• BMB Reports
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• v.45 no.2
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• pp.85-90
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• 2012

Our previous study demonstrated that CopA3, a disulfide dimer of the coprisin peptide analogue (LLCIALRKK), has antibacterial activity. In this study, we assessed whether CopA3 caused cellular toxicity in various mammalian cell lines. CopA3 selectively caused a marked decrease in cell viability in Jurkat T, U937, and AML-2 cells (human leukemia cells), but was not cytotoxic to Caki or Hela cells. Fragmentation of DNA, a marker of apoptosis, was also confirmed in the leukemia cell lines, but not in the other cells. CopA3-induced apoptosis in leukemia cells was mediated by apoptosis inducing factor (AIF), indicating induction of a caspase-independent signaling pathway.

• Bulletin of the Korean Mathematical Society
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• v.55 no.6
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• pp.1667-1690
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• 2018

We consider the minimum order of a graph G with a given lazy cop number $c_L(G)$. Sullivan, Townsend and Werzanski [7] showed that the minimum order of a connected graph with lazy cop number 3 is 9 and $k_3{\square}k_3$ is the unique graph on nine vertices which requires three lazy cops. They conjectured that for a graph G on n vertices with ${\Delta}(G){\geq}n-k^2$, $c_L(G){\leq}k$. We proved that the conjecture is true for k = 4. Furthermore, we showed that the Petersen graph is the unique connected graph G on 10 vertices with ${\Delta}(G){\leq}3$ having lazy cop number 3 and the minimum order of a connected graph with lazy cop number 4 is 16.

• Korean Journal of Applied Biomechanics
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• v.20 no.4
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• pp.479-486
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• 2010

The purpose of this study was to determine the effects of high-heeled shoe on the quiet standing and gait balance. Twenty women (mean height: $161.6{\pm}3.3\;cm$, mean body mass: $53.8{\pm}6.3\;kg$, mean age: $23.8{\pm}2.7$ yrs..) who were without history or complain of lower limb pain took part in this study. They were asked to stand quietly on a force platform for 30 sec and walk on it at their preferred walking speed (mean speed $3.14{\pm}0.5\;km/hr$.) with wearing three different high-heeled shoe, 3, 7, 9 cm high for collecting data. Data were randomly recorded to collect two trials for quiet standing and five trials for walking The parameters to have been analyzed for comparison between three conditions of the height of high-heeled shoe were COP(Center of Pressure) range, COP velocity, sway area, and free moment on the static balance and COP range, COP velocity, and free moment on the dynamic balance. In this study, high-heel height affected on the COP range and velocity in the ante-posterior direction during walking, dynamic balance, but didn't affect on the quiet standing, static balance.

• The Korean Journal of Mycology
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• v.35 no.1
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• pp.1-10
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• 2007

The cell wall is essential for the survival and osmotic integrity of fungal cells. It is the framework to which biologically active proteins such as cell adhesion molecules and hydrolytic enzymes are attached or within which they act. Recently it was shown that mutations in ${\alpha}-COP$, a subunit of COPI vesicle, is responsible for the thermo-sensitive osmo-fragile phenotype of fungi, such as Saccharomyces cerevisiae and Aspergillus nidulans, and suggested that ${\alpha}-COP$ may play a crucial role in translocation of protein(s) of the ${\beta}-1,3-gulcan$ synthase complex and cell wall proteins, thus may contribute to the maintenance of cell wall integrity. In this review, we summarized the relationship between the intra-cellular protein translocation machinery, especially the ${\alpha}-COP$ of COPI vesicle, and cell wall biogenesis in fungi. We also discussed potential use of secretory mutants in basic and applied research of the fungal cell walls.

• Korean Journal of Applied Biomechanics
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• v.22 no.3
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• pp.261-268
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• 2012

The purpose of this study was to qualitatively analyze pressure intensity and the center of pressure(COP) trajectory according to shoe type. Subjects were ten first-year female university students. The EMED-AT 25/D(Novel, Germany) was used to measure pressure intensity and COP trajectory. The COP Excursion Index(CPEI) was used for within subject test design. Independent variables were bare feet and six types of shoes. Dependent variables were center of pressure trajectory and pressure intensity. Barefeet and five toed shoes had a similar pressure intensity and COP trajectory. COP trajectory for all other shoe types showed a medial wobble at the heel. Pressure intensity for all other shoe types was related to the structure of the shoes. In conclusion, different shoe types can not only affect gait, but they can also influence foot deformities, pain, and dysfunction.

• Korean Journal of Applied Biomechanics
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• v.32 no.3
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• pp.80-86
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• 2022

Objective: The purpose of this study was to investigate the effects of three rotational jump conditions (standing jump, left rotational jump and right rotational jump) on stability through center of pressure (COP) and EMG variables analysis. Method: A total of 16 college students (age: 24.13 ± 7.17 years, height: 169.24 ± 8.23 cm, weight: 65.65 ± 13.88 kg) participated in this study. The study used wireless two COP plates and wireless eight channel EMG. The analyized variables were 11 variables for COP and RMS for EMG, which were analyzed using one-way analysis of variance with repeated measures according to three rotational jump conditions. Results: Among the COP variables, left rotational jump (LRJ) and right rotational jump (RRJ) were larger than standing jump (SJ) for left and right amplitude, area, total displacement, and average velocity for both feet among the variables of COP, and for area of the left foot, RRJ was larger than that of SJ. Among the EMG variables, there was no statistical difference between the muscle activations, but the muscle activity was significantly higher in the order of RRJ, LRJ, and SJ according to direction of rotation. Conclusion: Although the results of COP and EMG were not consistent through this study, it can be expected that the differences in COP was due to the amount of rotation during rotational jump-landing in the left and right directions, and that the EMG is determined by the lateral movements required for rotation.

