• 한국미생물·생명공학회지
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• 제49권4호
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• pp.478-484
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• 2021

Cellular resources including transcriptional and translational machineries in bacteria are limited, yet microorganisms depend upon them to maximize cellular fitness. Bacteria have evolved strategies for using resources economically. Regulatory networks for the gene expression system enable the cell to synthesize proteins only when necessary. At the same time, regulatory interactions enable the cell to limit losses when the system cannot make a cellular profit due to fake substrates. Also, the architecture of the gene expression flow can be advantageous for clustering functionally related products, thus resulting in effective interactions among molecules. In addition, cellular systems modulate the investment of proteomes, depending upon nutrient qualities, and fast-growing cells spend more resources on the synthesis of ribosomes, whereas nonribosomal proteins are synthesized in nutrient-limited conditions. A deeper understanding of cellular mechanisms underlying the optimal allocation of cellular resources can be used for biotechnological purposes, such as designing complex genetic circuits and constructing microbial cell factories.

• 한국의류산업학회지
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• 제20권2호
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• pp.156-166
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• 2018

The purpose of this study is to present the suitable material that can be a real help to make the creativity development teaching method for creative inspirations of fashion design. To achieve these goals, researched and analyzed the creativity studies in the fields of psychology, education, and design (visual design, product design, fashion design, etc.) published in the national journal. Through this analysis, were extracted the characteristics of creativity, teaching methods for creativity learning, and expression methods. Based on this, intend to provide the creativity characteristic, the expression method, and the problem solving process in teaching methods for promoting fashion design ability. After the analysis, the results are as follows; First, the classical 4P (Place, Person, Process, Product) is important to a creativity development teaching method for fashion design. The elements of creativity of a creativity development teaching method for fashion design are 5elements; curiosity, openness, originality, patience, and synthetic ability. Second, the typical method is a drawing (such as a sketch) when visually express and embody ideas in fashion design. Drawing is an important activity that is working with the right brain and the left brain. Drawing exercises will reduce the burden of expressing ideas, providing pleasure and fulfillment in the development of creative ideas. Third, offered 5stages to solve problems of a creativity development teaching method for fashion design; understanding stage, idea stage, visualization stage, evaluation stage, and verification stage. Abstract intangible ideas are concreted and elaborated through stages of visual manifestation such as language, symbol, and drawing.

• 한국실내디자인학회논문집
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• 제14권6호
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• pp.75-85
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• 2005

The 1990s' characteristics of Ecological architectural design would be choosing the traditional materials of the region's, the creative usage of construction methods, the expressive properties of materiality in spatial forms and so on. The overall organic relationships between human and men-made environments have been sublimated by the expression of poetic qualities of perception in ecological man-made environment. Hannover Expo 2000 did set up an opportunity to exposure the fact that Ecological Architecture will be the major trend in 21st Century's Architecture and its exploration in possible ways will be the most important matter. Japanese Architect Shigeru Ban's Japan Pavilion in this Exposition has shown the meaning of this turning point in Ecological Architectural thinking, which would be recognized as the convincing possibilities for the future architectural practice to the public. Thus this research has the purpose to study the meaning of the constructing action in Shigeru Ban's recent architectural space-making practice with the Paper Tube structural system. The creative foundation of Shigeru Ban's own method to apply paper tube -that is impossible material to pre-estimate- and other materials in the creation of architectural spaces would be searched in this paper. The period to this research will be between 1990s and 2000s, and the subject will be the experimental architecture of Shigeru Ban. The range of this research Is including the process of development in the paper tube architectural structure and joint system. This study would contribute to understand the intrinsic value of Shigeru Ban's Ecological architecture of the paper tube system, in which the relationship between the regional environment and human regaining the ecological abiogenesis.

• 복식문화연구
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• 제18권5호
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• pp.1003-1016
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• 2010

The purpose of this study is to reorganize any rusty image including natural modeling characteristic presented from the natural phenomenon to certain patterns in order to create the fashion design that are valued in the expansion of independently expressional area and modeling art. As a method for research, the author analyzed the concept and characteristic for rust with a base of theoretical background by the documental research and realistic consideration, analyzed its modeling characteristic through domestic and overseas pictures, and e-documents as data, inspected the modeling activities of various categories that various images were adapted related to rust, looked into the concept of Digital Textile Printing and its producing procedure as an expressional method, and analyzed the examples of modern dress and its ornament making use of Digital Textile Printing. The conclusions of this study are as below. First, the rust occurred due to the natural phenomenon is the bond with different material like metal, each unique modeling characteristic occurs and harmony of various patterns has abundant aesthetic value. Second, the author could endowed sensible characteristic and speciality with works and could produce creative fashion design that painting, abstractive pattern and harmony of unique sense of colors are significant by using the image of rust, Third, to emphasize natural feeling of rust, the author could develop creative design that simple silhouette and impressive pattern look significant by reorganizing and applying rust according to repetition, increment, rhythm, contract, emphasis and harmony. Fourth, Digital Textile Printing method is used to induce visual effect by the expression of feels of rust, and the author could express the natural patterns, delicate expression for the feels of a material and unique design of emotion.

