Browse > Article
http://dx.doi.org/10.5352/JLS.2019.29.1.112

Single Dose Oral Toxicity Test of Water Extract of Corni Fructus in ICR Mice  

Hwang-Bo, Hyun (Anti-Aging Research Center, Dong-eui University)
Kwon, Da Hye (Anti-Aging Research Center, Dong-eui University)
Kim, Min Young (Anti-Aging Research Center, Dong-eui University)
Ji, Seon Yeong (Anti-Aging Research Center, Dong-eui University)
Choi, Eun Ok (Anti-Aging Research Center, Dong-eui University)
Kim, Sung Ok (Department of Food Science and Biotechnology, College of Engineering, Kyungsung University)
Jeong, Ji-Suk (Gurye-gun Agricultural Center and Gurye Wildflower Institute)
Hong, Su Hyun (Anti-Aging Research Center, Dong-eui University)
Choi, Sung Hyun (Department of System Management, Korea Lift College)
Park, Cheol (Department of Molecular Biology, College of Natural Sciences and Human Ecology, Dong-eui University)
Choi, Yung Hyun (Anti-Aging Research Center, Dong-eui University)
Publication Information
Journal of Life Science / v.29, no.1, 2019 , pp. 112-117 More about this Journal
Abstract
Herbal medicines are widely used as therapeutic products in many countries. Corni fructus (CF), the dried ripe sarcocarp of Cornus officinalis Sieb. et Zucc (Cornaceae), has been used for thousands of years in traditional medicine and has been reported to be effective for the prevention and treatment of various diseases, such as kidney diseases and diabetes. Recent research on CF has documented a wide spectrum of therapeutic properties, which include anti-inflammatory, ant-oxidative, immunomodulatory, and anti-cancer effects. However, there is no information on its safety. Therefore, in this study, the toxicity of water extract of CF to ICR mice was investigated. The mice received a single dose of water extract of CF (1,000, 2,000, and 5,000 mg/kg of body weight) via the oral route. Mortality, clinical signs, body weight changes, gross findings, and weights of the principal organs after 14 d were then assessed. The results revealed no adverse effects of CF as determined by clinical signs, body weights, or organ weights and no gross pathological findings in any of the treatment groups. These results suggest that the 50% lethal dose and approximated lethal dose of CF extract is over 5,000 mg/kg. The findings provide scientific evidence for the safety of CFs.
Keywords
Corni Fructus; ICR mice; single dose oral toxicity; safety;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
연도 인용수 순위
1 An, Y. A., Hwang, J. Y., Lee, J. S. and Kim, Y. C. 2015. Cornus officinalis methanol extract upregulates melanogenesis in melan-a cells. Toxicol. Res. 31, 165-172.   DOI
2 Chan, G. K., Wu, R., Chen, V. P., Zhu, K. Y. and Du, Y. 2018. Quality control on herbal medicine and its application. Evid. Based Complement. Alternat. Med. 2018, 3294398.
3 Chen, Y., Wu, Y., Gan, X., Liu, K., Lv, X., Shen, H., Dai, G. and Xu, H. 2016. Iridoid glycoside from Cornus officinalis ameliorated diabetes mellitus-induced testicular damage in male rats: Involvement of suppression of the AGEs/RAGE/p38 MAPK signaling pathway. J. Ethnopharmacol. 194, 850-860.   DOI
4 Coates, A., Abraham, S., Kaye, S. B., Sowerbutts, T., Frewin, C., Fox, R. M. and Tattersall, M. H. 1983. On the receiving end-patient perception of the side-effects of cancer chemotherapy. Eur. J. Cancer Clin. Oncol. 19, 203-208.   DOI
5 Park, C. H., Noh, J. S., Kim, J. H., Tanaka, T., Zhao, Q., Matsumoto, K., Shibahara, N. and Yokozawa, T. 2011. Evaluation of morroniside, iridoid glycoside from Corni Fructus, on diabetes-induced alterations such as oxidative stress, inflammation, and apoptosis in the liver of type 2 diabetic db/db mice. Biol. Pharm. Bull. 34, 1559-1565.   DOI
6 Food and Drug Safety. 2000. Research for establishing rational management system of functional foods.
7 Jang, I., Yang, C., Lee, S. and Han, C. 2007. A review of herbal medicinal products associated with toxic events in Korea. J. Kor. Oriental Med. 28, 1-10.