• Journal of the Ergonomics Society of Korea
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• v.36 no.5
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• pp.395-409
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• 2017

Objective: The purpose of this study was to optimize the number and positions of foot pressure sensors using the reliability analysis of the center of pressure (COP) in smart shoes. Background: Foot pressure can be different according to foot region, and it is important which region of the foot pressure needs to be measured. Method: Thirty adults (age: $20.5{\pm}1.8years$, body weight: $71.4{\pm}6.5kg$, height: $1.76{\pm}0.04m$) participated in this study. The foot pressure data were collected using the insole of Pedar-X system (Novel GmbH, USA) with a sampling frequency of 100Hz during 1.3m/s speed walking on the treadmill (Instrumented treadmill, Bertec, USA). The intraclass correlation coefficients (ICC) were calculated between the COP positions using 4, 5, 6, 7, 8, and 99 sensors, while one-way repeated measure ANOVA was performed between the standard deviation (SD) of the COP positions. Results: The medio-lateral (M/L) COP position using 99 sensors was positively correlated with the M/L COP positions using 6, 7, and 8 sensors; however, it was not correlated with the M/L COP positions using 4 and 5 sensors during landing phase (1~4%) (p<.05). The antero-posterior (A/P) COP position using 99 sensors was positively correlated with the A/P COP positions using 4, 5, 6, 7, and 8 sensors (p<.05). The SD of the COP position using 99 sensors was smaller than the SD of the M/L COP positions using 4, 5, 6, 7, and 8 sensors (p<.05). Conclusion: Based on our findings, it is desirable to arrange at least 6 sensors in smart shoes. Application: The study of optimizing the number and positions of foot pressure sensors would contribute to developing more effective smart shoes using foot pressure technology.

• The Journal of Korean Physical Therapy
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• v.35 no.5
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• pp.156-161
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• 2023

Purpose: This study examined the effects of subjective visual vertical perception and head orientation on static balance control. Methods: The subjects were 25 young and healthy adults. The vertical perception was measured using a subjective visual vertical (SVV), and the Center of pressure (COP) parameter was analyzed by continuously measuring the movement of the COP to determine the changes in static postural control. The group was divided based on a deviation of 3° in SVV (11 of SVV≥3°, 14 of SVV<3°) and measured with different head orientations: front, up, down, left, and right in the upright and tandem positions, respectively. Results: In the upright position, the SVV≥3° group had significantly larger values for all COP parameters (Sway length, Surface, Delta X, Delta Y, and Average speed) compared to the SVV<3° group (p<0.05). In the tandem stance, only the Ellipse Surface value was significantly larger among the COP parameters in the group with SVV≥3° compared to the group with SVV<3°(p<0.05). In contrast, the other COP parameters were not significantly different (p>0.05). The effects of static balance control on the head orientation were not statistically significant (p>0.05), and the interactions between the subjective vertical perception and head orientation were not significant (p>0.05). Conclusion: These results suggest that pathological deviations in SVV are associated with impaired static balance performance. This study can provide a therapeutic rationale for using visuospatial cognitive feedback training to improve the static balance.

• 한국신재생에너지학회:학술대회논문집
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• 2011.05a
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• pp.202-202
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• 2011

Performance of the raw water-source heat pump system with a thermal storage tank has been analyzed in winter season. The raw water is transferred through the multi-regional water supply system from Han river. Raw water is large temperature difference resource compared with groundwater. Although the raw water temperature drops to $0.6^{\circ}C$ due to the heavy snowfall and the severe cold in late January and early February, 2010, the system has been normally operated without any trouble this winter. The unit COP and system COP considered all pump power consumption were estimated based on the second-by-second data of the all sensors. The monthly averaged unit COP and system COP are 3.37 and 2.76 respectively with $1.4^{\circ}C$ of raw water in January, 3.55 and 2.89 with $1.6^{\circ}C$ raw water in February, 3.82 and 3.15 with $5.4^{\circ}C$ raw water in March. The performance of the system are increased with raw water temperature, and the COPs are higher than the water-to-air heat pump system using relatively high temperature raw water from Daecheong reservoir because the water-to-water system was operated on the full load condition and was stopped when the thermal storage tank was full of the high temperature water.

• The Journal of Korean Physical Therapy
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• v.21 no.3
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• pp.75-80
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• 2009

Purpose: The purpose of this study was to examine the effect of an obstacle height on the balance control of older adults while stepping over an obstacle from a position of quiet stance. Methods: Fifteen community-dwelling healthy older adults (mean age, $74.4\pm4.27$ yrs; age range, 67-82 yrs) volunteered to participate in this study. The subjects performed gait initiation (GI) and they stepped over obstacles of two different heights (10 cm and 18 cm) at a self-paced speed from a position of quiet stance. Their performance was assessed by recording the changes in the displacement of the COP in the anteroposterior (A-P) and mediolateral (M-L) directions using a force platform. Results: The M-L displacement of the COP significantly increased for an 18 cm obstacle height condition as compared to the GI and a 10 cm obstacle height condition (p<0.01). Furthermore, the M-L displacement of the COP for a 10 cm high obstacle was significantly greater for that for the GI (p<0.01). However, the mean of the A-P displacement of the COP was similar between the stepping conditions for the A-P displacement of the COP (p>0.05). Conclusion: This study suggests that the M-L COP displacement could be a better parameter to identify the dynamic balance control in older adults when negotiating obstacles.