• Korean Journal of Plant Resources
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• v.1 no.1
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• pp.23-32
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• 1988

The Plants medicinal resources of Mt. Mohu were investigated 12 times from July 1, 1987 to July 28, 1988. In order to analyze the vegetation of Mt. Mohu area,herb plants structure and distribution. Herb plants of Mohu Mt. consisted of 58families, 230 species in all. The resources of important herb drugs were plant-aginaceae, Labiatae, Amarantaceae, Campanulaceae, Asclepiaclaceae, Leguminosae,Gentianaceae, Liliaceae, lilicaceae, Dioscoreaceae, Compositae, Caprifoliaceae,Ranuncvlaceae, Lauraceae, Lardizabalaceae, Araliaceae, Solanaceae, Cornaceae,Fagaceae and Rosaceae. The herb drugs were comparatively more than in othermountains in our country.

• Korean Journal of Pharmacognosy
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• v.27 no.2
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• pp.101-104
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• 1996

Hydrogen peroxide is one of major chemicals mediating antitumor and antimicrobial activities of macrophages. We searched natural products enhancing hydrogen peroxide generation from murine macrophage-like cell line J774. Among 21 methanol extracts of Korean medicinal plants, the extract from Cornus officinalis was the most effective. The active component from the fractions was searched by activity guided fractionation, and identified as ursolic acid by spectral data.

• Proceedings of the Korean Society of Postharvest Science and Technology of Agricultural Products Conference
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• 2003.10a
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• pp.133.2-134
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• 2003

산수유(Cornus officinalis)는 층층나무과(Cornaceae)에 속하는 약용식물로, 그 열매(Corni Fructus)는 길이 1.5cm 내외인 중추원형의 모양으로 생김새가 촉나라 대추 같고 신맛이 두드러지기 때문에 촉산초라고도 불린다. 그 효능으로 이뇨작용, 혈압강하작용, 항균작용이 있고, 햇볕에 말린 과육은 간과 콩팥의 기능에 효과가 있는 것으로 알러져 있다. 따라서 산수유의 이용 확대 및 제품화 가능성을 검토하기 위한 기초연구의 일환으로 산수유 열매의 화학성분을 분석하였다. 산수유 열매의 일반성분을 건량 기준으로 측정해 본 결과, 탄수화물 88.6%, 조단백질 2.3%, 조지방 4.5%, 회분 4.6%이었다. 산수유 열매의 지방산 중 포화지방산 함량은 30.8%, 총 불포화지방산 함량은 69.2%이었다. 불포화지방산중 다가불포화지방산은 54.9%, 일가불포화지방산은 14.3%로 다가불포화지방산의 함량이 높게 나타났다. 지방산 조성을 살펴보면 linoleic acid가 33.3%로 가장 높았고, palmitic acid(25.1%), linolenic acid(21.6%) 순으로 높게 나타났다. 아미노산 조성으로는 산성아미노산인 aspartic acid가 523 mg%, glutamic acid가 347 mg%로 높게 나타났다. 무기질 함량은 칼륨함량이 건물기준으로 2067.5 mg%로 가장 높았고 그 다음으로는 Ca 372.9 mg%이었다. 유기산 함량은 건물량 기준으로 formic acid가 19,478 mg/100 g으로 가장 그 함량이 높았으며, 그 다음으로는 succinic acid (18,167 mg/100 g), malonic acid (14,487 mg/100 g), malic acid (13,018 mg/100 g) 순이었다.

• Korean Journal of Environment and Ecology
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• v.16 no.4
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• pp.345-358
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• 2003

The vascular plant species in the areas of Gonamsan and Shiribong in the Baekdudaegan were summarized as 295 texa: 89 families, 193 genus, 245 species, 44 varieties and 6 forms.10 taxa were recorded in the surveyed areas as the Korean endemic plants: Hosta capitat (Liliacease), Polygonatum lasianthum var. corenum (Liliaceae), Chloranthus japonicus (Cloranthaceae), Salix hulteni (Salicaoeae), Clematis richotoma (Ranunculaceae), Spiraea prunifolia for. simpliciflora (Rosaceae), Vicia unijuga (Fabaceae), Viola albida (Violaceae), cornus walter(Cornaceae), Weigela subsessilis (Caprifoliaceae).According to the list of Korean rare and endangered plants complied in the studied areas:Iris ensata var. spoyanea(Iridaceae), Viola albida (Vioaceae) and Aristolochia contorta (aristolochiaceae) Due to the rapid destruction and increase of visitors and the studied areas are located close to the villages, the naturalized plant species in the areas were more frequently appeared than the rare and endangered plant species.

