• 제목/요약/키워드: Cooling Therapy

검색결과 45건 처리시간 0.028초

항암작용(抗癌作用)이 있는 동물류(動物類)에 대(對)한 문헌적(文獻的) 고찰(考察) (Investigation of Literature Refered to the Animal of Anti-cancer)

  • 임낙철;로석선;강승원
    • 대한한의학회지
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    • 제16권2호
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    • pp.149-176
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    • 1995
  • The results were as follow: 1. In classification of the virulence of medicines, it is the virulent animal that have a deadly poison and the rest is the animal of weak nor non-toxic. 2. In classification of the channel distribution, the most is the medicine that belongs to liver channel, the next are the stomach, lung, kidney and spleen channel. 3. In classification of four characters, the most parts are cool, common and warm medicine and there is a few that is hot and cooling. 4. In classification of five tastes, the most numerous tastes are sweet and salty and the next are acrid, bitter and sour tastes. 5. In classification of the medical action, there are few medicine of invigorating vital energy, tonic therapy and astringent and a great part of the medicine are regulating vital energy and blood, removing blood stasis and mass, clearing away heat-evil and eliminating sputum, calming the river to inhibit the wind-evil and pain control. 6. In classification of the application of cancer, the most numerous disease is the liver cancer and the next are stomach cancer, esophageal cancer, lung cancer, leukemia, uterine cancer,mastitis, brain tumor.

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탈모의 한의학적 치료에 대한 국내 현황 : 증례보고를 중심으로 (The Current Status of Korean Medicine Treatment of Alopecia : Focusing on Case Reports)

  • 권소현;홍석훈
    • 한방안이비인후피부과학회지
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    • 제32권3호
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    • pp.164-185
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    • 2019
  • Objectives : This study is carried out to analyze the use of Korean medical treatments on alopecia in Korean medicine clinical studies published in South Korea. Methods : Based on OASIS and KTKP with the keyword 'alopecia', published in 1996-2019.4.23., total 23 studies have been found and analyzed. We analyzed Korean medical treatment used in each cases, and investigated the tendency of use for each treatment. Results : 369 cases in 23 research papers were selected. Herbal medicine, acupuncture, pharmacopuncture, external medicine and other therapy were used as treatment for Alopecia. Herbal medicine with a cooling effect was mainly used. The acupoints mainly used were GV20, ST8, GB5, ST36, HT8, PC6, BL66. Pharmacopunctures used to treat alopecia were CF, HP, HH, BV, etc. The average duration of Korean medicine treatment was 144 days. After Korean medicine treatment, 292 cases presented improvement or complete recovery. Conclusions : According to the results, we were able to discover the current status of Korean medicine treatment of alopecia. Based on this result, further studies will be needed to establish the primary treatment direction of alopecia.

한의학의 항종양 면역치료에 관한 연구 -1990년 이후 발표된 실험논문을 중심으로- (Compilation of 104 Experimental Theses on the Antitumor and Immuno-activating therapies of Oriental Medicine)

