• Clinical and Experimental Pediatrics
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• v.54 no.1
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• pp.1-5
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• 2011

Asthma in childhood is a heterogeneous disease with different phenotypes and variable clinical manifestations, which depend on the age, gender, genetic background, and environmental influences of the patients. Several longitudinal studies have been conducted to classify the phenotypes of childhood asthma, on the basis of the symptoms, triggers of wheezing illness, or pathophysiological features of the disease. These studies have provided us with important information about the different wheezing phenotypes in young children and about potential mechanisms and risk factors for the development of chronic asthma. The goal of these studies was to provide a better insight into the causes and natural course of childhood asthma. It is well-known that complicated interactions between genes and environmental factors contribute to the development of asthma. Because childhood is a period of rapid growth in both the lungs and the immune system, developmental factors should be considered in the pathogenesis of childhood asthma. The pulmonary system continues to grow and develop until linear growth is completed. Longitudinal studies have reported significant age-related immune development during postnatal early life. These observations suggest that the phenotypes of childhood asthma vary among children and also in an individual child over time. Improved classification of heterogeneous conditions of the disease will help determine novel strategies for primary and secondary prevention and for the development of individualized treatment for childhood asthma.

• Journal of Environmental Impact Assessment
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• v.13 no.3
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• pp.137-151
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• 2004

Many of today's environmental problems are regional in scope and their effects overlap and interact. The purpose of this paper is to developed a simple method for an integrated assessment of environmental conditions across the Mid-Nakdong River Region, by combining data on land use, impervious cover, roads, streams, riparian areas, forest patches, population, pollutant loadings, soil erosion and topography. A cluster analysis was used to identify groups of sub-watersheds with similar environmental characteristics. The mean value for each group was used to find watershed that may be more vulnerable to future environmental degradation. Watersheds in cluster I and II had high amount of forest, but the amount of riparian vegetation was low. Watersheds in cluster III, which located in the middle Geumho River and the main course of Nakdong River, had a greater proportion of their agriculture, a greater proportion of agriculture on steep slopes, and less forest adjacent to streams. Watersheds in cluster IV and V were in the most urbanized areas of the region. The principal adverse impacts for watersheds in this group were high scores for urban area, impervious cover, pollutant loadings, population density, forest fragmentation, and low amounts of forest and riparian forest cover. Notwithstanding the exploratory nature of cluster analysis, it appears to be a useful tool for grouping watersheds with similar environmental characteristics.

• Journal of Chest Surgery
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• v.24 no.4
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• pp.421-427
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• 1991

Atrial fibrillation[Af] is closely related to thrombus in left atrium, systemic embolism, and loss of the contribution of atrial contraction to cardiac output. Therefore maintenance of sinus rhythm[SR] is undoubtedly hemodynamically superior to Af in the clinical course of mitral valvular disease especially in the unstable period immediately after surgery. In this article, the conversion rate and the factors influencing the conversion of Af to SR after surgery were studied. Ninety-three patients with mitral valvular replacement at Chungnam National University Hospital were analysed with electrocardiography before and after surgery during the period from June 1985 to June 1990. Eighty patients presented Af before surgery. Twenty-four[30Yo] of the patients were converted to SR[A group] and fifty six presented continuous Af after surgery[B group]. The duration of preoperative Af, preoperative left atrial dimension[LAD], preoperative functional status[NYHA classification] and cardiothoracic[CT] ratio were factors influencing the conversion of Af to SR after surgery. The mean preoperative duration of Af was 3.5$\pm$2.6yr in group A and 7.6$\pm$4.9yr in group B. The mean preoperative LAD was 53. 7$\pm$9.4mm in group A and 62.5$\pm$11.2mm in group B. Before surgery, eleven patients[46%] were belong to NYHA class I, II in group A and eight[14%] in group B. The preoperative CT ratio was 62$\pm$6% in group A and 69$\pm$8% in group B.

• Journal of Engineering Education Research
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• v.12 no.2
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• pp.89-95
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• 2009

This thesis investigated way of employment, education course of a training school of Programmable Logic Controller a Field. I inquired into a demand of an engineer and a necessary level of professional education. As a result, I have a purpose in what offer the information that cared for a beginning to work elevation and education training and boat development of a student more than. Faced a human power demand in an education demand and a field rehearsal student demand and analyzed it. The sample extraction used industrial classification, work of scale, Assignment sample extraction way (quota sampling). All data called at a silver phone and the investigated, The data parser analyzed the statistics that used Microsoft Excel.

