• Journal of Microbiology
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• v.37 no.2
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• pp.90-96
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• 1999

The core protein of the hepatitis C virus (HCV) is a multifunctional protein. The HCV core protein was reported to regulate cellular gene expression and transform primary rat embryo fibroblast cells. However, the role of the core protein in the pathogenesis of HCV-associated liver diseases is not well understood. To investigate the functional role of the core protein in cytophathogenicity, we have constructed stable expression systems of full length or truncated HCV core protein lacking the C-terminal hyderophobic domains and established HepG2 cell clones constitutively expressing the core protein. The full length core protein was localized in the cytoplasm and the C-terminal truncated core protein was localized in the nucleus. HepG2 cells expressing nuclear, truncated core protein showed elevated cell death during cultivation compared to untransfected cells and full length core-expressing cells. In the treatment with bleomycin, both cell clones expressing full length or truncated core protein appeared to be more sensitive to blemoycin than the parental HepG2 cells. These results suggest that the core protein may play a role in HCV pathogenesis promoting apoptotic cell death of infected cells.

• BMB Reports
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• v.37 no.6
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• pp.735-740
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• 2004

Hepatitis C virus (HCV) is a causal agent of the chronic liver infection. To understand HCV morphogenesis, we studied the assembly of HCV structural proteins in insect cells. We constructed recombinant baculovirus expression vectors consisting of either HCV core alone, core-E1, or core-E1-E2. These structural proteins were expressed in insect cells and were examined to assemble into particles. Neither core-E1 nor core-E1-E2 was capable of assembling into virus-like particles (VLPs). It was surprising that the core protein alone was assembled into core-like particles. These particles were released into the culture medium as early as 2 days after infection. In our system, HCV structural proteins including envelope proteins did not assemble into VLPs. Instead, the core protein itself has the intrinsic capacity to assemble into amorphous core-like particles. Furthermore, released core particles were associated with HCV RNA, indicating that core proteins were assembled into nucleocapsids. These results suggest that HCV may utilize a unique core release mechanism to evade the hosts defense mechanism, thus contributing to the persistence of HCV infection.

• Journal of the Korean Institute of Intelligent Systems
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• v.21 no.2
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• pp.276-282
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• 2011

CoreNet is a valuable resource to use in the domain of natural language processing including Korean-Chinese-Japanese multilingual text analysis, and translation among natural languages. CoreNet is mapped to SUMO in order to encourage its application in broader fields and enhance its international status as a multilingual lexical semantic network. To do this, indirect and direct mapping methodologies are used. Through the indirect mapping among CoreNet-KorLex-PWN-SUMO, we alleviate the difficulty of translating CoreNet concept terms in Korean into SUMO concepts in English, and maximize recall of SUMO concepts corresponding to the concept of CoreNet.

• The Korean Journal of Emergency Medical Services
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• v.14 no.2
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• pp.25-40
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• 2010

Purpose : The purpose of this study was to develop and apply a Core Skill-TLP(Core Skill-Tutorial, Laboratory, Practicum) package in Patient Management and to effect of core skill-TLP education. Methods : This study was used to developed Patient Management' Core Skill-TLP package throughout 14 steps of Core Skill-TLP package development model. Then, Core Skill-TLP Learning methodology was implemented in first year student in the undergraduate emergency medical technology, and survey was done. Results : 1. Core Skill-TLP package model was presented based on conceptual model of PBL(S-PBL). 2, The student in OSCE did significantly better in clinical patient management core skills performance. 3. As to the satisfaction of Core Skill-TLP package management, student, tutor and self-satisfaction score was 3.21, 3.42, 3.38 respectively. Conclusion : This study was suggested that Core Skill-TLP education would be necessary with well-structured package and achieved advantage of simulation and PBL.

• IEIE Transactions on Smart Processing and Computing
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• v.5 no.1
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• pp.43-48
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• 2016

We propose plain fingerprint classification based on a core stochastic algorithm that effectively uses a core stochastic model, acquiring more fingerprint minutiae and direction, in order to increase matching performance. The proposed core stochastic algorithm uses core presence/absence and contains a ridge direction and distribution map. Simulations show that the fingerprint classification accuracy is improved by more than 14%, on average, compared to other algorithms.

