• Korean Journal of Biological Psychiatry
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• v.18 no.4
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• pp.232-238
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• 2011

Objectives Optimized voxel based morphometry (VBM) has been increasingly applied to investigate differences in the brain morphology between a group of patients with mild cognitive impairment (MCI) and control subjects. Optimized VBM permits comparison of gray matter (GM) volume at voxel-level from the entire brain. The purpose of this study was to assess the regional GM volume change measured by optimized VBM in MCI subjects compared to controls. Methods Twenty patients with MCI and 20 control subjects with normal cognition were recruited for this study. We applied the optimized VBM protocol to the image data including study-specific template and the modulation of the data with the Jacobian determinants. GM volume differences between the MCI subjects and the control subjects and their correlations with the neuropsychological performances were investigated. Results Optimized VBM analysis revealed GM volume reduction in hippocampus, precentral gyrus, insula and parietal operculum in the MCI group compared to the control group (family wise error corrected p < 0.05). Korean version of the Consortium to Establish a Registry for Alzheimer's disease (CERAD-K) word list recall scores were significantly correlated with the GM volumes of hippocampus, precuneus and posterior cingulate in the MCI group (FWE corrected p < 0.05). Conclusions The results confirm previous findings of atrophic changes in medial temporal lobe and parietal lobe in the MCI group and suggest that these abnormalities may be related with cognitive decline and prognosis in patients with MCI.

• The Journal of Korean Medicine
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• v.30 no.2
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• pp.117-126
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• 2009

Objectives: This study was performed to investigate the effects of Semen Persicae (SP) on infarct volume, COX-2 protein expression in the middle cerebral artery occlusion (MCAo) rats. Methods: Twenty-eight rats were randomly assigned to four groups (MCAo experimental group, MCAo control group, sham experimental group, control group). The middle cerebral artery (MCA) was occluded in the MCAo group by proximal focal cerebral ischemia rat model, while the MCA was not occluded in the sham group. SP extraction was administrated for 4 days to each experimental group. Neuroprotective effects were investigated by measurement of brain damage using 2, 3, 5-triphenyltetrazolium chloride staining and analysis of COX-2 protein expression by western blotting. Results: The occurrence of infarct volume in the SP oral administration group decreased compared to the control group. COX-2 protein expression in the SP oral administration group decreased compared to the control group. Conclusions: The present study demonstrates the effect of SP in reducing infarct volume and decreasing COX-2 expression.

• Journal of the Semiconductor & Display Technology
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• v.21 no.1
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• pp.33-38
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• 2022

This study investigates the outlet temperature of coolant heater based on heat and flow volume conditions. Through computer simulation, the coolant temperature at the outlet was analyzed to investigate the heat and flow volume conditions of the coolant heater, and the optimal conditions were derived. Results show that heat and flow volume conditions, it was confirmed that heat condition is 0.424 W/mm³, and flow volume condition is 500 l/h, demonstrates optimal conditions. The results of this study can be utilized to efficiently control the coolant temperature through various heat and flow volume conditions.

• Imaging Science in Dentistry
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• v.46 no.1
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• pp.9-16
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• 2016

Purpose: To evaluate the upper airway dimensions of obstructive sleep apnea (OSA) and control subjects using a cone-beam computed tomography (CBCT) unit commonly applied in clinical practice in order to assess airway dimensions in the same fashion as that routinely employed in a clinical setting. Materials and Methods: This was a retrospective analysis utilizing existing CBCT scans to evaluate the dimensions of the upper airway in OSA and control subjects. The CBCT data of sixteen OSA and sixteen control subjects were compared. The average area, average volume, total volume, and total length of the upper airway were computed. Width and anterior-posterior (AP) measurements were obtained on the smallest axial slice. Results: OSA subjects had a significantly smaller average airway area, average airway volume, total airway volume, and mean airway width. OSA subjects had a significantly larger airway length measurement. The mean A-P distance was not significantly different between groups. Conclusion: OSA subjects have a smaller upper airway compared to controls with the exception of airway length. The lack of a significant difference in the mean A-P distance may indicate that patient position during imaging (upright vs. supine) can affect this measurement. Comparison of this study with a future prospective study design will allow for validation of these results.

