• The Korean Journal of Physiology and Pharmacology
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• 제6권2호
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• pp.121-125
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• 2002

The pathophysiological implications of aldosterone and adrenomedullin in the cardiac ventricular hypertrophy were examined. Male Sprague-Dawley rats were treated with deoxycorticosterone acetate (DOCA)-salt and monocrotaline (MCT) to selectively elicit left and right ventricular (LV, RV) hypertrophy, respectively. The mRNA expression of aldosterone synthase and adrenomedullin in LV and RV was determined by reverse transcription-polymerase chain reaction. The expression of aldosterone synthase and adrenomedullin was increased in LV, while not altered significantly in RV of DOCA-salt-treated rats. On the contrary, the expression was not significantly altered in LV, but increased in RV of MCT-treated rats. The enhanced expression of aldosterone synthase may be causally related with the development of ventricular hypertrophy, and the increased expression of adrenomedullin may act as a counter-regulatory mechanism.

• Safety and Health at Work
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• 제7권4호
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• pp.381-388
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• 2016

Background: Relationships among portable scanning mobility particle sizer (P-SMPS), condensation particle counter (CPC), and surface area monitor (SAM), which are different metric measurement devices, were investigated, and two widely used research grade (RG)-SMPSs were compared to harmonize the measurement protocols. Methods: Pearson correlation analysis was performed to compare the relation between P-SMPS, CPC, and SAM and two common RG-SMPS. Results: For laboratory and engineered nanoparticle (ENP) workplaces, correlation among devices showed good relationships. Correlation among devices was fair in unintended nanoparticle (UNP)-emitting workplaces. This is partly explained by the fact that shape of particles was not spherical, although calibration of sampling instruments was performed using spherical particles and the concentration was very high at the UNP workplaces to allow them to aggregate more easily. Chain-like particles were found by scanning electron microscope in UNP workplaces. The CPC or SAM could be used as an alternative instrument instead of SMPS at the ENP-handling workplaces. At the UNP workplaces, where concentration is high, real-time instruments should be used with caution. There are significant differences between the two SMPSs tested. TSI SMPS showed about 20% higher concentration than the Grimm SMPS in all workplaces. Conclusions: For nanoparticle measurement, CPC and SAM might be useful to find source of emission at laboratory and ENP workplaces instead of P-SMPS in the first stage. An SMPS is required to measure with high accuracy. Caution is necessary when comparing data from different nanoparticle measurement devices and RG-SMPSs.

• Journal of Microbiology and Biotechnology
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• 제20권1호
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• pp.45-53
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• 2010

We have developed an efficient and precise method for genome manipulations in Bacillus subtilis that allows rapid alteration of a gene sequence or multiple gene sequences without altering the chromosome in any other way. In our approach, the Escherichia coli toxin gene mazF, which was used as a counter-selectable marker, was placed under the control of a xylose-inducible expression system and associated with an antibiotic resistance gene to create a "mazF-cassette". A polymerase chain reaction (PCR)-generated fragment, consisting of two homology regions joined to the mazF-cassette, was integrated into the chromosome at the target locus by homologous recombination, using positive selection for antibiotic resistance. Then, the excision of the mazF-cassette from the chromosome by a single-crossover event between two short directly repeated (DR) sequences, included in the design of the PCR products, was achieved by counter-selection of mazF. We used this method efficiently and precisely to deliver a point mutation, to inactivate a specific gene, to delete a large genomic region, and to generate the in-frame deletion with minimal polar effects in the same background.

