• Journal of Chest Surgery
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• v.32 no.2
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• pp.108-118
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• 1999

Background: To evaluate the risk factor and long-term result of arterial switch operation , a retrospective study was done. Material and Method: A retrospective analysis was done to evaluate the early and long-term results on 58 patients who underwent an arterial switch operation(ASO) for transposition of the great arteries(TGA) with intact ventricular septum, between January 1988 and December 1996. Beforesurgery, 36 patients(62.1%) underwent balloon atrial septostomy, 32 patients(51.7%) received PGE1 infusion, and preparatory banding of pulmonary artery was performed on 6 patients(mean LV/RV pressure ratio 0.53$\pm$0.11). Result: The age at operation ranged from 1 to 137 days(mean 24$\pm$26 days) and the weights ranged from 1.8 to 6.8 kg (mean 3.5$\pm$0.8 kg). There were 14 early deaths(24.1%), but of the last 24 patients operated on since 1994, there were only 2 early deaths(8.3%). In the risk factor analysis, the date of operation was the only risk factor for early death(p-value < 0.01). Eight of the 14 early deaths were due to acute myocardial failure(mainly inadequate coronary blood flow). The length of follow-up ranged from 2 months to 8 years, average of 36$\pm$27 months. The follow-up included sequential noninvasive evaluations and 21 catheterizations and angiographic studies performed 5 to 32 months postoperatively with particular attention to the great vessel and coronary anastomosis, ventricular function, valvular competence, and cardiac rhythm. There were 5 late deaths(11.4%), one of thesedeaths was related to the late coronary problems, two to aspiration, one to uncontrolled chronic mediastinitis, and one to progressive aortic insufficiency and heart failure. The most frequent postoperative hemodynamic abnormality was supravalvular stenosis and the degree of pulmonary or aortic obstruction had slowly progressed in some cases, however there were no children who had to undergo a reoperation for supravalvular pulmonary or aortic stenosis. Aortic regurgitation was identified in 9 patients, which was mild in 7 and moderate in 2 and had progressed in some cases. Two patients who had an unremarkable perioperative course were identified as having coronary artery obstructions. The other late survivors were in good condition, were in sinus rhythm, and had normal LV functions. Actuarial survival rate at 8 years was 68.8%. Conclusion: We concluded that anatomic correction will be established as the optimal approach to the TGA with intact ventricular septum, though further long-term evaluations are needed.

• Journal of Korean Ophthalmic Optics Society
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• v.20 no.1
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• pp.61-66
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• 2015

Purpose: In this study, dynamic stereoacuity of 20s' adults were measured by using the Howard-Dolman test(H-D TEST, Bernell, U.S.A), and compared of male and female. And the correlation between dynamic stereoacuity and PD(pupillary distance), and between dynamic stereoacuity and anisometropia caused by difference in the spherical refractive power of the left and right eyes were analyzed. Methods: The mean age of $22.68{\pm}0.50$(20~29)years old, 20s' 63 adults (30 male, 33 female) were conducted for this experiments. After the full correction of subject's refractive error, dynamic stereoacuity was measured 5 times for 1 subject at 2.5 m distance using the H-D test. at 2.5 distance. Results: The mean of dynamic stereoacuity was $28.44{\pm}25.03$ sec of arc for total subjects, $28.23{\pm}23.34$ sec of arc for male, and $28.63{\pm}26.83$ sec of arc for female. In the dynamic stereoacuity classified by the range of inter-pupil distance (IPD), the dynamic stereoacuity was $33.87{\pm}18.53$ sec for the IPD being under 59.80 mm, $26.24{\pm}25.26$ sec of arc for 59.81~66.15 mm, $34.60{\pm}25.65$ sec of arc for over 66.15 mm. However, there were no significant differences between 3 groups (P=0.73, r=0.03). In dynamic stereoacuity classified by the refractive error difference between two eyes, dynamic stereoacuity was $26.81{\pm}24.86$ sec of arc for the under 1 D, $41.45{\pm}24.18$ sec of arc for over 1 D, and there was no significant difference between two groups (P=0.15, r=0.15). Conclusions: Dynamic stereacuity by the H-D test in 20s adults showed that there was no significant differences between male and female, and PD and anisometropia did not have a significant impact upon the dynamic stereoacuity.

