Browse > Article

Screening of Herbal Medicines from China with Inhibitory Activity on Advanced Glycation End Products Formation (XIII)  

Choi, So Jin (Korean Medicine Convergence Research Group, Korea Institute of Oriental Medicine)
Kim, Young Sook (Korean Medicine Convergence Research Group, Korea Institute of Oriental Medicine)
Kim, Joo Hwan (Department of Life Science, Gachon University)
Hang, Sun (Laboratory of Biodiversity and Biogeography, Kunming Institute of Botany, Chinese Academy of Sciences)
Kim, Jin Sook (Korean Medicine Convergence Research Group, Korea Institute of Oriental Medicine)
Publication Information
Korean Journal of Pharmacognosy / v.46, no.3, 2015 , pp. 260-267 More about this Journal
Abstract
Advanced glycation end products (AGEs) have been postulated to play a central role in the development of diabetic complications. A variety of different agents that inhibit AGEs have been under investigation. In this study, 111 herbal medicines from China have been investigated with an in vitro evaluation system using AGEs formation inhibitory activity. Of these, 9 herbal medicines (IC50: <5 μg/ml) were found to have significant AGEs formation inhibitory activity. Particularly, herbal medicines Barleria cristata (leaves), Calotropis gigantea (stems), Ardisia virens (leaves), Dalbergia yunnanensis (leaves) Pittosporum runcatum (leaves), Ardisia japonica (leaves), Rhododendron racemosum (twigs), Oxyria sinensiss (aerial parts), Pyrrosia calvata (whole plants), showed more potent inhibitory activity (approximately 15-40 fold) than the positive control aminoguanidine (IC50: 76.47 μg/ml).
Keywords
Advanced glycation end products (AGEs); Diabetic complications; Herbal medicines;
Citations & Related Records
연도 인용수 순위
  • Reference