• Clinical and Experimental Pediatrics
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• 제54권1호
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• pp.1-5
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• 2011

Asthma in childhood is a heterogeneous disease with different phenotypes and variable clinical manifestations, which depend on the age, gender, genetic background, and environmental influences of the patients. Several longitudinal studies have been conducted to classify the phenotypes of childhood asthma, on the basis of the symptoms, triggers of wheezing illness, or pathophysiological features of the disease. These studies have provided us with important information about the different wheezing phenotypes in young children and about potential mechanisms and risk factors for the development of chronic asthma. The goal of these studies was to provide a better insight into the causes and natural course of childhood asthma. It is well-known that complicated interactions between genes and environmental factors contribute to the development of asthma. Because childhood is a period of rapid growth in both the lungs and the immune system, developmental factors should be considered in the pathogenesis of childhood asthma. The pulmonary system continues to grow and develop until linear growth is completed. Longitudinal studies have reported significant age-related immune development during postnatal early life. These observations suggest that the phenotypes of childhood asthma vary among children and also in an individual child over time. Improved classification of heterogeneous conditions of the disease will help determine novel strategies for primary and secondary prevention and for the development of individualized treatment for childhood asthma.

• 환경영향평가
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• 제13권3호
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• pp.137-151
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• 2004

Many of today's environmental problems are regional in scope and their effects overlap and interact. The purpose of this paper is to developed a simple method for an integrated assessment of environmental conditions across the Mid-Nakdong River Region, by combining data on land use, impervious cover, roads, streams, riparian areas, forest patches, population, pollutant loadings, soil erosion and topography. A cluster analysis was used to identify groups of sub-watersheds with similar environmental characteristics. The mean value for each group was used to find watershed that may be more vulnerable to future environmental degradation. Watersheds in cluster I and II had high amount of forest, but the amount of riparian vegetation was low. Watersheds in cluster III, which located in the middle Geumho River and the main course of Nakdong River, had a greater proportion of their agriculture, a greater proportion of agriculture on steep slopes, and less forest adjacent to streams. Watersheds in cluster IV and V were in the most urbanized areas of the region. The principal adverse impacts for watersheds in this group were high scores for urban area, impervious cover, pollutant loadings, population density, forest fragmentation, and low amounts of forest and riparian forest cover. Notwithstanding the exploratory nature of cluster analysis, it appears to be a useful tool for grouping watersheds with similar environmental characteristics.

• Journal of Chest Surgery
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• 제24권4호
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• pp.421-427
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• 1991

Atrial fibrillation[Af] is closely related to thrombus in left atrium, systemic embolism, and loss of the contribution of atrial contraction to cardiac output. Therefore maintenance of sinus rhythm[SR] is undoubtedly hemodynamically superior to Af in the clinical course of mitral valvular disease especially in the unstable period immediately after surgery. In this article, the conversion rate and the factors influencing the conversion of Af to SR after surgery were studied. Ninety-three patients with mitral valvular replacement at Chungnam National University Hospital were analysed with electrocardiography before and after surgery during the period from June 1985 to June 1990. Eighty patients presented Af before surgery. Twenty-four[30Yo] of the patients were converted to SR[A group] and fifty six presented continuous Af after surgery[B group]. The duration of preoperative Af, preoperative left atrial dimension[LAD], preoperative functional status[NYHA classification] and cardiothoracic[CT] ratio were factors influencing the conversion of Af to SR after surgery. The mean preoperative duration of Af was 3.5$\pm$2.6yr in group A and 7.6$\pm$4.9yr in group B. The mean preoperative LAD was 53. 7$\pm$9.4mm in group A and 62.5$\pm$11.2mm in group B. Before surgery, eleven patients[46%] were belong to NYHA class I, II in group A and eight[14%] in group B. The preoperative CT ratio was 62$\pm$6% in group A and 69$\pm$8% in group B.

• 공학교육연구
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• 제12권2호
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• pp.89-95
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• 2009

본 논문은 PLC분야의 인력수요, 채용과정, 훈련소의 교육내용을 조사하였다. 기술인력의 수요와 직업교육의 요구 수준을 파악하였따. 따라서 학생의 취업향상과 교육 훈련과정 개발을 위한 정보를 제공함에 목적이 있다. 인력수요 및 교육수요와 현장 실습생 수요에 대해 분석하였다. 표본 추출은 업종별, 규모별 할당표본 추출방법(quota Sampling)을 사용하였다. 조사방법은 전화 및 방문하여 조사하였으며 자료분석은 엑셀을 이용한 통계 분석을 하였다.

• 대한공간정보학회지
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• 제1권1호
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• pp.153-158
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• 1993

농촌 지역의 토지를 계획 관리하는 새로운 방안의 하나로서 토양의 잠재 생산력과 주거를 고려하여 대상지구(경기도 안성군 죽산면)의 토지 이용 방향을 분석하였다. 지리정보시스템(소프트웨어 ARC/INFO)을 이용하여 토지이용계획의 분석과정을 객관화하고, 논과 밭, 주거지에 대한 토지의 적합성을 분석하여 5등급으로 분류하여 제시하였다. 그리고, 토지 용도의 적합성 구분은 농촌 지역의 개발계획을 수립하는 기초 자료로 활용할 수 있다는 것을 알 수 있었다.

