• Radiation Oncology Journal
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• v.12 no.1
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• pp.73-80
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• 1994

From December 1989 to February 1993, 108 patients with Non-Small Cell Lung Cancers(NSCLC) were studied retrospectively to evaluate radiotherapeutic significance of serum levels of NSE. We considered elevated serum neuron specific enolase(S-NSE) level as one of the neuroendocrine features in NSCLC. Histopathologic evaluation revealed 86 squamous cell carcinomas, 11 adenocarcinomas.3 large cell carcinomas, 3 mucoepidermoid carcinomas, and 5 unknown pathology. Eight Patients had stage 1,40 stage IlIA, and 60 stage lIIB.S-NSE level greater than 15 ng/ml was considered as elevated, and below this considered as normal. All patients recieved radiotherapy as primary treatment modality. The responders to radiotherapy had significantly higher mean S-NSE level than non-responders (28.5 ng/ml vs 20 ng/ml, p=0.01). Overall 2-year survival rate(YSR) was 23.6$ \% $. According to radiotherapy response, 2 YSR for Patients with CR, PR, and NR were 39.2$ \% $, 28.6$ \% $, and 6.2$ \% $ respectively(p=0.001). 2 YSR for patients with elevated and normal S-NSE were 14.6$ \% $ and 31.7$ \% $(p=0.02). The patients with NR showed no difference in survival according to S-NSE level. When we considered all patients, S-NSE level showed no significant impact on response. But for squamous cell carcinomas alone, patients with elevated S-NSE had more responders(80$ \% $ vs 61$ \% $, p=0.05). There was no correlation between tumor characteristics and S-NSE level. But the patients with elevated S-NSE had more patients with higher nodal stage, Based on our and other datas, NSCLC with neuroendocrine features have different response to treatment and clinical behavior compared to other NSCLC. Thus, this subgroup may need different treatment modality, and S-NSE level may have prognostic significance.

• Proceedings of the Korean Society of Organic Agriculture Conference
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• 2009.12a
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• pp.289-289
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• 2009

당근은 우리나라에서 재배되고 있는 채소 중에서 대표적인 비타민 A의 급원으로서 매우 중요한 근채류이다. 최근 친환경농산물에 대한 관심과 요구가 급증하면서 소비자들은 고품질 당근을 선호하고 있으나 유기농 당근생산에 대한 연구가 미비한 실정이다. 본 연구는 관행 및 유기농 재배가 당근의 생육과 품질에 미치는 영향을 구명하고자 실시하였다. 본 실험에 사용된 공시품종은 '조춘5촌당근'(세미니스, A), '선홍봄5촌당근'(농우종묘, B), '홍심5촌당근'(대농종묘, C), '춘홍5촌당근'(사카타, D), '하파5촌당근'(신젠타종묘, E), '홍심5촌당근'(경신종묘, F)으로 전체 6개 품종이며, 경기도 평택시 유천동 대농종묘(주) 육종연구소 N2, N3 하우스에 9월 8일 파종하였고 재배방법은 유기농 및 관행재배표준법에 준하여 실시하였다. 관행과 유기농 재배 후 12월 3일에 수확하여 엽중, 근중, 근장, 근경, 코어, 추근성, 근피색과 가용성 당함량을 조사하였다. 근피색은 Colorimeter(Minolta, CR-400)를 이용하여 Hunter값인 L(밝기), a(녹색-적색), 그리고 b(파란색-노란색)로 표시하였다. 가용성 당함량 조사는 HPLC를 이용하여 분석하였다. 엽중은 유기농 재배 F품종에서 26.0g으로 가장 무거웠고 전체적으로 유기농 재배구에 비해 관행 재배구에서 엽중이 무거웠다. 근장은 모든 품종에서 관행구에 비해 유기농 재배구에서 현저히 길게 나타나 재배 방법 간의 유의차를 보였으며 유기농 재배의 경우 근장이 17.9cm ~ 19.0cm 범위로 품종간 유의성은 없었다. 근중은 전체적으로 관행 재배구가 우수하거나 유기농 재배구와 비슷한 경향을 보였고, 특히 관행 재배구 B품종이 58.1g, A품종이 57.1g으로 가장 무겁게 나타나 재배방법 및 품종간 비교에서 우위를 나타냈다. 당근 뿌리의 명도를 나타내는 Hunter L값은 모든 품종에서 관행 재배구가 높게 나타났으며 특히 관행재배구의 최하위 L값(45.80)이 유기농 재배구의 최상위 L값(44.81)이 보다 높게 나타나 관행 재배를했을 경우 뿌리 광택이 더욱 우수함을 알 수 있었다. Hunter b값은 노란색을 나타내는데 B품종에서 유기농 재배구 19.68, 관행 재배구 19.55로 모든 품종 중에서 가장 높은 수치를 보였다. Fructose 함량은 D품종이 관행 재배구와 유기농 재배구에서 각각 $8.5mg{\cdot}g^{-1}FW,\;8.3mg{\cdot}g^{-1}FW$을 함유하여 가장 많게 나타났고, glucose 함량은 관행 재배구에서 D품종이 $41.5mg{\cdot}g^{-1}FW$을 함유하여 가장 많았고 유기농 재배구에서도 역시 D품종이 $35.7mg{\cdot}g^{-1}FW$을 함유하여 가장 많게 나타났다. Sucrose 함량은 모든 품종의 관행 재배구에서 현저하게 높게 나타났다. 가용성 당함량은 F품종만이 유기농 재배구에서 높게 나타났지만, 다른 5개 품종의 관행 재배구와 비교했을 때는 가장 적은 수치를 나타내 적절한 비배관리를 통한 관행 재배 방법이 가용성 당함량을 증가시킨 것으로 생각된다. 결론적으로 생육 및 품질은 관행재배에서 유기농 재배에 비해 우수하였고 근장은 유기농재배에서 길게 나타났고 가용성당람량 역시 관행재배에서 대체적으로 높게 나타났지만 품종에 따라 유기농재배에서도 높게 조사된 것도 있어 앞으로 유기농 재배에 적합한 당근 품종선발이 필요하다.