• Journal of computational fluids engineering
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• v.16 no.3
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• pp.95-103
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• 2011

In the block type VHTR core, there are inevitable gaps among core blocks for the installation and refueling of the fuel blocks. These gaps are called bypass gap and the bypass flow is defined as a coolant flows through the bypass gap. Distribution of core bypass flow varies according to the reactor operation since the graphite core blocks are deformed by the fast neutron irradiation and thermal expansion. Furthermore, the cross-flow through an interfacial gap between the stacked blocks causes flow mixing between the coolant holes and bypass gap, so that complicated flow distribution occurs in the core. Since the bypass flow affects core thermal margin and reactor efficiency, accurate prediction and evaluation of the core bypass flow are very important. In this regard, experimental and computational studies were carried out to evaluate the core bypass flow distribution. A multi-block experimental apparatus was constructed to measure flow and pressure distribution. Multi-block effect such as cross flow phenomenon was investigated in the experiment. The experimental data were used to validate a CFD model foranalysis of bypass flow characteristics in detail.

• Journal of the Korea institute for structural maintenance and inspection
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• v.24 no.1
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• pp.116-124
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• 2020

In order to analyze the lateral-load resisting capability according to the core locations, three-dimensional structural analyses were performed for 20-story buildings with symmetric plan. Four analytical models for a center core, a single-axial eccentric core, and a double-axial eccentric core were constructed, and eigenvalue analyses, wind-load analyses, and earthquake-load analyses were performed. Torsion did not occur in the central core building, but the bending and torsion occurred in combination with the arrangement of the eccentric core, and the lateral-load resisting capability was degraded. The change in the wind load according to the eccentric core was small, but the maximum lateral displacement was found to increase greatly by the eccentric arrangement of the core. In addition, in case of the eccentric core, the seismic load was slightly reduced compared to the center core due to the decrease in the lateral stiffness, but it was found that the maximum story drift ratio increased significantly due to the torsional effect. Based on these results, the structural behavior according to the position of the core can be clearified and used as a guideline for core locations in the planning and design stage.

• Journal of Korea Society of Digital Industry and Information Management
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• v.13 no.4
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• pp.71-79
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• 2017

Recently, Fire watching and dangerous substances monitoring system has been being developed to enhance various fire related security. It is generally assumed that fire flame extraction plays a very important role on this monitoring system. In this study, we propose the fire flame extraction method of Non-Residential Facilities based on core object extraction in image. A core object is defined as a comparatively large object at center of the image. First of all, an input image and its decreased resolution image are segmented. Segmented regions are classified as the outer or the inner region. The outer region is adjacent to boundaries of the image and the rest is not. Then core object regions and core background regions are selected from the inner region and the outer region, respectively. Core object regions are the representative regions for the object and are selected by using the information about the region size and location. Each inner region is classified into foreground or background region by comparing its values of a color histogram intersection of the inner region against the core object region and the core background region. Finally, the extracted core object region is determined as fire flame object in the image. Through experiments, we find that to provide a basic measures can respond effectively and quickly to fire in non-residential facilities.

• The Journal of the Korea Contents Association
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• v.8 no.9
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• pp.27-33
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• 2008

This paper designs Shared Memory on the Dual Core system so that it operates a general System V IPC on the Linux O.S. Shared Memory is the technique that many processes can access to identical memory area. We treat Shared Memory which is SVR in a kernel step. We design a share memory facility of Linux operating system on the Dual Core System. In this paper the suggesting of share memory facility design plan in Dual Core system is enhance the performance in existing an unity processor system as a dual core practical use. We attemp a performance enhance in each CPU for each process which uses a share memory.

• Journal of computational fluids engineering
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• v.21 no.3
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• pp.8-14
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• 2016

A numerical analysis is conducted to estimate the core expansion and the energy behaviors induced by a core disruptive accident in a sodium-cooled fast reactor. The numerical formulation based on underwater explosion theory is carried out to simulate the core explosion inside the reactor vessel. The transient pressure, temperature and expansion of the core are examined by solving the equation of state and nonlinear governing equation of momentum conservation in one-dimensional spherical coordinates. The energy balance inside the computation domain is examined during the core expansion process. Heat transfer between the core and the sodium coolant, and the bubble rise during the expansion process are briefly investigated.