  • 강연이;김태임;박종오;김성훈;박종대;김동희
    • 동의생리병리학회지
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    • 제17권1호
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    • pp.1-24
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    • 2003
  • This study was done to compile 104 experimental theses which are related to the antitumor and immuno-activating therapies between February 1990 through February 2002. Master's and doctoral theses were dassified by schools, degrees, materials, effects, experimental methods of antitumor and immunoactivity, and results. The following results were obtained from this study : 1. Classifying the theses by the school, 34.6% were presented by Daejeon University, 29.8% by Kyung-hee University and 11.5% by Won-kwang University. Of all theses, 51.0% were aimed for the doctoral degree and 43.3% were for the master's degree. All of three universities have their own cancer centers. 2. Classifying the theses by herb materials, complex prescription accounted for 60.3%, single herb accounted for 24.8% and herbal acupuncture accounted for 14.2%. Considering the key principles of the traditional medicine, complex prescription was much more thoroughly studied than single herb prescription. The results showed that the complex prescription had both antitumor activity and immuno-activating activity, which might reflects on multi-activation mechanisms by complex components. 3. Classifying the theses by the efficacy of herbs examined, in single herb, invigorating spleen and supplementing was 35.5%, expelling toxin and cooling was 29.0%, activating blood flow and removing blood stasis was 12.9%. In herbal acupuncture, invigorating spleen and supplementing was 52.9%, expelling toxin and cooling was 29.4%. In complex prescription, pathogen-free status was 41.9%, strengthening healthy qi to eliminate pathogen was 35.5%, strengthening healthy qi was 22.6%. It is presumed that the antitumor and immunoactivating therapy based on syndrome differentiation is the best way to develop oriental oncology. 4. Classifying the theses by antitumor experiments, cytotoxic effect was 48.1 %, survival time was 48.1 % and change of tumor size was 42.3%. Survival rate was not necessarily correlated with cytotoxicity. These data reflect the characteristic, wholistic nature of the oriental medicine which is based on BRM (biological response modifier). 5. Classifying the theses by immunoactivating experiments, hemolysin titer was 51.0%, hemagglutinin titer was 46.2% and NK cell's activity was 44.2%. In the future studies, an effort to elucidate specific molecular and cellular mechanisms of cytokine production in the body would be crucial. 6. Classifying the theses according to the data in terms of antitumor activity, 50% was evaluated good, 24.0% was excellent, and 15.5% have no effect. In an evaluation of immuno-activating activity, 35.9% was excellent and 18.0% showed a little effect. The index point, as described here, may helps to use experimental data for clinical trials. Changes in index points by varying dosage implicate the importance of oriental medical theory for prescription. 7. In 167 materials, IIP (immunoactivating index point, mean : 3.12±0.07) was significantly higher than AIP(antitumor index point, mean : 2.83±0.07). These data demonstrate that the effect of herb medicine on tumor activity depends more on immunoactivating activity than antitumor activity. This further implies that the development of herbal antitumor drugs must be preceded by the mechanistic understanding of immunoactivating effect. 8. After medline-searching tumor and herb-related articles from NCBI web site, we conclude that most of the studies are primarily focused on biomolecular mechanisms and/or pathways. Henceforth, we need to define the biomolecular mechanisms and/or pathways affected by herbs or complicated prescriptions. 9. Therefore, the most important point of oriental medical oncology is to conned between experimental results and clinical trials. For the public application of herbal therapy to cancer, it is critical to present the data to mass media. 10. To develop the relationship of experimental results and clinical trials, university's cancer clinic must have a long-range plan related to the university laboratories and, at the same time, a regular consortium for this relationship is imperative. 11. After all these efforts, a new type herbal medicine for cancer therapy which is to take care of the long-term administering and safety problem must be developed. Then, it would be expected that anti-tumor herbal acupuncture can improve clinical symptoms and quality of life (QOL) for cancer patients. 12. Finally, oriental medical cancer center must be constructed in NCC (National Cancer Center) or government agency for the development of oriental medical oncology which has international competitive power.

TOMO 치료 시 체온 유지를 위한 물질 사용에 따른 조직 내 선량 변화 평가 (In Tomotherapy, for the Maintenance of Body Temperature due to Substance Use, Changes in Dose Assessment in the Organization)

  • 황재웅;정도형;김대웅;양진호;최계숙
    • 대한방사선치료학회지
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    • 제22권2호
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    • pp.131-134
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    • 2010
  • 목 적: TOMO 치료는 일반 방사선 치료와 달리 상대적으로 긴 Beam time과 온도에 민감한 CT 검출기 등으로 치료실 내 적정온도($20{\sim}21^{\circ}$)를 유지하기 위하여 자체 Cooling system 이외에도 항온 항습기를 작동시키고 있다. 이로 인해 TOMO 치료실 내 온도가 저하되어 환자들의 체온 유지를 위해서 치료 부위에 이불 등을 덮어준다. 따라서 이러한 물질들이 조직 내 선량에 어떠한 변화를 주는지 알아보고자 한다. 대상 및 방법: 조직 내 선량변화를 비교하기 위하여 치즈팬텀(Cheese Phantom)을 사용하였고, CT-simulation 촬영 후 치즈팬텀의 중심점을 PTV (Planning Target Volume, 치료계획 표적 용적)로 설정하여 Daily dose 200 cGy, 3회의 치료계획을 세웠다. PTV, PTV+7 cm, PTV+14 cm, 총 세지점에서 Ion chamber를 사용하여 팬텀에 아무 물질도 덮지 않은 상태에서 선량을 측정하고, 치료 중 가장 많이 사용하는 이불을 포함한 빈번하게 사용하는 4가지 물질(방포 0.8 mm, 가운 1.4 mm, 담요 3.3 mm, 이불 13.7 mm)을 팬텀에 덮었을 때의 선량을 동일한 위치에서 각각 3회 측정하여 비교 분석하였다. 결 과: PTV, PTV+7 cm, PTV+14 cm 지점에서 아무물질도 덮지 않은 상태에서 측정한 결과와 4가지 물질(방포, 가운, 담요, 이불)을 덮은 상태에서 측정한 결과를 비교해본 결과, PTV에서 각각 -0.17%, -0.44%, -0.53%, -0.9% 변화하였고, PTV+7 cm에서 각각 -0.04%, +0.07%, +0.06%, +0.07% 변화하였고, PTV+14 cm에서 각각 0%, -0.06%, -0.02%, +0.6% 변화하였다. 결 론: 본 실험 결과 TOMO 치료 시 환자들의 체온 유지를 위하여 사용하는 물질에 의해 PTV에서는 물질의 두께에 비례하여 감소하는 것으로 나타났다. 그러나 PTV+7 cm 지점에서는 미세한 변화를 보였고, PTV+14 cm 지점에서 선량은 조금 증가하는 것으로 나타났다. 세지점 모두 그 차이가 치료 허용오차 범위인 ${\pm}3%$로 안에 들어오는 것으로 확인이 되어 치료효과에는 큰 영향을 미치지 않을 것으로 사료된다.

