YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Synthesis of Coumarin Analogues and their Antitumor Activity

쿠마린 유도체의 합성과 그들의 항암효과

  • Lee, Jee-Hyun (College of Pharmacy, Chungnam National University) ;
  • Lee, Jae-Ho (Department of Oncology, Graduate School of East-West Medical Science, Kyunghee University) ;
  • Kim, Hyun-Kwan (Department of Oncology, Graduate School of East-West Medical Science, Kyunghee University) ;
  • Kim, Eui-Geom (College of Pharmacy, Chungnam National University) ;
  • Shen, Gui-nan (College of Pharmacy, Chungnam National University) ;
  • Cho, Soo-Hyun (College of Pharmacy, Chungnam National University) ;
  • Myung, Chang-Seon (College of Pharmacy, Chungnam National University) ;
  • Kim, Dong-Hee (College of Oriental Medicine, Daejon University) ;
  • Yun, Mi-Young (College of Oriental Medicine, Daejon University) ;
  • Choi, Yong-Seok (College of Life Sciences and Biotechnology, Korea University) ;
  • Kim, Sung-Hoon (Department of Oncology, Graduate School of East-West Medical Science, Kyunghee University) ;
  • Song, Gyu-Yong (College of Pharmacy, Chungnam National University)
  • Published : 2006.10.01
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Abstract

A novel series of 4-senecioyloxymethyl-6,7-dimethoxycoumarin, isolated from Crinum latifolium, was prepared by reacting 4-bromomethyl or 4-bromomethyl-6,7- dimethoxycoumarin with various carboxylic acids and examined for their anti-angiogenic activities in human umbilical vein endothelial cells (HUVECs). Among them, 4e, 4f, 4g and 4i with noncyclic moiety exhibited potent anti-angiogenic activity. However, compounds with cyclic moiety such as phenyl, pyridinyl, thiophenyl and furanyl group did not exhibit any anti-angiogenic activity. Also, compounds 4f and 4g which exhibited strong anti-angiogenic activity in a dose-dependent manner showed antitumor activity.

Keywords

References

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