• Polymer(Korea)
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• v.31 no.3
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• pp.189-193
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• 2007

We developed the doxorubicin-loaded PLGA double-layered microspheres using relatively simple oil-in-water (O/W) solvent evaporation method for sustained release of doxorubicin and investigated the release behavior according to PLGA molecular weight and initial drug loading. The double-layered microsphere was characterized on the surface, the cross-section morphology, the behavior of doxorubicin release for 5 weeks by SEM and fluorescence spectrophotometer. Double-layered microspheres showed smooth surfaces and clear difference between core and outer-shell. As the PLGA molecular weight increased, the release rate of doxorubicin-loaded, double-layered microspheres decreased. These results showed that the release behaviors can be controlled by the variation of molecular weight of PLGA.

• Journal of the Korean Magnetics Society
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• v.25 no.3
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• pp.83-86
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• 2015

Nowadays the weapon systems are employed air bursting munition (ABM) as smart programmable 40 mm shells which have been developed in order to hit the target with programmed munition that can be air burst after a set distance in the battlefield. In order to improve the accuracy of such a bursting time, by measuring the speed of the munition from the barrel, weapon systems calculate the exact time of flight to the target and then the time information must be inputted to the munition. In this study, we introduce a device capable of detecting a shot at K4 40 mm automatic grenade. The shot is composed of a rotating copper band to convert linear motion into rotary motion when it passes through the barrel, the steel section is exert the effect of fragment and aluminum section to give fuze information. The aluminum section was used to detect munition using eddy current method. To measure muzzle velocity by means of non-contact method, two eddy current probes separated 10 cm was employed. Time interval between two eddy current probe detection times was used as muzzle velocity. The eddy current probe was fabricated U-shape Mn-Zn ferrite core with enamelled copper wire, and 200 kHz alternating current was used to detect inductance change. Measured muzzle velocity using the developed sensor was compared to the Doppler radar system. The difference was smaller than 1%.

• Education of Primary School Mathematics
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• v.14 no.3
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• pp.237-259
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• 2011

Mathematics learning disabilities is a specific learning disorder affecting the normal acquisition of arithmetic and spatial skills. Reported prevalence rates range from 5 to 10 percent and show high rates of comorbid disabilities, such as dyslexia and ADHD. In this study, the characteristics and the causes of this disorder has been examined. The core cause of mathematics learning disabilities is not clear yet: it can come from general cognitive problems, or disorder of innate intuitive number module could be the cause. Recently, researchers try to subdivide mathematics learning disabilities as (1) semantic/memory type, (2) procedural/skill type, (3) visuospatial type, and (4) reasoning type. Each subtype is related to specific brain areas subserving mathematical cognition. Based on these findings, the author has performed a basic research to develop grade specific diagnostic tests: number processing test and math word problems for lower grades and comprehensive math knowledge tests for the upper grades. The results should help teachers to find out prior knowledge, specific weaknesses of students, and plan personalized intervention program. The author suggest diagnostic tests are organized into 6 components. They are number sense, conceptual knowledge, arithmetic facts retrieval, procedural skills, mathematical reasoning/word problem solving, and visuospatial perception tests. This grouping will also help the examiner to figure out the processing time for each component.

• Journal of the Korean Society of Food Science and Nutrition
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• v.30 no.4
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• pp.646-650
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• 2001

In this study, we investigated the thermotropic behavior of Daucus carota L. (DCS) extracts in phosphatidylcholine(PC) liposomes using high-sensitivity differential scanning calorimetry (nano-DSC). We used dipalmitoylphosphatidylcholine (DPPC) bilayers which made most stable liposomes among the other phosphatidylcholine. The sample DCS was extracted and fractionated to four different types, hexane(DCSMH), ethylacetate (DCSMEA), butanol (DCSMB) and aqueous(DCSMA) fractions. Compared to the other fractions of Daucus carota L., the DCSMH and DCSMEA fractions markedly affected the thermotropic properties of DPPC liposomes, broadened and shifted the thermograms of transition to lower temperatures. The incorporation of DCSMH and DCSMEA in DPPC liposomes were preferentially located in the hydrophobic core of DPPC bilayers, where it reduced the lipid packing orderness (cooperative unit) in the gel state compared to it in the liquid-crystalline state. These results suggest that the activities of the Daucus carota L. extracts to enhance the fluidity of the liposomal membrane have implication in their biological activities.

