• Steel and Composite Structures
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• v.27 no.5
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• pp.633-646
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• 2018

This study investigated the seismic performance of a hybrid damper composed of a steel slit plate and friction pads, and an optimum retrofit scheme was developed based on life cycle cost. A sample hybrid damper was tested under cyclic loading to confirm its validity as a damping device and to construct its nonlinear analysis model. The effectiveness of the optimum damper distribution schemes was investigated by comparing the seismic fragility and the life cycle costs of the model structure before and after the retrofit. The test results showed that the damper behaved stably throughout the loading history. Numerical analysis results showed that the slit-friction hybrid dampers optimally distributed based on life cycle cost proved to be effective in minimizing the failure probability and the repair cost after earthquakes.

• Proceedings of the KSR Conference
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• 2008.06a
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• pp.1097-1104
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• 2008

Life cycle costing is one of the most effective approaches for the cost analysis of long-term life products, like as railroad vehicle. Life cycle costing includes the cost of concept design, development, manufacture, operating, maintenance and disposal. Especially, life cycle costing in the railroad industry has been focused on the maintenance cost. In this paper, we investigated the standard, guide and maintenance information of railroad vehicle. For this purpose, we suggested the unique templates of railroad vehicle maintenance information. We also performed maintenance cost analysis on the some sub-system of railroad vehicle for the case study.

• Land and Housing Review
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• v.11 no.1
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• pp.95-101
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• 2020

In the past few decades, the global population growth and rapid economic development have resulted in significant increases in building energy consumption. To reduce greenhouse-gas emissions and building energy consumption, building materials and energy technologies must be optimized. Building retrofitting is a more efficient method than reconstruction to improve the building energy performance. In order to improve the energy performance of existing buildings, this study proposed energy-efficiency retrofit plans and derived cost-effective retrofit plan. The energy efficient retrofit method is achieved through the packaging of energy technology and the energy and cost reduction effect of the energy efficiency retrofit package are analyzed. As a result of the study, the energy-efficiency retrofit package showed an energy reduction effect of up to 60% or more and a construction cost reduction of about 30%. This study argues that optimal energy and construction cost reduction of existing buildings are possible through the packaging of energy efficiency technology.

• Proceedings of the Korean Institute of Building Construction Conference
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• 2023.05a
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• pp.277-278
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• 2023

The need for maintenance of bridge infrastructure is increasing due to aging, and the cost of maintaining the infrastructure must be calculated for effective budget distribution. Therefore, in this study, representative defects according to bridge superstructure type are derived to calculate the cost for each repair method. First of all, the representative bridges, PSCI girder bridge, Rahmen bridge, Steel box girder bridge, and RC slab bridge, were selected as superstructures using BMS data, and repair methods for defects were presented. In addition, the cost of the repair method by superstructure type was compared. This result is expected to predict total maintenance costs in consideration of the maintenance cycle.

• Proceedings of the KIEE Conference
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• 2001.05a
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• pp.112-115
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• 2001

This paper illustrates a new nodal effective load model for nodal probabilistic production cost simulation of the load point in a composite power system. The new effective load model includes capacities and uncertainties of generators as well as transmission lines. The CMELDC based on the new effective load model at HLII has been developed also. The CMELDC can be obtain from convolution integral processing of the outage capacity probabilistic distribution function of the fictitious generator and the original load duration curve given at the load point. It is expected that the new model for the CMELDC proposed. In this study will provide some solutions to many problems based on nodal and decentralized operation and control of an electric power systems under competition environment in future. The CMELDC based on the new model at HLII will extend the application areas of nodal probabilistic production cost simulation, outage cost assessment and reliability evaluation etc. at load points. The characteristics and effectiveness of this new model are illustrated by a case study of a test system.

• Proceedings of the Earthquake Engineering Society of Korea Conference
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• 1999.04a
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• pp.178-185
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• 1999

Minimum life-cycle cost helps to evaluate cost effectiveness of base-isolated bridges under specific condition. Life-cycle cost mainly consists of the initial construction cost and the expected damage cost. Damage cost estimation needs proper model of input ground motion failure probability evaluation method and limit states definition. We model the input ground motion as spectral density function compatible with the response spectra defined at each seismicity and site condition. Spectrum analysis and crossing theory is suitable for reseating calculation of failure probabilities in the process of cost minimization. Limit states of base-isolated bridges re defined for superstructure isolator and pier respectively The method is applied to both base-isolated bridges and conventional bridges under the same conditions to investigate cost effectiveness of base isolation in low and moderate seismic region. the results show that base-isolation of bridges are more effective in low and moderate seismic region and that the site effects on the economical efficiency may not be negligible in such a region.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.2
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• pp.799-805
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• 2016

