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http://dx.doi.org/10.3839/jksabc.2008.055

Constituents of the seeds of Cornus officinalis with Inhibitory Activity on the Formation of Advanced Glycation End Products (AGEs)  

Lee, Ga-Young (Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine)
Jang, Dae-Sik (Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine)
Lee, Yun-Mi (Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine)
Kim, Young-Sook (Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine)
Kim, Jin-Sook (Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine)
Publication Information
Applied Biological Chemistry / v.51, no.4, 2008 , pp. 316-320 More about this Journal
Abstract
Ten compounds, (+)-pinoresinol (1), (-)-balanophonin (2), gallicin (3), vanillin (4), 4-hydroxybenzaldehyde (5), coniferaldehyde (6), betulinic acid (7), ursolic acid (8), 5-hydroxymethyl furfural (9), and malic acid (10), were isolated from a EtOAc-soluble fraction of the seeds of Cornus officinalis. The structures of these compounds were elucidated by spectroscopic methods as well as by comparison with reported values. Compounds 1, 2, and 4-7 were isolated from this species for the first time. All the isolates (1-10) were subjected to an in vitro bioassay to evaluate their inhibitory activity against advanced glycation end products (AGEs) formation. Among these, compounds 2 and 3 showed the significant inhibitory activity on AGEs formation with $IC_{50}$ values of 27.81 and 18.04${\mu}M$, respectively.
Keywords
advanced glycation end products (AGEs); (-)-balanophonin; Cornaceae; Cornus officinalis; diabetic complications; gallicin;
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