• Title/Summary/Keyword: Covid-19 pandemics

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Development of Rapid Antibody-based Therapeutic Platform Correspondence for New Viruses Using Antigen-specific Single Cell Memory B Cell Sorting Technology (항원 특이적 단일 기억 B 세포 분리를 이용한 신종 바이러스 대응 신속 항체 플랫폼 개발)

  • Jiyoon Seok;Suhan Jung;Ye Gi Han;Arum Park;Jung Eun Kim;Young Jo Song;Chi Ho Yu;Hyeongseok Yun;Se Hun Gu;Seung-Ho Lee;Yong Han Lee;Gyeunghaeng Hur;Woong Choi
    • Journal of the Korea Institute of Military Science and Technology
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    • v.27 no.1
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    • pp.116-125
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    • 2024
  • The COVID-19 pandemic is not over despite the emergency use authorization as can see recent COVID-19 daily confirmed cases. The viruses are not only difficult to diagnose and treat due to random mutations, but also pose threat human being because they have the potential to be exploited as biochemical weapons by genetic manipulation. Therefore, it is inevitable to the rapid antibody-based therapeutic platform to quickly respond to future pandemics by new/re-emerging viruses. Although numerous researches have been conducted for the fast development of antibody-based therapeutics, it is sometimes hard to respond rapidly to new viruses because of complicated expression or purification processes for antibody production. In this study, a novel rapid antibody-based therapeutic platform using single B cell sorting method and mRNA-antibody. High immunogenicity was caused to produce antibodies in vivo through mRNA-antigen inoculation. Subsequently, antigen-specific antibody candidates were selected and obtained using isolation of B cells containing antibody at the single cell level. Using the antibody-based therapeutic platform system in this study, it was confirmed that novel antigen-specific antibodies could be obtained in about 40 days, and suggested that the possibility of rapid response to new variant viruses.

The Effects of VR-based Cultural Heritage Experience on Visit Intention (VR 기반 문화유산 체험이 방문의도에 미치는 영향)

  • Yoo, Kun Woo;Hwang, Kyunghwa;Kwon, Ohbyung
    • The Journal of Society for e-Business Studies
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    • v.26 no.2
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    • pp.95-122
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    • 2021
  • As it recently became a non-face-to-face society because of the COVID-19 Pandemics, attempts have been made to experience heritage based on virtual reality (VR). Despite the satisfaction of VR contents, however, questions are being raised about whether the VR experience leads to visit a heritage tour or reduces to visit a heritage tour. This study examined how VR-based heritage experiences affect the visit intention of heritage sites. In addition, this study investigated how VR-based experiences differently affect the visit intention compared to web-based experiences. To this end, based on the information success model proposed by DeLone and McLean, this study examined how the perception for system quality and information quality through VR (vs. web) experience affects the intention of visiting the historical site. The results demonstrated that satisfaction was positively influenced by the convenience of system quality and the presence and usefulness of information quality and that the presence and satisfaction positively affected continuance intention. In addition, continuous intention to use positively affected the visit intention of heritage sites. Lastly, it has been shown that the usefulness of information quality in groups experiencing content through the Web (vs. VR) has a greater impact on the intent of continuous use. Based on the results of this study, we discussed ways to organize tourism content to increase the intention of visiting heritage sites.

Bacterial Filtration Efficiencies of KF94 Masks According to Wearing Duration (착용 기간에 따른 KF94 마스크 세균여과효율 변화 연구)

  • Jongmin Park;Yeram Yang;SungJun Park;Kiyoung Lee;Cheonghoon Lee;Chungsik Yoon
    • Journal of Korean Society of Occupational and Environmental Hygiene
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    • v.34 no.1
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    • pp.48-56
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    • 2024
  • Objectives: The coronavirus pandemic that began in 2019(COVID-19) has been one of the worst pandemics of the 21st century. Masks have been used to prevent COVID-19, but there are currently no standards for the long-term use of masks in the Republic of Korea. This study was conducted to assess the microbiological safety of KF94(Korea Filter 94) disposable face masks according to wearing duration by evaluating the bacterial filtration efficiencies of masks worn by research participants. Methods: A commercially available KF94 mask certified by the Ministry of Food and Drug Safety(MFDS) in the Republic of Korea was selected as the test mask. The research participants(n = 15) wore masks for the durations of one, three, and seven days. Participants also reported several parameters, including wearing time, makeup frequency, and storage. Bacterial filtration efficiencies of the worn masks were measured by a mask bioaerosol filtration tester. Staphylococcus aureus(S. aureus) was used as the test bacteria and quantitatively measured through the cultivation method. Then, bacterial filtration efficiency was calculated using the formula suggested by the MFDS. Results: All worn masks showed over 99.98% of mean bacterial filtration efficiency for S. aureus. There were no significant differences among bacterial filtration efficiencies of face masks according to wearing duration. There was also no significant difference among bacterial filtration efficiencies among participants. There was no correlation between the results of bacterial filtration efficiencies and reported parameters from participants. Conclusions: In the absence of significant external damage to the mask, the bacterial filtration efficiency of the mask can be maintained even after seven days of wearing. This result suggests that KF94 masks certified by the MFDS can be used repeatedly for about a week without loss of bacterial filtration efficiency.

