• Title/Summary/Keyword: Crinum latifolium

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Synthesis of Coumarin Analogues and their Antitumor Activity (쿠마린 유도체의 합성과 그들의 항암효과)

  • Lee, Jee-Hyun;Lee, Jae-Ho;Kim, Hyun-Kwan;Kim, Eui-Geom;Shen, Gui-nan;Cho, Soo-Hyun;Myung, Chang-Seon;Kim, Dong-Hee;Yun, Mi-Young;Choi, Yong-Seok;Kim, Sung-Hoon;Song, Gyu-Yong
    • YAKHAK HOEJI
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    • v.50 no.5
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    • pp.338-344
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    • 2006
  • A novel series of 4-senecioyloxymethyl-6,7-dimethoxycoumarin, isolated from Crinum latifolium, was prepared by reacting 4-bromomethyl or 4-bromomethyl-6,7- dimethoxycoumarin with various carboxylic acids and examined for their anti-angiogenic activities in human umbilical vein endothelial cells (HUVECs). Among them, 4e, 4f, 4g and 4i with noncyclic moiety exhibited potent anti-angiogenic activity. However, compounds with cyclic moiety such as phenyl, pyridinyl, thiophenyl and furanyl group did not exhibit any anti-angiogenic activity. Also, compounds 4f and 4g which exhibited strong anti-angiogenic activity in a dose-dependent manner showed antitumor activity.