• Journal of Korean Ophthalmic Optics Society
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• v.20 no.1
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• pp.67-73
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• 2015

Purpose: This study was investigated the relationship between the male and female of near stereoacuity and phoria, and was examined the correlations between near stereoacuity and phoria and refractive error. Methods: Adult 83 (male 36, female 47, mean age $21.09{\pm}1.74$(19~29) years old) target was examined after full correction of refractive error. Near stereoacuity was measured by using Titmus-fly Stereotest(Stereo Optical Co., Inc., Chicago, IL, USA), and RANDOT Stereotest (Stereo Optical Co., Inc., Chicago, IL, USA), phoria was measured by using modified torrington method, at distance 40 cm. Results: In near stereoacuity, male was better good than female, and there was no difference between male and female (p>0.05). In near phoria, female was more higher than male, and there was a significant difference between male and female (p<0.05). Near stereoacuity by Titmus-fly test and Randot test result respectively was $262.17{\pm}562.43$ sec (second of arc) $243.08{\pm}68.04$ sec in esophoria, $148.42{\pm}269.54$ sec, $107.40{\pm}263.74$ sec in orthophoria, $113.94{\pm}152.46$ sec, $79.70{\pm}136.83$ sec in exophoria, there was a no difference between three phoria groups (p>0.05), and was a high correlation between phoria and near stereoacity(r=0.68). In addition, near stereoacuity in the refractive error respectively was $80.00{\pm}571.43$ sec, $68.75{\pm}36.82$ sec in myopia, $133.57{\pm}224.15$ sec, $93.14{\pm}214.95$ sec in hyperopia, $511.20{\pm}855.00$ sec, $511.4{\pm}855.60$ sec, there was a significant difference between three phoria groups (p<0.05). when was classfiied near stersoacuity into degree of refractive error, near stersoacuity was best in emmetropia, and was reduced when refractive error was highest in high degree myopia, and hyperopia. Conclusions: Titmus-fly Stereotest and RANDOT Stereotest result, near stereoacuity of adults, when esophoria and high degree refractive error, was reduced, there was a relationship between near stereoacuity with phoria, and refractive error. In this both stereotests if was bad when near stereoacuity can expect a phoria and refractive error.

• Journal of Korean Ophthalmic Optics Society
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• v.21 no.3
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• pp.259-264
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• 2016

Purpose: To establish the cause of decrease in body stability and to analyze the effects on sensory organs maintaining static balance according to the induced astigmatic blur. Methods: Twenty subjects (10 males, 10 females; mean age, $23.40{\pm}2.70years$) were participated in this study. To induce myopic simple astigmatism, the axis directions of cylindrical lenses were placed $180^{\circ}$ on both eyes (with-the-rule), $90^{\circ}$ on both eyes (against-the-rule), and $45^{\circ}$ on both eyes (oblique). Cylindrical lenses of +0.50, +1.00, +1.50, +2.00, +3.00, +4.00, and +5.00 D were used to increase astigmatic blur in each astigmatism types. General stability (ST) and sway power (SP) in frequencies by each sensory organs were analyzed using the TETRAX biofeedback system. Results: ST in the all astigmatism types were raised with increase of astigmatic blur compared to full corrected condition, but a significant difference only showed in the induced oblique astigmatism. According to the results of correlation analysis between ST and SP in the each frequencies with increase of astigmatic blur, the causes of increased ST in the induced oblique astigmatism showed to have a high correlation in order of somatosensory system (high-medium frequency), central nervous system (high frequency), peripheral vestibular system (low-medium frequency), and visual system (low frequency). Conclusions: The visual information by uncorrected oblique astigmatism may disturb the normal functions of all sensory organs maintaining body balance, consequently, the body stability can be reduced. Therefore, optimal correction of astigmatism can play an important role for reducing the instability of body balance.

• Clinical and Experimental Pediatrics
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• v.49 no.3
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• pp.287-291
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• 2006

Purpose : Aneurysms of sinus valsalva are rare anormalies thought to be primarily congenital in origin, progressing into death by acute heart failure in cases of rupture. Surgical correction is the only method of treatment. With these clinical implications, we reviewed the clinical characteristics and surgical results of patients with ruptured sinus of valsalva aneurysm. Methods : Between January 1991 and February 2004, 17 patients with ruptured sinus of valsalva aneurysm were retrospectively reviewed for their clinical symptoms, physical findings, past history, coexistent cardiac anormalies, surgical results, and mid-term prognosis. Results : The 17 patients included 13 men and four women, with a mean age of 30 years(10-59 years). Preoperatively accompanying cardiac anormalies were ventricular septal defect(VSD, eight cases of doubly committed juxta-arterial VSD) and aortic insufficiency(11 cases). During operations, patterns of fistulous tracts were found to be right colonary sinus-right ventricle in 13 patients, right coronary sinus-right atrium in one, noncoronary sinus - right ventricle in two, noncoronary sinus - right atrium in one, and VSD was noticed in 14 patients(all were doubly committed juxta-arterial in type). The defects were closed with a patch in 13 patients, without a patch in four, with concommitant aortic valve replacement in four and with aortic valvuloplasty in two. There were no mortalities during operations or the mid-term follow-up periods($40{\pm}49$ months). Conclusion : Because, at least in Orientals, VSD(especially doubly committed juxta-arterial) was accompanied in large numbers of patients with aneurysms of sinus valsalva, preoperative evaluations of this congenital heart disease should be made very careful. And we may need to revise the algorithm of treatment policy in small sized doubly committed juxta-arterial VSD.

