• 한국자원식물학회:학술대회논문집
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• 한국자원식물학회 2023년도 임시총회 및 춘계학술대회
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• pp.15-15
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• 2023

The chloroplast (cp) is an autonomous plant organelle with an individual genome that codes for essential cellular functions. The architecture and gene content of the cp genome is highly conserved in angiosperms. The plastome of Corydalis belongs to the Papaveraceae family, and the genome is comprised of unusual rearrangements and gene content. Thus far, no extensive comparative studies have been carried out to understand the evolution of Corydalis chloroplast genomes. Therefore, the Corydalis platycarpa cp genome was sequenced, and wide-scale comparative studies were conducted using publicly available twenty Corydalis plastomes. Comparative analyses showed that an extensive genome rearrangement and IR expansion occurred, and these events evolved independently in the Corydalis species. In addition, the protein-coding genes accD and the ndh gene loss events occurred in the common ancestor of the Corydalis and sub-clade of the Corydalis lineage, respectively. The gene ndh lost in the Corydalis-sub clade species is distributed predominantly in the Qinghai-Tibetan plateau (QTP) region. The molecular clock analysis suggests that the divergence time of all the ndh gene lost Corydalis sub-clade species occurred in the 44.31 - 15.71 mya. These results coincide very well with the uplift of the Qinghai-Tibet Plateau in the Oligocene and Miocene periods, and maybe during this period, it probably triggered the radiation of the Corydalis species. To the best of the authors' knowledge, this is the first large-scale comparative study of Corydalis plastomes and their evolution. The present study may provide insights into the plastome architecture and the molecular evolution of Corydalis species.

• 식물분류학회지
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• 제38권4호
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• pp.531-537
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• 2008

한국의 중부지방에서 발견한 현호색속 (Corydalis) Corydalis절에 속하는 미기록 식물, 수염현호색 [Corydalis caudata (Lam.) Pers.]을 채집하여 기재 및 도해하였다. 수염현호색은 수염 모양의 꽃받침, 위쪽을 향해 굽은 거, 가지가 다수 분지되는 특징 등에서 현호색속의 다른 종들과 쉽게 구분이 된다. 수염 모양의 꽃받침 특징을 살려 수염현호색으로 명명하였다.

• 대한한의학회지
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• 제24권4호
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• pp.34-42
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• 2003

This study was designed to investigate the modulation of the Corydalis tuber on glycine-activated ion current in rat periaqueductal gray (PAG) neurons. Aqueous extract from Corydalis tuber has been widely used for pain control such as dysmenorrhea, irregular menstruation or amenorrhea with abdominal cramping, neuralgia, headache and gastrointestinal spasm. The PAG region of the brain is known to be involved heavily with nociception. Modulation of the Corydalis tuber on glycine-induced ion current in rat periaqueductal gray (PAG) neurons was studied by a nystatin-perforated patch-clamp technique. High concentrations of Corydalis tuber elicited ion current, which was suppressed by strychnine application. Low concentrations of Corydalis tuber reduced glycine-induced ion currents in the PAG neurons. Inhibitory action of Corydalis tuber on glycine-activated ion current was reduced by treatment with naltrexone, a non- selective opioid antagonist. Application of N-methylmalemide (NEM), a sulfhydryl alkylating agent, also reduced the inhibitory action of Corydalis tuber on glycine-activated ion current in the PAG neurons. These results suggest that the inhibitory effect of Corydalis tuber on glycine-activated ion current in the PAG neurons is one of the analgesic mechanisms of the Corydalis tuber, which may activate descending pain control system in PAG neurons.

• 한방안이비인후피부과학회지
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• 제24권3호
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• pp.17-26
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• 2011

Objectives : Corydalis tuber has been used for promoting blood circulation and for relieving pain in Oriental medicine. In the present study, we focused on the antimicrobial activity of Corydalis tuber and compared its antimicrobial activity with the processed Corydalis tuber. Methods : Processing of Corydalis tuber was accomplished by immersing in 5% of acetic acid for 12 h and then by roasting at $250^{\circ}C$ for indicated time periods(0-30 min). Minimum inhibitory concentration(MIC) and the zone of growth inhibition were determined against Propionibacterium acnes(P. acnes). Results : The methanolic extracts of Corydalis tuber showed potent antimicrobial effect(MIC 62.5 ${\mu}g/ml$). Its alkaloidal component, dehydrocorydaline, also exhibited antibacterial activity(MIC 25.0 ${\mu}g/ml$). After processing of Corydalis tuber, its inhibitory effect on the growth of P. acnes was significantly enhanced compared with that of unprocessed Corydalis tuber. Furthermore, elevated content of dehydrocorydaline was found in the processed than the unprocessed Corydalis tuber. However, the different roasting minutes effected on antimicrobial activity. The best roasting time of Corydalis tuber was 10 min, while roasting for the time above 15 min resulted in diminishing antimicrobial activity. Thus, it was concluded that the standardized processing condition of Corydalis tuber should be established to obtain enhanced antimicrobial(P. acnes) activity. Conclusion : For antimicrobial effect against P. acnes, the best processing condition of Corydalis tuber is immersing in 5% of acetic acid for 12 h and by roasting at $250^{\circ}C$ for 10 min.