Background: There is no standard treatment for patients with platinum-resistant or refractory epithelial ovarian cancer. Single agent chemotherapies have evidence of more efficacy and less toxicity than combination therapy. Most are very expensive, with appreciable toxicity and minimal survival. Since it is difficult to make comparison between outcomes, economic analysis of single-agent chemotherapy regimens and best supportive care may help to make decisions about an appropriate management for the affected patients. Objective: To evaluate the cost effectiveness of second-line chemotherapy compared with best supportive care for patients with platinum-resistant or refractory epithelial ovarian cancer. Materials and Methods: A Markov model was used to estimate the effectiveness and total costs associated with treatments. The hypothetical patient population comprised women aged 55 with platinum-resistant or refractory epithelial ovarian cancer. Four types of alternative treatment options were evaluated: 1) gemcitabine followed by BSC; 2) pegylated liposomal doxorubicin (PLD) followed by BSC; 3) gemcitabine followed by topotecan; and 4) PLD followed by topotecan. Baseline comparator of alternative treatments was BSC. Time horizon of the analysis was 2 years. Health care provider perspective and 3% discount rate were used to determine the costs of medical treatment in this study. Quality-adjusted life-years (QALY) were used to measure the treatment effectiveness. Treatment effectiveness data were derived from the literature. Costs were calculated from unit cost treatment of epithelial ovarian cancer patients at various stages of disease in King Chulalongkorn Memorial Hospital (KCMH) in the year 2011. Parameter uncertainty was tested in probabilistic sensitivity analysis by using Monte Carlo simulation. One-way sensitivity analysis was used to explore each variable's impact on the uncertainty of the results. Results: Approximated life expectancy of best supportive care was 0.182 years and its total cost was 26,862 Baht. All four alternative treatments increased life expectancy. Life expectancy of gemcitabine followed by BSC, PLD followed by BSC, gemcitabine followed by topotecan and PLD followed by topotecan was 0.510, 0.513, 0.566, and 0.570 years, respectively. The total cost of gemcitabine followed by BSC, PLD followed by BSC, gemcitabine followed by topotecan and PLD followed by topotecan was 113,000, 124,302, 139,788 and 151,135 Baht, respectively. PLD followed by topotecan had the highest expected quality-adjusted life-years but was the most expensive of all the above strategies. The incremental cost-effectiveness ratios (ICER) of gemcitabine followed by BSC, PLD followed by BSC, gemcitabine followed by topotecan and PLD followed by topotecan was 344,643, 385,322, 385,856, and 420,299 Baht, respectively. Conclusions: All of the second-line chemotherapy strategies showed certain benefits due to an increased life-year gained compared with best supportive care. Moreover, gemcitabine as second-line chemotherapy followed by best supportive care in progressive disease case was likely to be more effective strategy with less cost from health care provider perspective. Gemcitabine was the most cost-effective treatment among all four alternative treatments. ICER is only an economic factor. Treatment decisions should be based on the patient benefit.

• Korean Journal of Computational Design and Engineering
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• v.15 no.4
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• pp.261-270
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• 2010

These days, architectural projects are becoming larger and more complex. And lots of information occurs through each phases and areas. For these reason, it is emphasized that collaboration with other parts. Therefore we need more effective architectural design process. However, it is difficult to collaborate in early stage with existing design process and it causes unnecessary spending of time and cost because of 2D-based working system. For solving these problem, we should introduce BIM-based Integrated Design Process which makes it possible to collaborate with other parts from early stage. Now the AEC industry in Korea has been trying to introduce BIM, and promoting variety of related business. However, for actual application of this system, it is unfortunately necessary to change various system throughout the construction industry. And this will cause lots of effort and expense. It is essential that scientific analysis and evaluation of efficiency and validity about this investment, because estimation of the investment and accompanying effects will provide reasonable standard of judgment for investment decision. Thus, this research conducted Cost-Benefit Analysis about BIM-based Integrated Design Process compared to existing design process. It is expected that this paper can be used for preliminary data in the future BIM market.

• Journal of the Korea institute for structural maintenance and inspection
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• v.6 no.4
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• pp.189-199
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• 2002

This study is intended to propose a systematic procedure for the development of the conditional assessment based on the safety of structures and the cost effective performance criteria for designing and upgrading of bridge structures. As a result, a set of cost function models for a life cycle cost analysis of bridge structures is proposed and thus the expected total life cycle costs (ETLCC) including initial (design, testing and construction) costs and direct/indirect damage costs considering repair and replacement costs, human losses and property damage costs, road user costs, and indirect regional economic losses costs. Also, the optimum safety indices are presented based on the expected total cost minimization function using only three parameters of the failure cost to the initial cost (${\tau}$), the extent of increased initial cost by improvement of safety (${\nu}$) and the order of an initial cost function (n). Through the enough numerical invetigations, we can positively conclude that the proposed optimum design procedure for bridge structures based on the ETLCC will lead to more rational, economical and safer design.

• Journal of Animal Science and Technology
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• v.62 no.6
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• pp.933-947
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• 2020

This study was conducted to develop an effective heparin extraction method by using low-cost and highly effective enzymes from six pig by-products (liver, lung, heart, stomach, small intestine, and large intestine), and analyze their bioavailability. Low-cost and highly effective enzymes (alkaline-AK and papain) and a common enzyme (trypsin) were used for the heparin extraction. The angiotensin I- converting enzyme (ACE) inhibitory activity and the antimicrobial activity of extracted heparin were analyzed to verify their bioavailability. The average amount of heparin extracted per kilogram of pig by-products was 439 mg from the liver, 127 mg from the lung, 398 mg from the heart, 261 mg from the stomach, 197 mg from the small intestine, and 239 mg from the large intestine. Various enzymes were used to extract heparin, and the amount of extracted heparin was similar. Based on 1 g of pig by-product, the enzymes trypsin, papain, and alkaline-AK could extract 1,718 mg, 1,697 mg, and 1,905 mg of heparin, respectively. Heparin extracted from pig by-products showed antihypertensive activity and antimicrobial activity against Staphylococcus aureus at low populations. These results indicated that heparin can be obtained from pig by-products at a low cost.