Single Dose Oral Toxicity Test of Water Extract of Corni Fructus in ICR Mice |
Hwang-Bo, Hyun
(Anti-Aging Research Center, Dong-eui University)
Kwon, Da Hye (Anti-Aging Research Center, Dong-eui University) Kim, Min Young (Anti-Aging Research Center, Dong-eui University) Ji, Seon Yeong (Anti-Aging Research Center, Dong-eui University) Choi, Eun Ok (Anti-Aging Research Center, Dong-eui University) Kim, Sung Ok (Department of Food Science and Biotechnology, College of Engineering, Kyungsung University) Jeong, Ji-Suk (Gurye-gun Agricultural Center and Gurye Wildflower Institute) Hong, Su Hyun (Anti-Aging Research Center, Dong-eui University) Choi, Sung Hyun (Department of System Management, Korea Lift College) Park, Cheol (Department of Molecular Biology, College of Natural Sciences and Human Ecology, Dong-eui University) Choi, Yung Hyun (Anti-Aging Research Center, Dong-eui University) |
1 | An, Y. A., Hwang, J. Y., Lee, J. S. and Kim, Y. C. 2015. Cornus officinalis methanol extract upregulates melanogenesis in melan-a cells. Toxicol. Res. 31, 165-172. DOI |
2 | Chan, G. K., Wu, R., Chen, V. P., Zhu, K. Y. and Du, Y. 2018. Quality control on herbal medicine and its application. Evid. Based Complement. Alternat. Med. 2018, 3294398. |
3 | Chen, Y., Wu, Y., Gan, X., Liu, K., Lv, X., Shen, H., Dai, G. and Xu, H. 2016. Iridoid glycoside from Cornus officinalis ameliorated diabetes mellitus-induced testicular damage in male rats: Involvement of suppression of the AGEs/RAGE/p38 MAPK signaling pathway. J. Ethnopharmacol. 194, 850-860. DOI |
4 | Coates, A., Abraham, S., Kaye, S. B., Sowerbutts, T., Frewin, C., Fox, R. M. and Tattersall, M. H. 1983. On the receiving end-patient perception of the side-effects of cancer chemotherapy. Eur. J. Cancer Clin. Oncol. 19, 203-208. DOI |
5 | Park, C. H., Noh, J. S., Kim, J. H., Tanaka, T., Zhao, Q., Matsumoto, K., Shibahara, N. and Yokozawa, T. 2011. Evaluation of morroniside, iridoid glycoside from Corni Fructus, on diabetes-induced alterations such as oxidative stress, inflammation, and apoptosis in the liver of type 2 diabetic db/db mice. Biol. Pharm. Bull. 34, 1559-1565. DOI |
6 | Food and Drug Safety. 2000. Research for establishing rational management system of functional foods. |
7 | Jang, I., Yang, C., Lee, S. and Han, C. 2007. A review of herbal medicinal products associated with toxic events in Korea. J. Kor. Oriental Med. 28, 1-10. |
8 | Jeng, H., Wu, C. M., Su, S. and Chang, W. C. 1997. A substance isolated from Cornus officinalis enhances the motility of human sperm. Am. J. Chin. Med. 25, 301-306. DOI |
9 | Kennedy, B. K., Berger, S. L., Brunet, A., Campisi, J., Cuervo, A. M., Epel, E. S., Franceschi, C., Lithgow, G. J., Morimoto, R. I., Pessin, J. E., Rando, T. A., Richardson, A., Schadt, E. E., Wyss-Coray, T. and Sierra, F. 2014. Geroscience: linking aging to chronic disease. Cell 159, 709-713. DOI |
10 | Kim, H. and Song, M. 2011. Analysis and recordings of orally transmitted knowledge about medicinal plants in the southern mountainous region of Korea. J. Ethnopharmacol. 134, 676-696. DOI |
11 | Kim, H. U., Ryu, J. Y., Lee, J. O. and Lee, S. Y. 2015. A systems approach to traditional oriental medicine. Nat. Biotechnol. 33, 264. DOI |
12 | Kim, S., Kim, B. and Lee, Y. 2012. Effects of Corni fructus on ovalbumin-induced airway inflammation and airway hyper-responsiveness in a mouse model of allergic asthma. J. inflamm (Lond). 9, 9. DOI |