• Childhood Kidney Diseases
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• v.16 no.2
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• pp.73-79
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• 2012

Purpose: The association of mitochondrial DNA (mtDNA) mutations, deletions and copy number with progressive changes in patients with some glomerular disease and end-stage renal disease have been reported. In this study, we performed mtDNA mutation analysis in children with IgA nephropathy to investigate its role in progressive clinical course. Methods: Seven children with IgA nephropathy were involved in this study. MtDNA isolated from platelet was amplified by PCR and sequenced entirely. Results: The mean age at renal biopsy was $11.5{\pm}2.2$ year and the mean age at latest evaluation was $17.9{\pm}3.2$ year. The mean follow-up period were $7.8{\pm}3.1$ years. Patients was divided into 2 groups according to the amount of proteinuria at presenting manifestation. Group 2 patients were nephrotic syndrome. Renal function reveals within normal range in all patients. In group 2 patients, the mean serum albumin level was significantly lower than those of group 1 ($3.7{\pm}0.6g/dL$ vs. $4.7{\pm}0.2g/dL$, P=0.0241) and the mean total cholesterol level was significantly higher than those of group 1 ($222.7{\pm}35.7mg/dL$ vs. $148.3{\pm}29.1mg/dL$, P=0.0283). In Group 2 patients, total amount of protein of 24 hour collected urine also significantly higher than those of group 1 ($1,466.0{\pm}742.5mg$ vs. $122.5{\pm}48.1mg$, P=0.0135). Pr/Cr ratio in random urine sample was also higher in group 2 than those of group 1 but the statistical significance was not noted ($1.8{\pm}1.6$ vs. $0.2{\pm}0.2$, P=0.0961). Deletion of mtDNA nt 8272-8281 were observed in two patients, one patient in each groups, respectively. This is noncoding lesion. No patients demonstrated the mtDNA mutations. Conclusions: We have identified a deletion of mtDNA nt 8272-8281 in two children with IgA nephropathy. Further studies are needed to clarify the role of mitochondrial function in the progressive change of IgA nephropathy.