• 디지털융복합연구
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• 제14권1호
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• pp.1-11
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• 2016

현재 우리 정부는 플랫폼 전자정부 도입을 서두르고 빅데이터와 클라우드 컴퓨팅 기술과 시스템을 모색하여 궁극적으로는 공공기관 각각의 이종 대민서비스를 단일창구에서 맞춤형으로 제공하고자 한다. 따라서 이 연구에서는 창구의 프런트오피스 민원인의 다양한 서비스 제공요청에 대응해서 백오피스에서 단일한 방식으로 맞춤형 공공서비스를 제공하기 위해서는 먼저 백오피스 차원에서 공공데이터가 연동되어야하므로 각 행정기관이나 부처의 공공데이터를 기반으로 백오피스에서 통합차원에서 민원인에 대해서 단일한 서비스를 제공할 수 있는 별도의 응용프로그램으로서 앱과 데이터 단위에서 공유를 효율적으로 수행하는 이종서비스 상호 간의 정보시스템 통합이 가능한 새로운 메타데이터정보시스템을 제안하였다. 제안된 시스템이 구현되면, 민원인의 프런트오피스 차원의 생활공간에 존재하는 서비스 수요사슬과 백오피스 차원의 공무원의 사무공간에서 이루어지는 서비스 공급사슬의 일원화를 통한 단일 창구에서의 연동이 유기적으로 되면서, 민원인에 대한 맞춤형 공공서비스 달성을 한발 앞당길 수 있다.

• 통상정보연구
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• 제12권2호
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• pp.133-158
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• 2010

Since 11 September 2001, the awareness of terrorists' actions has clearly risen. The potential threat of terrorists using containers poses a large risk to our economies and to our societies. In order to protect cargo from damage and terrorist threats, business and government turn to RFID and IC tags, and tradition container is replaced by IC smart container. In this study, presented application of IC tag and future tasks to Container transport by sea in viewpoint of security strengthening. First, realization and international SCM realization structural order that cover container supply chain whole of international standardization and association between industry are certainly needed. Second, it may have to try in technical development for IC tag Ratio that can read elevation moment develop suitable IC tag or reader in International Standard. Third, Need to establish concrete use policy as soon as possible in national dimension at the same time effort for international standard normalization of frequency. Finally, it shows to uses jointly with electron sealing and must solve problem about usable plan and information leak.

• 지식경영연구
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• 제15권3호
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• pp.189-208
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• 2014

In spite of its popularity among practitioner and academic audiences, few existing studies go into any detail in examining the mechanisms of creating shared value (CSV), especially as applicable to the context of everyday operations. Nor do they provide recommendations to practitioners with regard to facilitating CSV concept. In response to this problem, I introduce benefit-sharing practice which I argue provides a solid route to the concept of CSV. Based on observations from the case study, 10 networks' benefit-sharing practices are analyzed and its featured characteristics are extracted accordingly. Findings demonstrate that such benefit-sharing models as 'Green-Development', 'Protection of the Environment', and 'Accreditation for Food Safety Management' can solve critical societal challenges while simultaneously driving greater profitability for both buyers and suppliers. The findings also suggest that benefit-sharing is a good vehicle of the realization of the CSV concept. I conclude by assessing how the findings add to the existing debate around collaborative supply-relationship and shared value. I suggest that benefit-sharing can contribute positively to the feasibility of CSV concept and, thereby, counter the assertion that CSV is the only immature-concept that lacks clear criteria of demarcation and cases for businesses to follow.

• Bulletin of the Korean Chemical Society
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• 제26권10호
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• pp.1543-1548
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• 2005

Two isostructural new alkaline earth germanium nitrides, $Sr_6Ge_5N_2\;and\;Ba_6Ge_5N_2$, were obtained as single crystals from constituent elements in molten Na. They both crystallize in space group $P_{mmn}$ (No. 59) with a = 4.0007(8), b = 17.954(3), c = 9.089(2) $\AA$, Z = 2, and a = 4.1620(2), b = 18.841(1), c = 9.6116(5) $\AA$, Z = 2, for $Sr_6Ge_5N_2\;and\;Ba_6Ge_5N_2$, respectively. Their crystal structure contains features for both Zintl and nitride phases: zigzag anionic chain of $_{\infty}Ge^{2-}$, and dumbbell-shaped bent anion of ${GeN_2}^{4-}$. Counter cations of Sr or Ba wrap these anionic units in a channel-like arrangement. Unlike in other germanium nitrides, bond lengths of both Ge-N arms of the ${GeN_2}^{4-}$, are same in $Sr_6Ge_5N_2\;and\;Ba_6Ge_5N_2$.

