• Journal of Genetic Medicine
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• v.20 no.2
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• pp.39-45
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• 2023

As advanced sequencing technologies continue to uncover an increasing number of variants in genes associated with human genetic diseases, there is a growing demand for systematic approaches to assess the impact of these variants on human development, health, and disease. While in silico analyses have provided valuable insights, it is essential to complement these findings with model organism studies to determine the functional consequences of genetic variants in vivo. Drosophila melanogaster is an excellent genetic model for such functional studies due to its efficient genetic technologies, high gene conservation with humans, accessibility to mutant fly resources, short life cycles, and cost-effectiveness. The traditional GAL4-UAS system, allowing precise control of gene expression through binary regulation, is frequently employed to assess the effects of monoallelic variants. Recombinase medicated cassette exchange or CRISPR-Cas9-mediated GAL4 insertion within coding introns or substitution of gene body with Kozak-Gal4 result in the loss-of-function of the target gene. This GAL4 insertion strategy also enables the expression of reference complementary DNA (cDNA) or cDNA carrying genetic variants under the control of endogenous regulatory cis elements. Furthermore, the CRISPR-Cas9-directed tissue-specific knockout and cDNA rescue system provides the flexibility to investigate candidate variants in a tissue-specific and/or developmental-timing dependent manner. In this review, we will delve into the diverse genetic techniques available in Drosophila and their applications in diagnosing and studying numerous undiagnosed diseases over the past decade.

• Journal of Internet Computing and Services
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• v.23 no.4
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• pp.35-43
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• 2022

Makeup is the most common way to improve a person's appearance. However, since makeup styles are very diverse, there are many time and cost problems for an individual to apply makeup directly to himself/herself.. Accordingly, the need for makeup automation is increasing. Makeup transfer is being studied for makeup automation. Makeup transfer is a field of applying makeup style to a face image without makeup. Makeup transfer can be divided into a traditional image processing-based method and a deep learning-based method. In particular, in deep learning-based methods, many studies based on Generative Adversarial Networks have been performed. However, both methods have disadvantages in that the resulting image is unnatural, the result of makeup conversion is not clear, and it is smeared or heavily influenced by the makeup style face image. In order to express the clear boundary of makeup and to alleviate the influence of makeup style facial images, this study divides the makeup area and calculates the loss function using HoG (Histogram of Gradient). HoG is a method of extracting image features through the size and directionality of edges present in the image. Through this, we propose a makeup transfer network that performs robust learning on edges.By comparing the image generated through the proposed model with the image generated through BeautyGAN used as the base model, it was confirmed that the performance of the model proposed in this study was superior, and the method of using facial information that can be additionally presented as a future study.

• Journal of the Korean Society of Safety
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• v.26 no.3
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• pp.15-22
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• 2011

Explosion and fire cause about 30 reported industrial major accidents a year by ignition source which discharge of electrostatic generated to flammable gas, vapor, dust and mixtures. It brings economically and humanly very large loss that accident was caused by fire and explosion from electrostatic discharge. Thus, it is very important that electrostatic discharge energy is to be control below not to be igniting flammable mixtures. There are two kinds of analysis model for electrostatic discharge, human body model and machine model. Human body model is available the parameter of human's electrical equivalent that capacitance is 100 pF, resistance is $1.5k{\Omega}$. To simulate and visualize the electrostatic discharge from human body need a very expensive and high voltage simulator. In this paper, we measured the value of capacitance and resistance concerned with test materials and sizing of specimen and the value of charged voltage concerned with test specimen and distance to develop an electrostatic charge/discharge simulating tool for teaching with which concerned industrial employee and students. The result of experiments, we conformed that the minimum ignition energy of methane-oxygen mixtures meets well the equation $W=1/2CV^2$, and found out that the insulating material and sizing of equivalent value having human body mode are the poly ethylene of 200 mm and 300 mm of diameter. Developed electrostatic charge/discharge simulating tool has many merits; simple mechanism, low cost, no need of electric power and so on.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.10
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• pp.153-162
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• 2017

Weapon systems have been developed with high technology electronic equipment due to technology growth. In addition, the capital, operational and maintenance costs of weapon systems have all increased. However, cost of operation and maintenance for weapon systems has been decreased relatively compared to the increased capital cost of weapon systems. Therefore, the defense industry needs to research the life cycle cost of weapon systems that have high operational and maintenance costs. This paper focuses on maintenance equipment for the operation and maintenance of weapon systems. Recently, it seems that the weapon systems that have periodic calibration with maintenance equipment are valid. The equipment requires periodic calibration by the manufacturer to check its own validation. Basically, customers demand high reliability devices from foreign companies that have qualified in the global market. Therefore, the tools need to be calibrated overseas. In other words, weapon systems are not available when the equipment has to be calibrated overseas because the systems require validation with valid maintenance equipment. A purpose of this paper is to compare the loss costs that arise from the calibration of the equipment overseas and the purchasing cost of the tools. Finally, the research shows the number of equipment that customers need to minimize the cost. This research will help to improve the efficiency of operation of weapon systems and solve the problems associated with the need for maintenance overseas.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.27 no.3C
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• pp.201-210
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• 2002

A number or MPLS ATM switching system have been proposed to increase the access speed or current routers, but they cannot satisfy the Internet users who use diverse applications. So they are required to support the so-called differential service, which discriminates service behaviors according to the service class. In this paper, to support this differential service we suggest an LSP control method, which uses the extended LDP message and establishes several different LSPs for each FEC according to the service class. Also, we propose an marking algorithm using the cell loss priority field or ATM cells in order to process the differential service according to application categories. In addition, we present a forwarding procedure based on the LSP control method and the marking algorithm. A forwarding model applied this forwarding procedure can be easily implemented with a minimum modification of existing MPLS ATM switching systems. Therefore, we can save cost and time needed to implement the proposed model. Finally, we estimate the performance behaviors of the proposed application-based forwarding model by the AweSim simulation package.