• Radiation Oncology Journal
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• v.5 no.2
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• pp.97-104
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• 1987

From January 1970 through December 1984, 15 patients with sinonasal Non-Hodgkin's lymphoma combined to the head and neck were treated by external irradiation.13 patients were stage It and 2 were stage IIE by Ann Arbor Classification. However, when using TNM system, 7 were locally advanced T3, T4 lesions. All patients had follow up from 3.7 to 16 years with the median follow-up of 8.5 years. The overall actuarial 5-year survival rates were $25\%,\;28\%$ for IE and $0\%$ for IIE. Total tumor dose varied from 40 to 68 Gy. $100\%$ complete response with a total tumor dose of more than 55 Gy and $73\%$ complete response with less than 55Gy. When the disease was staged using the TNM (AJC) system, the five-year disease free survival for T1 and T2 patients was $50\%$ as compared with $14\%$ for T3 and T4. Failure rate by stage was $33\%(2/6)$ for T1 and T2, $86\%(6/7)$ for T3 and T4, and $100\%$(2/2) for IIE. The results suggest that 1. Higher CR could be obtained with a total tuner dose of more than 55 Gy. 2. Use of TNM staging system is as important as Ann arbor in management of sinonasal NHL. 3. The addition of combination chemotherapy should be considered for T3, T4 and IIE the sinonasal Non-Hodgkin's lymphoma although the disease is limited to head and neck.

• Radiation Oncology Journal
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• v.22 no.3
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• pp.177-183
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• 2004

Purpose: Authors would report the results of sequential CHOP chemotherapy (cyclophosphamide, adriamycin, vincristine, and prednisone) and involved field radiotherapy (IFRT) for early stage nasal natural killer/T-cell Iymphoma (NKTCL). Materials and Methods: Fourteen among 17 patients, who were registered at the Samsung Medical Center tumor registry with stage I and II nasal NKTCL from March 1995 to December 1999 received this treatment protocol. Three to four cycles of CHOP chemotherapy were given at 3 weeks' interval, which was followed by local IFRT including the known tumor extent and the adjacent draining lymphatics. Results: Favorable responses after chemotherapy (before IFRT) were achievable only in seven patients (5 CR's+2 PR's: 50%), while seven patients showed disease progression. There were six patients with local failures, two with distant relapses, and none with regional lymphatic failure. The actuarial overall survival and progression-free survival at 3 years were 50.0% and 42.9%. All the failures and deaths occurred within 13 months of the treatment start. The factors that correlated with the improved survival were the absence of 'B' symptoms, the favorable response to chemotherapy and overall treatment, and the low risk by international prognostic index on univariate analyses. Conclusion: Compared with the historic treatment results by IFRT either alone or followed by chemotherapy, the current trial failed to demonstrate advantages with respect to the failure pattern and survival. Development of new treatment strategy in combining IFRT and chemotherapy is required for improving outcomes.

• Economic and Environmental Geology
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• v.42 no.2
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• pp.121-131
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• 2009

The distribution characteristics of heavy metals for surface sediments in east oceanic dumping area (EDA) and west oceanic dumping area (WDA) are evaluated by grain sizes, minerals, sedimentation rates and compositions of heavy metals. The mean grain sizes in EDA and WDA range from $7.95{\Phi}$ to $8.51{\Phi}$ and $7.42{\Phi}$ to $8.15{\Phi}$, respectively. These are mostly belonging to the M (mud) type. Minerals in the surface sediments consist of illite with chlorite, smectite, and kaolinite. Sedimentation rates estimated by $^{210}Pb$ method in EDA and WDA are 1.11 mm/yr$\sim$1.73 mm/yr and 1.87 mm/yr, respectively. According to the interrelationship, concentrations of Ni, Cu, Cr, and Zn are closely associated with mean grain size, Al, and Fe, whereas concentrations of Cd and Pb are poorly associated with ones. The enrichment factors of these elements are higher than 1.5, suggesting that the concentrations of Cd and Pb in the surface sediments are affected by anthropogenic sources. The $I_{geo}$-class numbers of Cd and Pb in the surface sediments are mostly classified in 2 to 4, showing moderate to strongly polluted. These numbers in EDA are higher than that of WDA, and the highest number is 4, indicative of the strongly polluted class. Our results show that the disposed wastes at EDA include mineralogical wastes, dredged materials from sewage disposals, and sludges from constructions having materials of WDA. The annual amount of oceanic dumping in EDA is double than that in WDA.