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전환장애(轉換障碍)로 입원(入院)한 환자(患者) 41례(例)에 대(對)한 임상적(臨床的) 고찰(考察) (Clinical Study for Conversion Disorder in 41 Admission Cases)

  • 김명진;최병만;이상룡
    • 동의신경정신과학회지
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    • 제11권2호
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    • pp.131-140
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    • 2000
  • The clinical study was carried out the 41 patients with conversion disorder who were treated in Dae Jeon University Oriental Hospital from 26 september 1998 to 21 september 2000.The results were summarized as follows.1. The ratio of male and female was 4:37 and in the age distribution, the highest frequence was 40s, in descending order over 50s, 30s, 20s, 10s and mental attack was the most inducing factor.2. In distribution of the period of the clinical history. within one day was the highest percentage and in admission period most of the patients were from four days to seven days.3. In symptoms and signs, physical symptoms were more than mental symptoms, physical symptoms had many muscle-skeleton-system symptoms and they were in descending order general body weakness. headache, anorexia, chest discomfort, dyspepsia, dizziness, four extremities numbness, insomnia, dysarthria, anxiety, four extremities tremor. palpitation. nausea, vomiting, facial numbness.4. In classification of Four Human coporeal constitution the number of patients, Sho-Eum-In(少陰人) was remarked mostly and most of female patients had no past history of the conversion disorder.5. In distribution of the prescription, drugs of regulating gi such as BUNSIMGIEUM(分心氣飮) were many, in descending order drugs of growing heart and warming gall bladder such as ONDAMTANGGAMI(溫膽湯加味), drugs of maintaining patency for the flow of gi such as CHUNGGANSOYOSAN(淸肝逍遙散), drugs of decomposing food and asending gi such as PYUNGJINGUNBITANG(平陳健脾湯), drugs of storing blood and relaxing the mind such as SAMULGUIBITANG(四物歸脾湯). drugs of removing sputum and cooling heart such as CHUNGSIMDODAMTANG 淸心導痰湯).6. In distribution of the treatments, the group of drug and acupuncture and aroma-therapy was many, in acup uncture TAEGUKCHIMBUP(太極針法) was mainly used. in therapy inhalation type of Lavender and Rosewood was many and the type of Peppermint and Rosemary massaging epigastric-chest, and neck was many.7. In distribution of the treatment result, in 15 patients(36.6%) symptoms were eliminated from four to seven days, in 13 patients(31.7%) symptoms were not changed. in 12 patients(29.3%) symptoms were eliminated from two to three days. in 1 patients(2.4%) symptoms were eliminated whin one day.