• The Journal of Fisheries Business Administration
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• v.45 no.2
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• pp.39-59
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• 2014

Recently the rapid changes of the social environment make both university and every each department should have to renovate and adjust all of the educational components. The most dominant and issuable change of business administration education is the Business Education Accreditation which was certified by the KABEA(Korean Association of Business Education Accreditation). And the only two department of fisheries business administration which in Gyeongsang National University and Pukyong National University has been accredited recently. Though The department of fisheries business administration in Korea has been influenced by that Accreditation, there is few research and analysis on educational change. So it is very important that research on the curricular constitution and change of the curriculum for considering the its own effect and influence. This paper aims to explore the curricular constitution, change and course fulfillment of fisheries business administration after the business education accreditation based on the case of the department of fisheries business administration in Gyeongsang National University. The analysis of fisheries business administration change will help develop sustainable curriculum and give more guideline for identifying the core of fisheries business administration. The method of analysing that in this research has adopt the social network analysis(SNA) and automated software tool which is the most dominant technique in contents analysis including the Krkwics and Pajek. The SNA is evaluated that most popular, rigorous and firm methodology for analyzing, examining and revising some concepts or objects in the context of semantics. The result of this study shows that the ratio of fisheries business administration class has been decreased but still the most fulfilled course. And English mediated class has been avoided though that sort of the class has been increased. In the view point of course fulfillment, it has been potential and inefficient problems that some classes that including financial related and accounting related class would not been accomplished appropriately. The findings of a graduate depth interview which has been done about 4 years for understanding that student show that there's some recognition gap of fisheries business administration in staffs of human resource management. And the level of job satisfaction in fisheries business still somewhat low and even worse the chance of recruitment also unsteady.

• Journal of the East Asian Society of Dietary Life
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• v.26 no.4
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• pp.346-358
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• 2016

Local food reflects the identity and image of a specific region. It is also a core element for determining tourists' experience of a region. The purpose of the present study was to develop a Jeju food tour package using local foods and estimate the economic value of the suggested tour package using Contingent Valuation Method (CVM). Five food tour packages were developed by researchers. In order to modify and measure the value of each package, an expert panel survey was conducted, and 'package 5' was selected as a food tour scenario for the tourist survey. A survey was conducted on 295 domestic tourists who visited Jeju within the past 10 years in order to evaluate the economic value and feasibility of the Jeju food tour package. A total fo 72.9% of respondents answered that they were willing to pay for the Jeju local food tour, and the willingness to pay (WTP) range was between ￦45,000 and ￦105,000. The primary factors correlated with WTP was food expenses, followed by leisure experience expenses, interest in local foods, education level, visit frequency and age. The WTP of the Jeju local food tour was calculated with the significantly affected factors using stepwise regression model. The result of the present study reveal that tourists' WTP increased with higher food expenses, education level, and age group. The average value of food expenses, education level, and age were substituted into the formula derived from the regression analysis, yielding 58,385.752 KRW as the WTP. The expected economic value created by exploiting the Jeju local food tour was shown to be 700 billion KRW per year, calculated by multiplying WTP of the food tour packages by the number of tourists. This study examined the feasibility and plan of the food tour package to increase the economic value of Jeju local food. In the case of the culinary tour program based on Jeju local food launching, the estimated economic effect was great. Therefore, in-depth research to merchandise the Jeju local food tour program is needed.

• Korean Business Review
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• v.19 no.2
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• pp.23-46
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• 2006

In modern economic societies, individuals are governed by organizations and they managed their daily lives in one way or another. through such organizations. All activities of the organizations are carried out by the job performance of individuals. Job is a very important factor for both individuals and organizations. The study is the explore. the effect of job characteristics and organizational characteristics on the job satisfaction in the small- and medium- sized firms in Namdong und Banwool Area. Job characteristics and organizational justice were hypothesized to be positively related to job satisfaction. To examine the influence of job characteristics and organizational justice on job satisfactions, data were collected from 320 employees of the small- and medium- sized manufacturing companies in Namdong und Banwool Area. This research took independent variables as the core job characteristics of the job characteristic theory such as skill variety, job stagnation, job importance, autonomy, feed back, and organizational justice as distributive and procedural justice. As a result, I can make the following suggestions. First, The Results show that job characteristics and organizational justice were significant and important predictors of job satisfaction. Secondarily, to raise the job desire of organizational members, job must be designed in such a way that the members can highly recognize their job characteristics.

• The Journal of Society for e-Business Studies
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• v.22 no.2
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• pp.19-38
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• 2017

The core of the smartphone business environment is changing from H/W to S/W and with it the paradigm of an enterprise's base of competition is changing from H/W to service. In accordance with this paradigm, in this study we have determined H/W, S/W and telecommunication service as smartphone business factors. The purpose of this study is to first analyze the influence business factors has on consumer satisfaction and customer loyalty. Secondly, to analyze the influence switching cost has on customer loyalty. As a result, the factor that has a notable influence on customer satisfaction turned out to be the H/W factor. On the other hand S/W factor and communication service turned out to have very little influence. In addition, the factors influencing customer loyalty turned out to be H/W factor and S/W factor. Telecommunication service did not have much of an influence. Customer satisfaction turned out to act as mediation effect between H/W factor and customer loyalty. Like the result of other preceding researches, switching cost turned out to have a significant influence on customer loyalty. This study differs from other studies in that while other existing studies analyzed H/W, S/W and communication service separately, this study analyzed the influence H/W, S/W and communication service as a whole has on customer satisfaction and customer loyalty. We speculate that the results of this study would provide some insight both in an academic and practical level for stagnant smartphone industry.