• Clinical and Experimental Pediatrics
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• v.50 no.5
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• pp.476-483
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• 2007

Purpose : The objective of this study was to assess ventricular function by tissue Doppler imaging (TDI) in children with congenital heart disease (CHD) who have been undergoing open heart surgery (OHS) using cardiopulmonary bypass. We tried to compare the parameters of tissue Doppler imaging before and after OHS in patients with congenital heart disease. Methods : This study was conducted on 32 patients with CHD after OHS from January 2005 to December 2005 at Kyungpook National University hospital. Patients who underwent 2-D echocardiography before and after their OHS. All patients were divided into three groups, left ventricular volume overloading group (group 1), and right ventricular volume overloading group (group 2), and right ventricular pressure overloading group (group 3). The TDIs were examined before and 1 to 3 months after OHS. Peak early diastolic (E), and peak late diastolic (A) velocity of transmitral flow were measured by pulsed wave Doppler examination. Peak systolic (Sm), peak early diastolic (Em), and peak late diastolic (Am) velocity in apical 4-chamber and 2-chamber views were measured by TDI. The author calculated E/Em ratio. Results : The patients were 14 boys and 18 girls and the average age of patients was 2 years and 3 months. The congenital heart diseases which have to get OHS were ventricular septal defect (13 cases), atrial septal defect (7), atrioventricular septal defect (3), isolated pulmonary stenosis (2) and tetralogy of Fallot (7). There were significant decrease of Sm, Em, Am measured on tricuspid annulus and E/Em measured on mitral annulus in apical 4 chamber view (P<0.05). Conclusion : This study showed significant decrease of Sm, Em, Am measured on tricuspid annulus and E/Em measured on mitral annulus in apical 4 chamber view after OHS. These changes might be due to the effects of cardiopulmonary bypass in OHS and/or hemodynamic changes after correction of congenital heart disease. To clarify these changes, further study on more patients is needed.

• Journal of Chest Surgery
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• v.32 no.4
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• pp.388-393
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• 1999

Background: Correct preoperative staging of esophageal cancer is a prerequisite for adequate treatment. We prospectively compared the accuracy of positron emission tomography (PET) with [fluorine-18]FDG in the staging of esophageal cancer to that of computed tomography (CT). Material and Method: The findings of FDG PET and of chest CT including lower neck and the upper abdomen of 20 biopsy-proven squamous cell carcinoma patients (male, 19; female, 1; mean age, 61) were compared with the pathologic findings obtained from a curative esophagectomy with lymph node dissection. Result: The sensitivities of FDG PET and CT for diagnosis of primary tumor were the same, 90.0% (18/20). Both FDG PET and CT failed to show the primary tumor in 2 of 20 patients; one had a 1cm sized carcinoma in situ and the other had T1 stage cancer. By using the results of the pathologic examinations of 193 removed lymph node groups, we calculated the diagnostic sensitivities, specificities and accuracies of PET and CT (*$\chi$2 p < 0.005). Sensitivity** Specificity Accuracy* PET 55.6%(30/54) 97.1%(135/139) 85.5%(165/193) CT 13.0%(7/54) 98.6%(137/139) 74.6%(144/193) One of four patients with a false-positive for PEThad had active pulmonary tuberculosis. Among the 24 tumor involved lymph node groups, PET failed to show tumor metastasis in 5 lymph node groups abutting the tumor and in 14 lymph node groups located where the decay correction was not performed. Conclusion: Based on the above findings, it is suggested that [F-18]FDG-PET is superior to CT in the detection of nodal metastases and in the staging of patients with esophageal cancer.

