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Synthesis of Coumarin Analogues and their Antitumor Activity  

Lee, Jee-Hyun (College of Pharmacy, Chungnam National University)
Lee, Jae-Ho (Department of Oncology, Graduate School of East-West Medical Science, Kyunghee University)
Kim, Hyun-Kwan (Department of Oncology, Graduate School of East-West Medical Science, Kyunghee University)
Kim, Eui-Geom (College of Pharmacy, Chungnam National University)
Shen, Gui-nan (College of Pharmacy, Chungnam National University)
Cho, Soo-Hyun (College of Pharmacy, Chungnam National University)
Myung, Chang-Seon (College of Pharmacy, Chungnam National University)
Kim, Dong-Hee (College of Oriental Medicine, Daejon University)
Yun, Mi-Young (College of Oriental Medicine, Daejon University)
Choi, Yong-Seok (College of Life Sciences and Biotechnology, Korea University)
Kim, Sung-Hoon (Department of Oncology, Graduate School of East-West Medical Science, Kyunghee University)
Song, Gyu-Yong (College of Pharmacy, Chungnam National University)
Publication Information
YAKHAK HOEJI / v.50, no.5, 2006 , pp. 338-344 More about this Journal
Abstract
A novel series of 4-senecioyloxymethyl-6,7-dimethoxycoumarin, isolated from Crinum latifolium, was prepared by reacting 4-bromomethyl or 4-bromomethyl-6,7- dimethoxycoumarin with various carboxylic acids and examined for their anti-angiogenic activities in human umbilical vein endothelial cells (HUVECs). Among them, 4e, 4f, 4g and 4i with noncyclic moiety exhibited potent anti-angiogenic activity. However, compounds with cyclic moiety such as phenyl, pyridinyl, thiophenyl and furanyl group did not exhibit any anti-angiogenic activity. Also, compounds 4f and 4g which exhibited strong anti-angiogenic activity in a dose-dependent manner showed antitumor activity.
Keywords
Crinum latifolium; coumarin; anti-angiogenesis; antitumor activity;
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