• Journal of Mechanical Science and Technology
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• v.15 no.7
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• pp.1041-1050
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• 2001

Control of bone cement volume (PMMA) may be critical for preventing complications in vertebroplasty, the percutaneous injection of PMMA into vertebra. The purpose of this study was to predict the optimal volume of PMMA injection based on CT images. For this, correlation between PMMA volume and textural features of CT images was examined before and after surgery to evaluate the appropriate PMMA amount. The gray level run length analysis was used to determine the textural features of the trabecular bone. Extimation of PMMA volume was done using 3D visualization with semi-automatic segmentation on postoperative CT images. Then, finite element (FE) models were constructed based on the CT image data of patients and PMMA volume. Appropriate material properties for the trabecular bone were assigned by converting BMD to elastic modulus. Structural reinforcement due to the changes in PMMA volume and BMD was assessed in terms of axial displacement of the superior endplate. A strong correlation was found between the injected PMMA volume and the area of the intertrabecular space and that of trabecular bone calculated from the CT images (r=0.90 and -0.90, respectively). FE results suggested that vertebroplasty could effectively reinforce the osteoporotic vertebra regardless of BMD or PMMA volume. Effectiveness of additional PMMA injection tended to decrease. For patients with BMD well lower than 50mg/ml, injection of up to 30% volume of the vertebral body is recommended. However, less than 30% is recommended otherwise to avoid any complications from excessive PMMA because the strength has already reached the normal level.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.9 no.2
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• pp.229-238
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• 1997

A third-order simulation model of VM heat pumps has been developed. This model allows consideration of the major losses such as heat conduction losses through regenerators and displacers, pumping losses and wall-to-gas heat transfer losses in working volumes, in addition to the heat exchanger and regenerator losses. The working volume was divided into 12 control volumes and conservation equations of mass and energy were applied to each control volume. Pressure drop was considered in regenerators only. Thermodynamic behavior of working fluid in a VM heat pump was investigated and effects of major losses on the performance of a VM heat pump were shown.

• Proceedings of the KSME Conference
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• 2003.11a
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• pp.1384-1387
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• 2003

Pressurization test is usually required in aircraft full-scale static test. There are several test conditions including pressurization of cockpit, fuselage fuel tank, air inlet duct for T-50 full-scale static test. In this paper, the test conditions, equipment, piping analysis for the pressurization test are introduced. Tank simulation test is performed to verify the validity of piping analysis and to find good tuning parameters for the pressurization channel in the servo controller. Several test setup for pressurization of T-50 test is introduced. Test article volume is filled by form, $60%{\sim}80%$ volume is reduced for the T-50 full-scale static test. Pressurization system is connected to servo controller which also controls hydraulic actuator. Load and pressure control is synchronized by using the same servo controller during T-50 test. Typical control result for pressurization test condition is shown. Pressurization tests of T-50 full-scale static test was completed successfully.

• Tribology and Lubricants
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• v.18 no.1
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• pp.24-33
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• 2002

The basic equations are derived for the analysis of a staggered labyrinth gas seal which are generally used in high performance compressors and steam turbines. The Bulk-flow is assumed for a single cavity control volume and the flow is assumed to be completely turbulent in circumferential direction. Moody's wall-friction-factor formula is used for the calculation of wall shear stresses in the single cavity control volume. For the reaction force developed by the seal, linearized zeroth-order and first-order perturbation equations are developed for small motion about a centered position. Integration of the resultant first-order pressure distribution along and around the seal defines the rotordynamic coefficients of the staggered labyrinth gas seal. Theoretical results of leakage and rotordynamic characteristics for the staggered labyrinth gas seal are compared with those of the plain seal and see-through labyrinth seal.

• International Journal of Air-Conditioning and Refrigeration
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• v.6
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• pp.80-92
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• 1998

A third-order simulation model of a Vuilleumier{VM) heat pump has been developed. This model takes into account the major losses such as the heat conduction losses through regenerators and displacers, the pumping losses and the wall-to-gas heat transfer losses in active volumes, in addition to the heat exchanger and regenerator losses. The working volume was divided into 12 control volumes and the conservation equations of mass and energy were applied to each control volume. Pressure drops were considered in regenerators only. Thermodynamic behavior of the working gas in a VM heat pump was investigated and effects of the major losses and operating conditions on the performance of a VM heat pump were shown.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 2002.04a
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• pp.377-384
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• 2002

In this palter, a finite element technique is applied to both reinforced concrete and prestressed concrete containment vessels to predict the ultimate pressure capacity of the vessels subjected to internal pressure due to accident. The so-called volume-control technique is utilized to control the change in volume enclosed by the cylindrical containment vessels and layered shell elements equipped with a pressure node is utilizing to model the PSC vessels. The finite element analysis is carried out to obtain both global and local failure behavior of prestressed concrete nuclear containment vessels. nalytical results are verified by comparison with experimental data.