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초음파에 의한 전완 국소 온도와 정중 운동 신경전도 속도의 변화 (Alteration of Forearm Local Temperature and Median Nerve Conduction Velocity by Therapeutic Ultrasound in Healthy Adult Subjects)

  • 전차선;김택연
    • 대한정형도수물리치료학회지
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    • 제12권1호
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    • pp.37-43
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    • 2006
  • PURPOSE: Previous studies have documented the lack of ultrasound's non-thermal effects on nerve conduction using frequencies of 1 MHz and 870 kHz. The purpose of this study was to determine the biophysical effects of continuous ultrasound on median local forearm temperature and motor nerve conduction velocities using frequencies of 3.0 MHz. SUBJECTS: Twelve healthy subjects (6 males, 6 females, age $22.30{\pm}2.41$ yrs, weight $61.33{\pm}10.16$ kg, height $167.58{\pm}8.04$ cm) without a history of neurological or musculoskeletal injury to their dominant arm volunteered for this study. METHODS AND MATERIALS: Each subject received a total of five treatments, one each at .0, 0.5, 1.0, 1.5, 2.0 W/$cm^2$ of 3 MHz continuous ultrasound on the anterior surface of the middle area of dominant forearm for 10 minutes. Dependent measures for forearm local temperature and median motor nerve conduction velocity (MNCV) were taken pretreatment and immediately post-treatment. One-way ANOVA were used for each dependent measure. RESULTS: The posttreatment forearm local temperature were differed significantly (p<0.001) between intensities of ultrasound. The posttreatment forearm local temperature of the ultrasound treated with 1.0 w/$cm^2$, 1.5 w/$cm^2$ and 2.0 w/$cm^2$ were significantly higher than 0.5 w/$cm^2$ and 0.0 w/$cm^2$ of ultrasound (p<0.05). The posttreatment median MNCV were differed significantly from the respective pretreatment velocities (p<0.001). The MNCV of the ultrasound treated with 0.0 w/$cm^2$ and 0.5 w/$cm^2$ were significantly (p<0.05) slower than that observed pretreatment, while the three ultrasound intensities produced significantly increased posttreatment MNCV: 1.0 w/$cm^2$ and 1.5 w/$cm^2$ and 2.0 W/$cm^2$. The posttreatment MNCV at 2.0 w/$cm^2$ and 1.5 w/$cm^2$ was significantly faster than that at 0 w/$cm^2$, 0.5 w/$cm^2$ and 1.0 w/$cm^2$ (p<0.05), the MNCV at 1.0 w/$cm^2$ was significantly faster than that associated with 0 w/$cm^2$ and 0.5 w/$cm^2$ of ultrasound (p<0.05). CONCLUSIONS: The decreased median motor forearm local temperature and MNCV of the ultrasound treated with 0.0 w/$cm^2$ and 0.5 w/$cm^2$ were attributed to the cooling effect by ultrasound transmission gel. Local forearm temperature and nerve conduction velocity were directly related to the intensity of ultrasound. Alterations in MNCV from ultrasound on healthy nerves appeared to be related to temperature changes induced by thermal effects of ultrasound.

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종양의 온열치료를 위한 마이크로잔 조사장치의 제작과 응용 (Fabrication of Microwave Applicator for Hyperthermia and Thermal Distribution in Tissues)

  • 추성실;이종태;김귀언
    • Radiation Oncology Journal
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    • 제2권1호
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    • pp.11-20
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    • 1984
  • The renewed interest in the use of hyperthermia in cancer therapy is bases on radiobiological and clinical evidence indicated that there may be a significant therapeutic advantage with the use of heat alone or combined with radiation or chemotherapy, There are many methods for generating heat for localized tumor as like radiofrequency, microwave, electromagnetic induction and ultrasound. But it is very difficult to be even thermal dose distribution and stable output of power and then the detection of temperature in tumor is difficult to be precise with thermocouples and semiconductor sensors. We designed the microwave heating generator, dipole antenna applicators and autometic temperature controlled thermocouples for localized hyperthermia on skin and in cavities. 1. The microwave generator with 120 W, 2,450MHz magnetron could be heating up to $40^{\circ}C\~50^{\circ}C\;for\;1\~2$ hours in living tissues. 2. The thermal dose distribution in tissue with microwave was described $42^{\circ}C\~44^{\circ}C$ with in 3 cm depth and $2\~6cm$ diameter area. 3. Skin surface heating applicator with spiral 3 times wave length antenna radiated high Power of microwave. 4, Intracavitary heating applicator with dipole antenna with autometic control temperature sensor kept up continuously constant temperature in tissue. 5. For constant thermal distribution, applied two steps power with 10W microwave after $17\~20W$ during first 10 minutes. 6. The cooling rate by blood flew in living tissue was rised as $10\%$ then meats.