8 Jeng, H., Wu, C. M., Su, S. and Chang, W. C. 1997. A substance isolated from Cornus officinalis enhances the motility of human sperm. Am. J. Chin. Med. 25, 301-306.   DOI
9 Kennedy, B. K., Berger, S. L., Brunet, A., Campisi, J., Cuervo, A. M., Epel, E. S., Franceschi, C., Lithgow, G. J., Morimoto, R. I., Pessin, J. E., Rando, T. A., Richardson, A., Schadt, E. E., Wyss-Coray, T. and Sierra, F. 2014. Geroscience: linking aging to chronic disease. Cell 159, 709-713.   DOI
10 Kim, H. and Song, M. 2011. Analysis and recordings of orally transmitted knowledge about medicinal plants in the southern mountainous region of Korea. J. Ethnopharmacol. 134, 676-696.   DOI
11 Kim, H. U., Ryu, J. Y., Lee, J. O. and Lee, S. Y. 2015. A systems approach to traditional oriental medicine. Nat. Biotechnol. 33, 264.   DOI
12 Kim, S., Kim, B. and Lee, Y. 2012. Effects of Corni fructus on ovalbumin-induced airway inflammation and airway hyper-responsiveness in a mouse model of allergic asthma. J. inflamm (Lond). 9, 9.   DOI
13 Korea Food & Drug Administration. 2015. Toxicity test standards for medicines. Korea Food and Drug Administration Notice (2015-82).
14 Korea Health Industry Development Institute. 2006. The tendency of research and development of internal and external natural source remedies. The second: Plan for Promotion of Natural Medicine Research & Development. 1-20.
15 Kwon, C., Lee, B., Suh, H., Chung, S. and Kim, J. W. 2018. Efficacy and safety of auricular acupuncture for cognitive impairment and dementia: A systematic review. Evid. Based Complement Alternat. Med. 2018, 3426078.
16 Lee, S. J., Kim, E. H. and Lee, H. G. 2008. Development of rice wines using Cornus officinalis and Sutellaria baicalensis by antioxidant activity tests. Kor. J. Food Sci. Technol. 40, 21-30.
17 Lee, S., Kim, S. Y., Han, S., Kim, H., Ham, S. and Kang, I. 2006. Corni fructus scavenges hydroxy radicals and decreases oxidative stress in endothelial cells. J. Med. Food 9, 594-598.   DOI
18 Mau, J., Chen, C. and Hsieh, P. 2001. Antimicrobial effect of extracts from Chinese chive, cinnamon, and corni fructus. J. Agr. Food Chem. 49, 183-188.   DOI
19 McGeer, P. L. and Mcgeer, E. G. 2004. Inflammation and the degenerative diseases of aging. Ann. N. Y. Acad. Sci. 1035, 104-116.   DOI
20 Miller, G. E., Chen, E. and Parker, K. J. 2011. Psychological stress in childhood and susceptibility to the chronic diseases of aging: Moving toward a model of behavioral and biological mechanisms. Psychol. Bull. 137, 959.   DOI
21 Misra, R. 1998. Modern drug development from traditional medicinal plants using radioligand receptor-binding assays. Med. Res. Rev. 18, 383-402.   DOI
22 Molkara, T., Akhlaghi, F., Ramezani, M. A., Salalri, R., Vakili, V., Kamalinejad, M., Bordbar, M. R. F., Ghorbani, A. and Motavasselian, M. 2018. Effects of a food product (based on Daucus carota) and education based on traditional Persian medicine on female sexual dysfunction: a randomized clinical trial. Electron. Physician 10, 6577-6587.   DOI
23 Newman, D. J., Cragg, G. M. and Snader, K. M. 2000. The influence of natural products upon drug discovery. Nat. Prod. Rep. 17, 215-234.   DOI
24 Park, C. H., Xu, F. H., Roh, S., Song, Y. O., Uebaba, K., Noh, J. S. and Yokozawa, T. 2015. Astaxanthin and Corni Fructus protect against diabetes-induced oxidative stress, inflammation, and advanced glycation end product in livers of streptozotocin- induced diabetic rats. J. Med. Food 18, 337-344.   DOI
25 Peng, Q., Wei, Z. and Lau, B. H. 1998. Fructus corni attenuates oxidative stress in macrophages and endothelial cells. Am. J. Chin. Med. 26, 291-300.   DOI
26 Tao, J., Zhao, M., Joang, S., Pu, X. and Wei, X. 2018. Comparative metabolism of two major compounds in Fructus Corni extracts by gut microflora from normal and chronic nephropathy rats in vitro by UPLC-Q-TOF/MS. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 1073, 170-176.   DOI
27 Tokuyasu, N., Shomori, K., Amano, K., Honjo, S., Sakamoto, T., Watanabe, J., Amisaki, M., Morimoto, M., Uchinaka, E., Yagyu, T., Saito, H., Ito, H. and Fujiwara, Y. 2018. Indirubin, a constituent of the Chinese herbal medicine Qing-Dai, attenuates dextran sulfate sodium-induced murine colitis. Yonago Acta. Med. 61, 128-136.   DOI