• Journal of Technologic Dentistry
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• v.37 no.3
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• pp.121-127
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• 2015

Purpose: This study was intended to investigate the effect of applying liner for chemical bonding and physical surface roughness created on zirconia by using a sandpaper before sintering on the bond strength between the two materials. Methods: Zirconia blocks were cut using a low-speed cutter. Plate-shaped specimen($6mm{\times}6mm{\times}3mm$) was fabricated by sintering after giving surface roughness according to four kinds of sandpapers. Depending on whether or not to use liner, 60 specimens were divided into two groups ZN(non-liner), ZL(liner), and the two groups were subdivided into four groups respectively in accordance with sandpaper used, totaling eight groups (n=10). The surface roughness (Ra) values and shapes before sintering were observed, and shear bond strength after pressing ceramic plasticity was measured with a universal testing machine. For a test of the significance, a one-way ANOVA was performed, and Tukey's multiple comparison test was conducted. Results: The observation of the surface roughness was SB04($2.22{\pm}1.16{\mu}m$), SB08($2.98{\pm}0.33{\mu}m$), SB12($2.44{\pm}1.32{\mu}m$), SB20($2.34{\pm}0.59{\mu}m$) and SA04($2.34{\pm}0.67{\mu}m$), SA08($1.28{\pm}0.90{\mu}m$), SA12($2.03{\pm}1.60{\mu}m$), SA20($2.19{\pm}1.73{\mu}m$). In the case of ZN Group, the shear bond strength was ZN04($23.26{\pm}3.83MPa$), ZN08($21.76{\pm}2.33MPa$), ZN12($20.49{\pm}3.01MPa$), ZN20($24.98{\pm}4.22MPa$)(p<0.05). As for ZL Group, the shear bond strength was ZL04($25.09{\pm}5.67MPa$), ZL08($22.98{\pm}2.26MPa$), ZL12($21.54{\pm}5.70MPa$), ZL20($23.98{\pm}3.23MPa$)(p<0.05). Conclusion: The research results showed that the bond strength of Zirconia core and Pressing ceramic was further improved by physical surface treatment before sintering, rather than by chemical bonding through liner surface treatment.

• International Journal of Oral Biology
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• v.32 no.4
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• pp.119-125
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• 2007

Dlx3 is a homeodomain protein and is known to play a role in development and differentiation of many tissues. Deletion of four base pairs in DLX3 (NT3198) is causally related to tricho-dento-osseous (TDO) syndrome (OMIM #190320), a genetic disorder manifested by taurodontism, hair abnormalities, and increased bone density in the cranium. The molecular mechanisms that explain the phenotypic characteristics of TDO syndrome have not been clearly determined. In this study, we examined phenotypic characteristics of wild type DLX3(wtDlx3) and 4-BP DEL DLX3 (TDO mtDlx3) in C2C12 cells. To investigate how wtDlx3 and TDO mtDlx3 differentially regulate osteoblastic differentiation, reporter assays were performed by using luciferase reporters containing the promoters of alkaline phosphatase, bone sialoprotein or osteocalcin. Both wtDlx3 and TDO mtDlx3 enhanced significantly all the reporter activities but the effect of mtDlx3 was much weaker than that of wtDlx3. In spite of these differences in reporter activity, electrophoretic mobility shift assay showed that both wtDlx3 and TDO mtDlx3 formed similar amounts of DNA binding complexes with Dlx3 binding consensus sequence or with ALP promoter oligonucleotide bearing the Dlx3 binding core sequence. TDO mtDlx3 exhibits a longer half-life than wtDlx3 and it corresponds to PESTfind analysis result showing that potential PEST sequence was missed in carboxy terminal of TDO mtDlx3. In addition, co-immunoprecipitation demonstrated that TDO mtDlx3 binds to Msx2 more strongly than wtDlx3. Taken together, though TDO mtDlx3 acted as a weaker transcriptional activator than wtDlx3 in osteoblastic cells, there is possibility that during in vivo osteoblast differentiation TDO mtDlx3 may antagonize transcriptional repressor activity of Msx2 more effectively and for longer period than wtDlx3, resulting in enhancement of osteoblast differentiation.