easily and efficiently to exchange document between company this XML messaging system.

• Journal of Microbiology
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• v.37 no.3
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• pp.154-158
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• 1999

The arginine residue at position 243 (Arg 243) of the yeast transcription factor, Gcn4p, is invariably conserved among bZIP transcription factors. Using site-directed oligonucleotide saturation mutagenesis involving two-step polymerase chain reaction (PCR) amplification, random mutations were successfully introduced at the codon of 243 in the basic domain of Gcn4p. This mutant library was transformed ito Gcn4p defective yeast strain and selected for the transcriptionally active colonies. All colonies which were transcriptionally active had arginines in the codon 243. In this study, the strand preference by Taq polymerase during mutagenesis was also tested. Oligonucleotides were specially designed to test whether or not the polymerase was preferred using the strand as a template. A population of randomly mutated products were cloned into an appropriate vector and characterized by DNA sequencing analysis. Saturation mutagenesis which was performed efficiently by this method revealed a strong bias in terms of strand preference of Taq polymerase by an approximate ratio of 3 to 1 in this study.

• Journal of Information Technology Services
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• v.5 no.2
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• pp.125-136
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• 2006

In general, the distribution structure of marine products is very vulnerable to the uncertainties in the process from the production to the sale, and a lot of difficulty is thus inevitable in the supply control. Such a distribution structure is a very critical issue in securing the suability of marine products through systematic quality and hygiene control of marine products, and it is thus time to discuss the method to innovate and restructuring the distribution structure of marine products. From this point of view, this study approached the flow from production to consumption in view of SCM(supply chain management) beyond the partial discussion conducted so far for the distribution structure in the field of marine products. Further, this study suggested the establishment of electronic commerce systems with a traceability system built in RFID for marine products as an alternative of redesigning distribution infrastructure in the ubiquitous environment. From the results, we assured that such an electronic commerce system would be a new measure to improve the structure currently causing inefficiency and excessive distribution cost for the distribution structure of marine products.

• Journal of the Korean Society of Clothing and Textiles
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• v.24 no.7
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• pp.1065-1072
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• 2000

The molecular areas and the interfacial tension behavior of ten nonionic surfactants, i.e., Span 20 and Tween 20, 40, 60. 80, 21, 61, 81, 65, & 85 are tested to assay their effects on the wetting and liquid retention properties of hydrophilic and hydrophobic fibrous materials. The molecular areas at water/air interface are derived from Gibbs’adsorption equations. The following conclusions are drawn from the results: 1) Span 20 is efficient in lowering the interfacial tension and effective in adsorption at the water/air interface, resulting in the low interfacial tension at critical micelle concentration (${\gamma}$$_{CMC}$) and a small molecular area($\omega$), 2) when the hydrophiles of the surfactants are constant, $\omega$’s increase as hydrophobe carbon numbers of the surfactants increase, 3) when the hydrophobes are constant, ${\gamma}$$_{CMC}$’s and $\omega$’s increase as the hydrophile ethylene oxide units increase, indicating effectiveness and efficiency is parallel in this case, 4) the ethylene oxide unit length as a hydrophile has greater influence on u than the hydrophobe chain length.han the hydrophobe chain length.gth.

• Journal of Korea Society of Digital Industry and Information Management
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• v.12 no.4
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• pp.89-96
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• 2016

Before an IT product is used, there is a sequence of the process such as the components supply-demand of the product, their assembly and production, their logistics and delivery, and then finally, the product can be used by a user. During this sequence of the process, there can be many security exposures and risks. In this paper, we show, by examining security cases of various IT products, that there are many security exposures in the process of IT products from their production to their delivery to end users and in their use, and also show how critical the security exposures are. Even though there are various security theories, technologies and security controls, there is still weak link from the production of an IT product to its use, and this weak link can lead to security vulnerabilities and risks. This paper tries to call attention to the importance of the execution of the security control and the control components. We examine the practical cases to find out how the security control is paralyzed, and to show how it is compromised by asymmetric security resources. Lastly, from the cases, we examine and review the possible domestic security issues and their countermeasures.

• Journal of Korea Technical Association of The Pulp and Paper Industry
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• v.35 no.2
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• pp.33-38
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• 2003

In order to design the high strength corrugated fiberboard containers for agricultural products that can be used for the cold chain system, a large number of individual boxes were placed in various humidity environments at two different temperature of 5 and $20^{\circ}C$. The results indicated that temperature changes do not effect on physical strength of corrugated fiberboard containers as much as humidity changes did. The main conclusion from this study was that compression strength of corrugated fiberboard containers dropped significantly at high humidity condition, but the rates varied depending on the number of walls, temperature, and perimeter of containers. The packaging designer must consider the corrugated fiberboard boxes are also greatly affected by dimensional variations such as the length versus width ratio. Based on this study, water-resistant board would not be necessary if the ambient relative humidity does not reach to a critical point, 85 percent in the cold chain system. However, the designer must count for the unexpected fluctuation of rotative humidity resulting in severe loss of the compression strength of corrugated fiberboard container.

• Bulletin of the Korean Chemical Society
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• v.23 no.4
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• pp.549-554
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• 2002

Thermosensitive poly(organophosphazenes) bearing methoxy-poly(ethylene glycol) (MPEG) and alkylamines as substituents have been synthesized and characterized by elemental analysis, NMR spectroscopy, GPC, and DSC. All the polymers exhibited crystallinity, which was probably induced by the MPEG side chain of the polymers. All the polymers exhibited the lower critical solution temperature (LCSTs) in the range of 28 to $94^{\circ}C$ depending on several factors such as mole ratio of the substituents, kinds of PEG and alkylamines. The higher content of MPEG and shorter chain length of alkylamines of the polymers afforded the higher LCST. The LCSTs of the polymers exhibited almost concentration-independent behavior in the range of 3-30 wt % of the polymers in aqueous solutions. The polymers showed the higher LCSTs in the acidic solutions than in the neutral and basic solutions. The ionic strength of the polymer solution affected the LCST, which decreased with increased NaCl concentration. The polymer bearing almost equimolar substitutuents with the -N-P-N- unit has shown the LCST more sensitive to NaCl and pH than that with the -N-P-O- unit. The polymers were found to degrade in acidic solution but be very stable in alkali solution as well as in the buffer solution of pH 7.4.