• 청정기술
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• 제28권1호
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• pp.32-37
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• 2022

Food waste is produced from food factories, food services, and home kitchens. The generated mass reached 5.4 million tons/year in 2020. The basic management technology for such waste has been biological degradation under an anaerobic environment. However, the whole process is intrinsically slow and considerably affected by the inner physicochemical properties of the waste and other surrounding conditions, which makes optimization of the process difficult. The most promising options to counter this massive generation of waste are eco-friendly treatments or recycling. As a preliminary step for these options, attempts were made to evaluate the feasibility and usability of three simulative models based on reaction kinetics. Model (A) predicted relative changes over reaction time for reactant, intermediate, and product. Overall, an increased reaction rate produced less intermediate and more product, thereby leading to a shorter total reaction time. Particle diminishing model (B) predicted reduction of the total waste mass. The smaller particles diminished faster along with the dominant effect of microbial reaction. In Model (C), long-chain cellulose was predicted to transform into reducing sugar. At a standard condition, 48% of cellulose molecules having 10⁵ repeating units turned into reducing sugar after 100 h. Also it was found that the optimal enzyme concentration where the highest amount of remnant sugar was harvested was 1 mg L^-1.

• 국제지역연구
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• 제14권4호
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• pp.27-52
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• 2011

키르기스스탄은 다자간 안보시스템에 의존한 군사안보 확보와 등거리 외교를 통한 국가안보를 국가정책의 주요 목표로 두고 추진하고 있다. 부연하자면, 중앙아시아의 소국으로서 자주권의 확립과 국가발전이라는 과제를 추진하기 위하여 나름의 군사안보정책을 통하여 해결점을 찾으려 한다는 것이다. 그러나 한 국가가 단순히 외교와 외부의 안보시스템에 의존하여 국가의 자주성과 발전을 담보할 수는 없을 것이다. 이 논문에서는 키르기스스탄의 국방력과 군사력을 해부해 봄으로써 키르기스스탄이 최소한의 자위적 차원의 국방력을 가지고 있는가를 살펴보는 것과 국방력 증강에 대한 가능성을 살펴보는 것이 중요하다고 본다. 해양세력과 대륙세력, 그 양대 세력의 신-그레이트 게임속에서 등거리외교와 다자간 안보협력기구를 통하여 국가자주성을 확보해 나가는 균형 외교전략의 한계와 미래를 살펴봄으로서 앞으로의 키르기스스탄 독립과 자주 문제를 파악, 예측 해 보는 것이 본 논문의 목적이다.

• Journal of the Korean Data and Information Science Society
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• 제26권4호
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• pp.781-790
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• 2015

파론도 역설은 두 개의 지는 게임이 결합하여 이기게 되거나, 두 개의 이기는 게임이 결합하여 지게 되는 역설적인 현상을 말한다. 본 논문에서는 한 투자가가 여러 개의 주식 계좌를 과거의 투자 결과에 의해 투자 종목이 결정되는 과거의존 파론도 게임의 규칙에 따라 관리하는 경우를 고려한다. 주식의 매매만으로는 전체 계좌의 평균 누적 수익금이 점차 감소하지만 주식 투자를 진행하는 중 계좌간에 일정한 금액을 재분배하면 전체 계좌의 평균 누적 수익금이 증가하는 파론도 현상이 존재할 수 있음을 2012년부터 2014년까지의 3년간의 한국거래소의 주식 데이터를 이용하여 확인한다. 반대로 계좌 간의 금액 재분배로 인해 점차 증가하는 평균 누적 수익금이 오히려 감소하는 역 파론도 현상이 발생할 수 있음도 함께 확인한다.