13 | Korea Food & Drug Administration. 2015. Toxicity test standards for medicines. Korea Food and Drug Administration Notice (2015-82). |
14 | Korea Health Industry Development Institute. 2006. The tendency of research and development of internal and external natural source remedies. The second: Plan for Promotion of Natural Medicine Research & Development. 1-20. |
15 | Kwon, C., Lee, B., Suh, H., Chung, S. and Kim, J. W. 2018. Efficacy and safety of auricular acupuncture for cognitive impairment and dementia: A systematic review. Evid. Based Complement Alternat. Med. 2018, 3426078. |
16 | Lee, S. J., Kim, E. H. and Lee, H. G. 2008. Development of rice wines using Cornus officinalis and Sutellaria baicalensis by antioxidant activity tests. Kor. J. Food Sci. Technol. 40, 21-30. |
17 | Lee, S., Kim, S. Y., Han, S., Kim, H., Ham, S. and Kang, I. 2006. Corni fructus scavenges hydroxy radicals and decreases oxidative stress in endothelial cells. J. Med. Food 9, 594-598. DOI |
18 | Mau, J., Chen, C. and Hsieh, P. 2001. Antimicrobial effect of extracts from Chinese chive, cinnamon, and corni fructus. J. Agr. Food Chem. 49, 183-188. DOI |
19 | McGeer, P. L. and Mcgeer, E. G. 2004. Inflammation and the degenerative diseases of aging. Ann. N. Y. Acad. Sci. 1035, 104-116. DOI |
20 | Miller, G. E., Chen, E. and Parker, K. J. 2011. Psychological stress in childhood and susceptibility to the chronic diseases of aging: Moving toward a model of behavioral and biological mechanisms. Psychol. Bull. 137, 959. DOI |
21 | Misra, R. 1998. Modern drug development from traditional medicinal plants using radioligand receptor-binding assays. Med. Res. Rev. 18, 383-402. DOI |
22 | Molkara, T., Akhlaghi, F., Ramezani, M. A., Salalri, R., Vakili, V., Kamalinejad, M., Bordbar, M. R. F., Ghorbani, A. and Motavasselian, M. 2018. Effects of a food product (based on Daucus carota) and education based on traditional Persian medicine on female sexual dysfunction: a randomized clinical trial. Electron. Physician 10, 6577-6587. DOI |
23 | Newman, D. J., Cragg, G. M. and Snader, K. M. 2000. The influence of natural products upon drug discovery. Nat. Prod. Rep. 17, 215-234. DOI |
24 | Park, C. H., Xu, F. H., Roh, S., Song, Y. O., Uebaba, K., Noh, J. S. and Yokozawa, T. 2015. Astaxanthin and Corni Fructus protect against diabetes-induced oxidative stress, inflammation, and advanced glycation end product in livers of streptozotocin- induced diabetic rats. J. Med. Food 18, 337-344. DOI |
25 | Peng, Q., Wei, Z. and Lau, B. H. 1998. Fructus corni attenuates oxidative stress in macrophages and endothelial cells. Am. J. Chin. Med. 26, 291-300. DOI |
26 | Tao, J., Zhao, M., Joang, S., Pu, X. and Wei, X. 2018. Comparative metabolism of two major compounds in Fructus Corni extracts by gut microflora from normal and chronic nephropathy rats in vitro by UPLC-Q-TOF/MS. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 1073, 170-176. DOI |
27 | Tokuyasu, N., Shomori, K., Amano, K., Honjo, S., Sakamoto, T., Watanabe, J., Amisaki, M., Morimoto, M., Uchinaka, E., Yagyu, T., Saito, H., Ito, H. and Fujiwara, Y. 2018. Indirubin, a constituent of the Chinese herbal medicine Qing-Dai, attenuates dextran sulfate sodium-induced murine colitis. Yonago Acta. Med. 61, 128-136. DOI |