• 식물분류학회지
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• 제36권2호
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• pp.137-144
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• 2006

현호색과 현호색속 현호색절의 1신종인 각시현호색이 한국의 경기도 및 강원도에서 발견되어 기재되었다. 신종은 타원형 내지 선형의 소엽 형태, 전연 내지 선단이 약간 치아상인 탁엽 및 넓고 마름모형이 하측 외화판을 가지며, 또한 14개의 돌기가 있는 주두와 종자가 1열로 배열하는 선형의 삭과를 가짐으로써, 이와 가까운 유연관계가 있다고 판단되는 남도현호색과 뚜렷이 구별되었다.

• 식물분류학회지
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• 제34권3호
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• pp.265-271
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• 2004

현호색과 현호색속 현호색절의 1신종인 남도현호색이 한국의 중부 및 남부 지방에서 발견되어 기재되었다. 신종은 매우 다양한 엽형과 넓고 편평한 방추형 열매를 가짐으로써, 또한 삭과 내에 종자가 거의 2열로 배열하고, 내화판의 정단이 V자 모양으로 함몰하며, 다소 제한된 분포역을 가짐으로써, 이와 유사한 흰현호색과 뚜렷이 구별되었다.

• 생약학회지
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• 제26권4호
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• pp.419-425
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• 1995

Corydalis remota Fish. ex Max. (Papaveraceae) is a well known medicinal plant being used as analgesics or anticonvulsive in oriental medicine. As the alkaloid content is known to vary depending on the environmental factors, the technology of plant tissue culture can be adopted as source of Corydalis-alkaloids. The present study describes an establishment of tissue cultures of Corydalis which produce alkaloids consistently. Callus were induced from immature seeds of Corydalis remota by placing the seeds on MS static media containing NAA(0.25, 1.0 and 4.0 mg/l, respectively). The combined treatment of NAA(1.0 mg/l) with cytokinin(BAP 0.5 mg/l) improved the induction of callus. TLC scanning data followed by sequential extraction and purification revealed that the induced callus contains a significant amount of alkaloids. Cell suspension cultures were established by transferring the induced callus into the liquid media with the same condition of plant growth regulators as the callus culture.

• 식물분류학회지
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• 제37권3호
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• pp.217-224
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• 2007

현호색과 현호색속 현호색절 1신종인 쇠뿔현호색이 한국의 경상북도 경산시에서 발견되어 기재되었다. 신종은 꽃의 색과 형태에서 다른 현호색속 현호색절에 속하는 종들과 뚜렷이 구별되는데, 꽃 색은 자줏빛이 도는 흰색이고, 위아래 외화판에 짙은 자주색 두 줄 무늬가 있으며, 아래 외화판 선단 모양이 쇠뿔형이다. 소엽은 선형으로 남도현호색 또는 현호색의 댓잎형 잎과 비슷하나 보다 좁고 길다. 포는 선형 또는 피침형으로 현호색과 남도현호색의 타원형과 구분된다.

• 식물분류학회지
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• 제40권2호
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• pp.79-83
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• 2010

현호색과 현호색속의 1신종인 날개현호색이 한국의 경상북도 포항시에서 발견되어 기재하고 도해하였다. 날개현호색은 괴경의 내부 표면은 백색이고, 하측 외화판의 기부는 전저이며, 더 작은 종자를 가짐으로써, 이와 근연종인 점현호색과 뚜렷이 구별되었다.

• 동의생리병리학회지
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• 제19권3호
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• pp.785-791
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• 2005

Corydalis Tuber has traditionally been used for the treatment of water retention in the body. Administration of the aqueous extract of Corydalis Tuber has been known to be effective for the control of pain and treatment of arthritis. It was reported that Corydalis Tuber possesses anti-inflammatory activity and modulates the intestinal immune system. The effect of Corydalis Tuber against LPS-stimulated expressions of COX-2, iNOS, and $IL-1{\beta}$ in cells of the murine RAW 264.7 macrophages was investigated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, reverse transcription-polymerase chain reaction (RT-PCR), $PGE_2$ immunoassay, and NO detection. The aqueous extract of Corydalis Tuber was shown to suppress $PGE_2$ production by inhibition on the LPS-stimulated enhancement of COX-2 enzyme activity, $IL-1{\beta}$, and iNOS expression in the RAW 264.7 macrophages. Present results suggest that Corydalis Tuber exerts anti-inflammatory and analgesic effects probably by suppressing of COX-2, iNOS, and $IL-1{\beta}$ expressions, resulting in inhibition of $PGE_2$ synthesis. Corydalis Tuber has anti-inflammatory and analgesic effects probably by suppressing of COX-2, iNOS, and $IL-1{\beta}$ mRNA expressions, resulting in inhibition of $PGE_2$ and NO synthesis.