• Journal of international Conference on Electrical Machines and Systems
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• v.3 no.1
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• pp.78-82
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• 2014

Power Transformers with more than one secondary winding are not uncommon in industrial applications. But new classes of applications where very large number of independent secondaries are used are becoming popular in controlled converters for medium and high voltage applications. Cascade H-bridge medium voltage drives and Pulse Step Modulation (PSM) based high voltage power supplies are such applications. Regulated high voltage power supplies (Fig. 1) with 35-100 kV, 5-10 MW output range with very fast dynamics (${\mu}S$ order) uses such transformers. Such power supplies are widely used in fusion research. Here series connection of isolated voltage sources with conventional switching semiconductor devices is achieved by large number of separate transformers or by single unit of multi-secondary transformer. Naturally, a transformer having numbers of secondary windings (~40) on single core is the preferred solution due to space and cost considerations. For design and simulation analysis of such a power supply, the model of a multi-secondary transformer poses special problem to any circuit analysis software as many simulation softwares provide transformer models with limited number (3-6) of secondary windings. Multi-Secondary transformer models with 3 different schemes are available. A comparison of test results from a practical Multi-secondary transformer with a simulation model using magnetic component is found to describe the behavior closer to observed test results. Earlier models assumed magnetising inductance in a linear loss less core model although in actual it is saturable core made-up of CRGO steel laminations. This article discusses a more detailed representation of flux coupled magnetic model with saturable core properties to simulate actual transformers very close to its observed parameters in test and actual usage.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.24 no.4
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• pp.421-428
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• 2011

The communication of each others is lack between planing, design, construction and maintenance in domestic construction industry. This problem makes the omission of information and the loss of cost. So, the introduction of BIM can be the solution about that. BIM manages all information generated during all life-cycle of a structure and consequently maximizes the efficiency of utilizing information. This is done through 3D information model associated with a three-dimensional(3D) parametric CAD. This study proposes the seismic analysis process of steel box bridge for structural design of bridge construction project based on BIM. The additional process is needed for the purpose that structural data is inherent in the property information of 3D information model. This process has 3D modeling progress done by using the information decided in design phase. The design document of seismic analysis can be derived with the proposed process to steel box bridge.

• Journal of the Korea Institute of Building Construction
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• v.19 no.1
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• pp.77-86
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• 2019

Due to the increasing demand for and complexity of plant construction projects, unpredictable risk factors are on the consequent increase. For that reason, the quantitative risk analysis is being called for, in order for the development of a risk assessment model using risk indicators for the plant construction projects. This study used the claim payout data collected at a global insurance company to reflect the actual financial losses in plant construction projects as dependent variables in the risk assessment model. In terms of independent variables, the geographic information, i. e., landform, and the construction information including test-run, schedule rate, total cost and duration are adopted. In addition, this study suggests that the regression model containing such independent variables that are statistically significant can be applied to as a foundational guideline for the plant construction project risk analysis during the phase of construction and commissioning.

• Journal of the Korean Society of Marine Environment & Safety
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• v.20 no.2
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• pp.130-142
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• 2014

The Korean government is considering implementation of the marine ecosystem restoration technology program (MERTP) to analyze the current status of the marine ecosystems and causes for the ecosystem deterioration as well as to eventually establish a master strategic plan for restoring ecosystem functions and preventing ecosystem functional loss. In order to determine likelihood of successful implementation, it is essential to perform an analysis of the economic feasibility of the program. The present study assessed economic feasibility of the MERTP. To this end, the dichotomous choice contingent valuation (CV) method is used. In particular, dichotomous choice (DC) format is employed as a method of eliciting willingness-to-pay (WTP) response to incentive-compatible mechanisms. The study also employed the spike model to deal with zero WTP responses from the DC CV survey. This survey of 1,000 randomly selected households in accordance with the guidelines provided by the National Oceanic and Atmospheric Administration (USA) was carried out nationwide in 2013. And, the respondents were asked in person-to-person interviews about their WTP for implementing the MERTP. The results showed that the annual mean WTP was estimated to be 5,414 won per household. Consequently, the annual benefit from the MERTP would be about 98.6 billion won for the next five years. Economic feasibility assessment utilizing the MERTP investment cost and expansion cost of the value provided that net present value, benefit/cost ratio, and internal rate of return are 337.8 billion won, 5.20, and 65.9 %, respectively, which are bigger than 0, 1.0, and 5.5 %, and that the MERTP passes the cost-benefit analysis.

• Korean Journal of Construction Engineering and Management
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• v.23 no.5
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• pp.108-116
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• 2022

Started in 1989 as Public Permanent Rental Housing scheme, public rental housing lease policy is increasing target residents and supply in each government by introducing new supply types. However, public housing business entities have difficulties in expanding the supply due to cumulated deficit. The research suggested long-term public rental housing reconstruction business as a method to preserve the cumulated deficit from the previous. Minimum floor area ratio mathematical model was suggested by defining the floor area ratio of reconstruction business as minimum, since housing sales profit after reconstruction could preserve aggregated deficit, and mathematically approached by considering the traits of long-term public rental housing reconstruction. The determinant for minimum floor area ratio mathematical model comprise cumulated deficit of the existing long-term public rental housing, land size of reconstructed sale housing, housing sales price per unit area, and business cost per unit area. Minimum floor area ratio mathematical model is expected to be the milestone for supporting decision making regarding the economic part of old long-term public lease housings' reconstruction scale, and expanding housing supply within urban area.