• Journal of The Korean Society of Inherited Metabolic disease
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• v.15 no.1
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• pp.1-8
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• 2015

Purpose: 3-methylcrotonyl CoA carboxylase deficiency (3MCCD) is leucine metabolic disorder caused by mutation in MCCC1 or MCCC2 gene. Clinical manifestations are variable, ranging from fatal neonatal onset to asymptomatic individuals. There is no retrospective study of Korean patients undergoing long-term treatment for 3MCCD. We reported this study to find out clinical symptoms and gene analysis of 3MCCD patients. Methods: This study was based on data of patients diagnosed with 3MCCD in Soonchunhyang university hospital between April 2009 and September 2013. We report clinical, enzymatic and mutation data of 3MCCD patients found by newborn screening. Results: In tandem mass spectrometry, 3-OH-isovalerylcarnitine (C5OH) of all patients increased. And all 7 patients were elevated 3-methylcrotonylglycine (3MCG) and 3-hydroxyisovaleric acid (3HIVA) in urine. MCCC mutation was identified in 2 patients and MCCC2 was mutated in 5 patients. We found mutation occurred in 8 different parts of nucleotide and such mutation caused 7 different types of changes in amino acid. All patients are on medication of L-carnitine and L-glycine. 4 patients are taking biotin. And 4 patients are eating leucine free formula. After starting treatment, there were no significant changes of urine 3MCG and 3HIVA levels. Conclusions: According to our data, MCCC2 gene mutation was more common than MCCC1 gene mutation. But the level of 3HIVA or 3MCG in urine has no correlation with phenotype. All patients has no symptoms and are shown normal development.

• Restorative Dentistry and Endodontics
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• v.22 no.1
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• pp.254-266
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• 1997

This study was to know the usefulness of argon laser for composite resin, to prove the polymerized effect of heat treatment of composite resin inlay and to get the curing method for optimal physical properties of composite resin inlay. In this study we used four light curing units and one heat curing unit: Visilux $II^{TM}$, a visible light gun: $SPECTRUM^{TM}$, an argon laser: Unilux AC$^{(R)}$ and Astorn XL$^{(R)}$, visible light curing unit: CRC-$100^{TM}$ for heat treatment. Compared to a control group, we divided the experemental groups into five as follows: Control group: Light curing(Visilux $II^{TM}$) Experimental group 1 : Light curing(Visilux $II^{TM}$) + Light curing(Unilux AC$^{(R)}$) Experimental group 2: Light curing(Visilux $II^{TM}$) + Light curing(Astron XL$^{(R)}$) + Heat treatment(CRC-$100^{TM}$) Experimental group 3 : Laser curing($SPECTRUM^{TM}$) Experimental group 4 : Laser curing($SPECTRUM^{TM}$) + Light curing(Unilux AC$^{(R)}$) Experimental group 5 : Laser curing($SPECTRUM^{TM}$) + Light curing(Astron XL$^{(R)}$) + Heat treatment (CRC-$100^{TM}$) According to the above classification, we made samples through the curing of Clearfil CR Inlay$^{(R)}$, which is a composite resin for inlay, in a separable cylindrical metal mold and polycarbonate plate. And then, we measured and compared the value of compressive strength, diametral tensile strength and the surface micro hardness of each sample. The results were as follows : 1. Among the experimental groups, group 5 showed the highest value of compressive strength, $157.50{\pm}10.24$ kgf and control group showed the lowest value of compressive strength, $103.93{\pm}21.93$ kgf. Control group showed significant difference with the experimental groups(p<0.001). Group 2 which was treated by the heat showed higher compressive strength than that of group 1 which was not, and there was significant difference between group 1 and group 2(p<0.001). Group 5 which was treated by heat showed higher compressive strength than group 4 which was not, and there was significant difference group 4 and group 5(p<0.001). 2. Among the experimental groups, group 5 showed the highest value of diametral tensile strength, $95.84{\pm}1.97$ kgf and control group showed the lowest value of diametral tensile strength, $81.80{\pm}2.17$ kgf. Control group which was cured by visible light showed higher diametral tensile strength than group 3 which was cured Argon Laser. Group 2 which was treated by heat showed higher compressive strength than that of group 1 which was not, and there was significant difference between group 1 and group 2(p<0.001). Group 5 which was treated by heat showed higher compressive strength than group 4 which was not, and there was a significant difference group 4 and group 5(p<0.001). 3. Among the experimental groups, group 5 showed the highest value of microhardness of top surface, $148.42{\pm}9.57$ kgf and control group showed the lowest value of microhardness, $111.43{\pm}7.63$ kgf. In the case of bottom surface, group 5 showed the highest value of $146.19{\pm}7.62$ kgf, and control group showed the lowest, $104.03{\pm}11.05$ kgf. Group 3 which was cured by Argon Laser showed higher diametral tensile strength than control group which was cured only with a visible light gun. Group 2 which was treated by heat showed higher compressive strength than that of group 1 which was not, and there was a significant difference between group 1 and group 2(p<0.001). Group 5 which was treated by heat showed higher compressive strength than group 4 which was not, and there was a significant difference group 4 and group 5(p<0.001). 4. According to the above results, we took a conclusion that argon laser can be used as a useful unit for curing the composite resin and heat treatment can improve the physical properties of the composite resin inlay.