A Humanity-Centered Vision of Soft Power for Public Diplomacy's Global Mandate

  • Zaharna, R.S.
    • Journal of Public Diplomacy
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    • v.1 no.2
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    • pp.27-48
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    • 2021
  • Remarkably, despite the growing frequency and severity of global problems such as climate change, earthquakes and health pandemics, public diplomacy has remained largely focused on the goals of state actors and threats from other actors. The Covid-19 pandemic exposed the consequences of focusing on individual actors of public diplomacy, including their competitive quest for soft power, over the more pressing needs of humanity and public diplomacy's global mandate. The aim of this piece is to expand the vision of soft power from a competitive state-centric perspective to a broader and more collaborative, humanity-centered perspective. Although public diplomacy's link to power may appear recent and linked to Nye's (2004) concept of soft power, research suggests that it may stem from the traditional diplomacy's "diplomacy of imperialism" (Langer, 1935) that immediately preceded public diplomacy's rise. While this diplomatic heritage may currently dominate public diplomacy perspectives, humankind's global heritages and evolutionary capacity for cooperation suggest another vision is possible. The paper draws upon Alexander Vuving's (2009) explanation of how soft power works in a comparative analysis with Nye's original works to sketch out a new humanity-centered perspective of soft power. The paper concludes with implications of a humanity-centered perspective of soft power for public diplomacy's global mandate.

Indoor air quality evaluation in intercity buses in real time traffic

  • Kazim O. Demirarslan;Serden, Basak
    • Advances in environmental research
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    • v.11 no.1
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    • pp.17-30
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    • 2022
  • Road transport allows all forms of land conditions to be met at less cost. Because of this function, despite numerous disadvantages, it becomes the most frequently used method of transport, especially in underdeveloped or developing countries. One of the most significant factors used in evaluating the atmosphere's air quality is the amount of CO2, increasing people's density in indoor spaces. The amount of CO2 indoors is, therefore, vital to determine. In this study, CO2 and temperature measurements made on nine different bus journey was made in Turkey. The minimum and maximum values were recorded as 555 ppm and 3000 ppm CO2, respectively, in the measurements. On all journeys, the average concentration is 1088.72 ppm. The minimum and maximum values were measured as 17.4℃ and 32.7℃ in the temperature measurements, and the average of all trips was calculated to be 25.76℃. In this study conducted before the Covid-19 pandemic, it was determined that the amount of CO2 increased with the density and insufficient ventilation in the buses. The risk of infection increases in places with high human density and low clean air. For situations such as pandemics, CO2 measurement is a rapid indicator of determining human density.

DATA-BASED OPERATION PLAN FOR CHILGAPSAN OBSERVATORY (데이터에 기반한 칠갑산천문대의 운영방안 연구)

  • Sangkyeong Choi;Junhyeok Jeon;Yonggi Kim
    • Publications of The Korean Astronomical Society
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    • v.38 no.3
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    • pp.111-123
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    • 2023
  • In this study, quantitative analysis is attempted on data collected from Chilgapsan Observatory Star Park in Cheongyang-gun, Chungcheongnam-do. The aim of this experimental study in which quantitative analysis of the Astronomical Science Museum in Korea is conducted is to investigate its current situation and secure basic data. As of July 31, 2023, it has had 283,931 cumulative visitors in total. It had the largest number of visitors when it opened (2009 year), after which their number reduced steadily until the pandemic (COVID-19, 2020-2022). Recently, however, the number of visitors has increased. Generally, the number of visitors is highest in August (20.8%) and least in April (4.1%). The visit rate is higher on weekends (Saturday and Sunday) than on weekdays (Monday-Friday), and groups comprise only about 5.3% of the total number of visitors. Moreover, it can be confirmed that the number of visitors increases sharply during events. Finally, it was confirmed that the visit rate was unaffected by weather conditions. Considering these results, we propose the following strategies: 1) Establish a special program that reflects "the weekend effect." 2) Prepare a plan to attract group visitors during the weekdays using "the event effect." 3) Arrange alternative programs (e.g., experiential activities) that can be conducted indoors regardless of weather conditions. We think that our findings will help establish a roadmap for the direction the Astronomical Science Museum should take and aid in preparing a strategic foundation to preemptively respond to unexpected situations (e.g., pandemics).

