• 생약학회지
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• 제46권3호
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• pp.260-267
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• 2015

Advanced glycation end products (AGEs) have been postulated to play a central role in the development of diabetic complications. A variety of different agents that inhibit AGEs have been under investigation. In this study, 111 herbal medicines from China have been investigated with an in vitro evaluation system using AGEs formation inhibitory activity. Of these, 9 herbal medicines (IC₅₀: <5 μg/ml) were found to have significant AGEs formation inhibitory activity. Particularly, herbal medicines Barleria cristata (leaves), Calotropis gigantea (stems), Ardisia virens (leaves), Dalbergia yunnanensis (leaves) Pittosporum runcatum (leaves), Ardisia japonica (leaves), Rhododendron racemosum (twigs), Oxyria sinensiss (aerial parts), Pyrrosia calvata (whole plants), showed more potent inhibitory activity (approximately 15-40 fold) than the positive control aminoguanidine (IC₅₀: 76.47 μg/ml).

• 생약학회지
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• 제47권4호
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• pp.312-318
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• 2016

Advanced glycation end products (AGEs) such as $N^{\varepsilon}$-(carboxy-methyl)lysine (CML) have been implicated in the development of diabetic nephropathy. The aim of this study was to investigate the inhibitory effects of ethanolic extract of Aster koraiensis (AKE) on AGEs formation and AGEs-collagen cross-linking in vitro and CMLs formation in streptozotocin (STZ)-induced diabetic rats. AKE significantly inhibited AGEs formation ($IC_{50}$ value of $18.74{\mu}g/mL$) and AGEs-collagen cross-linking ($IC_{50}$ value of 0.274 mg/mL) in vitro than the well-known glycation inhibitor aminoguanidine ($IC_{50}$ value of $72.12{\mu}g/mL$ and 1.99 mg/mL, respectively). AKE (100 mg/kg per day) was given to diabetic rats for 9 weeks. In STZ-induced diabetic rats, severe hyperglycemia was developed, and urinary CMLs and plasma CMLs were markedly increased. Immunohistochemical stain revealed that CMLs were accumulated within renal glomerulus in STZ-induced diabetic rats. However, AKE significantly reduced urinary CMLs and plasma CMLs in diabetic rats. CMLs accumulation was inhibited by AKE treatment in the renal glomerulus. These results suggest that AKE had an inhibitory effect of AGE accumulation in the glomeruli of diabetic rat and could be an inhibitor of AGE-induced protein cross-linking. The oral administration of AKE may significantly help to prevent the progression of diabetic nephropathy in patients with diabetes.

• 생약학회지
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• 제46권3호
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• pp.250-259
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• 2015

Advanced glycation end products (AGEs) have been implicated in diabetic complications. In this study, the inhibitory effect on AGEs formation of 156 Korean herbal medicines has been evaluated. Among them, 15 Korean herbal medicines were showed to have significant effect (IC₅₀: <10 μg/ml) compared to positive reference, aminoguandine (IC₅₀: 76.47±4.81 μg/ml). Especially, four herbal medicines, Alnus firma (leaves, IC₅₀: 3.25±0.10 μg/ml), Juncus decipiens (whole plants, IC₅₀: 4.30±0.44 μg/ml), Smilax china (stems, IC₅₀: 3.55±0.21 μg/ml), and Vicia amoena (Aerial parts, IC₅₀: 4.25±0.06 μg/ml) showed more potent inhibitory activity approximately 8-24 fold) than the positive control aminoguanidine.

• 생약학회지
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• 제46권3호
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• pp.268-278
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• 2015

In this study, 80 herbal medicines from Vietnam have been investigated with an in vitro evaluation system using advanced glycation end products (AGEs) formation inhibitory activity. Of these, 10 herbal medicines (IC₅₀: <5 μg/ml) were found to have significant AGEs formation inhibitory activity. Particularly, herbal medicines Strobilanthes pateriformis (aerial parts), Rhodamnia dumetorum (twigs), Glochidion rubrum (twigs), Dipterocarpus obtusifolius (twigs), Bombax ceiba (twigs), Amesiodendron chinense (twigs), Bauhinia coccinea (twigs), Lithocarpus laouanensis (twigs), Bauhinia bracteata (twigs) and Connarus paniculatus (twigs), showed more potent inhibitory activity (approximately 16-31 fold) than the positive control aminoguanidine (IC₅₀: 76.47 μg/ml).