• 한국경영과학회:학술대회논문집
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• 대한산업공학회/한국경영과학회 2002년도 춘계공동학술대회
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• pp.678-685
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• 2002

e-business curriculum needs to be developed reflecting requirements of the stakeholder which involve a close relation with a industrial and educational job performed in the field. In this paper, we present a new methodology for developing a market-oriented and stakeholder-led e-business curriculum using quality function deployment(QFD) and conjoint analysis. For this purpose, we analyze the data resulting from the surveyed opinions of respondents working for e-business companies, the interviewed results with professors and students and evaluate the importance of each course being involved in the curriculum with respect to the job classification (e.g.. Web planner. Web master. Web programmer. Web marketer. Web designer), and then. complete a curriculm flow diagram(CFD) considering precedence and relative difficulty among the selected courses. The e-business curriculum developed by the proposed method is useful to provide guidelines for determining courses required toward a desired job and for making a partial amendment of the curriculum.

• 대한안전경영과학회지
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• 제8권5호
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• pp.17-25
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• 2006

Nowadays most colleges are confronting with a serious problem because many students have left their majors at the colleges. In order to make a countermeasure for reducing major separation rate, many universities are trying to find a proper solution. As a similar endeavor, the objective of this paper Is to find a predicting model of students leaving their majors. The sample for this study was chosen from a university in Kangwon-Do during seven years(2000.3.1 $\sim$ 2006. 6.30). In this study, the ratio of training sample versus testing sample among partition data was controlled as 50% : 50% for a validation test of data division. Also, this study provides values about accuracy, sensitivity, specificity about three kinds of algorithms including CHAID, CART and C4.5. In addition, ROC chart and gains chart were used for classification of students leaving their majors. The analysis results were very informative since those enable us to know the most important factors such as semester taking a course, grade on cultural subjects, scholarship, grade on majors, and total completion of courses which can affect students leaving their majors.

• 한국항해항만학회지
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• 제34권5호
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• pp.343-348
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• 2010

해상 교통량이 증가함에 따라 높아지는 선박 사고위험을 줄이기 위해 안전 운항을 위한 시스템은 필수적이다. 국제해사기구의 SOLAS에서는 선박에 AIS(Automatic Identification System)의 탑재를 의무화 하였다. AIS는 육상과 타 선박에 신원, 종류, 위치, 항해 상태를 포함한 각종 항해정보와 선박상태를 자동으로 알리는 시스템이다. 안전운항을 위한 응용서비스 개발의 대부분의 경우에 AIS는 활용될 수 있으므로, 체계적인 정보의 관리가 필요하다. 본 논문에서는 수신된 메시지 정보를 관리하기 위해 데이터베이스를 도입하였다. AIS메시지를 정적정보와 동적정보로 나누어 저장하고, 전자해도 기반 AIS 정보를 디스플레이하는 시스템 구현을 통해 설계의 결과를 확인했다.

• Clinical and Experimental Pediatrics
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• 제62권9호
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• pp.325-333
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• 2019

Allergic diseases, including allergic rhinitis, asthma, and atopic dermatitis, are common heterogeneous diseases that encompass diverse phenotypes and different pathogeneses. Phenotype studies of allergic diseases can facilitate the identification of risk factors and their underlying pathophysiology, resulting in the application of more effective treatment, selection of better treatment responses, and prediction of prognosis for each phenotype. In the early phase of phenotype studies in allergic diseases, artificial classifications were usually performed based on clinical features, such as triggering factors or the presence of atopy, which can result in the biased classification of phenotypes and limit the characterization of heterogeneous allergic diseases. Subsequent phenotype studies have suggested more diverse phenotypes for each allergic disease using relatively unbiased statistical methods, such as cluster analysis or latent class analysis. The classifications of phenotypes in allergic diseases may overlap or be unstable over time due to their complex interactions with genetic and encountered environmental factors during the illness, which may affect the disease course and pathophysiology. In this review, diverse phenotype classifications of allergic diseases, including atopic dermatitis, asthma, and wheezing in children, allergic rhinitis, and atopy, are described. The review also discusses the applications of the results obtained from phenotype studies performed in other countries to Korean children. Consideration of changes in the characteristics of each phenotype over time in an individual's lifespan is needed in future studies.

• Journal of Genetic Medicine
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• 제18권1호
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• pp.31-37
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• 2021

Purpose: To summarize the results of chromosomal microarray analysis (CMA) for copy number variants (CNVs) detection and clinical utility in a single tertiary hospital. Materials and Methods: We performed CMA in 46 patients over the course of two years. Detected CNVs were classified into five categories according to the American College of Medical Genetics and Genomics guidelines and correlated with clinical manifestations. Results: A total of 31 CNVs were detected in 19 patients, with a median CNV number per patient of two CNVs. Among these, 16 CNVs were classified as pathogenic (n=3) or likely pathogenic (LP) (n=11) or variant of uncertain significance (n=4). The 16p11.2 deletion and 16p13.11 deletion classified as LP were most often detected in 6.5% (3/46), retrospectively. CMA diagnostic yield was 24.3% (9/37 patients) for symptomatic patients. The CNVs results of the commercial newborn screening test using next generation sequencing platforms showed high concordance with CMA results. Conclusion: CMA seems useful as a first-tier test for developmental delay with or without congenital anomalies. However, the classification and interpretation of CMA still remained a challenge. Further research is needed for evidence-based interpretation.