• International Journal of Computer Science & Network Security
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• 제24권4호
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• pp.127-134
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• 2024

The article highlights the problems of the digitalization of the educational process, which affect the pedagogical cluster and are of a psychological nature. The authors investigate the transformational changes in education in general and the individual beliefs of each subject of the educational process, caused by both the change in the format of learning (distance, mixed), and the use of new technologies (digital, communication). The purpose of the article is to identify the strategic trend of the educational process, which is a synergistic combination of pedagogical methodology and psychological practice and avoiding dialectical opposition of these components of the educational space. At the same time, it should be noted that the introduction of digital technologies in the educational process allows for short-term difficulties, which is a usual phenomenon for innovations in the educational sphere. Consequently, there is a need to differentiate the fundamental problems and temporary shortcomings that are inherent in the new format of learning (pedagogical features). Based on the awareness of this classification, it is necessary to develop psychological techniques that will prevent a negative reaction to the new models of learning and contribute to a painless moral and spiritual adaptation to the realities of the present (psychological characteristics). The methods used in the study are divided into two main groups: general-scientific, which investigates the pedagogical component (synergetic, analysis, structural and typological methods), and general-scientific, which are characterized by psychological direction (dialectics, observation, and comparative analysis). With the help of methods disclosed psychological and pedagogical features of the process of digitalization of education in a mixed learning environment. The result of the study is to develop and carry out methodological constants that will contribute to the synergy for the new pedagogical components (digital technology) and the psychological disposition to their proper use (awareness of the effectiveness of new technologies). So, the digitalization of education has demonstrated its relevance and effectiveness in the pedagogical dimension in the organization of blended and distance learning under the constraints of the COVID-19 pandemic. The task of the psychological cluster is to substantiate the positive aspects of the digitalization of the educational process.

• 대한한의학원전학회지
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• 제37권2호
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• pp.49-76
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• 2024

Objectives : The purpose of this paper is to examine the mechanism and treatment of the Zangfu warm disease in the Beijiqianjinyaofang. Methods : This study examined the Zangfu warm disease content in the Beijiqianjinyaofang, Shanghanzongbinglun, Saninfang, based on the Neijing explanation of the pathological mechanism. Treatment was analyzed among the three texts in terms of their similarity and difference. Results & Conclusions : 1. Zangfu warm disease is caused by seasonally inappropriate qi, which is infectious, epidemic, and seasonal. 2. While the Qingjinqian disease pattern was explained in terms of the relationship between Shaoyin and Shaoyang, the actual disease pattern happened more in the Taiyang channel, and partly in the Shaoyang channel. For treatment of Fu deficiency pattern, the Chaihudihuangtang was listed in the Qianjinyaofang and the Shanghanzongbinglun, while in the Sanyinfang, the formula was modified to extinguish heat and thin phlegm, while reinforcing healthy qi. 3. The Chimaifei disease pattern was explained in terms of the relationship between Shaoyin and Taiyang that is deeply associated with Wei qi. For treatment of Fu deficiency the Qianjinyaofang and Shanghanzongbinglun used the Shigaodihuangtang, while the Sanyinfang reinforced healthy qi and eliminated pathogenic qi. 4. The Huangrousui disease pattern was explained as being caused by problems in the Taiyin and Yangming, in which the Triple Burner fails to control and manage cold dampness. In treating Zang excessiveness, the Qianjinyaofang and Shanghanzongbinglun used the Xuanshenhanshuishitang, while the Sanyinfang instructed to reinforce healthy qi and eliminate pathogenic qi. In treating Fu deficiency, the Sanyinfang instructed to warm the center and dry dampness, tonifying the Spleen and reinforcing qi. 5. The Baiqili disease pattern was explained within the relationship between Taiyin and Taiyang. In treating Fu deficiency, the Qianjinyaofang and Shanghanzongbinglun used the Shigaoxingrentang, while the Sanyinfang instructed to reinforce healthy qi and eliminate pathogenic qi. In treating Zang excessiveness, the Qianjinyaofang and Shanghanzongbinglun used the Shigaocongbaitang, while the Sanyinfang instructed to reinforce healthy qi and eliminate pathogenic qi. 6. The Heiguwen disease pattern was explained as being caused by stagnation and obstruction in the Triple Burner due to clash between Taiyang and Shaoyin. In treating Zang excessiveness, the Qianjinyaofang and Shanghanzongbinglun used the Kushenshigaotang, while the Sanyinfang instructed to reinforce healthy qi and eliminate pathogenic qi. The Zangfu Warm Disease is a infectious disease concept which is based on the Five Zang that integrates the meridian aspect together with the Six Fu with which there is an external/internal relationship. This concept and treatment could be considered in dealing with COVID-19.