• 한국콘텐츠학회논문지
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• 제13권7호
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• pp.110-119
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• 2013

매체와 양식, 기술과 표현 사이의 고정관념에서 벗어나는 창작의 본질을 추구하는 창의적 실험을 위한 노력은 미술과 사진을 기반으로 20세기 초반 이후 끊임없이 이어져 왔다. 새로운 표현을 위한 예술적 시도로서 포토몽타주는 탄생했다. 본질적으로 다른 이미지들의 결합으로 새로운 의미를 만들어내는 작업으로서 포토몽타주는 의도적으로 선택한 다양한 이미지를 조합하고 합성하는 방식으로 메시지를 강조하여 시각적으로 구성된다. 이미지와 텍스트의 변증법적 시각예술로서 기존의 예술적 개념을 벗어나 새로운 형식을 추구하며 발전해온 포토몽타주는 그 개념이 현대의 다원예술과 유사하다. 포토몽타주의 가치는 사진의 표현영역을 사실의 묘사와 재현에 국한하지 않고 상상력을 자유롭게 표현할 수 있는 데포르마시옹으로서 새로운 가능성을 모색하고 일상의 경험을 창의적으로 표현하는 작업을 위한 기법의 구현에 있다.

• 한국주거학회논문집
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• 제23권1호
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• pp.89-96
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• 2012

The purpose of this study is to find out the characteristics of activity areas according to the age difference and provide the alternatives for space planning of activity areas in classroom of childcare centers. This study used the content analysis method for field survey data collected from 36 classrooms of 9 childcare centers in the Daejeon area. Floor plans were converted to Autocad drawings to analyze the characteristics of activity areas. The results of this study were as follows; 1) In case of 0 to 2-year-old classrooms, they had 6 activity areas such as gross-motor area, role play, block building, language, creative expression, exploration/manipulation area. The activity area with the most low frequency was gross-motor area. 2) In case of 0 to 2-year-old classrooms, the size of activity area was in order of gross-motor area > role play > block building > language > creative expression > exploration/manipulation area. In case of 3 to 5-year-old classrooms, the size of activity area was in order of language > art > role play > math > block building > science > tone and rhythmic area. 3) The central areas with easy access in 0 to 2-year-old classrooms were Large-motor and Imaginary Play Areas. Also, more isolated areas were Manupulatives and Block Areas. The central areas with easy access in 3 to 5-year-old classrooms were Arts, Numbers and Manupulatives. While more isolated areas were Music, Movement and Science Areas.

• 한국의상디자인학회지
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• 제9권3호
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• pp.151-166
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• 2007

The purpose of this study was to examine the Russian abstract artist Kazimir Malevich's works during the period of absolutism and thereupon, suggest some knitwear designs practical, decorative and creative. For this purpose, the researcher reviewed domestic and foreign literature, dissertations and academic journals to determine the Russian abstract fine art and the significance of Kazimir Malevich's works in the history of arts and thereupon, examined Malevich's works or the champions of absolutism in terms of their geometric formative elements or forms and colors. The results of this study can be summarized as follows; First, paintings may be important motives for the contemporary costume designs, while being a major driving power for development of some original designs depending on artists' personal thoughts and expression techniques. Second, this study is deemed to suggest creative and original techniques and motive applications for fashion designs by introducing the elements of Kazimir Malevich's paintings into costume designs, and provide for an opportunity to suggest new values by combining arts and fashion. Third, the knit jacquard technique, one of the major techniques for the knit design works using Kazimir Malevich's absolutism works, is considered a tubular jacquard featuring the deepest sense of thickness. The intarsia technique is preferred in the recent trend for light fabric because it features clear background patterns and allows for thinner fabric. Lastly, it is hoped that this study will serve to expand the domain of expression by means of an art marketing or meeting between arts and fashion in our contemporary industries.