Extracorporeal Membrane Oxygenation for Coronavirus Disease 2019: Expert Recommendations from The Korean Society for Thoracic and Cardiovascular Surgery

  • Jeong, In Seok;Kim, Woong-Han;Baek, Jong Hyun;Choi, Chang-Hyu;Choi, Chang Woo;Chung, Euy Suk;Jang, Jae Seok;Jang, Woo Sung;Jung, Hanna;Jung, Jae-Seung;Kang, Pil Je;Kim, Dong Jung;Kim, Do Wan;Kim, Hyoung Soo;Kim, Jae Bum;Kim, Woo-Shik;Kim, Young Sam;Kwak, Jae Gun;Lee, Haeyoung;Lee, Seok In;Lim, Jae Woong;Oh, Se Jin;Oh, Tak-Hyuck;Park, Chun Soo;Ryu, Kyoung Min;Shim, Man-Shik;Son, Joohyung;Son, Kuk Hui;Song, Seunghwan;The Korean Society for Thoracic and Cardiovascular Surgery COVID-19 ECMO Task Force Team
    • Journal of Chest Surgery
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    • v.54 no.1
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    • pp.2-8
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    • 2021
  • Since the first reported case of coronavirus disease 2019 (COVID-19) in December 2019, the numbers of confirmed cases and deaths have continued to increase exponentially despite multi-factorial efforts. Although various attempts have been made to improve the level of evidence for extracorporeal membrane oxygenation (ECMO) treatment over the past 10 years, most experts still hesitate to take an active position on whether to apply ECMO in COVID-19 patients. Several ECMO management guidelines have been published recently, but they reflect some important differences from the Korean medical system and aspects of real-world medical practice in Korea. We aimed to find evidence on the efficacy of ECMO for COVID-19 patients by reviewing the published literature and to propose expert recommendations by analyzing the Korean COVID-19 ECMO registry data.

A Study on the Influence of Quality Factors on User Satisfaction in Government Remote Service (GVPN): Focused on Users of Government Department (정부원격근무서비스(GVPN)의 품질요인이 이용자 만족도에 미치는 영향에 관한 연구: 정부부처 이용자 중심으로)

  • Lee, Won Suk;Jang, Sang-hyun;Kim, Yeongdae;Shin, Yongtae
    • KIPS Transactions on Computer and Communication Systems
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    • v.10 no.1
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    • pp.15-28
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    • 2021
  • As the social distance has been strengthened by the COVID-19 Pandemics, telecommuting has spread, and government agencies have also begun telecommuting since March and are still maintaining a certain level. The Government's remote work service, Government Virtual Private Network (GVPN), which is essential to telecommuting of government agencies, is expected to cause a number of problems with the rapid increase in users in a short period of time. Therefore, a survey and statistical analysis were conducted to analyze the impact of the quality factors of GVPN on the users' satisfaction to the public officials of the government departments who are directly using it, and based on these results, we intend to derive the implications necessary for the improvement of GVPN for remote work in preparation for the full-fledged spread of the non-contact era.

A Study of The Purchasing Tendency of Health-care Masks Based on The User-centered Design Concept-centered on the Form and Color of the Mask (사용자 중심 디자인개념에 기초한 보건용 마스크의 구매 경향성에 관한 연구 - 마스크의 형태와 색상 중심으로)

  • Ma, Lin;Kim, Myung-Soo
    • Journal of the Korea Convergence Society
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    • v.11 no.9
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    • pp.143-154
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    • 2020
  • Due to the widespread of COVID-19 pandemics, as the health care supplies. Thus the facial mask has been transformed from personal health product into social epidemic prevention product, and its design is more inclined to be User-centered design. First employed health facial mask which is sold in the market as the method subject, under the concept of " User-centered design", this article analyzes the design elements such as appearance and color of the facial mask. Second used the analysis approach of sample, character and positioning map, this article conducts the comparative analysis research of collected sample and data and find the relationship of User-centered design, purchase tendency and health care facial mask. When the users purchase the mask, through the research on the relationship between the choice of form or color of mask and design element of mask, it can compensate for the blank spot of design and has some references.