• Applied Biological Chemistry
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• v.51 no.4
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• pp.316-320
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• 2008

Ten compounds, (+)-pinoresinol (1), (-)-balanophonin (2), gallicin (3), vanillin (4), 4-hydroxybenzaldehyde (5), coniferaldehyde (6), betulinic acid (7), ursolic acid (8), 5-hydroxymethyl furfural (9), and malic acid (10), were isolated from a EtOAc-soluble fraction of the seeds of Cornus officinalis. The structures of these compounds were elucidated by spectroscopic methods as well as by comparison with reported values. Compounds 1, 2, and 4-7 were isolated from this species for the first time. All the isolates (1-10) were subjected to an in vitro bioassay to evaluate their inhibitory activity against advanced glycation end products (AGEs) formation. Among these, compounds 2 and 3 showed the significant inhibitory activity on AGEs formation with $IC_{50}$ values of 27.81 and 18.04${\mu}M$, respectively.

• Korean Journal of Environment and Ecology
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• v.11 no.3
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• pp.334-351
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• 1997

To study restoration model of evergreen broad-leaved forests in warm temperate region, vegetation structure was studied at Wando(Island) as a case study. Quercus acuta was a dominant species at evergreen broad-leaved forests in Wando(Island). Majority of evergreen broad-leaved forests was a thirty years old coppice forest. Reforested vegetation and deciduous broad-leaved forests was developed at a mid-slope districts and a piedmont. Deciduous broad-leaved forestsconsisted of Quercus serrata, Carpinus tschonoskii, Carpinus coreana, etc., was developed at a ridge and higher districts. Evergreen broad-leaved woody plants were growing at a forest floor of deciduous broad-leaved forests. The species over sixty percent of constanty ratio in forty seven plots were Ligustrum japonicum, Trachelospermum asiaticum var. intermedium, Quercus acuta and Eury japonica. The vascular plants in the Wando(Island) was summarized as 488 taxa which composed as 101 families, 321 genus, 426 species, 56 varieties, 5 forms and 1 hyvrid. Evergreen broad-leaved woody stecies was 32 taxa which composed as 23 genus, 30 species and 2 varieties. The species such as Liliope platyphylla of Liliaceae and Pueraria thunbergii of Leguminosae, etc. was recorded as the highest values for their widely distribution in the areas. On the contrary, and forty taxa of plants such as Viburnum erosum of Caprifoliaceae, Traceholospermum asiaticum var. intermedium was recorded as over 50% of constancy ratio. Two hundred and nine taxa of plants such as Juglans manshurica of Juglandaceae, Cornus walteri of Cornaceae and Rodotypos scandens of Rosaceae, etc. was showed the specific trends due to long-term artificial disturbance. The forest of Pinus thunbergii showde the highest species diversities(155 species per 600m$^{2}$), while the Cinnamomum japonicum-Tracheolospermum asiaticum var. intermedium community showed the lowest species diversities(23 species per 600m$^{2}$).

• Korean Journal of Food Science and Technology
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• v.36 no.6
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• pp.1001-1007
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• 2004

Chloroform layer from methanol extract of Corni fructus (Cornaceae) showed strong antiproliferation effect on human cancer cell lines by SRB assay. Anticarcinogenic-active compound was isolated and purified by silica gel column and thin layer chromatograpies, and identified as ursolic acid ($3{\beta}$-hydroxyrus-12-ene-28-oic acid, MW:456) by mass and IR spectrophotometries, and $^1H-and\;^{13}C-NMRs$. The compound inhibited proliferation of A549 (human lung cancer cell line) and MCF-7 (human breast cancer cell line) cells in dose-dependant manner when treated for 48 hr. Inhibition rates of both cells were over 40% and 90% compared with control cells at the $30\;{\mu}g/mL\;and\;100\;{\mu}g/mL$, respectively. Morphology of cells treated with the compound for 15 hr at $10\;{\mu}g/mL$ was distorted with shrinked cell mass, and cell number was lower than that of control cells. Cell cycle analysis showed sub-G1 phase arrest in both cell lines following 15 hr exposure to the compound; % of cell phase increased to 11.7 and 11.2% compared to the control of 4.0% and 2.1% in A549 and MCP-7 cells, respectively.

• Journal of Life Science
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• v.29 no.1
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• pp.112-117
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• 2019

Herbal medicines are widely used as therapeutic products in many countries. Corni fructus (CF), the dried ripe sarcocarp of Cornus officinalis Sieb. et Zucc (Cornaceae), has been used for thousands of years in traditional medicine and has been reported to be effective for the prevention and treatment of various diseases, such as kidney diseases and diabetes. Recent research on CF has documented a wide spectrum of therapeutic properties, which include anti-inflammatory, ant-oxidative, immunomodulatory, and anti-cancer effects. However, there is no information on its safety. Therefore, in this study, the toxicity of water extract of CF to ICR mice was investigated. The mice received a single dose of water extract of CF (1,000, 2,000, and 5,000 mg/kg of body weight) via the oral route. Mortality, clinical signs, body weight changes, gross findings, and weights of the principal organs after 14 d were then assessed. The results revealed no adverse effects of CF as determined by clinical signs, body weights, or organ weights and no gross pathological findings in any of the treatment groups. These results suggest that the 50% lethal dose and approximated lethal dose of CF extract is over 5,000 mg/kg. The findings provide scientific evidence for the safety of CFs.