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동결 보호제(DMSO) 농도에 따른 돼지 중간엽 줄기세포의 Caspase 3과 7 발현 (Activation of Caspase-3 and -7 on Porcine Bone Marrow Derived Mesenchymal Stem Cells (pBM-MSCs) Cryopreserved with Dimethyl Sulfoxide (DMSO))

  • 옥선아;노규진
    • 한국수정란이식학회지
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    • 제27권3호
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    • pp.183-187
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    • 2012
  • Adult stem cell transplantation has been increased every year, because of the lack of organ donors for regenerative medicine. Therefore, development of reliable and safety cryopreservation and bio-baking method for stem cell therapy is urgently needed. The present study investigated safety of dimethyl sulfoxide (DMSO) such as common cryoprotectant on porcine bone marrow derived mesenchymal stem cells (pBM-MSCs) by evaluating the activation of Caspase-3 and -7, apoptosis related important signal pathway. pBM-MSCs used for the present study were isolated density gradient method by Ficoll-Paque Plus and cultured in A-DMEM supplemented 10% FBS at $38.5^{\circ}C$ in 5% $CO_2$ incubator. pBM-MSCs were cryopreserved in A-DMEM supplemented either with 5%, 10% or 20% DMSO by cooling rate at $-1^{\circ}C$/min in a Kryo 360 (planner 300, Middlesex, UK) and kept into $LN_2$. Survival rate of cells after thawing did not differ between 5% and 10% DMSO but was lowest in 20% DMSO by 0.4% trypan blue exclusion. Activation of Caspase-3 and -7 by Vybrant FAM Caspase-3 and -7 Assay Assay Kit (Molecular probes, Inc.OR, USA) was analyzed with a flow cytometer. Both of cryopreserved and control groups (fresh pBM-MSCs) were observed after the activation of Caspase-3 and -7. The activation did not differ between 5% and 10% DMSO, but was observed highest in 20% DMSO. Therefore 5% DMSO can be possibly used for cell cryopreservation instead of 10% DMSO.

Effect of Lithospermi Radix on Contact Dermatitis Induced by Dinitrofluorobenzene in Mice

  • Kim, Han-Na;Kim, Mi-Young;Choi, Chan-Hun;Kim, Byung-Joo;Kim, Kyung-Yoon;Kim, Gye-Yeop;Jeong, Hyun-Woo;Kim, Hyung-Woo
    • 대한약침학회지
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    • 제15권2호
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    • pp.7-10
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    • 2012
  • Objectives: The root of Lithospermum erythrorhizon Sieb. et Zucc. (Lithospermi Radix, LR) is a kind of heat clearing and blood cooling medicinal herbs. It can clear away heat and cool the blood, reduce toxins and disperse maculae. LR has long been used as efficacious therapy for inflammation, burns, frostbite and skin diseases such as eczema and psoriasis. Methods: In the present study, we investigate anti-allergic and anti-inflammatory effects of LR by using the 1-fluoro-2, 4- dinitrofluorobenzene (DNFB)-induced contact dermatitis mouse model. Results: Topical application of 10 mg/mL of LR effectively inhibited skin lesions induced by repeated paintings with DNFB. Topical application of LR also inhibited hyperplasia, edema, spongiosis and infiltrations of mononuclear cells. In addition, production levels of total immunoglobulin and IgG1 in serum were decreased by using LR in vivo. Conclusions: These data suggest that LR acts as an antiinflammatory agent, improving skin lesions in CD mice.

환기시스템의 굴절 및 평판형 열교환기 형상에 따른 성능비교 (A Comparison of Performance on the Orthogonal and Refraction Heat Exchanger Shape in Air Ventilation System)

  • 현형호;정병호;김지원;이강연
    • 한국융합학회논문지
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    • 제10권7호
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    • pp.281-287
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    • 2019
  • 최적의 환기시스템 활용과 에너지 절약을 위한 급 배기공기 간의 열교환을 적용시킨 열회수시스템의 활용과 보급은 에너지관리시스템에서 필수적이다. 이러한 기술은 특히, 겨울철과 여름철의 냉난방에너지를 절약할 수 있어 고효율에너지 빌딩의 기반기술의 주요 요소이다. 본 논문에서는 균일한 형상과 동일한 유동조건에서 열교환기 성능을 비교하기 위해 종이, 플라스틱, 알루미늄을 재질로 시뮬레이션을 통한 열전달효율을 검토하였다. 또한 평판형과 굴절형 구조를 갖는 열교환기의 형상에 따른 열전달 효율을 시험하였고, 그 결과를 토대로 열전달 성능과 압력손실에 대해 고성능의 열교환기를 제작하는데 기여를 할 수 있을 것으로 기대된다.