• IMMUNE NETWORK
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• 제23권4호
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• pp.33.1-33.13
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• 2023

Vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been acknowledged as an effective mean of preventing infection and hospitalization. However, the emergence of highly transmissible SARS-CoV-2 variants of concern (VOCs) has led to substantial increase in infections among children and adolescents. Vaccine-induced immunity and longevity have not been well defined in this population. Therefore, we aimed to analyze humoral and cellular immune responses against ancestral and SARS-CoV-2 variants after two shots of the BNT162b2 vaccine in healthy adolescents. Although vaccination induced a robust increase of spike-specific binding Abs and neutralizing Abs against the ancestral and SARS-CoV-2 variants, the neutralizing activity against the Omicron variant was significantly low. On the contrary, vaccine-induced memory CD4⁺ T cells exhibited substantial responses against both ancestral and Omicron spike proteins. Notably, CD4⁺ T cell responses against both ancestral and Omicron strains were preserved at 3 months after two shots of the BNT162b2 vaccine without waning. Polyfunctionality of vaccine-induced memory T cells was also preserved in response to Omicron spike protein. The present findings characterize the protective immunity of vaccination for adolescents in the era of continuous emergence of variants/subvariants.

• Design & Manufacturing
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• 제17권3호
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• pp.21-27
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• 2023

The mold industry in Japan, an advanced country in the mold industry, is also at a point of great change. The main causes are the Ukraine crisis and the collapse of the global supply chain (parts supply chain) caused by COVID-19. In addition, the prices of overseas products are rising sharply due to rapid exchange rate fluctuations (decrease in the value of the yen). Until now, Japan's monotsukuri industry has been actively pursuing overseas expansion, riding the trend of globalization. However, the trend began to rapidly reverse, and now the monotsukuri industry that had expanded overseas is showing a tendency to return to Japan. Another factor of change is the change in the automobile industry, which is the most demanded product in the mold industry. As the automobile industry evolves from gasoline cars to electric cars, the number of parts that make up a car will drastically decrease. This trend is expected to increase the demand for small-scale production of a variety of products in the mold industry, and furthermore, it is expected that short delivery times will be required in parts development. As in Korea, the production population working in the mold industry is rapidly decreasing in Japan as well. Even if you add up the total population working in manufacturing in Japan, it only accounts for about 15%. Even in Japan, it is judged that it will be difficult to sustain the monotsukuri industry with this small production population. Therefore, since improvement in production efficiency cannot be expected with the same manual dexterity as before, the mold industry is also demanding the development of mold technology at a different level than before to increase productivity. In this paper, I would like to introduce new Japanese mold technology collected through attending the Intermold exhibition. This is an example of applying a dedicated pin (Gastos) to a mold to prevent an increase in internal pressure during plastic injection molding, and a deep drawing press molding technology with an inherent hydraulic function.

• 산업융합연구
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• 제22권6호
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• pp.81-88
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• 2024

본 연구는 엑티브시니어의 온라인 동영상을 통한 노마드 체육활동이 신체적자기지각과 성공적 노화에 미치는 영향을 규명하여 학문적 기초자료를 제공하는데 목적이 있다. 본 연구의 목적을 달성하기 위해 D시의 엑티브시니어 10명을 선정한 후, 온라인동영상 신체활동 참가 동의를 받고 사전, 사후로 나누어 실시하였고 2022년 3월 14일~4월 22일까지 카카오톡 단톡방을 개설하여 12차시 온라인 신체활동 동영상을 시청하고 일주일에 2개의 동영상을 다운로드 받아 월~금까지 운동을 실시하였다. 연구문제를 해결하기 위해 SPSS Ver20.0통계 프로그램을 이용하여 빈도분석과 대응t-test, 를 실시하였다. 그 결과 첫째, 엑티브시니어의 노마드 체육활동을 통한 신체적자기지각의 사전·사후검사를 분석한 결과, 얼굴만족, 신체만족, 체력의 변화, 질병의 변화 모두 평균적으로 증가하였다. 둘째, 엑티브시니어의 노마드 체육활동을 통한 성공적 노화에 대한 사전·사후를 분석한 결과 타인수용, 자기완성지향, 자기수용, 자녀에 대한 만족은 증가하였으나 자율적 삶, 적극적인생참여는 감소하였다. 이러한 결과를 통해 사회적 거리두기로 활동의 제약을 받았던 코로나시기에서 엑티브시니어의 온라인동영상 신체활동은 신체적자기지각과 성공적노화에 긍정적인 영향을 미치며 앞으로 자기 스스로 활동할 수 있는 다양한 프로그램이 개발되어야 할 것이다.