• 대한수학교육학회지:학교수학
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• 제18권3호
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• pp.503-526
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• 2016

본 연구의 목적은 대입 수리논술고사의 평가요소를 통하여 수리논술고사에 대한 정체성을 규명하고 실제 수리논술고사가 어떻게 출제되고 있는지 살펴보는 것이다. 수리논술고사에 관한 이해를 얻기 위해 2016학년도에 수리논술고사를 실시한 우리나라 25개 대학교 홈페이지에 있는 논술자료집에서 수리논술고사의 평가목표 및 출제방향을 분석하여 수리논술고사의 평가요소를 추출하고, 2015학년도 기출문제를 분석하여 실제 수리논술고사가 어떻게 출제되고 있는지 살펴보았다. 수리논술고사의 평가목표 및 출제방향에 나타난 평가요소는 수학적 지식, 이해력, 논리 비판적 사고력, 문제해결력, 창의력, 표현력, 논증력으로 수리논술고사의 정체성은 이런 능력, 즉 수학적 지식을 포함하는 고차원적인 사고능력과 논술능력을 평가하기 위한 시험이라고 할 수 있다. 또한, 수리논술고사 평가요소에 따라 수리논술 평가기준을 정하고 수리논술고사 기출문제를 분석하였다. 이를 통해 수리논술고사는 평가요소 중 수학적 지식, 이해력, 문제해결력을 요구하는 문제 위주로 출제되고 있음을 알 수 있었다.

• Molecules and Cells
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• 제42권11호
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• pp.773-782
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• 2019

Cellular senescence is an irreversible form of cell cycle arrest. Senescent cells have a unique gene expression profile that is frequently accompanied by senescence-associated heterochromatic foci (SAHFs). Protein kinase CK2 (CK2) downregulation can induce trimethylation of histone H3 Lys 9 (H3K9me3) and SAHFs formation by activating SUV39h1. Here, we present evidence that the PI3K-AKT-mTOR-reactive oxygen species-p53 pathway is necessary for CK2 downregulation-mediated H3K9me3 and SAHFs formation. CK2 downregulation promotes SUV39h1 stability by inhibiting its proteasomal degradation in a p53-dependent manner. Moreover, the dephosphorylation status of Ser 392 on p53, a possible CK2 target site, enhances the nuclear import and subsequent stabilization of SUV39h1 by inhibiting the interactions between p53, MDM2, and SUV39h1. Furthermore, $p21^{Cip1/WAF1}$ is required for CK2 downregulation-mediated H3K9me3, and dephosphorylation of Ser 392 on p53 is important for efficient transcription of $p21^{Cip1/WAF}$. Taken together, these results suggest that CK2 downregulation induces dephosphorylation of Ser 392 on p53, which subsequently increases the stability of SUV39h1 and the expression of $p21^{Cip1/WAF1}$, leading to H3K9me3 and SAHFs formation.

• BMB Reports
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• 제54권3호
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• pp.170-175
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• 2021

Atherosclerosis arising from the pro-inflammatory conditions associated with chronic kidney disease (CKD) increases major cardiovascular morbidity and mortality. Rapamycin (RAPA) is known to inhibit atherosclerosis under CKD and non-CKD conditions, but it can cause dyslipidemia; thus, the co-application of lipid-lowering agents is recommended. Atorvastatin (ATV) has been widely used to reduce serum lipids levels, but its synergistic effect with RAPA in CKD remains unclear. Here, we analyzed the effect of their combined treatment on atherosclerosis stimulated by CKD in apolipoprotein E-deficient (ApoE-/-) mice. Oil Red O staining revealed that treatment with RAPA and RAPA＋ ATV, but not ATV alone, significantly decreased the atherosclerotic lesions in the aorta and aortic sinus, compared to those seen in the control (CKD) group. The co-administration of RAPA and ATV improved the serum lipid profile and raised the expression levels of proteins involved in reverse cholesterol transport (LXRα, CYP7A1, ABCG1, PPARγ, ApoA1) in the liver. The CKD group showed increased levels of various genes encoding atherosclerosispromoting cytokines in the spleen (Tnf-α, Il-6 and Il-1β) and aorta (Tnf-α and Il-4), and these increases were attenuated by RAPA treatment. ATV and RAPA＋ATV decreased the levels of Tnf-α and Il-1β in the spleen, but not in the aorta. Together, these results indicate that, in CKD-induced ApoE-/- mice, RAPA significantly reduces the development of atherosclerosis by regulating the expression of inflammatory cytokines and the co-application of ATV improves lipid metabolism.