• Journal of Korean Society for Geospatial Information Science
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• v.1 no.1 s.1
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• pp.153-158
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• 1993

The direction of land use for the subject district (Zuksan-myun, Anseong-gun, Kyeonggi-do) were analyzed as the basic model of new rural land management system connected to production and living. General land use planning was presented by land suitability classification which was applied to geographical information system(software ARC/INFO). The course of analysis of land suitability using the geographical information system were generalized and the results of analysis for paddy and upland fields and settlement were presented as 5 criteria of the suitability rank. It was found out that the analysis of land suitability is able to use as primary data of rural land use planning.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 2002.05a
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• pp.678-685
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• 2002

e-business curriculum needs to be developed reflecting requirements of the stakeholder which involve a close relation with a industrial and educational job performed in the field. In this paper, we present a new methodology for developing a market-oriented and stakeholder-led e-business curriculum using quality function deployment(QFD) and conjoint analysis. For this purpose, we analyze the data resulting from the surveyed opinions of respondents working for e-business companies, the interviewed results with professors and students and evaluate the importance of each course being involved in the curriculum with respect to the job classification (e.g.. Web planner. Web master. Web programmer. Web marketer. Web designer), and then. complete a curriculm flow diagram(CFD) considering precedence and relative difficulty among the selected courses. The e-business curriculum developed by the proposed method is useful to provide guidelines for determining courses required toward a desired job and for making a partial amendment of the curriculum.

• Journal of the Korea Safety Management & Science
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• v.8 no.5
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• pp.17-25
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• 2006

Nowadays most colleges are confronting with a serious problem because many students have left their majors at the colleges. In order to make a countermeasure for reducing major separation rate, many universities are trying to find a proper solution. As a similar endeavor, the objective of this paper Is to find a predicting model of students leaving their majors. The sample for this study was chosen from a university in Kangwon-Do during seven years(2000.3.1 $\sim$ 2006. 6.30). In this study, the ratio of training sample versus testing sample among partition data was controlled as 50% : 50% for a validation test of data division. Also, this study provides values about accuracy, sensitivity, specificity about three kinds of algorithms including CHAID, CART and C4.5. In addition, ROC chart and gains chart were used for classification of students leaving their majors. The analysis results were very informative since those enable us to know the most important factors such as semester taking a course, grade on cultural subjects, scholarship, grade on majors, and total completion of courses which can affect students leaving their majors.

• Journal of Navigation and Port Research
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• v.34 no.5
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• pp.343-348
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• 2010

As the marine transportation has increased, the safe maneuvering system has been required. SOLAS obligated regulations for carrying AIS(Automatic Identification System) onboard. This system provides navigational information including identification, classification, position, a ship's course and voyage status from own vessel to ground and other vessels. Being utilized in the most development of application service for safe maneuvering, they are to be managed systematic. In this paper, we introduce a database system to manage the voyage status and navigational information of AIS message. It is classified by static or dynamic. An electronic navigational chart display system is implemented to verify the design.

• Clinical and Experimental Pediatrics
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• v.62 no.9
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• pp.325-333
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• 2019

Allergic diseases, including allergic rhinitis, asthma, and atopic dermatitis, are common heterogeneous diseases that encompass diverse phenotypes and different pathogeneses. Phenotype studies of allergic diseases can facilitate the identification of risk factors and their underlying pathophysiology, resulting in the application of more effective treatment, selection of better treatment responses, and prediction of prognosis for each phenotype. In the early phase of phenotype studies in allergic diseases, artificial classifications were usually performed based on clinical features, such as triggering factors or the presence of atopy, which can result in the biased classification of phenotypes and limit the characterization of heterogeneous allergic diseases. Subsequent phenotype studies have suggested more diverse phenotypes for each allergic disease using relatively unbiased statistical methods, such as cluster analysis or latent class analysis. The classifications of phenotypes in allergic diseases may overlap or be unstable over time due to their complex interactions with genetic and encountered environmental factors during the illness, which may affect the disease course and pathophysiology. In this review, diverse phenotype classifications of allergic diseases, including atopic dermatitis, asthma, and wheezing in children, allergic rhinitis, and atopy, are described. The review also discusses the applications of the results obtained from phenotype studies performed in other countries to Korean children. Consideration of changes in the characteristics of each phenotype over time in an individual's lifespan is needed in future studies.

• Journal of Genetic Medicine
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• v.18 no.1
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• pp.31-37
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• 2021

Purpose: To summarize the results of chromosomal microarray analysis (CMA) for copy number variants (CNVs) detection and clinical utility in a single tertiary hospital. Materials and Methods: We performed CMA in 46 patients over the course of two years. Detected CNVs were classified into five categories according to the American College of Medical Genetics and Genomics guidelines and correlated with clinical manifestations. Results: A total of 31 CNVs were detected in 19 patients, with a median CNV number per patient of two CNVs. Among these, 16 CNVs were classified as pathogenic (n=3) or likely pathogenic (LP) (n=11) or variant of uncertain significance (n=4). The 16p11.2 deletion and 16p13.11 deletion classified as LP were most often detected in 6.5% (3/46), retrospectively. CMA diagnostic yield was 24.3% (9/37 patients) for symptomatic patients. The CNVs results of the commercial newborn screening test using next generation sequencing platforms showed high concordance with CMA results. Conclusion: CMA seems useful as a first-tier test for developmental delay with or without congenital anomalies. However, the classification and interpretation of CMA still remained a challenge. Further research is needed for evidence-based interpretation.