• 아태비즈니스연구
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• 제15권1호
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• pp.193-207
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• 2024

Purpose - With the increase of non-face-to-face activities due to the spread of COVID-19, O2O industry has grown rapidly which reduces contact points between suppliers and consumers. O2O platform is now recognized as an indispensable channel of distribution, but the voice is getting louder that it is necessary to check how it contributes to the performance of suppliers or how its fee system or contract terms affects the expansion of O2O industry as the leading companies tend to monopolize the market. Design/methodology/approach - In this study, the scope was limited to the restaurant industry in which transactions are the most active among the O2O industry and a regression analysis was done on 775 businesses that had used guarantor service from the Seoul Credit Guarantee Foundation. Findings - Analysis on the impact of O2O platform system, information, and service quality on the business performance of the sole proprietors revealed that the system quality represented by ease of use and the information quality determined by level of timely, accurate and reliable information provided to the consumers have a statistically significant effect on the improvement of business performance. In addition, the effect of business performance on the loyalty measured by the likelihood of users continuing to use the service as well as recommending it to others was moderated by the satisfaction with contract terms, not by the fee system. Research implications or Originality - Although the number of O2O platform providers has increased manyfold, the membership rate is no more than 20%, which means that the small business owners are still struggling with digital transformation. In order for the O2O industry, which is now commonplace, to form a healthy ecosystem that satisfies both suppliers and consumers, the standard contract guidelines that are acceptable to both parties must be established and the O2O providers must offer services that help suppliers to improve performance.

• Biomolecules & Therapeutics
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• 제32권4호
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• pp.481-491
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• 2024

Paxlovid is the first approved oral treatment for coronavirus disease 2019 and includes nirmatrelvir, a protease inhibitor targeting the main protease (M^pro) of SARS-CoV-2, as one of the key components. While some specific mutations emerged in M^pro were revealed to significantly reduce viral susceptibility to nirmatrelvir in vitro, there is no report regarding resistance to nirmatrelvir in patients and animal models for SARS-CoV-2 infection yet. We recently developed xenograft tumors derived from Calu-3 cells in immunodeficient mice and demonstrated extended replication of SARS-CoV-2 in the tumors. In this study, we investigated the effect of nirmatrelvir administration on SARS-CoV-2 replication. Treatment with nirmatrelvir after virus infection significantly reduced the replication of the parental SARS-CoV-2 and SARS-CoV-2 Omicron at 5 days post-infection (dpi). However, the virus titers were completely recovered at the time points of 15 and 30 dpi. The virus genomes in the tumors at 30 dpi were analyzed to investigate whether nirmatrelvir-resistant mutant viruses had emerged during the extended replication of SARS-CoV-2. Various mutations in several genes including ORF1ab, ORF3a, ORF7a, ORF7b, ORF8, and N occurred in the SARS-CoV-2 genome; however, no mutations were induced in the M^pro sequence by a single round of nirmatrelvir treatment, and none were observed even after two rounds of treatment. The parental SARS-CoV-2 and its sublineage isolates showed similar IC₅₀ values of nirmatrelvir in Vero E6 cells. Therefore, it is probable that inducing viral resistance to nirmatrelvir in vivo is challenging differently from in vitro passage.

• 심성연구
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• 제38권2호
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• pp.239-268
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• 2023

인류는 대재난(코로나, 전쟁, 지진 등)으로 파괴(혼돈)에 직면하였고, 새로운 복원을 기다리고 있다. 문명과 개체에게 있어서 창조 혹은 창조성은 정신적 발전에 필수적이다. 새로운 의식의 입장과 태도, 실재에 대한 새로운 적응이 인간 정신의 심층에서 절실히 요구될 때, 창조성은 한 개체를 갱신시키는 동인이다. 본 소고는 일련의 네 개의 꿈을 해석하면서, 꿈의 메시지가 제시하는 창조성의 본성과 특징에 대하여 탐색한 결과물이다. 먼저 동서양의 종교와 신화, 역사에서 창조성의 정의와 형태를 탐색하였다. 서양신화는 신으로부터 발화되는 창조 혹은 창조성에 대하여 언급하는 반면에, 고대 중국에서는 도의 움직임에 의한, 음양의 상호작용에 의하여 창조성이 발현되는 것으로 보았다. 동서양에서 창조는 형태적으로 무로부터의 창조 혹은 질료로부터 창조, 모체로부터 해체를 통한 창조 등이 있는데, 이는 심리학적으로 창조성 혹은 창조는 무한한 잠재력과 창조력의 모판인 무의식에서 기원함을 시사한다. 다음으로 두 번째 꿈의 통찰을 따라서 창조성의 특성을 기술하였고, 이는 초월적 기능과 '준거 틀을 넘어서기', 즉 초법성향을 통하여 창조성이 일어남을 살펴보았다. 셋째로, 무의식의 창조성은 재생을 목적으로 하며, 집단과 개인 안에서 자기 원형상의 갱신을 추동하는 것임을 탐색하였다. 궁극적으로 무의식의 창조성은 전체정신의 목표이자 전체가 되어가는 개성화를 지향한다. 무의식의 창조성을 실현하는 일은 두 번째 창조자로서 인간의 숙명이라 할 수 있다.