• 디지털융복합연구
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• 제13권7호
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• pp.349-357
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• 2015

미디어융복합 시대에서 거대캐릭터는 다양한 SF영화와 게임콘텐츠에서 많이 활용하고 있는 상황이며, 흥행에 성공하고 있는 대부분의 콘텐츠에 거대캐릭터의 차용은 불가결한 요소라고 사료된다. 본 연구에서는 SF영화와 게임에 등장하는 거대캐릭터를 정의하고, 거대캐릭터를 선별하여 외적특성과 내적특성 등 8가지로 분류하고 분석하였다. 외적특성으로는 모양, 실루엣, 크기, 색상으로 분류하였으며, 내적특성으로는 공포감, 악마성, 이미지 및 스토리 지향점, 유희성으로 분류하여 정의하였다. 이와 같은 8가지 특성을 근거로 SF영화와 게임 사례 분석을 통해 '거대캐릭터의 포지셔닝 모형'을 제안하였다. 거대캐릭터 포지셔닝 모형의 요소에는 어두움, 거대함, 비정형, 인간형, 동물형, 공포감, 악마성, 스토리 지향, 이미지 지향 및 유희성으로 구분하였으며, SF영화와 게임을 이 모형에 적용하여 제안하였다.

• 산업융합연구
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• 제11권1호
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• pp.31-44
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• 2013

This study was to identify the relationships among the autonomy, job stress, and job performance of nurses. For general characteristics, there was no difference was a difference in the job stress of the subjects in accordance with their ages and clinical nursing career. In conclusion, in order to enhance nursing specialty by offering qualitative nursing, To amerliorate job performance, it is necessary to improve the autonomy of nurses and to manage their job stress properly.

• Journal of Yeungnam Medical Science
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• 제34권1호
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• pp.1-10
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• 2017

The life history of man is summarized as a birth-aging-disease-death. Man eventually ages and dies. How long can humans live? What is aging? Why do we age? Is aging inevitable? Can we rejuvenate? Recent researches on biological aging suggest that humans might overcome aging and rejuvenate. In this paper, we review the biologic characteristics of aging and the latest results of biological aging research, implicating that aging can be controlled, further treated, and that humans can ultimately be rejuvenated.

• 디지털융복합연구
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• 제17권6호
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• pp.69-75
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• 2019

본 연구는 동양적 문화가치관과 서양적 문화가치관을 반영한 온라인 광고에 대한 반응이 연령별, 성별로 어떤 차이를 보이는 가를 검증하기 위한 목적으로 실시되었다. 서울에 거주하고 있는 10대에서 60대 남녀 180명을 대상으로 3가지 동양적 문화가치관과 3가지 서양적 문화가치관을 반영한 광고에 대한 소비자 반응 정도를 조사하였다. 이들 두 가지 상반된 문화적 가치관을 강조한 온라인 광고에 대한 소비자의 수용 정도는 연령대별로 차이를 보일 것인 반면 성별로는 차이가 없을 것이라는 가설을 세웠다. 연구결과는 전통매체 광고를 대상으로 실시되었던 기존의 연구 결과와 유사하게 온라인 광고를 대상으로 실시된 본 연구에서도 가설이 지지되었다. 본 연구는 온라인 광고표현은 문화적 가치관을 반영하고 소비자들은 광고를 평가하는데 있어서도 문화적 가치관에 영향을 받는 다는 것을 실증적으로 보여준 최초의 연구라는 점에서 이론적 가치와 실무적 기여도가 높다고 하겠다.

• 디지털콘텐츠학회 논문지
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• 제17권2호
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• pp.105-109
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• 2016

본 논문은 안드로이드 게임 콘텐츠 개발시 여러학문의 융합과 게임개발간의 관계에 대해서 개발자의 입장에서 고찰하고자 한다. 스마트폰의 대중화가 가속화됨에 따라 모바일 게임은 다양한 형태의 게임들이 모든 연령대의 유저들에게 어필되는 시대가 되고 있다. 본 연구에서는 기존의 보편화된 게임을 차별화시켜 남녀노소 즐길 수 있는 새로운 장르의 모바일 게임을 제작하며 이에 대한 경험을 설명하고자 한다. 실제 게임을 제작하는 과정을 통해서 게임기획, 기획된 내용을 바탕으로 게임제작을 한다. 동시에 각 프로세스별 여러학문간의 상관관계에 대해서 연구한다.

• Advances in concrete construction
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• 제11권4호
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• pp.307-314
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• 2021

Activated hwangtoh (ACT) is a natural resource abundant in South Korea, approximately 15.0% of soil. It is an efficient mineral admixture that has activated pozzolanic properties through high-temperature heating and rapid cooling. The purpose of this study is to improve a curb mixture that can reduce NOx outside and investigate durability performance. To this end, mortar curb specimens were manufactured by replacing OPC with ACT. The ACT substitution ratios of 0.0, 10.0, and 25.0% were considered, and mechanical and durability tests on the curb specimens were conducted at 28 and 91 days of age. Steam curing was carried out for three days for the production of curbs, which was very effective to strength development at early ages. The reduction in strength at early ages could be compensated through this process, and no significant performance degradation was evaluated in the tests on chloride attack, carbonation, and freezing and thawing. The mortar curb with an ACT of 10.0~25.0% replacement ratio exhibited clear NOx reduction through photocatalytic (TiO2) treatment. This is due to the increase in physical absorption through surface absorption and the photocatalyst-containing TiO2 coating. In this study, the reasonable range of the ACT replacement ratio for NOx reduction was quantitatively evaluated through a comprehensive analysis of each test.