• Development and Reproduction
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• v.5 no.1
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• pp.73-79
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• 2001

Recently many studies have reported that total and bioavailable androgens reduced in male and female athletes and that physical exercise reduces the body weight and increases the reproductive abnormalities such as oligomenorrhea, anovulation, inadequate luteal phase, and delayed puberty in women by the inhibition of the hypothalamic-pituitary-gonadal (HPG) axis . In addition, high mileage endurance 겨nning, psychological stress, and military endurance training in men also reduce the secretion of reproductive hormones. To investigate the efffcts of physical endurance exercise on the secretion of reproductive hormones in men, androgenic hormones from adrenal glands and testis were measured in serum by the conventional radioimmunoassays after long-term (more than3 months), short-term (1 week), and acute (1${sim}$2 hours) physical exercises. Androgenic hormones from adrenal glands and testis such as total testosterone (TT), free testosterone (fT), dehydroepiandrosterone (DHEA), and androstenedione (A) decreased after thesestrenuous endurance trainings, whereas ACTH, cortisol, and dehydroepiandrosterone sulfetes (DHEAS) increased. Conadotropins (LH and FSH) were not idluenced by the physical exercises. Based upon the present results, we assume that the decrease in adrenal and testicular androgens by physical endurance exercises might be associated with the reproductive abnormalities in athletes by unknown factor(s) in addition to the HPG axis disturbance.

• Korean Journal of Clinical Laboratory Science
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• v.50 no.2
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• pp.144-154
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• 2018

Metabolic disease is associated with abdominal obesity, high blood pressure, and dyslipidemia. Physical activity has beneficial effects on a variety of diseases. This study examined the relationship between metabolic diseases and physical activity according to age. Among a total of 7,295 subjects, the data from 382 individuals in the normal group and 1,525 persons in the metabolic disease group were analyzed. The data were analyzed statistically by one-way ANOVA, the Pearson's correlation coefficient, and multiple regression analysis. The levels of hemoglobin (HB), hematocrit (HCT), and creatinine (CR), were elevated when a high-intensity physical activity was performed, but they were reduced when a low-intensity physical activity was performed in the normal group aged 10~29 years and the metabolic disease group aged 50~69 years. In the normal group and metabolic disease group aged 30~49 years, the level of high density lipoprotein cholesterol (HDL-C) was elevated when high-intensity physical activity was conducted, whereas it was reduced when low-intensity physical activity was performed. No difference in the level of HDL-C depending on age and exercise intensity was observed in the normal group; the level of HDL-C decreased with age and increased with exercise intensity in the metabolic disease group. Physical activity has different effects in metabolic disease depending on age.