• Journal of Preventive Medicine and Public Health
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• v.36 no.2
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• pp.93-100
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• 2003

Objectives : Because shipyard workers are involved with various manufacturing process, they are exposed to many kinds of hazardous materials. Welders especially, are exposed to bisphenol-A (BPA) during the welding and flame cutting of coated steel, This study was conducted to assess the exposure status of the endocrine disrupter based on the job-exposure matrix. The effects of the genetic polymorphism of xenobiotic enzyme metabolisms involved in the metabolism of BPA on the levels of urinary metabolite were investigated. Methods : The study population was recruited from a shipyard company in the f province. A total of 84 shipbuilding workers 47 and 37 in the exposed and control groups, respectively, were recruited for this study. The questionnaire variables included, age, sex, use of personal protective equipment, smoking, drinking and work duration. The urinary metabolite was collected in the afternoon and correction made for the urinary creatinine concentration. The of the CYP1A1, CYP2E1 and UGT1A6 genotypes were investigated using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methods with the DNA extracted from venous blood. Results : The urinary BPA level in the welders group was significantly higher than in the control group (p<0.05). The urinary BPA concentration with the wild type UGT1A6 was higher than the other UGT1A6 genotypes, but with no statistical significant. From themultiple regression analysis of the urinary BPA, the regression coefficient for job grade was statistically significant (p<0.05). Conclusions : The grade of exposure to BPA affected the urinary BPA concentration was statistically significant. However, the genetic polymorphisms of xenobiotics enzyme metabolism were not statistically significant. Further investigation of the genetic polymorphisms with a larger sample size is needed.

• The Korean Journal of Nuclear Medicine Technology
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• v.18 no.1
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• pp.115-121
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• 2014

Purpose: In addition to improving the quality of the PET image, through much research, the development of various programs are performed. Astonish TF reconstruction techniques by Philips can confirm the improved contrast of the lesion. Also, It's image reconstruction of 2 mm is possible with rapid reconstruction rate than conventional. In this study, we compared and evaluated Standardized Uptake Value (SUV) in accordance with the 2 mm reconstruction techniques and traditional 4 mm from the $^{18}F-FDG$ PET whole body image. Materials and Methods: In the phantom experiment, NEMA IEC body phantom (sphere: 10, 13, 17, 22, 28, 37 mm) was used to obtain images by using GEMINI TF 64 PET/CT (Philips, Cleveland, USA). Also, In the clinical images, we performed $^{18}F-FDG$ PET/CT examination to 30 women (age: $55.1{\pm}11.3$, BMI: $24.1{\pm}2.9$) with a diagnosis of breast cancer. After that, we reconstructed images in 2 mm and 4 mm respectively. The region of interest was drawn to acquired images. Since then, we measured SUV and statistically analyzed with SPSS ver.18 by using EBW (Extended Brilliance Workstation) NM ver.1.0. Results: After analyzing the result of the phantom study, there was a tendency that the bigger hot sphere size, the higher SUV. If you compared the 2 mm reconstruction techniques to 4 mm, it increased 95.78% in 10 mm, 50.60% in 13 mm, 25.00% in 17 mm, 30.04% in 22 mm, 31.81% in 28 mm, and 27.84% in 37 mm. Through the result of the analysis of the 2 mm reconstruction techniques and 4 mm in clinical images, it appeared that SUV of 2 mm was higher than that of 4 mm. Also the smaller the volume was, the more the change rate increased. Conclusion: After analyzing the result of the clinical picture and phantom experiments applied by Astonish TF reconstruction techniques, as the size of the volume was small, the change rate of the SUV increased. Therefore, it was necessary to further research about the SUV correction for accurate and active utilization of 2 mm reconstruction techniques which had excellent lesion discrimination ability and contrast in clinic.

• Korean Journal of Biological Psychiatry
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• v.13 no.4
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• pp.289-298
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• 2006

Objectives : Autism is a complex neurodevelopmental spectrum disorder with a strong genetic component. Previous neurochemical and genetic studies suggested the possible involvement of glutamate N-methyl-D-aspartate(NMDA) receptor in autism. The aim of study was to investigate the association between the NMDA2B receptor gene(GRIN2B) and autism spectrum disorders(ASD) in the Korean population. Methods : The patients with ASD were diagnosed with Autism Diagnostic Interview-Revised and Autism Diagnostic Observation Schedule based on DSM-IV diagnostic classification. The present study was conducted with the detection of four single nucleotide polymorphisms(SNPs) in GRIK2 and family-based association analysis of the single nucleotide polymorphisms in Korean ASD trios using transmission disequilibrium test (TDT). Results : One hundred twenty six patients with ASD and their biological parents were analyzed. 86.5% were male and 85.1% were diagnosed as autistic disorder. The mean age was $71.9{\pm}31.6$ months(range : 26-185 months). We found that rs1805247 showed significantly preferential transmission(TDT ${\chi}^2$=12.8, p<0.001) in ASD. Conclusion : One SNP in GRIN2B gene was significantly associated with ASD in the Korean population. This result suggests the possible involvement of glutamate NMDA receptor gene in the development of ASD.