• Nutrition Research and Practice
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• 제18권1호
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• pp.149-164
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• 2024

BACKGROUND/OBJECTIVES: The economic recession caused by the coronavirus disease 2019 pandemic disproportionately affected poor and vulnerable populations globally. Better uunderstanding of vulnerability to shocks in food supply and demand in the Asia Pacific region is needed. SUBJECTS/METHODS: Using secondary data from rapid assessment surveys during the pandemic response (n = 10,420 in mid-2020; n = 6,004 in mid-2021) in India, Indonesia, Myanmar, and Vietnam, this study examined the risk factors for reported income reduction or job loss in mid-2021 and the temporal trend in food security status (household food availability, and market availability and affordability of essential items) from mid-2020 to mid-2021. RESULTS: The proportion of job loss/reduced household income was highest in India (60.4%) and lowest in Indonesia (39.0%). Urban residence (odds ratio [OR] range, 2.20-4.11; countries with significant results only), female respondents (OR range, 1.40-1.69), engagement in daily waged labor (OR range, 1.54-1.68), and running a small trade/business (OR range, 1.66-2.71) were significantly associated with income reduction or job loss in three out of 4 countries (all P < 0.05). Food stock availability increased significantly in 2021 compared to 2020 in all four countries (OR range, 1.91-4.45) (all P < 0.05). Availability of all essential items at markets increased in India (OR range, 1.45-3.99) but decreased for basic foods, hygiene items, and medicine in Vietnam (OR range, 0.81-0.86) in 2021 compared to 2020 (all P < 0.05). In 2021, the affordability of all essential items significantly improved in India (OR range, 1.18-3.49) while the affordability of rent, health care, and loans deteriorated in Indonesia (OR range, 0.23-0.71) when compared to 2020 (all P < 0.05). CONCLUSIONS: Long-term social protection programs need to be carefully designed and implemented to address food insecurity among vulnerable groups, considering each country's market conditions, consumer food purchasing behaviors, and financial support capacity.

• 문화기술의 융합
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• 제10권1호
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• pp.379-386
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• 2024

연구의 목적은 자연의 소중함을 깨닫게 된 코로나 시대를 거치면서 자연의 다양한 모티브 중에서 개체 수의감소가 환경오염의 척도로 상징되는 나비, 곤충 등의 표현 빈도가 증가하는 것에 주목하고자 하였다. 본 연구의 범위는 2019년부터 2023년까지의 패션컬렉션을 대상으로 온라인 <보그>지(www.vogue.com)의 시즌별 패션컬렉션 패션쇼 사진과 인터뷰 기사로 한정하였다. 연구 결과 185개의 나비모티브 의상이 나타났으며 평면적 표현방식의 유형으로는 디지털 프린팅 기법이 가장 많이 활용되었다. 이와 함께 퀼팅, 자수, 비딩 등의 기법들이 나비의 평면적 모티브를 표현하는 기법으로 많이 등장하였다. 입체적 표현 유형으로는 3D 프린팅, 레이저 컷팅, 코사지 기법, 드레이핑 기법을 사용한 유형들이 비슷한 비중으로 나타났다. 표현된 나비 모티브는 추상적인 표현보다는 나비의 형태를 그대로 묘사한 사실적인 디자인이 더 많았음을 알 수 있었다. 결론적으로 최근 5년간의 나비모티브 패션디자인은 과거의 나비모티브 패션에 비해 환경에 대한 메시지를 강하게 담고 있음을 알 수 있었다. 단순히 나비의 형태적 아름다움과 화려한 디자인 요소를 넘어서 친환경 메시지를 전달할 수 있는 상징적 의미가 큰 모티브임을 확인할 수 있었다.